Thomas Freret

Affiliations

INSERM UMR-S-1075, Université de Caen Normandie, 14000 Caen, France.

Publications (34)

Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Glenn Dallérac , Xia Li , Pierre Lecouflet , Nadège Morisot , Silvia Sacchi , Rachel Asselot , Thu Ha Pham , Brigitte Potier , David J G Watson , Staffan Schmidt , Grégoire Levasseur , Pascal Fossat , Andrey Besedin , Jean-Michel Rivet , Joseph T Coyle , Ginetta Collo , Loredano Pollegioni , Jan Kehr , Micaela Galante , Kevin C Fone , Alain M Gardier , Thomas Freret , Angelo Contarino , Mark J Millan , Jean-Pierre Mothet

Donecopride, a Swiss army knife with potential against Alzheimer's disease.

British journal of pharmacology

Avec: Christophe Rochais , Cédric Lecoutey , Katia Hamidouche , Patrizia Giannoni , Florence Gaven , Eleazere Cem , Serge Mignani , Kevin Baranger , Thomas Freret , Joël Bockaert , Santiago Rivera , Michel Boulouard , Patrick Dallemagne , Sylvie Claeysen

Author Correction: Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise.

Scientific reports

Avec: Tristan Martin , Yves Dauvilliers , Ouma-Chandrou Koumar , Valentine Bouet , Thomas Freret , Stéphane Besnard , François Dauphin , Nicolas Bessot

Functional Dysregulations in CA1 Hippocampal Networks of a 3-Hit Mouse Model of Schizophrenia.

International journal of molecular sciences

Avec: Solenn Percelay , Jean-Marie Billard , Thomas Freret , Annie Andrieux , Michel Boulouard , Valentine Bouet

Chronotype influence on the effects of COVID-19 lockdown on sleep and psychological status in France.

Journal of sleep research

Avec: Nicolas Bessot , Antoine Langeard , Fabrice Dosseville , Gaelle Quarck , Thomas Freret

Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise.

Scientific reports

Avec: Tristan Martin , Yves Dauvilliers , Ouma-Chandrou Koumar , Valentine Bouet , Thomas Freret , Stéphane Besnard , François Dauphin , Nicolas Bessot

Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis.

Cerebral cortex (New York, N.Y. : 1991)

Avec: Lou Rizzolo , Marianne Leger , Sophie Corvaisier , Mathilde Groussard , Hervé Platel , Valentine Bouet , Pascale Schumann-Bard , Thomas Freret

Combination of MAP6 deficit, maternal separation and MK801 in female mice: A 3-hit animal model of neurodevelopmental disorder with cognitive deficits.

Behavioural brain research

Avec: Solenn Percelay , Thomas Freret , Nicole Turnbull , Valentine Bouet , Michel Boulouard

Vulnerability of Spatial Pattern Separation in 5xFAD Alzheimer's Disease Mouse Model.

Journal of Alzheimer's disease : JAD

Avec: Lucas Gephine , Candice M Roux , Thomas Freret , Michel Boulouard , Marianne Leger

Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models.

Metabolism: clinical and experimental

Avec: Stephanie Zur Nedden , Motahareh S Safari , Dido Weber , Louisa Kuenkel , Carolin Garmsiri , Luisa Lang , Cyrille Orset , Tom Freret , Benoît Haelewyn , Madlen Hotze , Marcel Kwiatkowski , Bettina Sarg , Klaus Faserl , Dragana Savic , Ira-Ida Skvortsova , Anne Krogsdam , Sandro Carollo , Zlatko Trajanoski , Herbert Oberacher , Dominik Zlotek , Florian Ostermaier , Angus Cameron , Gottfried Baier , Gabriele Baier-Bitterlich

A new 2-hit model combining serine racemase deletion and maternal separation displays behavioral and cognitive deficits associated with schizophrenia.

Behavioural brain research

Avec: Caroline Lahogue , Michel Boulouard , François Menager , Thomas Freret , Jean-Marie Billard , Valentine Bouet

A Novel

Frontiers in aging neuroscience

Avec: Bérénice Hatat , Samir Yahiaoui , Cédric Lecoutey , Audrey Davis , Thomas Freret , Michel Boulouard , Sylvie Claeysen , Christophe Rochais , Patrick Dallemagne

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT

European journal of medicinal chemistry

Avec: François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis , Marc Since , Sophie Corvaisier , Thomas Freret , Jana Sopková-de Oliveira Santos , Sylvie Claeysen , Michel Boulouard , Patrick Dallemagne , Christophe Rochais

d-serine in physiological and pathological brain aging.

