Pavel Majer

Affiliations

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.

Publications (13)

Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.

European journal of medicinal chemistry

Avec: Václav Zima , Kateřina Radilová , Milan Kožíšek , Carlos Berenguer Albiñana , Elena Karlukova , Jiří Brynda , Jindřich Fanfrlík , Miroslav Flieger , Jan Hodek , Jan Weber , Jan Konvalinka , Aleš Machara

Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases.

ACS sensors

Avec: Martin Hadzima , Franco F Faucher , Kristýna Blažková , Joshua J Yim , Matteo Guerra , Shiyu Chen , Emily C Woods , Ki Wan Park , Pavel Šácha , Vladimír Šubr , Libor Kostka , Tomáš Etrych , Jan Konvalinka , Matthew Bogyo

Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Sarka Tumova , Matej Milacek , Ivan Šnajdr , Magesh Muthu , Roman Tuma , David Reha , Pavel Jedlicka , Lenka Bittova , Adela Novotna , David Sedlak , Marek Jindra

Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells.

International journal of molecular sciences

Avec: Jakub Ptacek , Ivan Snajdr , Jiri Schimer , Zsofia Kutil , Jana Mikesova , Petra Baranova , Barbora Havlinova , Werner Tueckmantel , Alan Kozikowski , Cyril Barinka

Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6).

ACS chemical biology

Avec: Lucia Motlová , Ivan Šnajdr , Zsófia Kutil , Erik Andris , Jakub Ptáček , Adéla Novotná , Zora Nováková , Barbora Havlínová , Werner Tueckmantel , Helena Dráberová , Mike Schutkowski , Alan Kozikowski , Lubomír Rulíšek , Cyril Bařinka

3'-Dehydroxypurpurogallin-4-carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, SAR Analysis, and Structural Characterization of Protein Complex.

ChemMedChem

Avec: Ales Machara , Michal Kral , Tomáš Kotačka , Robert Reiberger , Gabriela Panýrková , Kateřina Radilová , Zuzana Osifová , Miroslav Flieger , Jan Konvalinka , Milan Kožíšek

Discovery of

Journal of medicinal chemistry

Avec: Kateřina Novotná , Lukáš Tenora , Eva Prchalová , James Paule , Jesse Alt , Vijay Veeravalli , Jenny Lam , Ying Wu , Ivan Šnajdr , Sadakatali Gori , Vijaya Saradhi Mettu , Takashi Tsukamoto , Barbara S Slusher , Rana Rais

Formation of gadolinium-ferritin from clinical magnetic resonance contrast agents.

Nanoscale advances

Avec: Jitka Neburkova , Aaron M Rulseh , Shery L Y Chang , Helena Raabova , Jana Vejpravova , Martin Dracinsky , Jan Tarabek , Jan Kotek , Mohan Pingle , Josef Vymazal , Petr Cigler

A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.

Science translational medicine

Avec: Diane E Peters , Lauren D Norris , Lukáš Tenora , Ivan Šnajdr , András K Ponti , Xiaolei Zhu , Shinji Sakamoto , Vijayabhaskar Veeravalli , Manisha Pradhan , Jesse Alt , Ajit G Thomas , Rana Rais , Christine McDonald , Barbara S Slusher

The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.

Molecular cancer therapeutics

Avec: Kathryn M Lemberg , Liang Zhao , Ying Wu , Vijayabhaskar Veeravalli , Jesse Alt , Joanna Marie H Aguilar , Ranjeet P Dash , Jenny Lam , Lukáš Tenora , Chabely Rodriguez , Michael T Nedelcovych , Cory Brayton , Jaishri O Blakeley , Rana Rais , Barbara S Slusher

Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.

Journal of medicinal chemistry

Avec: Lukáš Tenora , Jesse Alt , Ranjeet P Dash , Alexandra J Gadiano , Kateřina Novotná , Vijayabhaskar Veeravalli , Jenny Lam , Quinn R Kirkpatrick , Kathryn M Lemberg , Rana Rais , Barbara S Slusher

Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.

Journal of medicinal chemistry

Avec: Radka Houštecká , Martin Hadzima , Jindřich Fanfrlík , Jiří Brynda , Lenka Pallová , Iva Hánová , Helena Mertlíková-Kaiserová , Martin Lepšík , Martin Horn , Martin Smrčina , Michael Mareš

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.

