Alexander L Satz

Affiliations

WuXi AppTec (Shanghai) Co., Ltd., 240 Hedan Road, Shanghai 200131, China.

ORCID: 0000-0003-1284-1977

Publications (21)

Triaging of DNA-Encoded Library Selection Results by High-Throughput Resynthesis of DNA-Conjugate and Affinity Selection Mass Spectrometry.

Bioconjugate chemistry

Avec: Wenji Su , Rui Ge , Duanchen Ding , Wenhua Chen , Wenqing Wang , Hao Yan , Weikun Wang , Youlang Yuan , Huan Liu , Meng Zhang , Jiyuan Zhang , Qisheng Shu , Alexander L Satz , Letian Kuai

DNA-Compatible Click Reaction Employing In Situ Generated Azides from Boronic Acids.

Current protocols

Avec: Yulong An , Hao Yan , Zhenzhen Dong , Alexander L Satz

Off-DNA DNA-Encoded Library Affinity Screening.

ACS combinatorial science

Avec: Amber L Hackler , Forrest G FitzGerald , Vuong Q Dang , Alexander L Satz , Brian M Paegel

Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.

Journal of medicinal chemistry

Avec: Francesco Rianjongdee , Stephen J Atkinson , Chun-Wa Chung , Paola Grandi , James R J Gray , Laura J Kaushansky , Patricia Medeiros , Cassie Messenger , Alex Phillipou , Alex Preston , Rab K Prinjha , Inmaculada Rioja , Alexander L Satz , Simon Taylor , Ian D Wall , Robert J Watson , Gang Yao , Emmanuel H Demont

Assessment of AI-Based Protein Structure Prediction for the NLRP3 Target.

Molecules (Basel, Switzerland)

Avec: Jian Yin , Junkun Lei , Jialin Yu , Weiren Cui , Alexander L Satz , Yifan Zhou , Hua Feng , Jason Deng , Wenji Su , Letian Kuai

Activity-Based DNA-Encoded Library Screening.

ACS combinatorial science

Avec: Wesley G Cochrane , Marie L Malone , Vuong Q Dang , Valerie Cavett , Alexander L Satz , Brian M Paegel

Analysis of DNA-Encoded Library Screening Data: Selection of Molecules for Synthesis.

Methods in molecular biology (Clifton, N.J.)

Avec: Alexander L Satz , Weiren Cui

DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor.

ACS medicinal chemistry letters

Avec: Anthony P Silvestri , Qi Zhang , Yan Ping , Erik W Muir , Jingsi Zhao , Sai Kumar Chakka , Gaonan Wang , Walter M Bray , Wenhua Chen , Jennifer L Fribourgh , Sarvind Tripathi , Yunyun He , Seth M Rubin , Alexander L Satz , Cameron R Pye , Letian Kuai , Wenji Su , Joshua A Schwochert

DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines.

Bioconjugate chemistry

Avec: Ke Li , Yi Qu , Yulong An , Eric Breinlinger , Matthew P Webster , Huanan Wen , Duanchen Ding , Meng Zhao , Xiaodong Shi , Jiangong Wang , Wenji Su , Weiren Cui , Alexander L Satz , Hongfang Yang , Letian Kuai , Andrew Little , Xuanjia Peng

Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering.

iScience

Avec: Ke Li , Xiaohong Liu , Sixiu Liu , Yulong An , Yanfang Shen , Qingxia Sun , Xiaodong Shi , Wenji Su , Weiren Cui , Zhiqiang Duan , Letian Kuai , Hongfang Yang , Alexander L Satz , Kaixian Chen , Hualiang Jiang , Mingyue Zheng , Xuanjia Peng , Xiaojie Lu

Development of DNA-Compatible Van Leusen Three-Component Imidazole Synthesis.

Organic letters

Avec: Stefanie N Geigle , Ann C Petersen , Alexander L Satz

DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.

