Marc Since

Affiliations

Centre d'Etudes et de Recherche sur le Médicament de Normandie, Normandie Univ., UNICAEN, CERMN, 14000 Caen, France.

Publications (26)

Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer.

International journal of pharmaceutics

Avec: A C Groo , S Hedir , M Since , E Brotin , L-B Weiswald , H Paysant , G Nee , M Coolzaet , D Goux , R Delépée , T Freret , L Poulain , A S Voisin-Chiret , A Malzert-Fréon

Nongenotoxic 3-Nitroimidazo[1,2-

ACS medicinal chemistry letters

Avec: Cyril Fersing , Louise Basmaciyan , Clotilde Boudot , Julien Pedron , Sébastien Hutter , Anita Cohen , Caroline Castera-Ducros , Nicolas Primas , Michèle Laget , Magali Casanova , Sandra Bourgeade-Delmas , Mélanie Piednoel , Alix Sournia-Saquet , Valère Belle Mbou , Bertrand Courtioux , Élisa Boutet-Robinet , Rachel Milne , Susan Wyllie , Alan H Fairlamb , Alexis Valentin , Pascal Rathelot , Pierre Verhaeghe , Patrice Vanelle , Nadine Azas

Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT

European journal of medicinal chemistry

Avec: Christophe Rochais , Cédric Lecoutey , Julien Lalut , Audrey Davis , Emilie Duval , Florence Gaven , Stacy Largillière , Gérald Née , Sophie Corvaisier , Jana Sopkova de Oliveira Santos , Thomas Freret , Romain Legrand , Noëlle Callizot , Sylvie Claeysen , Michel Boulouard , Patrick Dallemagne

Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes.

ChemMedChem

Avec: Martina De Pascale , Domenico Iacopetta , Sophie Corvaisier , Véronique Vie , Gilles Paboeuf , Didier Hennequin , Serge Perato , Marcella De Giorgi , Maria Stefania Sinicropi , Jana Sopkova-De Oliveira Santos , Anne-Sophie Voisin-Chiret , Aurélie Malzert-Freon

Novel multi target-directed ligands targeting 5-HT

European journal of medicinal chemistry

Avec: Caroline Lanthier , Hugo Payan , Irene Liparulo , Bérénice Hatat , Cédric Lecoutey , Audrey Davis , Christian Bergamini , Sylvie Claeysen , Patrick Dallemagne , Maria-Laura Bolognesi , Christophe Rochais

UHPLC-MS/MS method for the quantification of ultra-traces of irinotecan and its metabolites in red blood cells and plasma to detect caregivers' contamination.

Drug testing and analysis

Avec: Simon Rodier , Guillaume Saint-Lorant , Stéphanie Lagadu , Hubert Benoist , Agnès Palix , Jean-Marc Guilloit , Audrey Faveyrial , Fabienne Divanon , Raphaël Delépée

Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential.

Pharmaceuticals (Basel, Switzerland)

Avec: Omar Khoumeri , Sébastien Hutter , Nicolas Primas , Caroline Castera-Ducros , Sandra Carvalho , Susan Wyllie , Mohamed Lotfi Efrit , Dimitri Fayolle , Patrice Vanelle , Pierre Verhaeghe , Nadine Azas , Hussein El-Kashef

8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.

European journal of medicinal chemistry

Avec: Cyril Fersing , Clotilde Boudot , Caroline Castera-Ducros , Emilie Pinault , Sébastien Hutter , Romain Paoli-Lombardo , Nicolas Primas , Julien Pedron , Line Seguy , Sandra Bourgeade-Delmas , Alix Sournia-Saquet , Jean-Luc Stigliani , Jean-Yves Brossas , Luc Paris , Alexis Valentin , Susan Wyllie , Alan H Fairlamb , Élisa Boutet-Robinet , Sophie Corvaisier , Aurélie Malzert-Fréon , Alexandre Destere , Dominique Mazier , Pascal Rathelot , Bertrand Courtioux , Nadine Azas , Pierre Verhaeghe , Patrice Vanelle

New 8-Nitroquinolinone Derivative Displaying Submicromolar

ACS medicinal chemistry letters

Avec: Julien Pedron , Clotilde Boudot , Jean-Yves Brossas , Emilie Pinault , Sandra Bourgeade-Delmas , Alix Sournia-Saquet , Elisa Boutet-Robinet , Alexandre Destere , Antoine Tronnet , Justine Bergé , Colin Bonduelle , Céline Deraeve , Geneviève Pratviel , Jean-Luc Stigliani , Luc Paris , Dominique Mazier , Sophie Corvaisier , Aurélie Malzert-Fréon , Susan Wyllie , Rachel Milne , Alan H Fairlamb , Alexis Valentin , Bertrand Courtioux , Pierre Verhaeghe

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT

European journal of medicinal chemistry

Avec: François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis , Sophie Corvaisier , Thomas Freret , Jana Sopková-de Oliveira Santos , Sylvie Claeysen , Michel Boulouard , Patrick Dallemagne , Christophe Rochais

Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor.

