A Biomimetic Multiparametric Assay to Characterise Anti-Amyloid Drugs.
Alzheimer’s disease
Chicago sky blue
bexarotene
drug discovery
indomethacin
liposomes
β-amyloïd
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Nov 2023
30 Nov 2023
Historique:
received:
27
10
2023
revised:
24
11
2023
accepted:
27
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the most widespread form of senile dementia worldwide and represents a leading socioeconomic problem in healthcare. Although it is widely debated, the aggregation of the amyloid β peptide (Aβ) is linked to the onset and progression of this neurodegenerative disease. Molecules capable of interfering with specific steps in the fibrillation process remain of pharmacological interest. To identify such compounds, we have set up a small molecule screening process combining multiple experimental methods (UV and florescence spectrometry, ITC, and ATR-FTIR) to identify and characterise potential modulators of Aβ
Identifiants
pubmed: 38069305
pii: ijms242316982
doi: 10.3390/ijms242316982
pmc: PMC10707238
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : French Ministry of Scientific Research and Innovation
ID : Doctoral fellowship
Organisme : the Region Normandie and the European Union via the European Regional Development Fund (FEDER).
ID : equipment funds
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