Loïc Carrique

Affiliations

Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

ORCID: http://orcid.org/0000-0001-5332-8593

Publications (27)

Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.

Nature communications

Avec: Max Renner , Wanwisa Dejnirattisai , Loïc Carrique , Itziar Serna Martin , Dimple Karia , Serban L Ilca , Shu F Ho , Abhay Kotecha , Jeremy R Keown , Juthathip Mongkolsapaya , Gavin R Screaton , Jonathan M Grimes

Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.

Nature communications

Avec: Loïc Carrique , Lionel Ballut , Arpit Shukla , Neelakshi Varma , Resmi Ravi , Sébastien Violot , Bharath Srinivasan , Umesh Tippagondanahalli Ganeshappa , Sonia Kulkarni , Hemalatha Balaram , Nushin Aghajari

LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.

Nature communications

Avec: T Bertie Ansell , Wanling Song , Claire E Coupland , Loic Carrique , Robin A Corey , Anna L Duncan , C Keith Cassidy , Maxwell M G Geurts , Tim Rasmussen , Andrew B Ward , Christian Siebold , Phillip J Stansfeld , Mark S P Sansom

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.

Nature structural & molecular biology

Avec: Jiandong Huo , Audrey Le Bas , Reinis R Ruza , Helen M E Duyvesteyn , Halina Mikolajek , Tomas Malinauskas , Tiong Kit Tan , Pramila Rijal , Maud Dumoux , Philip N Ward , Jingshan Ren , Daming Zhou , Peter J Harrison , Miriam Weckener , Daniel K Clare , Vinod K Vogirala , Julika Radecke , Lucile Moynié , Yuguang Zhao , Javier Gilbert-Jaramillo , Michael L Knight , Julia A Tree , Karen R Buttigieg , Naomi Coombes , Michael J Elmore , Miles W Carroll , Loic Carrique , Pranav N M Shah , William James , Alain R Townsend , David I Stuart , Raymond J Owens , James H Naismith

The Dark Side of ADHD: Factors Associated With Suicide Attempts Among Those With ADHD in a National Representative Canadian Sample.

Archives of suicide research : official journal of the International Academy for Suicide Research

Avec: Esme Fuller-Thomson , Raphaël Nahar Rivière , Lauren Carrique , Senyo Agbeyaka

Results of Early Transplantation for Alcohol-Related Cirrhosis: Integrated Addiction Treatment With Low Rate of Relapse.

Gastroenterology

Avec: Lauren Carrique , Jill Quance , Adrienne Tan , Susan Abbey , Isabel Sales , Les Lilly , Mamatha Bhat , Zita Galvin , Mark Cattral , Anand Ghanekar , Ian McGilvray , Trevor Reichman , Gonzalo Sapisochin , Blayne Sayed , Markus Selzner , Marie-Josée Lynch , Nazia Selzner

Structural insights into Frizzled3 through nanobody modulators.

Nature communications

Avec: James Hillier , Yuguang Zhao , Loic Carrique , Tomas Malinauskas , Reinis R Ruza , Tao-Hsin Chang , Gangshun Yi , Helen M E Duyvesteyn , Jing Yu , Weixian Lu , Els Pardon , Jan Steyaert , Yanan Zhu , Tao Ni , E Yvonne Jones

Generalized anxiety disorder among adults with attention deficit hyperactivity disorder.

Journal of affective disorders

Avec: Esme Fuller-Thomson , Lauren Carrique , Andie MacNeil

Host ANP32A mediates the assembly of the influenza virus replicase.

Nature

Avec: Loïc Carrique , Haitian Fan , Alexander P Walker , Jeremy R Keown , Jane Sharps , Ecco Staller , Wendy S Barclay , Ervin Fodor , Jonathan M Grimes

Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.

Nature communications

Avec: Marina Escalera-Zamudio , Michael Golden , Bernardo Gutiérrez , Julien Thézé , Jeremy Russell Keown , Loic Carrique , Thomas A Bowden , Oliver G Pybus

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.

