Steve P Gygi

Affiliations
  • Department of Cell Biology, Harvard Medical School, Boston, MA.

Publications (83)

A Triple Knockout Isobaric-Labeling Quality Control Platform with an Integrated Online Database Search.

Journal of the American Society for Mass Spectrometry
Avec: Jeremy P Gygi , Ramin Rad , Jose Navarrete-Perea , Simon Younesi , Steven P Gygi , Joao A Paulo

Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.

Molecular cell
Avec: Zachary J Hauseman , Edward P Harvey , Catherine E Newman , Thomas E Wales , Joel C Bucci , Julian Mintseris , Devin K Schweppe , Liron David , Lixin Fan , Daniel T Cohen , Henry D Herce , Rida Mourtada , Yael Ben-Nun , Noah B Bloch , Scott B Hansen , Hao Wu , Steven P Gygi , John R Engen , Loren D Walensky

A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin.

eLife
Avec: Gergana Shipkovenska , Alexander Durango , Marian Kalocsay , Steven P Gygi , Danesh Moazed

Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF- and M-CSF-Differentiated Bone Marrow-Derived Cells.

Journal of proteome research
Avec: Michael A Giacomantonio , Andra M Sterea , Youra Kim , Joao A Paulo , Derek R Clements , Barry E Kennedy , Moamen J Bydoun , Ge Shi , David M Waisman , Steven P Gygi , Carman A Giacomantonio , J Patrick Murphy , Shashi Gujar

Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance.

Molecular cell
Avec: Nahid Iglesias , Joao A Paulo , Antonis Tatarakis , Xiaoyi Wang , Amanda L Edwards , Natarajan V Bhanu , Benjamin A Garcia , Wilhelm Haas , Steven P Gygi , Danesh Moazed

ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control.

Cell reports
Avec: Matthew C J Yip , Simonas Savickas , Steven P Gygi , Sichen Shao

Parallel Notched Gas-Phase Enrichment for Improved Proteome Identification and Quantification with Fast Spectral Acquisition Rates.

Journal of proteome research
Avec: Brian K Erickson , Devin K Schweppe , Qing Yu , Ramin Rad , Wilhem Haas , Graeme C McAlister , Steven P Gygi

Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity.

Molecular and cellular biology
Avec: Marco Jochem , Lukas Ende , Marta Isasa , Jessie Ang , Helena Schnell , Angel Guerra-Moreno , Yagmur Micoogullari , Meera Bhanu , Steven P Gygi , John Hanna

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs.

Nature chemistry
Avec: Yujia Wang , Melissa M Dix , Giulia Bianco , Jarrett R Remsberg , Hsin-Yu Lee , Marian Kalocsay , Steven P Gygi , Stefano Forli , Gregory Vite , R Michael Lawrence , Christopher G Parker , Benjamin F Cravatt

Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Journal of proteomics
Avec: Joao A Paulo , Jose Navarrete-Perea , Steven P Gygi

Web-Based Search Tool for Visualizing Instrument Performance Using the Triple Knockout (TKO) Proteome Standard.

Journal of proteome research
Avec: Jeremy P Gygi , Qing Yu , Jose Navarrete-Perea , Ramin Rad , Steven P Gygi , Joao A Paulo

Categorization of Phosphorylation Site Behavior during the Diauxic Shift in

Journal of proteome research
Avec: Brandon M Gassaway , Joao A Paulo , Steven P Gygi

Assessing interference in isobaric tag-based sample multiplexing using an 18-plex interference standard.

Proteomics
Avec: Jose Navarrete-Perea , Xinyue Liu , Ramin Rad , Jeremy P Gygi , Steven P Gygi , Joao A Paulo

Proteome-wide mapping of short-lived proteins in human cells.

Molecular cell
Avec: Jiaming Li , Zhenying Cai , Laura Pontano Vaites , Ning Shen , Dylan C Mitchell , Edward L Huttlin , Joao A Paulo , Brian L Harry , Steven P Gygi

Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney.

eLife
Avec: Yuka Takemon , Joel M Chick , Isabela Gerdes Gyuricza , Daniel A Skelly , Olivier Devuyst , Steven P Gygi , Gary A Churchill , Ron Korstanje

Improved Monoisotopic Mass Estimation for Deeper Proteome Coverage.