Biochimica et biophysica acta. Proteins and proteomics

Avec: E Ploux , T Freret , J-M Billard

5-HT6 Receptors Sex-Dependently Modulate Hippocampal Synaptic Activity through GABA Inhibition.

Biomolecules

Avec: Caroline Lahogue , Jean-Marie Billard , Thomas Freret , Valentine Bouet

Genetic Background Influence on Hippocampal Synaptic Plasticity: Frequency-Dependent Variations between an Inbred and an Outbred Mice Strain.

International journal of molecular sciences

Avec: Candice M Roux , Pierre Lecouflet , Jean-Marie Billard , Elise Esneault , Marianne Leger , Pascale Schumann-Bard , Thomas Freret

Core body temperature varies according to the time of exercise without affecting orexin-A production in the dorsal hypothalamus in male rats.

Journal of thermal biology

Avec: O C Koumar , T Martin , A Bataille , J Bulla , V Crunel , V Bouet , T Freret , K Boumediene , C Bauge , S Moussay , F Dauphin , N Bessot

Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury?

Cancer imaging : the official publication of the International Cancer Imaging Society

Avec: Carole Brunaud , Samuel Valable , Gwenn Ropars , Fatima-Azzahra Dwiri , Mikaël Naveau , Jérôme Toutain , Myriam Bernaudin , Thomas Freret , Marianne Léger , Omar Touzani , Elodie A Pérès

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease.

Molecules (Basel, Switzerland)

Avec: François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis , Marc Since , Sophie Corvaisier , Thomas Freret , Jana Sopkova de Oliveira Santos , Sylvie Claeysen , Michel Boulouard , Patrick Dallemagne , Christophe Rochais

Antipsychotic lurasidone: Behavioural and pharmacokinetic data in C57BL/6 mice.

Pharmacology, biochemistry, and behavior

Avec: Solenn Percelay , Marc Since , Stéphanie Lagadu , Thomas Freret , Valentine Bouet , Michel Boulouard

A new 3-hit mouse model of schizophrenia built on genetic, early and late factors.

Schizophrenia research

Avec: Valentine Bouet , Solenn Percelay , Elise Leroux , Boubacar Diarra , Marianne Léger , Nicolas Delcroix , Annie Andrieux , Sonia Dollfus , Thomas Freret , Michel Boulouard

Fast Anxiolytic-Like Effect Observed in the Rat Conditioned Defensive Burying Test, after a Single Oral Dose of Natural Protein Extract Products.

Nutrients

Avec: Thomas Freret , Stacy Largilliere , Gerald Nee , Melanie Coolzaet , Sophie Corvaisier , Michel Boulouard

Time-course of age-related temporal order memory decline in an object recognition paradigm in mice.

Behavioural brain research

Avec: Hassina Belblidia , Thomas Freret , Marianne Leger , Pascale Schumann-Bard

Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor-α in Healthy Aging: A Role for D-Serine?

International journal of molecular sciences

Avec: Jean-Marie Billard , Thomas Freret

Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer.

International journal of pharmaceutics

Avec: A C Groo , S Hedir , M Since , E Brotin , L-B Weiswald , H Paysant , G Nee , M Coolzaet , D Goux , R Delépée , T Freret , L Poulain , A S Voisin-Chiret , A Malzert-Fréon

Memory Disorders Related to Hippocampal Function: The Interest of 5-HT

International journal of molecular sciences

Avec: Candice M Roux , Marianne Leger , Thomas Freret

Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network.

International journal of molecular sciences

Avec: Eva Ploux , Valentine Bouet , Inna Radzishevsky , Herman Wolosker , Thomas Freret , Jean-Marie Billard

Interplay between 5-HT4 Receptors and GABAergic System within CA1 Hippocampal Synaptic Plasticity.

Cerebral cortex (New York, N.Y. : 1991)

Avec: Pierre Lecouflet , Candice M Roux , Brigitte Potier , Marianne Leger , Elie Brunet , Jean-Marie Billard , Pascale Schumann-Bard , Thomas Freret

The 3-hit animal models of schizophrenia: improving strategy to decipher and treat the disease?

Neuroscience and biobehavioral reviews

Avec: Solenn Percelay , Caroline Lahogue , Jean-Marie Billard , Thomas Freret , Michel Boulouard , Valentine Bouet

Association between road traffic accidents and drugs belonging to the antiseizure medications class: A pharmacovigilance analysis in VigiBase.

