Steven T Staben

Affiliations

Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.

Publications (20)

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.

Journal of medicinal chemistry

Avec: Peter S Dragovich , Thomas H Pillow , Robert A Blake , Jack D Sadowsky , Emel Adaligil , Pragya Adhikari , Sunil Bhakta , Nicole Blaquiere , Jinhua Chen , Josefa Dela Cruz-Chuh , Karen E Gascoigne , Steven J Hartman , Mingtao He , Susan Kaufman , Tracy Kleinheinz , Katherine R Kozak , Liang Liu , Liling Liu , Qi Liu , Ying Lu , Fanwei Meng , Melinda M Mulvihill , Aimee O'Donohue , Rebecca K Rowntree , Leanna R Staben , John Wai , Jian Wang , BinQing Wei , Catherine Wilson , Jianfeng Xin , Zijin Xu , Hui Yao , Donglu Zhang , Hongyan Zhang , Hao Zhou , Xiaoyu Zhu

Preclinical Assessment of the PI3Kα Selective Inhibitor Inavolisib and Prediction of Its Pharmacokinetics and Efficacious Dose in Human.

Xenobiotica; the fate of foreign compounds in biological systems

Avec: Laurent Salphati , Jodie Pang , Emile G Plise , Jonathan Cheong , Marie-Gabrielle Braun , Lori S Friedman , Rebecca Hong Thibodeau , Allan Jaochico , Ryan Johnson , Ning Liu , Michelle Nannini , Deepak Sampath , Kyung Song , Emily J Hannan ,

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.

Journal of the American Chemical Society

Avec: Willem den Besten , Kshitij Verma , Sayumi Yamazoe , Nicole Blaquiere , Wilson Phung , Anita Izrael-Tomasevic , Melinda M Mulvihill , Elizabeth Helgason , Sumit Prakash , Tatiana Goncharov , Domagoj Vucic , Erin Dueber , Wayne J Fairbrother , Ingrid Wertz , Kebing Yu ,

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

Journal of medicinal chemistry

Avec: Emily J Hanan , Marie-Gabrielle Braun , Robert A Heald , Calum MacLeod , Connie Chan , Saundra Clausen , Kyle A Edgar , Charles Eigenbrot , Richard Elliott , Nicholas Endres , Lori S Friedman , Emily Gogol , Xiao-Hui Gu , Rebecca Hong Thibodeau , Philip S Jackson , James R Kiefer , Jamie D Knight , Michelle Nannini , Raman Narukulla , Amanda Pace , Jodie Pang , Hans E Purkey , Laurent Salphati , Deepak Sampath , Stephen Schmidt , Steve Sideris , Kyung Song , Swathi Sujatha-Bhaskar , Mark Ultsch , Heidi Wallweber , Jianfeng Xin , SiewKuen Yeap , Amy Young , Yu Zhong ,

Targeted degradation via direct 26S proteasome recruitment.

Nature chemical biology

Avec: Charlene Bashore , Sumit Prakash , Matthew C Johnson , Ryan J Conrad , Ivy A Kekessie , Suzie J Scales , Noriko Ishisoko , Tracy Kleinheinz , Peter S Liu , Nataliya Popovych , Aaron T Wecksler , Lijuan Zhou , Christine Tam , Inna Zilberleyb , Rajini Srinivasan , Robert A Blake , Aimin Song , Yingnan Zhang , David Arnott , Wayne J Fairbrother , Scott A Foster , Ingrid E Wertz , Claudio Ciferri , Erin C Dueber

Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases.

Journal of medicinal chemistry

Avec: Nicole Blaquiere , Elisia Villemure ,

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

PLoS biology

Avec: Lieselotte Vande Walle , Irma B Stowe , Pavel Šácha , Bettina L Lee , Dieter Demon , Amelie Fossoul , Filip Van Hauwermeiren , Pedro H V Saavedra , Petr Šimon , Vladimír Šubrt , Libor Kostka , Craig E Stivala , Victoria C Pham , Sayumi Yamazoe , Jan Konvalinka , Nobuhiko Kayagaki , Mohamed Lamkanfi

Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

PLoS biology

Avec: Lieselotte Vande Walle , Irma B Stowe , Pavel Šácha , Bettina L Lee , Dieter Demon , Amelie Fossoul , Filip Van Hauwermeiren , Pedro H V Saavedra , Petr Šimon , Vladimír Šubr , Libor Kostka , Craig E Stivala , Victoria C Pham , Sayumi Yamazoe , Jan Konvalinka , Nobuhiko Kayagaki , Mohamed Lamkanfi

Selective activation of PFKL suppresses the phagocytic oxidative burst.