Journal of proteome research
Avec: Ramin Rad , Jiaming Li , Julian Mintseris , Jeremy O'Connell , Steven P Gygi , Devin K Schweppe

Tetracyclines promote survival and fitness in mitochondrial disease models.

Nature metabolism
Avec: Elizabeth A Perry , Christopher F Bennett , Chi Luo , Eduardo Balsa , Mark Jedrychowski , Katherine E O'Malley , Pedro Latorre-Muro , Richard Porter Ladley , Kamar Reda , Peter M Wright , Steven P Gygi , Andrew G Myers , Pere Puigserver

Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries.

Nature biotechnology
Avec: Miljan Kuljanin , Dylan C Mitchell , Devin K Schweppe , Ajami S Gikandi , David P Nusinow , Nathan J Bulloch , Ekaterina V Vinogradova , David L Wilson , Eric T Kool , Joseph D Mancias , Benjamin F Cravatt , Steven P Gygi

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia.

Nature methods
Avec: Jonathan D Lee , Joao A Paulo , Ryan R Posey , Vera Mugoni , Nikki R Kong , Giulia Cheloni , Yu-Ru Lee , Frank J Slack , Daniel G Tenen , John G Clohessy , Steven P Gygi , Pier Paolo Pandolfi

ADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity.

Redox biology
Avec: Rute A P E Costa , Daniela C Granato , Luciana D Trino , Sami Yokoo , Carolina M Carnielli , Rebeca Kawahara , Romênia R Domingues , Bianca Alves Pauletti , Leandro Xavier Neves , Aline G Santana , Joao A Paulo , Annelize Z B Aragão , Fernanda Aparecida Heleno Batista , Ana Carolina Migliorini Figueira , Francisco R M Laurindo , Denise Fernandes , Hinrich P Hansen , Fabio Squina , Steven P Gygi , Adriana F Paes Leme

A Compendium of Murine (Phospho)Peptides Encompassing Different Isobaric Labeling and Data Acquisition Strategies.

Journal of proteome research
Avec: Olesja Popow , Xinyue Liu , Kevin M Haigis , Steven P Gygi , Joao A Paulo

A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.

Nature
Avec: Peiqiang Feng , Xudong Wu , Satchal K Erramilli , Joao A Paulo , Pawel Knejski , Steven P Gygi , Anthony A Kossiakoff , Tom A Rapoport

Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.

The Journal of biological chemistry
Avec: Qianhui Dou , Anton A Turanov , Marco Mariotti , Jae Yeon Hwang , Huafeng Wang , Sang-Goo Lee , Joao A Paulo , Sun Hee Yim , Stephen P Gygi , Jean-Ju Chung , Vadim N Gladyshev

ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons.

Stem cell reports
Avec: Jacob A Klickstein , Michelle A Johnson , Pantelis Antonoudiou , Jamie Maguire , Joao A Paulo , Chris Weihl , Malavika Raman

A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast.

Nature communications
Avec: Ning Wang , Yoko Shibata , Joao A Paulo , Steven P Gygi , Tom A Rapoport

Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation.

bioRxiv : the preprint server for biology
Avec: Hao Li , Zhejian Ji , Joao A Paulo , Steven P Gygi , Tom A Rapoport

Synaptic Activity Causes Minute-scale Changes in BAF Complex Composition and Function.

bioRxiv : the preprint server for biology
Avec: S Gourisankar , W Wenderski , J A Paulo , S H Kim , K Roepke , C Ellis , S P Gygi , G R Crabtree

Sample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression.

Nature communications
Avec: Qing Yu , Xinyue Liu , Mark P Keller , Jose Navarrete-Perea , Tian Zhang , Sipei Fu , Laura P Vaites , Steven R Shuken , Ernst Schmid , Gregory R Keele , Jiaming Li , Edward L Huttlin , Edrees H Rashan , Judith Simcox , Gary A Churchill , Devin K Schweppe , Alan D Attie , Joao A Paulo , Steven P Gygi

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1α.

bioRxiv : the preprint server for biology
Avec: Phillip A Dumesic , Sarah E Wilensky , Symanthika Bose , Jonathan G Van Vranken , Steven P Gygi , Bruce M Spiegelman

The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia.

Developmental cell
Avec: Swapnil Rohidas Shinde , David U Mick , Erika Aoki , Rachel B Rodrigues , Steven P Gygi , Maxence V Nachury

Multi-omics analysis identifies drivers of protein phosphorylation.