Nature structural & molecular biology

Avec: Jiangdong Huo , Audrey Le Bas , Reinis R Ruza , Helen M E Duyvesteyn , Halina Mikolajek , Tomas Malinauskas , Tiong Kit Tan , Pramila Rijal , Maud Dumoux , Philip N Ward , Jingshan Ren , Daming Zhou , Peter J Harrison , Miriam Weckener , Daniel K Clare , Vinod K Vogirala , Julika Radecke , Lucile Moynié , Yuguang Zhao , Javier Gilbert-Jaramillo , Michael L Knight , Julia A Tree , Karen R Buttigieg , Naomi Coombes , Michael J Elmore , Miles W Carroll , Loic Carrique , Pranav N M Shah , William James , Alain R Townsend , David I Stuart , Raymond J Owens , James H Naismith

Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus.

Nature communications

Avec: Jack D Whitehead , Hortense Decool , Cédric Leyrat , Loic Carrique , Jenna Fix , Jean-François Eléouët , Marie Galloux , Max Renner

Publisher Correction: Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.

Nature communications

Avec: Marina Escalera-Zamudio , Michael Golden , Bernardo Gutiérrez , Julien Thézé , Jeremy Russell Keown , Loic Carrique , Thomas A Bowden , Oliver G Pybus

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.

Cell host & microbe

Avec: Jiandong Huo , Yuguang Zhao , Jingshan Ren , Daming Zhou , Helen M E Duyvesteyn , Helen M Ginn , Loic Carrique , Tomas Malinauskas , Reinis R Ruza , Pranav N M Shah , Tiong Kit Tan , Pramila Rijal , Naomi Coombes , Kevin R Bewley , Julia A Tree , Julika Radecke , Neil G Paterson , Piyada Supasa , Juthathip Mongkolsapaya , Gavin R Screaton , Miles Carroll , Alain Townsend , Elizabeth E Fry , Raymond J Owens , David I Stuart

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.

Nature communications

Avec: Ecco Staller , Loïc Carrique , Olivia C Swann , Haitian Fan , Jeremy R Keown , Carol M Sheppard , Wendy S Barclay , Jonathan M Grimes , Ervin Fodor

Accelerating drug target inhibitor discovery with a deep generative foundation model.

Science advances

Avec: Vijil Chenthamarakshan , Samuel C Hoffman , C David Owen , Petra Lukacik , Claire Strain-Damerell , Daren Fearon , Tika R Malla , Anthony Tumber , Christopher J Schofield , Helen M E Duyvesteyn , Wanwisa Dejnirattisai , Loic Carrique , Thomas S Walter , Gavin R Screaton , Tetiana Matviiuk , Aleksandra Mojsilovic , Jason Crain , Martin A Walsh , David I Stuart , Payel Das

Outcomes of re-referrals of patients with alcohol-associated liver disease, who were previously declined for liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Avec: Ben Cox , Lauren Carrique , Tommaso Di Maira , Isabel Sales , Caitlin Don , A Gomez-Aldana , Dilip Koshy , Susan Abbey , Les Lilly , Cynthia Tsien , Mamatha Bhat , Elmar Jaeckel , Marie-Josee Lynch , Nazia Selzner

Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II.

Journal of virology

Avec: Jeremy Keown , Alaa Baazaoui , Marek Šebesta , Richard Štefl , Loïc Carrique , Ervin Fodor , Jonathan M Grimes

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.

Nature structural & molecular biology

Avec: Daming Zhou , Helen M E Duyvesteyn , Cheng-Pin Chen , Chung-Guei Huang , Ting-Hua Chen , Shin-Ru Shih , Yi-Chun Lin , Chien-Yu Cheng , Shu-Hsing Cheng , Yhu-Chering Huang , Tzou-Yien Lin , Che Ma , Jiandong Huo , Loic Carrique , Tomas Malinauskas , Reinis R Ruza , Pranav N M Shah , Tiong Kit Tan , Pramila Rijal , Robert F Donat , Kerry Godwin , Karen R Buttigieg , Julia A Tree , Julika Radecke , Neil G Paterson , Piyada Supasa , Juthathip Mongkolsapaya , Gavin R Screaton , Miles W Carroll , Javier Gilbert-Jaramillo , Michael L Knight , William James , Raymond J Owens , James H Naismith , Alain R Townsend , Elizabeth E Fry , Yuguang Zhao , Jingshan Ren , David I Stuart , Kuan-Ying A Huang

Structures of influenza A virus RNA polymerase offer insight into viral genome replication.