European journal of medicinal chemistry

Avec: Mirjana Antonijevic , Despoina Charou , Isbaal Ramos , Maria Valcarcel , Achille Gravanis , Patricia Villace , Noelle Callizot , Patrick Dallemagne , Ioannis Charalampopoulos , Christophe Rochais

Molecular glue degraders: exciting opportunities for novel drug discovery.

Expert opinion on drug discovery

Avec: Thomas Lemaitre , Marie Cornu , Florian Schwalen , Charline Kieffer , Anne Sophie Voisin-Chiret

Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.

European journal of medicinal chemistry

Avec: Cyril Fersing , Clotilde Boudot , Romain Paoli-Lombardo , Nicolas Primas , Emilie Pinault , Sébastien Hutter , Caroline Castera-Ducros , Youssef Kabri , Julien Pedron , Sandra Bourgeade-Delmas , Alix Sournia-Saquet , Jean-Luc Stigliani , Alexis Valentin , Amaya Azqueta , Damián Muruzabal , Alexandre Destere , Susan Wyllie , Alan H Fairlamb , Sophie Corvaisier , Aurélie Malzert-Fréon , Carole Di Giorgio , Pascal Rathelot , Nadine Azas , Bertrand Courtioux , Patrice Vanelle , Pierre Verhaeghe

Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy.

European journal of medicinal chemistry

Avec: Romain Mustière , Prisca Lagardère , Sébastien Hutter , Viviana Dell'Orco , Nadia Amanzougaghene , Shahin Tajeri , Jean-François Franetich , Sophie Corvaisier , Aurélie Malzert-Fréon , Nicolas Masurier , Vincent Lisowski , Pierre Verhaeghe , Dominique Mazier , Nadine Azas , Patrice Vanelle , Nicolas Primas

Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-

Pharmaceuticals (Basel, Switzerland)

Avec: Romain Paoli-Lombardo , Nicolas Primas , Sandra Bourgeade-Delmas , Sébastien Hutter , Alix Sournia-Saquet , Clotilde Boudot , Emilie Brenot , Caroline Castera-Ducros , Sophie Corvaisier , Aurélie Malzert-Fréon , Bertrand Courtioux , Alexis Valentin , Pierre Verhaeghe , Nadine Azas , Pascal Rathelot , Patrice Vanelle

Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability.

European journal of medicinal chemistry

Avec: Prisca Lagardère , Romain Mustière , Nadia Amanzougaghene , Sébastien Hutter , Marion Casanova , Jean-François Franetich , Shahin Tajeri , Aurélie Malzert-Fréon , Sophie Corvaisier , Nadine Azas , Patrice Vanelle , Pierre Verhaeghe , Nicolas Primas , Dominique Mazier , Nicolas Masurier , Vincent Lisowski

A Biomimetic Multiparametric Assay to Characterise Anti-Amyloid Drugs.

International journal of molecular sciences

Avec: Willy Smeralda , Sophie Corvaisier , Dimitri Fayolle , Julien Cardin , Sylvain Duprey , Jean-Pierre Jourdan , Christophe Cullin , Aurélie Malzert-Freon

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease.

Molecules (Basel, Switzerland)

Avec: François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis , Sophie Corvaisier , Thomas Freret , Jana Sopkova de Oliveira Santos , Sylvie Claeysen , Michel Boulouard , Patrick Dallemagne , Christophe Rochais

Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Willy Smeralda , Sophie Corvaisier , Rémi Legay , Anne-Sophie Voisin-Chiret , Aurélie Malzert-Freon

Antipsychotic lurasidone: Behavioural and pharmacokinetic data in C57BL/6 mice.

Pharmacology, biochemistry, and behavior

Avec: Solenn Percelay , Stéphanie Lagadu , Thomas Freret , Valentine Bouet , Michel Boulouard

A functional m

The FEBS journal

Avec: Lorane Le Franc , Benoit Bernay , Bruno Petton , Pascal Favrel , Guillaume Rivière

Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment.