Genome biology
Avec: Tian Zhang , Gregory R Keele , Isabela Gerdes Gyuricza , Matthew Vincent , Catherine Brunton , Timothy A Bell , Pablo Hock , Ginger D Shaw , Steven C Munger , Fernando Pardo-Manuel de Villena , Martin T Ferris , Joao A Paulo , Steven P Gygi , Gary A Churchill

Covalent inhibition of pro-apoptotic BAX.

Nature chemical biology
Avec: Matthew W McHenry , Peiwen Shi , Christina M Camara , Daniel T Cohen , T Justin Rettenmaier , Utsarga Adhikary , Micah A Gygi , Ka Yang , Steven P Gygi , Thomas E Wales , John R Engen , James A Wells , Loren D Walensky

Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays.

bioRxiv : the preprint server for biology
Avec: Jonathan G Van Vranken , Jiaming Li , Julian Mintseris , Meagan Gadzuk-Shea , Steven P Gygi , Devin K Schweppe

Inserting Pre-analytical Chromatographic Priming Runs Significantly Improves Targeted Pathway Proteomics with Sample Multiplexing.

Journal of proteome research
Avec: Steven R Shuken , Qing Yu , Steven P Gygi

Structural transitions enable interleukin-18 maturation and signaling.

Immunity
Avec: Ying Dong , Jeffrey P Bonin , Pascal Devant , Zhuoyi Liang , Alexander I M Sever , Julian Mintseris , James M Aramini , Gang Du , Stephen P Gygi , Jonathan C Kagan , Lewis E Kay , Hao Wu

A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.

Cell
Avec: Juntao Yu , Yujie Zhang , Yimeng Fang , Joao A Paulo , Dadmehr Yaghoubi , Xu Hua , Gergana Shipkovenska , Takenori Toda , Zhiguo Zhang , Steven P Gygi , Songtao Jia , Qing Li , Danesh Moazed

Achieving a 35-Plex Tandem Mass Tag Reagent Set through Deuterium Incorporation.

Journal of proteome research
Avec: Nathan R Zuniga , Dustin C Frost , Karsten Kuhn , Myungsun Shin , Rebecca L Whitehouse , Ting-Yu Wei , Yuchen He , Shane L Dawson , Ian Pike , Ryan D Bomgarden , Steven P Gygi , Joao A Paulo

Structural basis of respiratory complex adaptation to cold temperatures.

Cell
Avec: Young-Cheul Shin , Pedro Latorre-Muro , Amina Djurabekova , Oleksii Zdorevskyi , Christopher F Bennett , Nils Burger , Kangkang Song , Chen Xu , Joao A Paulo , Steven P Gygi , Vivek Sharma , Maofu Liao , Pere Puigserver

UCP1 governs liver extracellular succinate and inflammatory pathogenesis.

Nature metabolism
Avec: Evanna L Mills , Cathal Harmon , Mark P Jedrychowski , Haopeng Xiao , Ryan Garrity , Nhien V Tran , Gary A Bradshaw , Accalia Fu , John Szpyt , Anita Reddy , Hannah Prendeville , Nika N Danial , Steven P Gygi , Lydia Lynch , Edward T Chouchani

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis.

Molecular cell
Avec: Nobuaki Takahashi , Patricia Cho , Laura M Selfors , Hendrik J Kuiken , Roma Kaul , Takuro Fujiwara , Isaac S Harris , Tian Zhang , Steven P Gygi , Joan S Brugge

Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity.

Cell chemical biology
Avec: Valentina Rossio , Joao A Paulo , Joel Chick , Bradley Brasher , Steven P Gygi , Randall W King

Targeting oncoproteins with a positive selection assay for protein degraders.

Science advances
Avec: Vidyasagar Koduri , Leslie Duplaquet , Benjamin L Lampson , Adam C Wang , Amin H Sabet , Mette Ishoey , Joshiawa Paulk , Mingxing Teng , Isaac S Harris , Jennifer E Endress , Xiaoxi Liu , Ethan Dasilva , Joao A Paulo , Kimberly J Briggs , John G Doench , Christopher J Ott , Tinghu Zhang , Katherine A Donovan , Eric S Fischer , Steven P Gygi , Nathanael S Gray , James Bradner , Jeffrey A Medin , Sara J Buhrlage , Matthew G Oser , William G Kaelin

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.