Nature

Avec: Haitian Fan , Alexander P Walker , Loïc Carrique , Jeremy R Keown , Itziar Serna Martin , Dimple Karia , Jane Sharps , Narin Hengrung , Els Pardon , Jan Steyaert , Jonathan M Grimes , Ervin Fodor

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Molecular cell

Avec: Claire E Coupland , Sebastian A Andrei , T Bertie Ansell , Loic Carrique , Pramod Kumar , Lea Sefer , Rebekka A Schwab , Eamon F X Byrne , Els Pardon , Jan Steyaert , Anthony I Magee , Thomas Lanyon-Hogg , Mark S P Sansom , Edward W Tate , Christian Siebold

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.

Nature communications

Avec: Jeremy R Keown , Zihan Zhu , Loïc Carrique , Haitian Fan , Alexander P Walker , Itziar Serna Martin , Els Pardon , Jan Steyaert , Ervin Fodor , Jonathan M Grimes

Exploring molecular determinants of polysaccharide lyase family 6-1 enzyme activity.

Glycobiology

Avec: Sébastien Violot , Frédéric Galisson , Loïc Carrique , Vinesh Jugnarain , Léa Conchou , Xavier Robert , Aurélien Thureau , William Helbert , Nushin Aghajari , Lionel Ballut

Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis.

Biomolecules

Avec: Lionel Ballut , Sébastien Violot , Frédéric Galisson , Isabelle R Gonçalves , Juliette Martin , Santosh Shivakumaraswamy , Loïc Carrique , Hemalatha Balaram , Nushin Aghajari

Atomic structure of a nudivirus occlusion body protein determined from a 70-year-old crystal sample.

Nature communications

Avec: Jeremy R Keown , Adam D Crawshaw , Jose Trincao , Loïc Carrique , Richard J Gildea , Sam Horrell , Anna J Warren , Danny Axford , Robin Owen , Gwyndaf Evans , Annie Bézier , Peter Metcalf , Jonathan M Grimes

Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs.

Nature structural & molecular biology

Avec: Gangshun Yi , Mingda Ye , Loic Carrique , Afaf El-Sagheer , Tom Brown , Chris J Norbury , Peijun Zhang , Robert J C Gilbert

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.

Cell

Avec: Pauline Lascaux , Gwendoline Hoslett , Sara Tribble , Camilla Trugenberger , Ivan Antičević , Cecile Otten , Ignacio Torrecilla , Stelios Koukouravas , Yichen Zhao , Hongbin Yang , Ftoon Aljarbou , Annamaria Ruggiano , Wei Song , Cristiano Peron , Giulio Deangeli , Enric Domingo , James Bancroft , Loïc Carrique , Errin Johnson , Iolanda Vendrell , Roman Fischer , Alvin Wei Tian Ng , Joanne Ngeow , Vincenzo D'Angiolella , Nuno Raimundo , Tim Maughan , Marta Popović , Ira Milošević , Kristijan Ramadan