Cell

Avec: Neri Amara , Madison P Cooper , Maria A Voronkova , Bradley A Webb , Eric M Lynch , Justin M Kollman , Taylur Ma , Kebing Yu , Zijuan Lai , Dewakar Sangaraju , Nobuhiko Kayagaki , Kim Newton , Matthew Bogyo , Vishva M Dixit

Identifying transcriptional programs underlying cancer drug response with TraCe-seq.

Nature biotechnology

Avec: Matthew T Chang , Frances Shanahan , Thi Thu Thao Nguyen , Lewis Gazzard , Sayumi Yamazoe , Ingrid E Wertz , Robert Piskol , Yeqing Angela Yang , Zora Modrusan , Benjamin Haley , Marie Evangelista , Shiva Malek , Scott A Foster , Xin Ye

Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).

ACS medicinal chemistry letters

Avec: Jianwen A Feng , Patrick Lee , Moulay Hicham Alaoui , Kathy Barrett , Georgette Castanedo , Robert Godemann , Paul McEwan , Xiaolu Wang , Ping Wu , Yamin Zhang , Seth F Harris ,

Monomeric Targeted Protein Degraders.

Journal of medicinal chemistry

Avec: Emily J Hanan , Jun Liang , Xiaojing Wang , Robert A Blake , Nicole Blaquiere ,

Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.

Bioorganic & medicinal chemistry letters

Avec: James J Crawford , Jianwen Feng , Hans D Brightbill , Adam R Johnson , Matthew Wright , Aleksandr Kolesnikov , Wendy Lee , Georgette M Castanedo , Steven Do , Nicole Blaquiere , Po-Chang Chiang , Peter W Fan , Matt Baumgardner , Susan Wong , Robert Godemann , Alice Grabbe , Catharina Wiegel , Swathi Sujatha-Bhaskar , Sarah G Hymowitz , Nicholas Liau , Peter L Hsu , Paul A McEwan , Moulay Hicham Alaoui Ismaili , Matthew L Landry

Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation.

Cell chemical biology

Avec: Scott C Rosenberg , Frances Shanahan , Sayumi Yamazoe , Marc Kschonsak , Yi J Zeng , James Lee , Emile Plise , Ivana Yen , Christopher M Rose , John G Quinn , Lewis J Gazzard , Benjamin T Walters , Donald S Kirkpatrick , Scott A Foster , Shiva Malek

Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability.

Journal of medicinal chemistry

Avec: Ena Ladi , Christine Everett , Craig E Stivala , Blake E Daniels , Matthew R Durk , Seth F Harris , Malcolm P Huestis , Hans E Purkey , Martin Augustin , Michael Blaesse , Stefan Steinbacher , Celine Eidenschenk , Rajita Pappu , Michael Siu

Heterobifunctional Molecules Induce Dephosphorylation of Kinases-A Proof of Concept Study.

Journal of medicinal chemistry

Avec: Sayumi Yamazoe , Jeffrey Tom , Yue Fu , Wenqiong Wu , Liang Zeng , Changlei Sun , Qi Liu , Jie Lin , Kui Lin , Wayne J Fairbrother ,

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).

Bioorganic & medicinal chemistry letters

Avec: Peter S Dragovich , Pragya Adhikari , Robert A Blake , Nicole Blaquiere , Jinhua Chen , Yun-Xing Cheng , Willem den Besten , Jinping Han , Steven J Hartman , Jintang He , Mingtao He , Ellen Rei Ingalla , Amrita V Kamath , Tracy Kleinheinz , Tommy Lai , Douglas D Leipold , Chun Sing Li , Qi Liu , Jiawei Lu , Ying Lu , Fanwei Meng , Lingyao Meng , Carl Ng , Kaishan Peng , Gail Lewis Phillips , Thomas H Pillow , Rebecca K Rowntree , Jack D Sadowsky , Deepak Sampath , Leanna Staben , John Wai , Kunpeng Wan , Xinxin Wang , BinQing Wei , Ingrid E Wertz , Jianfeng Xin , Keyang Xu , Hui Yao , Richard Zang , Donglu Zhang , Hao Zhou , Yongxin Zhao

A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.

Biochemistry

Avec: Micah Steffek , Elizabeth Helgason , Nataliya Popovych , Lionel Rougé , John M Bruning , Ke Sherry Li , Daniel J Burdick , Jianping Cai , Terry Crawford , Jing Xue , Willy Decurtins , Chunlin Fang , Felix Grubers , Michael J Holliday , Allyson Langley , Ann Petersen , Alexander Lee Satz , Aimin Song , Daniel Stoffler , Quentin Strebel , Jeffrey Y K Tom , Nicholas Skelton , Moreno Wichert , Melinda M Mulvihill , Erin C Dueber

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.