Cell
Avec: Francesca Petralia , Nicole Tignor , Boris Reva , Mateusz Koptyra , Shrabanti Chowdhury , Dmitry Rykunov , Azra Krek , Weiping Ma , Yuankun Zhu , Jiayi Ji , Anna Calinawan , Jeffrey R Whiteaker , Antonio Colaprico , Vasileios Stathias , Tatiana Omelchenko , Xiaoyu Song , Pichai Raman , Yiran Guo , Miguel A Brown , Richard G Ivey , John Szpyt , Sanjukta Guha Thakurta , Marina A Gritsenko , Karl K Weitz , Gonzalo Lopez , Selim Kalayci , Zeynep H Gümüş , Seungyeul Yoo , Felipe da Veiga Leprevost , Hui-Yin Chang , Karsten Krug , Lizabeth Katsnelson , Ying Wang , Jacob J Kennedy , Uliana J Voytovich , Lei Zhao , Krutika S Gaonkar , Brian M Ennis , Bo Zhang , Valerie Baubet , Lamiya Tauhid , Jena V Lilly , Jennifer L Mason , Bailey Farrow , Nathan Young , Sarah Leary , Jamie Moon , Vladislav A Petyuk , Javad Nazarian , Nithin D Adappa , James N Palmer , Robert M Lober , Samuel Rivero-Hinojosa , Liang-Bo Wang , Joshua M Wang , Matilda Broberg , Rosalie K Chu , Ronald J Moore , Matthew E Monroe , Rui Zhao , Richard D Smith , Jun Zhu , Ana I Robles , Mehdi Mesri , Emily Boja , Tara Hiltke , Henry Rodriguez , Bing Zhang , Eric E Schadt , D R Mani , Li Ding , Antonio Iavarone , Maciej Wiznerowicz , Stephan Schürer , Xi S Chen , Allison P Heath , Jo Lynne Rokita , Alexey I Nesvizhskii , David Fenyö , Karin D Rodland , Tao Liu , Steven P Gygi , Amanda G Paulovich , Adam C Resnick , Phillip B Storm , Brian R Rood , Pei Wang , Auteur inconnu , Auteur inconnu

Global proteomics of Ubqln2-based murine models of ALS.

The Journal of biological chemistry
Avec: Alexandra M Whiteley , Miguel A Prado , Stefanie A H de Poot , Joao A Paulo , Marissa Ashton , Sara Dominguez , Martin Weber , Hai Ngu , John Szpyt , Mark P Jedrychowski , Amy Easton , Steven P Gygi , Thimo Kurz , Mervyn J Monteiro , Eric J Brown , Daniel Finley

ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.

Proceedings of the National Academy of Sciences of the United States of America
Avec: Elijah L Mena , Callie J Donahue , Laura Pontano Vaites , Jie Li , Gergely Rona , Colin O'Leary , Luca Lignitto , Bearach Miwatani-Minter , Joao A Paulo , Avantika Dhabaria , Beatrix Ueberheide , Steven P Gygi , Michele Pagano , J Wade Harper , Robert A Davey , Stephen J Elledge

Optimized Workflow for Multiplexed Phosphorylation Analysis of TMT-Labeled Peptides Using High-Field Asymmetric Waveform Ion Mobility Spectrometry.

Journal of proteome research
Avec: Devin K Schweppe , Scott F Rusin , Steven P Gygi , Joao A Paulo

Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy.

Frontiers in neuroscience
Avec: Satoshi Muraoka , Mark P Jedrychowski , Harutsugu Tatebe , Annina M DeLeo , Seiko Ikezu , Takahiko Tokuda , Steven P Gygi , Robert A Stern , Tsuneya Ikezu

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.

Cell stem cell
Avec: Bruno Di Stefano , En-Ching Luo , Chuck Haggerty , Stefan Aigner , Jocelyn Charlton , Justin Brumbaugh , Fei Ji , Inés Rabano Jiménez , Katie J Clowers , Aaron J Huebner , Kendell Clement , Inna Lipchina , Marit A C de Kort , Anthony Anselmo , John Pulice , Mattia F M Gerli , Hongcang Gu , Steven P Gygi , Ruslan I Sadreyev , Alexander Meissner , Gene W Yeo , Konrad Hochedlinger

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.

Cell systems
Avec: Douglas K Brubaker , Joao A Paulo , Shikha Sheth , Emily J Poulin , Olesja Popow , Brian A Joughin , Samantha Dale Strasser , Alina Starchenko , Steven P Gygi , Douglas A Lauffenburger , Kevin M Haigis

Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors.

