Diethard Mattanovich

Affiliations

Austrian Centre of Industrial Biotechnology (ACIB GmbH), Muthgasse 18, Vienna, Austria; Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 18, Vienna, Austria. Electronic address: diethard.mattanovich@boku.ac.at.

Publications (48)

Engineering of the citrate exporter protein enables high citric acid production in Aspergillus niger.

Metabolic engineering

Avec: Matthias G Steiger , Alice Rassinger , Diethard Mattanovich , Michael Sauer

Pseudohyphal differentiation in Komagataella phaffii: investigating the FLO gene family.

FEMS yeast research

Avec: Sonakshi De , Corinna Rebnegger , Josef Moser , Nadine Tatto , Alexandra B Graf , Diethard Mattanovich , Brigitte Gasser

Downscaling screening cultures in a multifunctional bioreactor array-on-a-chip for speeding up optimization of yeast-based lactic acid bioproduction.

Biotechnology and bioengineering

Avec: Damiano Totaro , Mario Rothbauer , Matthias G Steiger , Torsten Mayr , Hsiang-Yu Wang , Yu-Sheng Lin , Michael Sauer , Martin Altvater , Peter Ertl , Diethard Mattanovich

Komagataella phaffii YPS1-5 encodes the alpha-factor degrading protease Bar1.

FEMS yeast research

Avec: Lina Heistinger , Brigitte Gasser , Diethard Mattanovich

Adaptive laboratory evolution and reverse engineering enhances autotrophic growth in Pichia pastoris.

Metabolic engineering

Avec: Thomas Gassler , Michael Baumschabl , Jakob Sallaberger , Michael Egermeier , Diethard Mattanovich

Fermenting Futures: an artistic view on yeast biotechnology.

FEMS yeast research

Avec: Anna Dumitriu , Alex May , Özge Ata , Diethard Mattanovich

Into the metabolic wild: Unveiling hidden pathways of microbial metabolism.

Microbial biotechnology

Avec: Özge Ata , Diethard Mattanovich

Pushing and pulling proteins into the yeast secretory pathway enhances recombinant protein secretion.

Metabolic engineering

Avec: Richard J Zahrl , Roland Prielhofer , Özge Ata , Kristin Baumann , Diethard Mattanovich , Brigitte Gasser

Single carbon metabolism - A new paradigm for microbial bioprocesses?

Synthetic and systems biotechnology

Avec: Michael Baumschabl , Özge Ata , Diethard Mattanovich

Systematic sequence engineering enhances the induction strength of the glucose-regulated GTH1 promoter of Komagataella phaffii.

Nucleic acids research

Avec: Mirelle Flores-Villegas , Corinna Rebnegger , Viktoria Kowarz , Roland Prielhofer , Diethard Mattanovich , Brigitte Gasser

The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO

Nature communications

Avec: Bernd M Mitic , Christina Troyer , Lisa Lutz , Michael Baumschabl , Stephan Hann , Diethard Mattanovich

Synthetic activation of yeast stress response improves secretion of recombinant proteins.

New biotechnology

Avec: Richard J Zahrl , Roland Prielhofer , Jonas Burgard , Diethard Mattanovich , Brigitte Gasser

Protein production dynamics and physiological adaptation of recombinant Komagataella phaffii at near-zero growth rates.

Microbial cell factories

Avec: Corinna Rebnegger , Benjamin L Coltman , Viktoria Kowarz , David A Peña , Axel Mentler , Christina Troyer , Stephan Hann , Harald Schöny , Gunda Koellensperger , Diethard Mattanovich , Brigitte Gasser

From natural to synthetic: Promoter engineering in yeast expression systems.

Biotechnology advances

Avec: Ly Nguyen , Bernhard Schmelzer , Stuart Wilkinson , Diethard Mattanovich

Efficient production of itaconic acid from the single-carbon substrate methanol with engineered Komagataella phaffii.

Biotechnology for biofuels and bioproducts

Avec: Manja Mølgaard Severinsen , Simone Bachleitner , Viola Modenese , Özge Ata , Diethard Mattanovich

A subcellular proteome atlas of the yeast Komagataella phaffii.

