Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT
5-HT(4)
Acetylcholinesterase
Alzheimer's disease
Pleiotropic
Serotonin
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
18 Oct 2024
18 Oct 2024
Historique:
received:
20
09
2024
revised:
15
10
2024
accepted:
15
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
25
10
2024
Statut:
aheadofprint
Résumé
In this work, we exemplified the "copride" family of drug candidates able to both inhibit acetylcholinesterase and to activate 5-HT
Identifiants
pubmed: 39454222
pii: S0223-5234(24)00856-0
doi: 10.1016/j.ejmech.2024.116975
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116975Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Patrick Dallemagne has patent #Acetylcholinesterase inhibitor compounds and 5-HT4 serotonergic receptor agonists with promnesia effect, their preparation and pharmaceutical compositions containing them pending to licensee. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.