Pharmaceutics

Avec: Thomas Adnet , Anne-Claire Groo , Céline Picard , Audrey Davis , Sophie Corvaisier , Frédéric Bounoure , Christophe Rochais , Loïc Le Pluart , Patrick Dallemagne , Aurélie Malzert-Fréon

Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones.

Journal of the American Chemical Society

Avec: Pedro Salas-Ambrosio , Antoine Tronnet , Sandra Bourgeade-Delmas , Jean-Luc Stigliani , Amelie Vax , Sébastien Lecommandoux , Bruno Dupuy , Pierre Verhaeghe , Colin Bonduelle

β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization.

International journal of biological macromolecules

Avec: Willy Smeralda , Julien Cardin , Sophie Corvaisier , Sophie Lecomte , Christophe Cullin , Aurélie Malzert-Fréon

Disruption of PHF6 Peptide Aggregation from Tau Protein: Mechanisms of Palmatine Chloride in Preventing Early PHF6 Aggregation.

ACS chemical neuroscience

Avec: Charline Fagnen , Johanna Giovannini , Thomas Vignol , Marco Catto , Anne Sophie Voisin-Chiret , Jana Sopkova-de Oliveira Santos

Towards New Anti-inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP-BIR2.

ChemMedChem

Avec: Marc Ragui Farag , Nicolas Guedeney , Florian Schwalen , Aymeric Zadorovnyj , Amélie Barczyk , Martin Giret , Kevin Antraygues , Alice Wang , Marie Cornu , Peggy Suzanne , Anne Sophie Voisin-Chiret , Laurence Dubrez , Natascha Leleu-Chavain , Charline Kieffer , Jana Sopkova-de Oliveira Santos