FEMS yeast research

Avec: Minoska Valli , Karlheinz Grillitsch , Clemens Grünwald-Gruber , Nadine E Tatto , Bernhard Hrobath , Lisa Klug , Vasyl Ivashov , Sandra Hauzmayer , Martina Koller , Nora Tir , Friedrich Leisch , Brigitte Gasser , Alexandra B Graf , Friedrich Altmann , Günther Daum , Diethard Mattanovich

The secretome of Pichia pastoris in fed-batch cultivations is largely independent of the carbon source but changes quantitatively over cultivation time.

Microbial biotechnology

Avec: Jonas Burgard , Clemens Grünwald-Gruber , Friedrich Altmann , Jürgen Zanghellini , Minoska Valli , Diethard Mattanovich , Brigitte Gasser

Detection and Elimination of Cellular Bottlenecks in Protein-Producing Yeasts.

Methods in molecular biology (Clifton, N.J.)

Avec: Richard J Zahrl , Brigitte Gasser , Diethard Mattanovich , Pau Ferrer

CRISPR/Cas9-Mediated Homology-Directed Genome Editing in Pichia pastoris.

Methods in molecular biology (Clifton, N.J.)

Avec: Thomas Gassler , Lina Heistinger , Diethard Mattanovich , Brigitte Gasser , Roland Prielhofer

Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient

G3 (Bethesda, Md.)

Avec: Jing Li , Mark Rinnerthaler , Johannes Hartl , Manuela Weber , Thomas Karl , Hannelore Breitenbach-Koller , Michael Mülleder , Jakob Vowinckel , Hans Marx , Michael Sauer , Diethard Mattanovich , Özge Ata , Sonakshi De , Gregor P Greslehner , Florian Geltinger , Bill Burhans , Chris Grant , Victoria Doronina , Meryem Ralser , Maria Karolin Streubel , Christian Grabner , Stefanie Jarolim , Claudia Moßhammer , Campbell W Gourlay , Jiri Hasek , Paul J Cullen , Gianni Liti , Markus Ralser , Michael Breitenbach

The metabolic growth limitations of petite cells lacking the mitochondrial genome.

Nature metabolism

Avec: Jakob Vowinckel , Johannes Hartl , Hans Marx , Martin Kerick , Kathrin Runggatscher , Markus A Keller , Michael Mülleder , Jason Day , Manuela Weber , Mark Rinnerthaler , Jason S L Yu , Simran Kaur Aulakh , Andrea Lehmann , Diethard Mattanovich , Bernd Timmermann , Nianshu Zhang , Cory D Dunn , James I MacRae , Michael Breitenbach , Markus Ralser

Conversion of CO

Proceedings of the National Academy of Sciences of the United States of America

Avec: Michael Baumschabl , Özge Ata , Bernd M Mitic , Lisa Lutz , Thomas Gassler , Christina Troyer , Stephan Hann , Diethard Mattanovich

Synthetic two-species allodiploid and three-species allotetraploid Saccharomyces hybrids with euploid (complete) parental subgenomes.

Scientific reports

Avec: Zsuzsa Antunovics , Adrienn Szabo , Lina Heistinger , Diethard Mattanovich , Matthias Sipiczki

A native phosphoglycolate salvage pathway of the synthetic autotrophic yeast

microLife

Avec: Michael Baumschabl , Bernd M Mitic , Christina Troyer , Stephan Hann , Özge Ata , Diethard Mattanovich

Knock-out of the major regulator Flo8 in Komagataella phaffii results in unique host strain performance for methanol-free recombinant protein production.

New biotechnology

Avec: Corinna Rebnegger , Mirelle Flores , Viktoria Kowarz , Sonakshi De , Amandine Pusterla , Hauke Holm , Nuria Adelantado , Christoph Kiziak , Diethard Mattanovich , Brigitte Gasser

The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO

Nature biotechnology

Avec: Thomas Gassler , Michael Sauer , Brigitte Gasser , Michael Egermeier , Christina Troyer , Tim Causon , Stephan Hann , Diethard Mattanovich , Matthias G Steiger

What makes Komagataella phaffii non-conventional?