British journal of clinical pharmacology

Avec: Basile Chrétien , Sophie Nguyen , Charles Dolladille , Pierre-Marie Morice , Marie Heraudeau , Magalie Loilier , Sophie Fedrizzi , Joanna Bourgine , Alexandre Cesbron , Joachim Alexandre , Marie-Laure Bocca , Thomas Freret , Véronique Lelong-Boulouard

Micropipette-guided Drug Administration (MDA) as a non-invasive chronic oral administration method in male rats.

Journal of neuroscience methods

Avec: Marie Heraudeau , Candice M Roux , Caroline Lahogue , Stacy Largilliere , Stéphane Allouche , Véronique Lelong-Boulouard , Thomas Freret

The mediating role of lower body muscle strength and IGF-1 levels in age related cognitive change. A MIDUS substudy.

Experimental gerontology

Avec: Evrim Gökçe , Navin Kaushal , Theo Fontanille , Tudor Vrinceanu , Kathia Saillant , Wouter Vints , Thomas Freret , Antoine Gauthier , Louis Bherer , Antoine Langeard

A Dual-Task Paradigm Combining Physical and Cognitive Training in Mice: Application to Aging.

Aging and disease

Avec: Elpidio Attoh-Mensah , Antoine Huret , Marianne Leger , Gilles Loggia , Gerald Nee , Stacy Largilliere , Daniel Zuba , Chantal Chavoix , Pascale Schumann-Bard , Thomas Freret

Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT

European journal of medicinal chemistry

Avec: Christophe Rochais , Cédric Lecoutey , Julien Lalut , Audrey Davis , Emilie Duval , Florence Gaven , Stacy Largillière , Gérald Née , Sophie Corvaisier , Jana Sopkova de Oliveira Santos , Marc Since , Thomas Freret , Romain Legrand , Noëlle Callizot , Sylvie Claeysen , Michel Boulouard , Patrick Dallemagne