Réseau de co-auteurs

Loic Carrique 12 collaborations

Jonathan M Grimes 7 collaborations

Jeremy R Keown 6 collaborations

Helen M E Duyvesteyn 6 collaborations

Reinis R Ruza 5 collaborations

Tomas Malinauskas 5 collaborations

Yuguang Zhao 5 collaborations

David I Stuart 5 collaborations

Ervin Fodor 5 collaborations

Gavin R Screaton 4 collaborations

Tiong Kit Tan 4 collaborations

Pramila Rijal 4 collaborations

Jingshan Ren 4 collaborations

Daming Zhou 4 collaborations

Julika Radecke 4 collaborations

Julia A Tree 4 collaborations

Pranav N M Shah 4 collaborations

Raymond J Owens 4 collaborations

Lauren Carrique 4 collaborations

Els Pardon 4 collaborations

Jan Steyaert 4 collaborations

Haitian Fan 4 collaborations

Itziar Serna Martin 3 collaborations

Juthathip Mongkolsapaya 3 collaborations

Lionel Ballut 3 collaborations

Sébastien Violot 3 collaborations

Nushin Aghajari 3 collaborations

Jiandong Huo 3 collaborations

Javier Gilbert-Jaramillo 3 collaborations

Michael L Knight 3 collaborations

Karen R Buttigieg 3 collaborations

Naomi Coombes 3 collaborations

Miles W Carroll 3 collaborations

William James 3 collaborations

Alain R Townsend 3 collaborations

James H Naismith 3 collaborations

Alexander P Walker 3 collaborations

Max Renner 2 collaborations

Wanwisa Dejnirattisai 2 collaborations

Dimple Karia 2 collaborations

Hemalatha Balaram 2 collaborations

T Bertie Ansell 2 collaborations

Claire E Coupland 2 collaborations

Christian Siebold 2 collaborations

Mark S P Sansom 2 collaborations

Audrey Le Bas 2 collaborations

Halina Mikolajek 2 collaborations

Maud Dumoux 2 collaborations

Philip N Ward 2 collaborations

Peter J Harrison 2 collaborations

Miriam Weckener 2 collaborations

Daniel K Clare 2 collaborations

Vinod K Vogirala 2 collaborations

Lucile Moynié 2 collaborations

Michael J Elmore 2 collaborations

Esme Fuller-Thomson 2 collaborations

Susan Abbey 2 collaborations

Isabel Sales 2 collaborations

Les Lilly 2 collaborations

Mamatha Bhat 2 collaborations

Nazia Selzner 2 collaborations

Gangshun Yi 2 collaborations

Jane Sharps 2 collaborations

Ecco Staller 2 collaborations

Wendy S Barclay 2 collaborations

Marina Escalera-Zamudio 2 collaborations

Michael Golden 2 collaborations

Bernardo Gutiérrez 2 collaborations

Julien Thézé 2 collaborations

Jeremy Russell Keown 2 collaborations

Thomas A Bowden 2 collaborations

Oliver G Pybus 2 collaborations

Neil G Paterson 2 collaborations

Piyada Supasa 2 collaborations

Elizabeth E Fry 2 collaborations

Frédéric Galisson 2 collaborations

Serban L Ilca 1 collaboration

Shu F Ho 1 collaboration

Abhay Kotecha 1 collaboration

Arpit Shukla 1 collaboration

Neelakshi Varma 1 collaboration

Resmi Ravi 1 collaboration

Bharath Srinivasan 1 collaboration

Umesh Tippagondanahalli Ganeshappa 1 collaboration

Sonia Kulkarni 1 collaboration

Wanling Song 1 collaboration

Robin A Corey 1 collaboration

Anna L Duncan 1 collaboration

C Keith Cassidy 1 collaboration

Maxwell M G Geurts 1 collaboration

Tim Rasmussen 1 collaboration

Andrew B Ward 1 collaboration

Phillip J Stansfeld 1 collaboration

Raphaël Nahar Rivière 1 collaboration

Senyo Agbeyaka 1 collaboration

Jill Quance 1 collaboration

Adrienne Tan 1 collaboration

Zita Galvin 1 collaboration

Mark Cattral 1 collaboration

Anand Ghanekar 1 collaboration

Ian McGilvray 1 collaboration

Trevor Reichman 1 collaboration

Gonzalo Sapisochin 1 collaboration

Blayne Sayed 1 collaboration

Markus Selzner 1 collaboration

Marie-Josée Lynch 1 collaboration

James Hillier 1 collaboration

Tao-Hsin Chang 1 collaboration

Jing Yu 1 collaboration

Weixian Lu 1 collaboration

Yanan Zhu 1 collaboration

Tao Ni 1 collaboration