FEMS yeast research

Avec: Özge Ata , Burcu Gündüz Ergün , Patrick Fickers , Lina Heistinger , Diethard Mattanovich , Corinna Rebnegger , Brigitte Gasser

Fine-Tuning of Transcription in

ACS synthetic biology

Avec: Michael Baumschabl , Roland Prielhofer , Diethard Mattanovich , Matthias G Steiger

Established tools and emerging trends for the production of recombinant proteins and metabolites in Pichia pastoris.

Essays in biochemistry

Avec: Sonakshi De , Diethard Mattanovich , Pau Ferrer , Brigitte Gasser

Two homologs of the Cat8 transcription factor are involved in the regulation of ethanol utilization in Komagataella phaffii.

Current genetics

Avec: Diane Barbay , Monika Mačáková , Leander Sützl , Sonakshi De , Diethard Mattanovich , Brigitte Gasser

Microscale Perfusion-Based Cultivation for Pichia pastoris Clone Screening Enables Accelerated and Optimized Recombinant Protein Production Processes.

Biotechnology journal

Avec: Damiano Totaro , Bojana Radoman , Bernhard Schmelzer , Mario Rothbauer , Matthias G Steiger , Torsten Mayr , Michael Sauer , Peter Ertl , Diethard Mattanovich

Genotypic and phenotypic diversity among Komagataella species reveals a hidden pathway for xylose utilization.

Microbial cell factories

Avec: Lina Heistinger , Juliane C Dohm , Barbara G Paes , Daniel Koizar , Christina Troyer , Özge Ata , Teresa Steininger-Mairinger , Diethard Mattanovich

The potential of CO

Nature communications

Avec: Simone Bachleitner , Özge Ata , Diethard Mattanovich

Customizing amino acid metabolism of Pichia pastoris for recombinant protein production.

Biotechnology journal

Avec: Hannes Rußmayer , Markus Buchetics , Matthias Mattanovich , Stefan Neubauer , Matthias Steiger , Alexandra B Graf , Gunda Koellensperger , Stephan Hann , Michael Sauer , Brigitte Gasser , Diethard Mattanovich

Efficient production of bacterial antibiotics aminoriboflavin and roseoflavin in eukaryotic microorganisms, yeasts.

Microbial cell factories

Avec: Kostyantyn V Dmytruk , Justyna Ruchala , Liubov R Fayura , Grzegorz Chrzanowski , Olena V Dmytruk , Andriy O Tsyrulnyk , Yuliia A Andreieva , Daria V Fedorovych , Olena I Motyka , Diethard Mattanovich , Hans Marx , Andriy A Sibirny

Disruption of vacuolar protein sorting components of the HOPS complex leads to enhanced secretion of recombinant proteins in Pichia pastoris.

Microbial cell factories

Avec: Lukas Marsalek , Verena Puxbaum , Markus Buchetics , Diethard Mattanovich , Brigitte Gasser

Engineering of alcohol dehydrogenase 2 hybrid-promoter architectures in Pichia pastoris to enhance recombinant protein expression on ethanol.

Biotechnology and bioengineering

Avec: Burcu Gündüz Ergün , Brigitte Gasser , Diethard Mattanovich , Pınar Çalık

Engineered Deregulation of Expression in Yeast with Designed Hybrid-Promoter Architectures in Coordination with Discovered Master Regulator Transcription Factor.

Advanced biosystems

Avec: Burcu Gündüz Ergün , İrem Demir , Tunçer H Özdamar , Brigitte Gasser , Diethard Mattanovich , Pınar Çalık

Microbe Profile:

Microbiology (Reading, England)

Avec: Lina Heistinger , Brigitte Gasser , Diethard Mattanovich

Characterization of methanol utilization negative Pichia pastoris for secreted protein production: New cultivation strategies for current and future applications.

Biotechnology and bioengineering

Avec: Domen Zavec , Brigitte Gasser , Diethard Mattanovich

Beyond alcohol oxidase: the methylotrophic yeast Komagataella phaffii utilizes methanol also with its native alcohol dehydrogenase Adh2.