ACS chemical biology

Avec: Hans Richter , Alexander L Satz , Marc Bedoucha , Bernd Buettelmann , Ann C Petersen , Anja Harmeier , Ricardo Hermosilla , Remo Hochstrasser , Dominique Burger , Bernard Gsell , Rodolfo Gasser , Sylwia Huber , Melanie N Hug , Buelent Kocer , Bernd Kuhn , Martin Ritter , Markus G Rudolph , Franziska Weibel , Judith Molina-David , Jin-Ju Kim , Javier Varona Santos , Martine Stihle , Guy J Georges , R Daniel Bonfil , Rafael Fridman , Sabine Uhles , Solange Moll , Christian Faul , Alessia Fornoni , Marco Prunotto

Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection.

SLAS discovery : advancing life sciences R & D

Avec: Rui Ge , Zuyuan Shen , Jian Yin , Wenhua Chen , Qi Zhang , Yulong An , Dewei Tang , Alexander L Satz , Wenji Su , Letian Kuai

A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.

Biochemistry

Avec: Micah Steffek , Elizabeth Helgason , Nataliya Popovych , Lionel Rougé , John M Bruning , Ke Sherry Li , Daniel J Burdick , Jianping Cai , Terry Crawford , Jing Xue , Willy Decurtins , Chunlin Fang , Felix Grubers , Michael J Holliday , Allyson Langley , Ann Petersen , Alexander Lee Satz , Aimin Song , Daniel Stoffler , Quentin Strebel , Jeffrey Y K Tom , Nicholas Skelton , Steven T Staben , Moreno Wichert , Melinda M Mulvihill , Erin C Dueber

DNA-Compatible Cyclization Reaction to Access 1,3,4-Oxadiazoles and 1,2,4-Triazoles.

Organic letters

Avec: Gaonan Wang , Yu Tan , Hanzhi Zou , Xihang Sui , Zhanlong Wang , Alexander L Satz , Letian Kuai , Wenji Su , Qi Zhang

Copper-Mediated DNA-Compatible One-Pot Click Reactions of Alkynes with Aryl Borates and TMS-N

Organic letters

Avec: Yi Qu , Huanan Wen , Rui Ge , Yanfen Xu , Hong Gao , Xiaodong Shi , Jiangong Wang , Weiren Cui , Wenji Su , Hongfang Yang , Letian Kuai , Alexander L Satz , Xuanjia Peng

Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis.

Biochemical and biophysical research communications

Avec: Yi Qu , Sixiu Liu , Huanan Wen , Yanfen Xu , Yulong An , Ke Li , Mengyuan Ni , Yanfang Shen , Xiaodong Shi , Wenji Su , Weiren Cui , Letian Kuai , Alexander L Satz , Hongfang Yang , Xiaojie Lu , Xuanjia Peng

High-Throughput Solid-Phase Building Block Synthesis for DNA-Encoded Libraries.

Organic letters

Avec: Claudio Zambaldo , Stefanie N Geigle , Alexander L Satz

Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets.

Bioorganic & medicinal chemistry letters

Avec: Alexander L Satz , Letian Kuai , Xuanjia Peng

Synthesis of 1,2-Amino Alcohols by Photoredox-Mediated Decarboxylative Coupling of α-Amino Acids and DNA-Conjugated Carbonyls.

Organic letters

Avec: Huanan Wen , Rui Ge , Yi Qu , Jialin Sun , Xiaodong Shi , Weiren Cui , Hao Yan , Qi Zhang , Yulong An , Wenji Su , Hongfang Yang , Letian Kuai , Alexander L Satz , Xuanjia Peng

Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.