Réseau de co-auteurs

Sophie Corvaisier 14 collaborations

Pierre Verhaeghe 9 collaborations

Aurélie Malzert-Fréon 8 collaborations

Sébastien Hutter 7 collaborations

Nicolas Primas 7 collaborations

Patrice Vanelle 7 collaborations

Nadine Azas 7 collaborations

Sandra Bourgeade-Delmas 6 collaborations

Christophe Rochais 6 collaborations

Patrick Dallemagne 6 collaborations

Clotilde Boudot 5 collaborations

Caroline Castera-Ducros 5 collaborations

Alix Sournia-Saquet 5 collaborations

Bertrand Courtioux 5 collaborations

Susan Wyllie 5 collaborations

Alexis Valentin 5 collaborations

Audrey Davis 5 collaborations

Julien Pedron 4 collaborations

Alan H Fairlamb 4 collaborations

Pascal Rathelot 4 collaborations

Cédric Lecoutey 4 collaborations

Thomas Freret 4 collaborations

Sylvie Claeysen 4 collaborations

Michel Boulouard 4 collaborations

Jean-Luc Stigliani 4 collaborations

Dominique Mazier 4 collaborations

Cyril Fersing 3 collaborations

Julien Lalut 3 collaborations

Aurélie Malzert-Freon 3 collaborations

Bérénice Hatat 3 collaborations

Emilie Pinault 3 collaborations

Romain Paoli-Lombardo 3 collaborations

Alexandre Destere 3 collaborations

Anne Sophie Voisin-Chiret 3 collaborations

Willy Smeralda 3 collaborations

Élisa Boutet-Robinet 2 collaborations

Rachel Milne 2 collaborations

Jana Sopkova de Oliveira Santos 2 collaborations

Anne-Sophie Voisin-Chiret 2 collaborations

Stéphanie Lagadu 2 collaborations

Dimitri Fayolle 2 collaborations

Jean-Yves Brossas 2 collaborations

Luc Paris 2 collaborations

Antoine Tronnet 2 collaborations

Colin Bonduelle 2 collaborations

François-Xavier Toublet 2 collaborations

Marie Cornu 2 collaborations

Florian Schwalen 2 collaborations

Charline Kieffer 2 collaborations

Romain Mustière 2 collaborations

Prisca Lagardère 2 collaborations

Nadia Amanzougaghene 2 collaborations

Shahin Tajeri 2 collaborations

Jean-François Franetich 2 collaborations

Nicolas Masurier 2 collaborations

Vincent Lisowski 2 collaborations

Julien Cardin 2 collaborations

Christophe Cullin 2 collaborations

Jana Sopkova-de Oliveira Santos 2 collaborations

A C Groo 1 collaboration

S Hedir 1 collaboration

M Since 1 collaboration

E Brotin 1 collaboration

L-B Weiswald 1 collaboration

H Paysant 1 collaboration

G Nee 1 collaboration

M Coolzaet 1 collaboration

D Goux 1 collaboration

R Delépée 1 collaboration

T Freret 1 collaboration

L Poulain 1 collaboration

A S Voisin-Chiret 1 collaboration

A Malzert-Fréon 1 collaboration

Louise Basmaciyan 1 collaboration

Anita Cohen 1 collaboration

Michèle Laget 1 collaboration

Magali Casanova 1 collaboration

Mélanie Piednoel 1 collaboration

Valère Belle Mbou 1 collaboration

Emilie Duval 1 collaboration

Florence Gaven 1 collaboration

Stacy Largillière 1 collaboration

Gérald Née 1 collaboration

Romain Legrand 1 collaboration

Noëlle Callizot 1 collaboration

Martina De Pascale 1 collaboration

Domenico Iacopetta 1 collaboration

Véronique Vie 1 collaboration

Gilles Paboeuf 1 collaboration

Didier Hennequin 1 collaboration

Serge Perato 1 collaboration

Marcella De Giorgi 1 collaboration

Maria Stefania Sinicropi 1 collaboration

Jana Sopkova-De Oliveira Santos 1 collaboration

Caroline Lanthier 1 collaboration

Hugo Payan 1 collaboration

Irene Liparulo 1 collaboration

Christian Bergamini 1 collaboration

Maria-Laura Bolognesi 1 collaboration

Simon Rodier 1 collaboration

Guillaume Saint-Lorant 1 collaboration

Hubert Benoist 1 collaboration

Agnès Palix 1 collaboration

Jean-Marc Guilloit 1 collaboration

Audrey Faveyrial 1 collaboration

Fabienne Divanon 1 collaboration

Raphaël Delépée 1 collaboration

Omar Khoumeri 1 collaboration

Sandra Carvalho 1 collaboration

Mohamed Lotfi Efrit 1 collaboration

Hussein El-Kashef 1 collaboration

Line Seguy 1 collaboration

Elisa Boutet-Robinet 1 collaboration

Justine Bergé 1 collaboration

Céline Deraeve 1 collaboration

Geneviève Pratviel 1 collaboration

Jana Sopková-de Oliveira Santos 1 collaboration

Mirjana Antonijevic 1 collaboration

Despoina Charou 1 collaboration

Isbaal Ramos 1 collaboration

Maria Valcarcel 1 collaboration

Achille Gravanis 1 collaboration

Patricia Villace 1 collaboration

Noelle Callizot 1 collaboration

Ioannis Charalampopoulos 1 collaboration

Thomas Lemaitre 1 collaboration

Youssef Kabri 1 collaboration

Amaya Azqueta 1 collaboration

Damián Muruzabal 1 collaboration

Carole Di Giorgio 1 collaboration

Viviana Dell'Orco 1 collaboration

Emilie Brenot 1 collaboration

Marion Casanova 1 collaboration

Sylvain Duprey 1 collaboration

Jean-Pierre Jourdan 1 collaboration

Rémi Legay 1 collaboration

Solenn Percelay 1 collaboration

Valentine Bouet 1 collaboration

Lorane Le Franc 1 collaboration

Benoit Bernay 1 collaboration

Bruno Petton 1 collaboration

Pascal Favrel 1 collaboration

Guillaume Rivière 1 collaboration

Thomas Adnet 1 collaboration

Anne-Claire Groo 1 collaboration

Céline Picard 1 collaboration

Frédéric Bounoure 1 collaboration

Loïc Le Pluart 1 collaboration

Pedro Salas-Ambrosio 1 collaboration

Amelie Vax 1 collaboration

Sébastien Lecommandoux 1 collaboration

Bruno Dupuy 1 collaboration

Sophie Lecomte 1 collaboration

Charline Fagnen 1 collaboration

Johanna Giovannini 1 collaboration

Thomas Vignol 1 collaboration

Marco Catto 1 collaboration

Marc Ragui Farag 1 collaboration

Nicolas Guedeney 1 collaboration

Aymeric Zadorovnyj 1 collaboration

Amélie Barczyk 1 collaboration

Martin Giret 1 collaboration

Kevin Antraygues 1 collaboration

Alice Wang 1 collaboration

Peggy Suzanne 1 collaboration

Laurence Dubrez 1 collaboration

Natascha Leleu-Chavain 1 collaboration