Journal of medicinal chemistry

Avec: Dennis X Hu , Snahel Patel , Huifen Chen , Shumei Wang , Yoana N Dimitrova , Heidi Ackerly Wallweber , Joanna Y Lee , Grace Ka Yan Chan , Christopher J Sneeringer , Madeleine S Prangley , John G Moffat , Kai C Wu , Leah K Schutt , Laurent Salphati , Jodie Pang , Erin McNamara , Haochu Huang , Yong Chen , Yunli Wang , Wensheng Zhao , Junghyun Lim , Aditya Murthy , Michael Siu

Overcoming Preclinical Safety Obstacles to Discover (

Journal of medicinal chemistry

Avec: Christopher McBride , Lynnie Trzoss , Davide Povero , Milos Lazic , Geza Ambrus-Aikelin , Angelina Santini , Rama Pranadinata , Gretchen Bain , Ryan Stansfield , Jeffrey A Stafford , James Veal , Ryan Takahashi , Justin Ly , Shu Chen , Liling Liu , Marika Nespi , Robert Blake , Arna Katewa , Tracy Kleinheinz , Swathi Sujatha-Bhaskar , Nandhini Ramamoorthi , Jessica Sims , Brent McKenzie , Mark Chen , Mark Ultsch , Matthew Johnson , Jeremy Murray , Claudio Ciferri , Michael J Townsend , Craig E Stivala

