Sarah G Hymowitz

Affiliations

Structural Biology, Genentech Inc., South San Francisco, CA, USA.

ORCID: 0000-0003-4743-4386

Publications (5)

Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies.

mAbs

Avec: Cholpon Tilegenova , Saeed Izadi , Jianping Yin , Christine S Huang , Jiansheng Wu , Diego Ellerman , Sarah G Hymowitz , Benjamin Walters , Cleo Salisbury , Paul J Carter

Structural basis for SHOC2 modulation of RAS signalling.

Nature

Avec: Nicholas P D Liau , Matthew C Johnson , Saeed Izadi , Luca Gerosa , Michal Hammel , John M Bruning , Timothy J Wendorff , Wilson Phung , Sarah G Hymowitz , Jawahar Sudhamsu

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.

Nature structural & molecular biology

Avec: Nicholas P D Liau , Timothy J Wendorff , John G Quinn , Micah Steffek , Wilson Phung , Peter Liu , Jia Tang , Flaviyan J Irudayanathan , Saeed Izadi , Andrey S Shaw , Shiva Malek , Sarah G Hymowitz , Jawahar Sudhamsu

Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation.

Biochemistry

Avec: Nicholas P D Liau , Avinashnarayan Venkatanarayan , John G Quinn , Wilson Phung , Shiva Malek , Sarah G Hymowitz , Jawahar Sudhamsu

Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.

Bioorganic & medicinal chemistry letters

Avec: James J Crawford , Jianwen Feng , Hans D Brightbill , Adam R Johnson , Matthew Wright , Aleksandr Kolesnikov , Wendy Lee , Georgette M Castanedo , Steven Do , Nicole Blaquiere , Steven T Staben , Po-Chang Chiang , Peter W Fan , Matt Baumgardner , Susan Wong , Robert Godemann , Alice Grabbe , Catharina Wiegel , Swathi Sujatha-Bhaskar , Sarah G Hymowitz , Nicholas Liau , Peter L Hsu , Paul A McEwan , Moulay Hicham Alaoui Ismaili , Matthew L Landry

Réseau de co-auteurs

Saeed Izadi 3 collaborations

Nicholas P D Liau 3 collaborations

Wilson Phung 3 collaborations

Jawahar Sudhamsu 3 collaborations

Timothy J Wendorff 2 collaborations

John G Quinn 2 collaborations

Shiva Malek 2 collaborations

Cholpon Tilegenova 1 collaboration

Jianping Yin 1 collaboration

Christine S Huang 1 collaboration

Jiansheng Wu 1 collaboration

Diego Ellerman 1 collaboration

Benjamin Walters 1 collaboration

Cleo Salisbury 1 collaboration

Paul J Carter 1 collaboration

Matthew C Johnson 1 collaboration

Luca Gerosa 1 collaboration

Michal Hammel 1 collaboration

John M Bruning 1 collaboration

Micah Steffek 1 collaboration

Peter Liu 1 collaboration

Jia Tang 1 collaboration

Flaviyan J Irudayanathan 1 collaboration

Andrey S Shaw 1 collaboration

Avinashnarayan Venkatanarayan 1 collaboration

James J Crawford 1 collaboration

Jianwen Feng 1 collaboration

Hans D Brightbill 1 collaboration

Adam R Johnson 1 collaboration

Matthew Wright 1 collaboration

Aleksandr Kolesnikov 1 collaboration

Wendy Lee 1 collaboration

Georgette M Castanedo 1 collaboration

Steven Do 1 collaboration

Nicole Blaquiere 1 collaboration

Steven T Staben 1 collaboration

Po-Chang Chiang 1 collaboration

Peter W Fan 1 collaboration

Matt Baumgardner 1 collaboration

Susan Wong 1 collaboration

Robert Godemann 1 collaboration

Alice Grabbe 1 collaboration

Catharina Wiegel 1 collaboration

Swathi Sujatha-Bhaskar 1 collaboration

Nicholas Liau 1 collaboration

Peter L Hsu 1 collaboration

Paul A McEwan 1 collaboration

Moulay Hicham Alaoui Ismaili 1 collaboration

Matthew L Landry 1 collaboration