Current drug metabolism

Avec: Jesse Alt , Sadakatali S Gori , Kathryn M Lemberg , Arindom Pal , Vijayabhaskar Veeravalli , Ying Wu , Joanna M H Aguilar , Ranjeet P Dash , Lukáš Tenora , Qi Sun , Barbara S Slusher , Rana Rais

Réseau de co-auteurs

Lukáš Tenora 5 collaborations

Jesse Alt 5 collaborations

Barbara S Slusher 5 collaborations

Rana Rais 5 collaborations

Ivan Šnajdr 4 collaborations

Vijayabhaskar Veeravalli 4 collaborations

Jan Konvalinka 3 collaborations

Jenny Lam 3 collaborations

Ying Wu 3 collaborations

Kathryn M Lemberg 3 collaborations

Ranjeet P Dash 3 collaborations

Kateřina Radilová 2 collaborations

Milan Kožíšek 2 collaborations

Jiří Brynda 2 collaborations

Jindřich Fanfrlík 2 collaborations

Miroslav Flieger 2 collaborations

Martin Hadzima 2 collaborations

Werner Tueckmantel 2 collaborations

Alan Kozikowski 2 collaborations

Kateřina Novotná 2 collaborations

Václav Zima 1 collaboration

Carlos Berenguer Albiñana 1 collaboration

Elena Karlukova 1 collaboration

Jan Hodek 1 collaboration

Jan Weber 1 collaboration

Aleš Machara 1 collaboration

Franco F Faucher 1 collaboration

Kristýna Blažková 1 collaboration

Joshua J Yim 1 collaboration

Matteo Guerra 1 collaboration

Shiyu Chen 1 collaboration

Emily C Woods 1 collaboration

Ki Wan Park 1 collaboration

Pavel Šácha 1 collaboration

Vladimír Šubr 1 collaboration

Libor Kostka 1 collaboration

Tomáš Etrych 1 collaboration

Matthew Bogyo 1 collaboration

Sarka Tumova 1 collaboration

Matej Milacek 1 collaboration

Magesh Muthu 1 collaboration

Roman Tuma 1 collaboration

David Reha 1 collaboration

Pavel Jedlicka 1 collaboration

Lenka Bittova 1 collaboration

Adela Novotna 1 collaboration

David Sedlak 1 collaboration

Marek Jindra 1 collaboration

Jakub Ptacek 1 collaboration

Ivan Snajdr 1 collaboration

Jiri Schimer 1 collaboration

Zsofia Kutil 1 collaboration

Jana Mikesova 1 collaboration

Petra Baranova 1 collaboration

Barbora Havlinova 1 collaboration

Cyril Barinka 1 collaboration

Lucia Motlová 1 collaboration

Zsófia Kutil 1 collaboration

Erik Andris 1 collaboration

Jakub Ptáček 1 collaboration

Adéla Novotná 1 collaboration

Zora Nováková 1 collaboration

Barbora Havlínová 1 collaboration

Helena Dráberová 1 collaboration

Mike Schutkowski 1 collaboration

Lubomír Rulíšek 1 collaboration

Cyril Bařinka 1 collaboration

Ales Machara 1 collaboration

Michal Kral 1 collaboration

Tomáš Kotačka 1 collaboration

Robert Reiberger 1 collaboration

Gabriela Panýrková 1 collaboration

Zuzana Osifová 1 collaboration

Eva Prchalová 1 collaboration

James Paule 1 collaboration

Vijay Veeravalli 1 collaboration

Sadakatali Gori 1 collaboration

Vijaya Saradhi Mettu 1 collaboration

Takashi Tsukamoto 1 collaboration

Jitka Neburkova 1 collaboration

Aaron M Rulseh 1 collaboration

Shery L Y Chang 1 collaboration

Helena Raabova 1 collaboration

Jana Vejpravova 1 collaboration

Martin Dracinsky 1 collaboration

Jan Tarabek 1 collaboration

Jan Kotek 1 collaboration

Mohan Pingle 1 collaboration

Josef Vymazal 1 collaboration

Petr Cigler 1 collaboration

Diane E Peters 1 collaboration

Lauren D Norris 1 collaboration

András K Ponti 1 collaboration

Xiaolei Zhu 1 collaboration

Shinji Sakamoto 1 collaboration

Manisha Pradhan 1 collaboration

Ajit G Thomas 1 collaboration

Christine McDonald 1 collaboration

Liang Zhao 1 collaboration

Joanna Marie H Aguilar 1 collaboration

Chabely Rodriguez 1 collaboration

Michael T Nedelcovych 1 collaboration

Cory Brayton 1 collaboration

Jaishri O Blakeley 1 collaboration

Alexandra J Gadiano 1 collaboration

Quinn R Kirkpatrick 1 collaboration

Radka Houštecká 1 collaboration

Lenka Pallová 1 collaboration

Iva Hánová 1 collaboration

Helena Mertlíková-Kaiserová 1 collaboration

Martin Lepšík 1 collaboration

Martin Horn 1 collaboration

Martin Smrčina 1 collaboration

Michael Mareš 1 collaboration

Sadakatali S Gori 1 collaboration

Arindom Pal 1 collaboration

Joanna M H Aguilar 1 collaboration

Qi Sun 1 collaboration