Stem cells (Dayton, Ohio)
Avec: Larry Sai Weng Loo , Heidrun Vethe , Andreas Alvin Purnomo Soetedjo , Joao A Paulo , Joanita Jasmen , Nicholas Jackson , Yngvild Bjørlykke , Ivan A Valdez , Marc Vaudel , Harald Barsnes , Steven P Gygi , Helge Raeder , Adrian Kee Keong Teo , Rohit N Kulkarni

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria.

eLife
Avec: Sara M Nowinski , Ashley Solmonson , Scott F Rusin , J Alan Maschek , Claire L Bensard , Sarah Fogarty , Mi-Young Jeong , Sandra Lettlova , Jordan A Berg , Jeffrey T Morgan , Yeyun Ouyang , Bradley C Naylor , Joao A Paulo , Katsuhiko Funai , James E Cox , Steven P Gygi , Dennis R Winge , Ralph J DeBerardinis , Jared Rutter

Selection of Heating Temperatures Improves the Sensitivity of the Proteome Integral Solubility Alteration Assay.

Journal of proteome research
Avec: Jiaming Li , Jonathan G Van Vranken , Joao A Paulo , Edward L Huttlin , Steven P Gygi

TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples.

Nature methods
Avec: Jiaming Li , Jonathan G Van Vranken , Laura Pontano Vaites , Devin K Schweppe , Edward L Huttlin , Chris Etienne , Premchendar Nandhikonda , Rosa Viner , Aaron M Robitaille , Andrew H Thompson , Karsten Kuhn , Ian Pike , Ryan D Bomgarden , John C Rogers , Steven P Gygi , Joao A Paulo

Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer.

Cancer discovery
Avec: Seth J Parker , Caroline R Amendola , Kate E R Hollinshead , Qijia Yu , Keisuke Yamamoto , Joel Encarnación-Rosado , Rebecca E Rose , Madeleine M LaRue , Albert S W Sohn , Doug E Biancur , Joao A Paulo , Steven P Gygi , Drew R Jones , Huamin Wang , Mark R Philips , Dafna Bar-Sagi , Joseph D Mancias , Alec C Kimmelman

O-GlcNAc regulates gene expression by controlling detained intron splicing.

Nucleic acids research
Avec: Zhi-Wei Tan , George Fei , Joao A Paulo , Stanislav Bellaousov , Sara E S Martin , Damien Y Duveau , Craig J Thomas , Steven P Gygi , Paul L Boutz , Suzanne Walker

Sample multiplexing for targeted pathway proteomics in aging mice.

Proceedings of the National Academy of Sciences of the United States of America
Avec: Qing Yu , Haopeng Xiao , Mark P Jedrychowski , Devin K Schweppe , Jose Navarrete-Perea , Jeffrey Knott , John Rogers , Edward T Chouchani , Steven P Gygi

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.

Cells
Avec: Satoshi Muraoka , Mark P Jedrychowski , Kiran Yanamandra , Seiko Ikezu , Steven P Gygi , Tsuneya Ikezu

Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities.

Molecular & cellular proteomics : MCP
Avec: Youra Kim , Prathyusha Konda , J Patrick Murphy , Joao A Paulo , Steven P Gygi , Shashi Gujar

Interrogating Kinase-Substrate Relationships with Proximity Labeling and Phosphorylation Enrichment.

Journal of proteome research
Avec: Tian Zhang , Anne Fassl , Laura P Vaites , Sipei Fu , Piotr Sicinski , Joao A Paulo , Steven P Gygi

NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma.

Molecular therapy oncolytics
Avec: Barry E Kennedy , Michael Giacomantonio , J Patrick Murphy , Samuel Cutler , Maryanne Sadek , Prathyusha Konda , Joao A Paulo , Gopal P Pathak , Saskia H J Renkens , Stacy Grieve , Jonathan Pol , Steven P Gygi , Christopher Richardson , Daniel Gaston , Anthony Reiman , Guido Kroemer , Manal O Elnenaei , Shashi A Gujar

Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR.

Cell reports
Avec: Mireia Perez Verdaguer , Tian Zhang , Sachin Surve , Joao A Paulo , Callen Wallace , Simon C Watkins , Steven P Gygi , Alexander Sorkin

Molecular definition of the endogenous Toll-like receptor signalling pathways.