E Yvonne Jones 1 collaboration

Andie MacNeil 1 collaboration

Jiangdong Huo 1 collaboration

Jack D Whitehead 1 collaboration

Hortense Decool 1 collaboration

Cédric Leyrat 1 collaboration

Jenna Fix 1 collaboration

Jean-François Eléouët 1 collaboration

Marie Galloux 1 collaboration

Helen M Ginn 1 collaboration

Kevin R Bewley 1 collaboration

Miles Carroll 1 collaboration

Alain Townsend 1 collaboration

Olivia C Swann 1 collaboration

Carol M Sheppard 1 collaboration

Vijil Chenthamarakshan 1 collaboration

Samuel C Hoffman 1 collaboration

C David Owen 1 collaboration

Petra Lukacik 1 collaboration

Claire Strain-Damerell 1 collaboration

Daren Fearon 1 collaboration

Tika R Malla 1 collaboration

Anthony Tumber 1 collaboration

Christopher J Schofield 1 collaboration

Thomas S Walter 1 collaboration

Tetiana Matviiuk 1 collaboration

Aleksandra Mojsilovic 1 collaboration

Jason Crain 1 collaboration

Martin A Walsh 1 collaboration

Payel Das 1 collaboration

Ben Cox 1 collaboration

Tommaso Di Maira 1 collaboration

Caitlin Don 1 collaboration

A Gomez-Aldana 1 collaboration

Dilip Koshy 1 collaboration

Cynthia Tsien 1 collaboration

Elmar Jaeckel 1 collaboration

Marie-Josee Lynch 1 collaboration

Jeremy Keown 1 collaboration

Alaa Baazaoui 1 collaboration

Marek Šebesta 1 collaboration

Richard Štefl 1 collaboration

Cheng-Pin Chen 1 collaboration

Chung-Guei Huang 1 collaboration

Ting-Hua Chen 1 collaboration

Shin-Ru Shih 1 collaboration

Yi-Chun Lin 1 collaboration

Chien-Yu Cheng 1 collaboration

Shu-Hsing Cheng 1 collaboration

Yhu-Chering Huang 1 collaboration

Tzou-Yien Lin 1 collaboration

Che Ma 1 collaboration

Robert F Donat 1 collaboration

Kerry Godwin 1 collaboration

Kuan-Ying A Huang 1 collaboration

Narin Hengrung 1 collaboration

Sebastian A Andrei 1 collaboration

Pramod Kumar 1 collaboration

Lea Sefer 1 collaboration

Rebekka A Schwab 1 collaboration

Eamon F X Byrne 1 collaboration

Anthony I Magee 1 collaboration

Thomas Lanyon-Hogg 1 collaboration

Edward W Tate 1 collaboration

Zihan Zhu 1 collaboration

Vinesh Jugnarain 1 collaboration

Léa Conchou 1 collaboration

Xavier Robert 1 collaboration

Aurélien Thureau 1 collaboration

William Helbert 1 collaboration

Isabelle R Gonçalves 1 collaboration

Juliette Martin 1 collaboration

Santosh Shivakumaraswamy 1 collaboration

Adam D Crawshaw 1 collaboration

Jose Trincao 1 collaboration

Richard J Gildea 1 collaboration

Sam Horrell 1 collaboration

Anna J Warren 1 collaboration

Danny Axford 1 collaboration

Robin Owen 1 collaboration

Gwyndaf Evans 1 collaboration

Annie Bézier 1 collaboration

Peter Metcalf 1 collaboration

Mingda Ye 1 collaboration

Afaf El-Sagheer 1 collaboration

Tom Brown 1 collaboration

Chris J Norbury 1 collaboration

Peijun Zhang 1 collaboration

Robert J C Gilbert 1 collaboration

Pauline Lascaux 1 collaboration

Gwendoline Hoslett 1 collaboration

Sara Tribble 1 collaboration

Camilla Trugenberger 1 collaboration

Ivan Antičević 1 collaboration

Cecile Otten 1 collaboration

Ignacio Torrecilla 1 collaboration

Stelios Koukouravas 1 collaboration

Yichen Zhao 1 collaboration

Hongbin Yang 1 collaboration

Ftoon Aljarbou 1 collaboration

Annamaria Ruggiano 1 collaboration

Wei Song 1 collaboration

Cristiano Peron 1 collaboration

Giulio Deangeli 1 collaboration

Enric Domingo 1 collaboration

James Bancroft 1 collaboration

Errin Johnson 1 collaboration

Iolanda Vendrell 1 collaboration

Roman Fischer 1 collaboration

Alvin Wei Tian Ng 1 collaboration

Joanne Ngeow 1 collaboration

Vincenzo D'Angiolella 1 collaboration

Nuno Raimundo 1 collaboration

Tim Maughan 1 collaboration

Marta Popović 1 collaboration

Ira Milošević 1 collaboration

Kristijan Ramadan 1 collaboration