Réseau de co-auteurs

Nicole Blaquiere 6 collaborations

Sayumi Yamazoe 6 collaborations

Robert A Blake 4 collaborations

Tracy Kleinheinz 4 collaborations

Craig E Stivala 4 collaborations

Qi Liu 3 collaborations

Melinda M Mulvihill 3 collaborations

Jianfeng Xin 3 collaborations

Laurent Salphati 3 collaborations

Jodie Pang 3 collaborations

Deepak Sampath 3 collaborations

Wayne J Fairbrother 3 collaborations

Swathi Sujatha-Bhaskar 3 collaborations

Scott A Foster 3 collaborations

Ingrid E Wertz 3 collaborations

Nobuhiko Kayagaki 3 collaborations

Peter S Dragovich 2 collaborations

Thomas H Pillow 2 collaborations

Jack D Sadowsky 2 collaborations

Pragya Adhikari 2 collaborations

Jinhua Chen 2 collaborations

Steven J Hartman 2 collaborations

Mingtao He 2 collaborations

Liling Liu 2 collaborations

Ying Lu 2 collaborations

Fanwei Meng 2 collaborations

Rebecca K Rowntree 2 collaborations

John Wai 2 collaborations

BinQing Wei 2 collaborations

Hui Yao 2 collaborations

Donglu Zhang 2 collaborations

Hao Zhou 2 collaborations

Marie-Gabrielle Braun 2 collaborations

Lori S Friedman 2 collaborations

Rebecca Hong Thibodeau 2 collaborations

Michelle Nannini 2 collaborations

Kyung Song 2 collaborations

Willem den Besten 2 collaborations

Elizabeth Helgason 2 collaborations

Sumit Prakash 2 collaborations

Kebing Yu 2 collaborations

Emily J Hanan 2 collaborations

Hans E Purkey 2 collaborations

Mark Ultsch 2 collaborations

Nataliya Popovych 2 collaborations

Aimin Song 2 collaborations

Claudio Ciferri 2 collaborations

Erin C Dueber 2 collaborations

Lieselotte Vande Walle 2 collaborations

Irma B Stowe 2 collaborations

Pavel Šácha 2 collaborations

Bettina L Lee 2 collaborations

Dieter Demon 2 collaborations

Amelie Fossoul 2 collaborations

Filip Van Hauwermeiren 2 collaborations

Pedro H V Saavedra 2 collaborations

Petr Šimon 2 collaborations

Libor Kostka 2 collaborations

Victoria C Pham 2 collaborations

Jan Konvalinka 2 collaborations

Mohamed Lamkanfi 2 collaborations

Frances Shanahan 2 collaborations

Shiva Malek 2 collaborations

Robert Godemann 2 collaborations

Seth F Harris 2 collaborations

Michael Siu 2 collaborations

Emel Adaligil 1 collaboration

Sunil Bhakta 1 collaboration

Josefa Dela Cruz-Chuh 1 collaboration

Karen E Gascoigne 1 collaboration

Susan Kaufman 1 collaboration

Katherine R Kozak 1 collaboration

Liang Liu 1 collaboration

Aimee O'Donohue 1 collaboration

Leanna R Staben 1 collaboration

Jian Wang 1 collaboration

Catherine Wilson 1 collaboration

Zijin Xu 1 collaboration

Hongyan Zhang 1 collaboration

Xiaoyu Zhu 1 collaboration

Emile G Plise 1 collaboration

Jonathan Cheong 1 collaboration

Allan Jaochico 1 collaboration

Ryan Johnson 1 collaboration

Ning Liu 1 collaboration

Emily J Hannan 1 collaboration

Kshitij Verma 1 collaboration

Wilson Phung 1 collaboration

Anita Izrael-Tomasevic 1 collaboration

Tatiana Goncharov 1 collaboration

Domagoj Vucic 1 collaboration

Erin Dueber 1 collaboration

Ingrid Wertz 1 collaboration

Robert A Heald 1 collaboration

Calum MacLeod 1 collaboration

Connie Chan 1 collaboration

Saundra Clausen 1 collaboration

Kyle A Edgar 1 collaboration

Charles Eigenbrot 1 collaboration

Richard Elliott 1 collaboration

Nicholas Endres 1 collaboration

Emily Gogol 1 collaboration

Xiao-Hui Gu 1 collaboration

Philip S Jackson 1 collaboration

James R Kiefer 1 collaboration

Jamie D Knight 1 collaboration

Raman Narukulla 1 collaboration

Amanda Pace 1 collaboration

Stephen Schmidt 1 collaboration

Steve Sideris 1 collaboration

Heidi Wallweber 1 collaboration

SiewKuen Yeap 1 collaboration

Amy Young 1 collaboration

Yu Zhong 1 collaboration

Charlene Bashore 1 collaboration

Matthew C Johnson 1 collaboration

Ryan J Conrad 1 collaboration

Ivy A Kekessie 1 collaboration

Suzie J Scales 1 collaboration

Noriko Ishisoko 1 collaboration

Peter S Liu 1 collaboration

Aaron T Wecksler 1 collaboration

Lijuan Zhou 1 collaboration

Christine Tam 1 collaboration

Inna Zilberleyb 1 collaboration

Rajini Srinivasan 1 collaboration

Yingnan Zhang 1 collaboration

David Arnott 1 collaboration

Elisia Villemure 1 collaboration

Vladimír Šubrt 1 collaboration

Vladimír Šubr 1 collaboration

Neri Amara 1 collaboration

Madison P Cooper 1 collaboration

Maria A Voronkova 1 collaboration

Bradley A Webb 1 collaboration

Eric M Lynch 1 collaboration

Justin M Kollman 1 collaboration

Taylur Ma 1 collaboration

Zijuan Lai 1 collaboration

Dewakar Sangaraju 1 collaboration

Kim Newton 1 collaboration

Matthew Bogyo 1 collaboration

Vishva M Dixit 1 collaboration

Matthew T Chang 1 collaboration

Thi Thu Thao Nguyen 1 collaboration