Nature
Avec: Daniel Fisch , Tian Zhang , He Sun , Weiyi Ma , Yunhao Tan , Steven P Gygi , Darren E Higgins , Jonathan C Kagan

Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins.

Bioorganic & medicinal chemistry letters
Avec: Gary Tin , Marko Cigler , Matthias Hinterndorfer , Kevin D Dong , Hana Imrichova , Steven P Gygi , Georg E Winter

Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice.

Nature metabolism
Avec: Helen A B Paterson , Sijia Yu , Natalia Artigas , Miguel A Prado , Nejc Haberman , Yi-Fang Wang , Andrew M Jobbins , Elena Pahita , Joao Mokochinski , Zoe Hall , Maryse Guerin , Joao A Paulo , Soon Seng Ng , Francesc Villarroya , Sheikh Tamir Rashid , Wilfried Le Goff , Boris Lenhard , Inês Cebola , Daniel Finley , Steven P Gygi , Christopher R Sibley , Santiago Vernia

Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics.

Nature communications
Avec: Hankum Park , Frances V Hundley , Qing Yu , Katherine A Overmyer , Dain R Brademan , Lia Serrano , Joao A Paulo , Julia C Paoli , Sharan Swarup , Joshua J Coon , Steven P Gygi , J Wade Harper

MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.

Cell reports
Avec: Michelle S Prew , Utsarga Adhikary , Dong Wook Choi , Erika P Portero , Joao A Paulo , Pruthvi Gowda , Amit Budhraja , Joseph T Opferman , Steven P Gygi , Nika N Danial , Loren D Walensky

Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis.

bioRxiv : the preprint server for biology
Avec: Lisa Elia , Bianca Herting , Amela Alijagic , Christina Buselli , Leela Wong , Grace Morrison , Miguel A Prado , Joao A Paulo , Steven P Gygi , Daniel Finley , Steven Finkbeiner

A proteome-wide atlas of drug mechanism of action.

Nature biotechnology
Avec: Dylan C Mitchell , Miljan Kuljanin , Jiaming Li , Jonathan G Van Vranken , Nathan Bulloch , Devin K Schweppe , Edward L Huttlin , Steven P Gygi

Enriching Cysteine-Containing Peptides Using a Sulfhydryl-Reactive Alkylating Reagent with a Phosphonic Acid Group and Immobilized Metal Affinity Chromatography.

Journal of proteome research
Avec: Xinyue Liu , Valentina Rossio , Steven P Gygi , Joao A Paulo

Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining.

bioRxiv : the preprint server for biology
Avec: Sierra N Cullati , Eric Zhang , Yufan Shan , Rodrigo X Guillen , Jun-Song Chen , Jose Navarrete-Perea , Zachary C Elmore , Liping Ren , Steven P Gygi , Kathleen L Gould

Global and tissue-specific aging effects on murine proteomes.

Cell reports
Avec: Gregory R Keele , Ji-Gang Zhang , John Szpyt , Ron Korstanje , Steven P Gygi , Gary A Churchill , Devin K Schweppe

Metabolic modulation of mitochondrial mass during CD4

Cell chemical biology
Avec: Kiran Kurmi , Dan Liang , Robert van de Ven , Peter Georgiev , Brandon Mark Gassaway , SeongJun Han , Giulia Notarangelo , Isaac S Harris , Cong-Hui Yao , Joon Seok Park , Song-Hua Hu , Jingyu Peng , Jefte M Drijvers , Sarah Boswell , Artem Sokolov , Stephanie K Dougan , Peter K Sorger , Steven P Gygi , Arlene H Sharpe , Marcia C Haigis

Deep Proteomic Compound Profiling with the Orbitrap Ascend Tribrid Mass Spectrometer Using Tandem Mass Tags and Real-Time Search.

Analytical chemistry
Avec: Steven R Shuken , Graeme C McAlister , William D Barshop , Jesse D Canterbury , David Bergen , Jingjing Huang , Romain Huguet , João A Paulo , Vlad Zabrouskov , Steven P Gygi , Qing Yu

The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment.