FEMS yeast research

Avec: Domen Zavec , Christina Troyer , Daniel Maresch , Friedrich Altmann , Stephan Hann , Brigitte Gasser , Diethard Mattanovich

The Degree and Length of O-Glycosylation of Recombinant Proteins Produced in Pichia pastoris Depends on the Nature of the Protein and the Process Type.

Biotechnology journal

Avec: Bojana Radoman , Clemens Grünwald-Gruber , Bernhard Schmelzer , Domen Zavec , Brigitte Gasser , Friedrich Altmann , Diethard Mattanovich

Going beyond the limit: Increasing global translation activity leads to increased productivity of recombinant secreted proteins in Pichia pastoris.

Metabolic engineering

Avec: Jennifer Staudacher , Corinna Rebnegger , Thomas Dohnal , Nils Landes , Diethard Mattanovich , Brigitte Gasser

Fermenting the future - on the benefits of a bioart collaboration.

FEMS yeast research

Avec: Diethard Mattanovich , Martin Altvater , Özge Ata , Simone Bachleitner

From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris.

Microbial cell factories

Avec: Nora Tir , Lina Heistinger , Clemens Grünwald-Gruber , Leo A Jakob , Stephan Dickgiesser , Nicolas Rasche , Diethard Mattanovich

Carbon efficient production of chemicals with yeasts.

Yeast (Chichester, England)

Avec: Evelyn Vásquez Castro , Golnaz Memari , Özge Ata , Diethard Mattanovich

Tailored extraction and ion mobility-mass spectrometry enables isotopologue analysis of tetrahydrofolate vitamers.

Analytical and bioanalytical chemistry

Avec: Bernd M Mitic , Diethard Mattanovich , Stephan Hann , Tim Causon

Overexpression of the transcriptional activators Mxr1 and Mit1 enhances lactic acid production on methanol in Komagataella phaffii.

Metabolic engineering

Avec: Simone Bachleitner , Manja Mølgaard Severinsen , Gregor Lutz , Diethard Mattanovich