Lewis Gazzard 1 collaboration

Robert Piskol 1 collaboration

Yeqing Angela Yang 1 collaboration

Zora Modrusan 1 collaboration

Benjamin Haley 1 collaboration

Marie Evangelista 1 collaboration

Xin Ye 1 collaboration

Jianwen A Feng 1 collaboration

Patrick Lee 1 collaboration

Moulay Hicham Alaoui 1 collaboration

Kathy Barrett 1 collaboration

Georgette Castanedo 1 collaboration

Paul McEwan 1 collaboration

Xiaolu Wang 1 collaboration

Ping Wu 1 collaboration

Yamin Zhang 1 collaboration

Jun Liang 1 collaboration

Xiaojing Wang 1 collaboration

James J Crawford 1 collaboration

Jianwen Feng 1 collaboration

Hans D Brightbill 1 collaboration

Adam R Johnson 1 collaboration

Matthew Wright 1 collaboration

Aleksandr Kolesnikov 1 collaboration

Wendy Lee 1 collaboration

Georgette M Castanedo 1 collaboration

Steven Do 1 collaboration

Po-Chang Chiang 1 collaboration

Peter W Fan 1 collaboration

Matt Baumgardner 1 collaboration

Susan Wong 1 collaboration

Alice Grabbe 1 collaboration

Catharina Wiegel 1 collaboration

Sarah G Hymowitz 1 collaboration

Nicholas Liau 1 collaboration

Peter L Hsu 1 collaboration

Paul A McEwan 1 collaboration

Moulay Hicham Alaoui Ismaili 1 collaboration

Matthew L Landry 1 collaboration

Scott C Rosenberg 1 collaboration

Marc Kschonsak 1 collaboration

Yi J Zeng 1 collaboration

James Lee 1 collaboration

Emile Plise 1 collaboration

Ivana Yen 1 collaboration

Christopher M Rose 1 collaboration

John G Quinn 1 collaboration

Lewis J Gazzard 1 collaboration

Benjamin T Walters 1 collaboration

Donald S Kirkpatrick 1 collaboration

Ena Ladi 1 collaboration

Christine Everett 1 collaboration

Blake E Daniels 1 collaboration

Matthew R Durk 1 collaboration

Malcolm P Huestis 1 collaboration

Martin Augustin 1 collaboration

Michael Blaesse 1 collaboration

Stefan Steinbacher 1 collaboration

Celine Eidenschenk 1 collaboration

Rajita Pappu 1 collaboration

Jeffrey Tom 1 collaboration

Yue Fu 1 collaboration

Wenqiong Wu 1 collaboration

Liang Zeng 1 collaboration

Changlei Sun 1 collaboration

Jie Lin 1 collaboration

Kui Lin 1 collaboration

Yun-Xing Cheng 1 collaboration

Jinping Han 1 collaboration

Jintang He 1 collaboration

Ellen Rei Ingalla 1 collaboration

Amrita V Kamath 1 collaboration

Tommy Lai 1 collaboration

Douglas D Leipold 1 collaboration

Chun Sing Li 1 collaboration

Jiawei Lu 1 collaboration

Lingyao Meng 1 collaboration

Carl Ng 1 collaboration

Kaishan Peng 1 collaboration

Gail Lewis Phillips 1 collaboration

Leanna Staben 1 collaboration

Kunpeng Wan 1 collaboration

Xinxin Wang 1 collaboration

Keyang Xu 1 collaboration

Richard Zang 1 collaboration

Yongxin Zhao 1 collaboration

Micah Steffek 1 collaboration

Lionel Rougé 1 collaboration

John M Bruning 1 collaboration

Ke Sherry Li 1 collaboration

Daniel J Burdick 1 collaboration

Jianping Cai 1 collaboration

Terry Crawford 1 collaboration

Jing Xue 1 collaboration

Willy Decurtins 1 collaboration

Chunlin Fang 1 collaboration

Felix Grubers 1 collaboration

Michael J Holliday 1 collaboration

Allyson Langley 1 collaboration

Ann Petersen 1 collaboration

Alexander Lee Satz 1 collaboration

Daniel Stoffler 1 collaboration

Quentin Strebel 1 collaboration

Jeffrey Y K Tom 1 collaboration

Nicholas Skelton 1 collaboration

Moreno Wichert 1 collaboration

Dennis X Hu 1 collaboration

Snahel Patel 1 collaboration

Huifen Chen 1 collaboration

Shumei Wang 1 collaboration

Yoana N Dimitrova 1 collaboration

Heidi Ackerly Wallweber 1 collaboration

Joanna Y Lee 1 collaboration

Grace Ka Yan Chan 1 collaboration

Christopher J Sneeringer 1 collaboration

Madeleine S Prangley 1 collaboration

John G Moffat 1 collaboration

Kai C Wu 1 collaboration

Leah K Schutt 1 collaboration

Erin McNamara 1 collaboration

Haochu Huang 1 collaboration

Yong Chen 1 collaboration

Yunli Wang 1 collaboration

Wensheng Zhao 1 collaboration

Junghyun Lim 1 collaboration

Aditya Murthy 1 collaboration

Christopher McBride 1 collaboration

Lynnie Trzoss 1 collaboration

Davide Povero 1 collaboration

Milos Lazic 1 collaboration

Geza Ambrus-Aikelin 1 collaboration

Angelina Santini 1 collaboration

Rama Pranadinata 1 collaboration

Gretchen Bain 1 collaboration

Ryan Stansfield 1 collaboration

Jeffrey A Stafford 1 collaboration

James Veal 1 collaboration

Ryan Takahashi 1 collaboration

Justin Ly 1 collaboration

Shu Chen 1 collaboration

Marika Nespi 1 collaboration

Robert Blake 1 collaboration

Arna Katewa 1 collaboration

Nandhini Ramamoorthi 1 collaboration

Jessica Sims 1 collaboration

Brent McKenzie 1 collaboration

Mark Chen 1 collaboration

Matthew Johnson 1 collaboration

Jeremy Murray 1 collaboration

Michael J Townsend 1 collaboration