Developmental cell
Avec: Leya Ledvin , Brandon M Gassaway , Jonathan Tawil , Olivia Urso , Donald Pizzo , Kaeli A Welsh , Derek L Bolhuis , Daniel Fisher , Azad Bonni , Steven P Gygi , Nicholas G Brown , Cole J Ferguson

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.

bioRxiv : the preprint server for biology
Avec: Wayne Mitchell , Ludger J E Goeminne , Alexander Tyshkovskiy , Sirui Zhang , Julie Y Chen , Joao A Paulo , Kerry A Pierce , Angelina H Choy , Clary B Clish , Steven P Gygi , Vadim N Gladyshev

Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.

Cell metabolism
Avec: Jee Hyung Sohn , Beste Mutlu , Pedro Latorre-Muro , Jiaxin Liang , Christopher F Bennett , Kfir Sharabi , Noa Kantorovich , Mark Jedrychowski , Steven P Gygi , Alexander S Banks , Pere Puigserver

Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms.

eLife
Avec: Yeyun Ouyang , Mi-Young Jeong , Corey N Cunningham , Jordan A Berg , Ashish G Toshniwal , Casey E Hughes , Kristina Seiler , Jonathan G Van Vranken , Ahmad A Cluntun , Geanette Lam , Jacob M Winter , Emel Akdoǧan , Katja K Dove , Sara M Nowinski , Matthew West , Greg Odorizzi , Steven P Gygi , Cory D Dunn , Dennis R Winge , Jared Rutter

Inserting Pre-Analytical Chromatographic Priming Runs Significantly Improves Targeted Pathway Proteomics With Sample Multiplexing.

bioRxiv : the preprint server for biology
Avec: Steven R Shuken , Qing Yu , Steven P Gygi

Structural insights into cytokine cleavage by inflammatory caspase-4.

Nature
Avec: Pascal Devant , Ying Dong , Julian Mintseris , Weiyi Ma , Steven P Gygi , Hao Wu , Jonathan C Kagan

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.

eLife
Avec: Wayne Mitchell , Ludger J E Goeminne , Alexander Tyshkovskiy , Sirui Zhang , Julie Y Chen , Joao A Paulo , Kerry A Pierce , Angelina H Choy , Clary B Clish , Steven P Gygi , Vadim N Gladyshev

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle.

Cell metabolism
Avec: Haejin Yoon , Jessica B Spinelli , Elma Zaganjor , Samantha J Wong , Natalie J German , Elizabeth C Randall , Afsah Dean , Allen Clermont , Joao A Paulo , Daniel Garcia , Hao Li , Olivia Rombold , Nathalie Y R Agar , Laurie J Goodyear , Reuben J Shaw , Steven P Gygi , Johan Auwerx , Marcia C Haigis

Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes.

Nature communications
Avec: Aditya S Paul , Alexandra Miliu , Joao A Paulo , Jonathan M Goldberg , Arianna M Bonilla , Laurence Berry , Marie Seveno , Catherine Braun-Breton , Aziz L Kosber , Brendan Elsworth , Jose S N Arriola , Maryse Lebrun , Steven P Gygi , Mauld H Lamarque , Manoj T Duraisingh

WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair.

Cell reports
Avec: Anna Socha , Di Yang , Alicja Bulsiewicz , Kelvin Yaprianto , Marian Kupculak , Chih-Chao Liang , Andreas Hadjicharalambous , Ronghu Wu , Steven P Gygi , Martin A Cohn

Réseau de co-auteurs

Steven P Gygi 79 collaborations
Joao A Paulo 46 collaborations
Devin K Schweppe 11 collaborations
Qing Yu 8 collaborations
Jose Navarrete-Perea 7 collaborations
Jiaming Li 7 collaborations
Tian Zhang 6 collaborations
Jonathan G Van Vranken 6 collaborations
Julian Mintseris 5 collaborations
Edward L Huttlin 5 collaborations
Mark P Jedrychowski 5 collaborations
Ramin Rad 4 collaborations
Xinyue Liu 4 collaborations
Gary A Churchill 4 collaborations
Steven R Shuken 4 collaborations
John Szpyt 4 collaborations
Jeremy P Gygi 3 collaborations
Hao Wu 3 collaborations
Loren D Walensky 3 collaborations
Danesh Moazed 3 collaborations
J Patrick Murphy 3 collaborations
Laura Pontano Vaites 3 collaborations
Dylan C Mitchell 3 collaborations
Christopher F Bennett 3 collaborations
Pedro Latorre-Muro 3 collaborations
Pere Puigserver 3 collaborations
Tom A Rapoport 3 collaborations
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None None 2 collaborations
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