Réseau de co-auteurs

Brigitte Gasser 24 collaborations

Özge Ata 13 collaborations

Stephan Hann 8 collaborations

Lina Heistinger 7 collaborations

Christina Troyer 7 collaborations

Michael Sauer 6 collaborations

Corinna Rebnegger 6 collaborations

Michael Baumschabl 6 collaborations

Matthias G Steiger 5 collaborations

Sonakshi De 5 collaborations

Roland Prielhofer 5 collaborations

Thomas Gassler 4 collaborations

Bernd M Mitic 4 collaborations

Simone Bachleitner 4 collaborations

Clemens Grünwald-Gruber 4 collaborations

Friedrich Altmann 4 collaborations

Alexandra B Graf 3 collaborations

Richard J Zahrl 3 collaborations

Viktoria Kowarz 3 collaborations

Bernhard Schmelzer 3 collaborations

Hans Marx 3 collaborations

Burcu Gündüz Ergün 3 collaborations

Domen Zavec 3 collaborations

Damiano Totaro 2 collaborations

Mario Rothbauer 2 collaborations

Torsten Mayr 2 collaborations

Martin Altvater 2 collaborations

Peter Ertl 2 collaborations

Michael Egermeier 2 collaborations

Lisa Lutz 2 collaborations

Jonas Burgard 2 collaborations

Gunda Koellensperger 2 collaborations

Manja Mølgaard Severinsen 2 collaborations

Minoska Valli 2 collaborations

Nora Tir 2 collaborations

Pau Ferrer 2 collaborations

Mark Rinnerthaler 2 collaborations

Johannes Hartl 2 collaborations

Manuela Weber 2 collaborations

Michael Mülleder 2 collaborations

Jakob Vowinckel 2 collaborations

Markus Ralser 2 collaborations

Michael Breitenbach 2 collaborations

Tim Causon 2 collaborations

Bojana Radoman 2 collaborations

Markus Buchetics 2 collaborations

Pınar Çalık 2 collaborations

Alice Rassinger 1 collaboration

Josef Moser 1 collaboration

Nadine Tatto 1 collaboration

Hsiang-Yu Wang 1 collaboration

Yu-Sheng Lin 1 collaboration

Jakob Sallaberger 1 collaboration

Anna Dumitriu 1 collaboration

Alex May 1 collaboration

Kristin Baumann 1 collaboration

Mirelle Flores-Villegas 1 collaboration

Benjamin L Coltman 1 collaboration

David A Peña 1 collaboration

Axel Mentler 1 collaboration

Harald Schöny 1 collaboration

Ly Nguyen 1 collaboration

Stuart Wilkinson 1 collaboration

Viola Modenese 1 collaboration

Karlheinz Grillitsch 1 collaboration

Nadine E Tatto 1 collaboration

Bernhard Hrobath 1 collaboration

Lisa Klug 1 collaboration

Vasyl Ivashov 1 collaboration

Sandra Hauzmayer 1 collaboration

Martina Koller 1 collaboration

Friedrich Leisch 1 collaboration

Günther Daum 1 collaboration

Jürgen Zanghellini 1 collaboration

Jing Li 1 collaboration

Thomas Karl 1 collaboration

Hannelore Breitenbach-Koller 1 collaboration

Gregor P Greslehner 1 collaboration

Florian Geltinger 1 collaboration

Bill Burhans 1 collaboration

Chris Grant 1 collaboration

Victoria Doronina 1 collaboration

Meryem Ralser 1 collaboration

Maria Karolin Streubel 1 collaboration

Christian Grabner 1 collaboration

Stefanie Jarolim 1 collaboration

Claudia Moßhammer 1 collaboration

Campbell W Gourlay 1 collaboration

Jiri Hasek 1 collaboration

Paul J Cullen 1 collaboration

Gianni Liti 1 collaboration

Martin Kerick 1 collaboration

Kathrin Runggatscher 1 collaboration

Markus A Keller 1 collaboration

Jason Day 1 collaboration

Jason S L Yu 1 collaboration

Simran Kaur Aulakh 1 collaboration

Andrea Lehmann 1 collaboration

Bernd Timmermann 1 collaboration

Nianshu Zhang 1 collaboration

Cory D Dunn 1 collaboration

James I MacRae 1 collaboration

Zsuzsa Antunovics 1 collaboration

Adrienn Szabo 1 collaboration

Matthias Sipiczki 1 collaboration

Mirelle Flores 1 collaboration

Amandine Pusterla 1 collaboration

Hauke Holm 1 collaboration

Nuria Adelantado 1 collaboration

Christoph Kiziak 1 collaboration

Patrick Fickers 1 collaboration

Diane Barbay 1 collaboration

Monika Mačáková 1 collaboration

Leander Sützl 1 collaboration

Juliane C Dohm 1 collaboration

Barbara G Paes 1 collaboration

Daniel Koizar 1 collaboration

Teresa Steininger-Mairinger 1 collaboration

Hannes Rußmayer 1 collaboration

Matthias Mattanovich 1 collaboration

Stefan Neubauer 1 collaboration

Matthias Steiger 1 collaboration

Kostyantyn V Dmytruk 1 collaboration

Justyna Ruchala 1 collaboration

Liubov R Fayura 1 collaboration

Grzegorz Chrzanowski 1 collaboration

Olena V Dmytruk 1 collaboration

Andriy O Tsyrulnyk 1 collaboration

Yuliia A Andreieva 1 collaboration

Daria V Fedorovych 1 collaboration

Olena I Motyka 1 collaboration

Andriy A Sibirny 1 collaboration

Lukas Marsalek 1 collaboration

Verena Puxbaum 1 collaboration

İrem Demir 1 collaboration

Tunçer H Özdamar 1 collaboration

Daniel Maresch 1 collaboration

Jennifer Staudacher 1 collaboration

Thomas Dohnal 1 collaboration

Nils Landes 1 collaboration

Leo A Jakob 1 collaboration

Stephan Dickgiesser 1 collaboration

Nicolas Rasche 1 collaboration

Evelyn Vásquez Castro 1 collaboration

Golnaz Memari 1 collaboration

Gregor Lutz 1 collaboration