ACS medicinal chemistry letters

Avec: Jun Liang , Michael J Lambrecht , Teresita L Arenzana , Samuel Aubert-Nicol , Linda Bao , Fabio Broccatelli , Jianping Cai , Celine Eidenschenk , Christine Everett , Thomas Garner , Felix Gruber , Pouyan Haghshenas , Malcolm P Huestis , Peter L Hsu , Ponien Kou , Araz Jakalian , Robin Larouche-Gauthier , Jean-Philippe Leclerc , Dennis H Leung , Aaron Martin , Jeremy Murray , Madeleine Prangley , Sascha Rutz , Satoko Kakiuchi-Kiyota , Alexander Lee Satz , Nicholas J Skelton , Micah Steffek , Daniel Stoffler , Jawahar Sudhamsu , Sophia Tan , Jian Wang , Shouliang Wang , Qiuyue Wang , Timothy J Wendorff , Moreno Wichert , Arun Yadav , Christine Yu , Xiaojing Wang

Réseau de co-auteurs

Letian Kuai 11 collaborations

Wenji Su 10 collaborations

Weiren Cui 7 collaborations

Yulong An 6 collaborations

Xuanjia Peng 6 collaborations

Xiaodong Shi 5 collaborations

Hongfang Yang 5 collaborations

Rui Ge 4 collaborations

Qi Zhang 4 collaborations

Yi Qu 4 collaborations

Huanan Wen 4 collaborations

Wenhua Chen 3 collaborations

Hao Yan 3 collaborations

Ke Li 3 collaborations

Duanchen Ding 2 collaborations

Vuong Q Dang 2 collaborations

Brian M Paegel 2 collaborations

Jian Yin 2 collaborations

Gaonan Wang 2 collaborations

Jiangong Wang 2 collaborations

Sixiu Liu 2 collaborations

Yanfang Shen 2 collaborations

Xiaojie Lu 2 collaborations

Stefanie N Geigle 2 collaborations

Ann C Petersen 2 collaborations

Micah Steffek 2 collaborations

Jianping Cai 2 collaborations

Alexander Lee Satz 2 collaborations

Daniel Stoffler 2 collaborations

Moreno Wichert 2 collaborations

Yanfen Xu 2 collaborations

Wenqing Wang 1 collaboration

Weikun Wang 1 collaboration

Youlang Yuan 1 collaboration

Huan Liu 1 collaboration

Meng Zhang 1 collaboration

Jiyuan Zhang 1 collaboration

Qisheng Shu 1 collaboration

Zhenzhen Dong 1 collaboration

Amber L Hackler 1 collaboration

Forrest G FitzGerald 1 collaboration

Francesco Rianjongdee 1 collaboration

Stephen J Atkinson 1 collaboration

Chun-Wa Chung 1 collaboration

Paola Grandi 1 collaboration

James R J Gray 1 collaboration

Laura J Kaushansky 1 collaboration

Patricia Medeiros 1 collaboration

Cassie Messenger 1 collaboration

Alex Phillipou 1 collaboration

Alex Preston 1 collaboration

Rab K Prinjha 1 collaboration

Inmaculada Rioja 1 collaboration

Simon Taylor 1 collaboration

Ian D Wall 1 collaboration

Robert J Watson 1 collaboration

Gang Yao 1 collaboration

Emmanuel H Demont 1 collaboration

Junkun Lei 1 collaboration

Jialin Yu 1 collaboration

Yifan Zhou 1 collaboration

Hua Feng 1 collaboration

Jason Deng 1 collaboration

Wesley G Cochrane 1 collaboration

Marie L Malone 1 collaboration

Valerie Cavett 1 collaboration

Anthony P Silvestri 1 collaboration

Yan Ping 1 collaboration

Erik W Muir 1 collaboration

Jingsi Zhao 1 collaboration

Sai Kumar Chakka 1 collaboration

Walter M Bray 1 collaboration

Jennifer L Fribourgh 1 collaboration

Sarvind Tripathi 1 collaboration

Yunyun He 1 collaboration

Seth M Rubin 1 collaboration

Cameron R Pye 1 collaboration

Joshua A Schwochert 1 collaboration

Eric Breinlinger 1 collaboration

Matthew P Webster 1 collaboration