Réseau de co-auteurs

Michel Boulouard 13 collaborations

Valentine Bouet 11 collaborations

Jean-Marie Billard 8 collaborations

Marianne Leger 7 collaborations

Christophe Rochais 5 collaborations

Cédric Lecoutey 5 collaborations

Patrick Dallemagne 5 collaborations

Sylvie Claeysen 5 collaborations

Solenn Percelay 5 collaborations

Sophie Corvaisier 5 collaborations

Pascale Schumann-Bard 5 collaborations

Candice M Roux 5 collaborations

Caroline Lahogue 4 collaborations

Audrey Davis 4 collaborations

Marc Since 4 collaborations

Pierre Lecouflet 3 collaborations

Nicolas Bessot 3 collaborations

Bérénice Hatat 3 collaborations

Julien Lalut 3 collaborations

T Freret 3 collaborations

Stacy Largilliere 3 collaborations

Brigitte Potier 2 collaborations

Florence Gaven 2 collaborations

Tristan Martin 2 collaborations

Yves Dauvilliers 2 collaborations

Ouma-Chandrou Koumar 2 collaborations

Stéphane Besnard 2 collaborations

François Dauphin 2 collaborations

Annie Andrieux 2 collaborations

Antoine Langeard 2 collaborations

François-Xavier Toublet 2 collaborations

Marianne Léger 2 collaborations

Jana Sopkova de Oliveira Santos 2 collaborations

Gerald Nee 2 collaborations

Marie Heraudeau 2 collaborations

Véronique Lelong-Boulouard 2 collaborations

Glenn Dallérac 1 collaboration

Xia Li 1 collaboration

Nadège Morisot 1 collaboration

Silvia Sacchi 1 collaboration

Rachel Asselot 1 collaboration

Thu Ha Pham 1 collaboration

David J G Watson 1 collaboration

Staffan Schmidt 1 collaboration

Grégoire Levasseur 1 collaboration

Pascal Fossat 1 collaboration

Andrey Besedin 1 collaboration

Jean-Michel Rivet 1 collaboration

Joseph T Coyle 1 collaboration

Ginetta Collo 1 collaboration

Loredano Pollegioni 1 collaboration

Jan Kehr 1 collaboration

Micaela Galante 1 collaboration

Kevin C Fone 1 collaboration

Alain M Gardier 1 collaboration

Angelo Contarino 1 collaboration

Mark J Millan 1 collaboration

Jean-Pierre Mothet 1 collaboration

Katia Hamidouche 1 collaboration

Patrizia Giannoni 1 collaboration

Eleazere Cem 1 collaboration

Serge Mignani 1 collaboration

Kevin Baranger 1 collaboration

Joël Bockaert 1 collaboration

Santiago Rivera 1 collaboration

Fabrice Dosseville 1 collaboration

Gaelle Quarck 1 collaboration

Lou Rizzolo 1 collaboration

Mathilde Groussard 1 collaboration

Hervé Platel 1 collaboration

Nicole Turnbull 1 collaboration

Lucas Gephine 1 collaboration

Stephanie Zur Nedden 1 collaboration

Motahareh S Safari 1 collaboration

Dido Weber 1 collaboration

Louisa Kuenkel 1 collaboration

Carolin Garmsiri 1 collaboration

Luisa Lang 1 collaboration

Cyrille Orset 1 collaboration

Tom Freret 1 collaboration

Benoît Haelewyn 1 collaboration

Madlen Hotze 1 collaboration

Marcel Kwiatkowski 1 collaboration

Bettina Sarg 1 collaboration

Klaus Faserl 1 collaboration

Dragana Savic 1 collaboration

Ira-Ida Skvortsova 1 collaboration

Anne Krogsdam 1 collaboration

Sandro Carollo 1 collaboration

Zlatko Trajanoski 1 collaboration

Herbert Oberacher 1 collaboration

Dominik Zlotek 1 collaboration

Florian Ostermaier 1 collaboration

Angus Cameron 1 collaboration

Gottfried Baier 1 collaboration

Gabriele Baier-Bitterlich 1 collaboration

François Menager 1 collaboration

Samir Yahiaoui 1 collaboration

Jana Sopková-de Oliveira Santos 1 collaboration

E Ploux 1 collaboration

J-M Billard 1 collaboration

Elise Esneault 1 collaboration

O C Koumar 1 collaboration

T Martin 1 collaboration

A Bataille 1 collaboration

J Bulla 1 collaboration

V Crunel 1 collaboration

V Bouet 1 collaboration

K Boumediene 1 collaboration

C Bauge 1 collaboration

S Moussay 1 collaboration

F Dauphin 1 collaboration

N Bessot 1 collaboration

Carole Brunaud 1 collaboration

Samuel Valable 1 collaboration

Gwenn Ropars 1 collaboration

Fatima-Azzahra Dwiri 1 collaboration

Mikaël Naveau 1 collaboration

Jérôme Toutain 1 collaboration

Myriam Bernaudin 1 collaboration

Omar Touzani 1 collaboration

Elodie A Pérès 1 collaboration

Stéphanie Lagadu 1 collaboration

Elise Leroux 1 collaboration

Boubacar Diarra 1 collaboration

Nicolas Delcroix 1 collaboration

Sonia Dollfus 1 collaboration

Melanie Coolzaet 1 collaboration

Hassina Belblidia 1 collaboration

A C Groo 1 collaboration

S Hedir 1 collaboration

M Since 1 collaboration

E Brotin 1 collaboration

L-B Weiswald 1 collaboration

H Paysant 1 collaboration

G Nee 1 collaboration

M Coolzaet 1 collaboration

D Goux 1 collaboration

R Delépée 1 collaboration

L Poulain 1 collaboration

A S Voisin-Chiret 1 collaboration

A Malzert-Fréon 1 collaboration

Eva Ploux 1 collaboration

Inna Radzishevsky 1 collaboration

Herman Wolosker 1 collaboration

Elie Brunet 1 collaboration

Basile Chrétien 1 collaboration

Sophie Nguyen 1 collaboration

Charles Dolladille 1 collaboration

Pierre-Marie Morice 1 collaboration

Magalie Loilier 1 collaboration

Sophie Fedrizzi 1 collaboration

Joanna Bourgine 1 collaboration

Alexandre Cesbron 1 collaboration

Joachim Alexandre 1 collaboration

Marie-Laure Bocca 1 collaboration

Stéphane Allouche 1 collaboration

Evrim Gökçe 1 collaboration

Navin Kaushal 1 collaboration

Theo Fontanille 1 collaboration

Tudor Vrinceanu 1 collaboration

Kathia Saillant 1 collaboration

Wouter Vints 1 collaboration

Antoine Gauthier 1 collaboration

Louis Bherer 1 collaboration

Elpidio Attoh-Mensah 1 collaboration

Antoine Huret 1 collaboration

Gilles Loggia 1 collaboration

Daniel Zuba 1 collaboration

Chantal Chavoix 1 collaboration

Emilie Duval 1 collaboration

Stacy Largillière 1 collaboration

Gérald Née 1 collaboration

Romain Legrand 1 collaboration

Noëlle Callizot 1 collaboration