Meng Zhao 1 collaboration

Andrew Little 1 collaboration

Xiaohong Liu 1 collaboration

Qingxia Sun 1 collaboration

Zhiqiang Duan 1 collaboration

Kaixian Chen 1 collaboration

Hualiang Jiang 1 collaboration

Mingyue Zheng 1 collaboration

Hans Richter 1 collaboration

Marc Bedoucha 1 collaboration

Bernd Buettelmann 1 collaboration

Anja Harmeier 1 collaboration

Ricardo Hermosilla 1 collaboration

Remo Hochstrasser 1 collaboration

Dominique Burger 1 collaboration

Bernard Gsell 1 collaboration

Rodolfo Gasser 1 collaboration

Sylwia Huber 1 collaboration

Melanie N Hug 1 collaboration

Buelent Kocer 1 collaboration

Bernd Kuhn 1 collaboration

Martin Ritter 1 collaboration

Markus G Rudolph 1 collaboration

Franziska Weibel 1 collaboration

Judith Molina-David 1 collaboration

Jin-Ju Kim 1 collaboration

Javier Varona Santos 1 collaboration

Martine Stihle 1 collaboration

Guy J Georges 1 collaboration

R Daniel Bonfil 1 collaboration

Rafael Fridman 1 collaboration

Sabine Uhles 1 collaboration

Solange Moll 1 collaboration

Christian Faul 1 collaboration

Alessia Fornoni 1 collaboration

Marco Prunotto 1 collaboration

Zuyuan Shen 1 collaboration

Dewei Tang 1 collaboration

Elizabeth Helgason 1 collaboration

Nataliya Popovych 1 collaboration

Lionel Rougé 1 collaboration

John M Bruning 1 collaboration

Ke Sherry Li 1 collaboration

Daniel J Burdick 1 collaboration

Terry Crawford 1 collaboration

Jing Xue 1 collaboration

Willy Decurtins 1 collaboration

Chunlin Fang 1 collaboration

Felix Grubers 1 collaboration

Michael J Holliday 1 collaboration

Allyson Langley 1 collaboration

Ann Petersen 1 collaboration

Aimin Song 1 collaboration

Quentin Strebel 1 collaboration

Jeffrey Y K Tom 1 collaboration

Nicholas Skelton 1 collaboration

Steven T Staben 1 collaboration

Melinda M Mulvihill 1 collaboration

Erin C Dueber 1 collaboration

Yu Tan 1 collaboration

Hanzhi Zou 1 collaboration

Xihang Sui 1 collaboration

Zhanlong Wang 1 collaboration

Hong Gao 1 collaboration

Mengyuan Ni 1 collaboration

Claudio Zambaldo 1 collaboration

Jialin Sun 1 collaboration

Jun Liang 1 collaboration

Michael J Lambrecht 1 collaboration

Teresita L Arenzana 1 collaboration

Samuel Aubert-Nicol 1 collaboration

Linda Bao 1 collaboration

Fabio Broccatelli 1 collaboration

Celine Eidenschenk 1 collaboration

Christine Everett 1 collaboration

Thomas Garner 1 collaboration

Felix Gruber 1 collaboration

Pouyan Haghshenas 1 collaboration

Malcolm P Huestis 1 collaboration

Peter L Hsu 1 collaboration

Ponien Kou 1 collaboration

Araz Jakalian 1 collaboration

Robin Larouche-Gauthier 1 collaboration

Jean-Philippe Leclerc 1 collaboration

Dennis H Leung 1 collaboration

Aaron Martin 1 collaboration

Jeremy Murray 1 collaboration

Madeleine Prangley 1 collaboration

Sascha Rutz 1 collaboration

Satoko Kakiuchi-Kiyota 1 collaboration

Nicholas J Skelton 1 collaboration

Jawahar Sudhamsu 1 collaboration

Sophia Tan 1 collaboration

Jian Wang 1 collaboration

Shouliang Wang 1 collaboration

Qiuyue Wang 1 collaboration

Timothy J Wendorff 1 collaboration

Arun Yadav 1 collaboration

Christine Yu 1 collaboration

Xiaojing Wang 1 collaboration