Cyril Bařinka

Affiliations

Laboratory of Structural Biology , Institute of Biotechnology of the Czech Academy of Sciences , Prumyslova 595 , 252 50 Vestec , Czech Republic.

Publications (20)

Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.

Journal of medicinal chemistry

Avec: Sida Shen , Melissa Hadley , Kseniya Ustinova , Jiri Pavlicek , Tessa Knox , Satish Noonepalle , Mauricio T Tavares , Chad A Zimprich , Guiping Zhang , Matthew B Robers , Cyril Bařinka , Alan P Kozikowski , Alejandro Villagra

Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.

ACS chemical neuroscience

Avec: Alan P Kozikowski , Sida Shen , Marta Pardo , Maurício T Tavares , Dora Szarics , Veronick Benoy , Chad A Zimprich , Zsófia Kutil , Guiping Zhang , Cyril Bařinka , Matthew B Robers , Ludo Van Den Bosch , James H Eubanks , Richard S Jope

Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors.

ACS omega

Avec: Zsófia Kutil , Jana Mikešová , Matthes Zessin , Marat Meleshin , Zora Nováková , Glenda Alquicer , Alan Kozikowski , Wolfgang Sippl , Cyril Bařinka , Mike Schutkowski

Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor.

ACS medicinal chemistry letters

Avec: Sida Shen , Michal Svoboda , Guangming Zhang , Maria A Cavasin , Lucia Motlova , Timothy A McKinsey , James H Eubanks , Cyril Bařinka , Alan P Kozikowski

The avian retroviral receptor Tva mediates the uptake of transcobalamin bound vitamin B12 (cobalamin).

Journal of virology

Avec: Veronika Krchlíková , Jana Mikešová , Josef Geryk , Cyril Bařinka , Ebba Nexo , Sergey N Fedosov , Jan Kosla , Dana Kučerová , Markéta Reinišová , Jiří Hejnar , Daniel Elleder

Cellular Delivery of Bioorthogonal Pretargeting Therapeutics in PSMA-Positive Prostate Cancer.

Molecular pharmaceutics

Avec: Sudath Hapuarachchige , Colin T Huang , Madeline C Donnelly , Cyril Bařinka , Shawn E Lupold , Martin G Pomper , Dmitri Artemov

Development of 5D3-DM1: A Novel Anti-Prostate-Specific Membrane Antigen Antibody-Drug Conjugate for PSMA-Positive Prostate Cancer Therapy.

Molecular pharmaceutics

Avec: Colin T Huang , Xin Guo , Cyril Bařinka , Shawn E Lupold , Martin G Pomper , Kathleen Gabrielson , Venu Raman , Dmitri Artemov , Sudath Hapuarachchige

Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms.

ACS chemical biology

Avec: Matthes Zessin , Marat Meleshin , Lucas Praetorius , Wolfgang Sippl , Cyril Bařinka , Mike Schutkowski

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.

Journal of medicinal chemistry

Avec: Sida Shen , Cristina Picci , Kseniya Ustinova , Veronick Benoy , Zsófia Kutil , Guiping Zhang , Maurício T Tavares , Jiří Pavlíček , Chad A Zimprich , Matthew B Robers , Ludo Van Den Bosch , Cyril Bařinka , Brett Langley , Alan P Kozikowski

A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging.

Nature communications

Avec: Jingming Zhang , Anastasia Rakhimbekova , Xiaojiang Duan , Qingqing Yin , Catherine A Foss , Yan Fan , Yangyang Xu , Xuesong Li , Xuekang Cai , Zsofia Kutil , Pengyuan Wang , Zhi Yang , Ning Zhang , Martin G Pomper , Yiguang Wang , Cyril Bařinka , Xing Yang

Predicting Effects of Site-Directed Mutagenesis on Enzyme Kinetics by QM/MM and QM Calculations: A Case of Glutamate Carboxypeptidase II.

The journal of physical chemistry. B

Avec: Daniel Bím , Michal Navrátil , Ondrej Gutten , Jan Konvalinka , Zsófia Kutil , Martin Culka , Václav Navrátil , Anastassia N Alexandrova , Cyril Bařinka , Lubomír Rulíšek

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatase Sulf-2.

Molecular & cellular proteomics : MCP

Avec: Aswini Panigrahi , Julius Benicky , Reem Aljuhani , Pritha Mukherjee , Zora Nováková , Cyril Bařinka , Radoslav Goldman

Development and therapeutic evaluation of 5D3(CC-MLN8237)

Frontiers in pharmacology

Avec: Ioanna Liatsou , Betelhem Assefa , Wathsala Liyanage , Sharmane Surasinghe , Zora Nováková , Cyril Bařinka , Kathleen Gabrielson , Venu Raman , Dmitri Artemov , Sudath Hapuarachchige

Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein.

The EMBO journal

Avec: Marek Kravec , Ondrej Šedo , Jana Nedvědová , Miroslav Micka , Marie Šulcová , Nikodém Zezula , Kristína Gömöryová , David Potěšil , Ranjani Sri Ganji , Sara Bologna , Igor Červenka , Zbyněk Zdráhal , Jakub Harnoš , Konstantinos Tripsianes , Carsten Janke , Cyril Bařinka , Vítězslav Bryja

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.

Biochemistry

Avec: Matthes Zessin , Zsófia Kutil , Marat Meleshin , Zora Nováková , Ehab Ghazy , Diana Kalbas , Martin Marek , Christophe Romier , Wolfgang Sippl , Cyril Bařinka , Mike Schutkowski

Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.

Journal of medicinal chemistry

Avec: Satish Noonepalle , Sida Shen , Jakub Ptáček , Maurício T Tavares , Guiping Zhang , Jan Stránský , Jiří Pavlíček , Glaucio M Ferreira , Melissa Hadley , Guido Pelaez , Cyril Bařinka , Alan P Kozikowski , Alejandro Villagra

Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers.

Angewandte Chemie (International ed. in English)

Avec: Benjamin P M Lake , Ryan G Wylie , Cyril Bařinka , Anthony F Rullo

SART3 associates with a post-splicing complex.

Journal of cell science

Avec: Klára Klimešová , Hana Petržílková , Cyril Bařinka , David Staněk

Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6).

ACS chemical biology

Avec: Lucia Motlová , Ivan Šnajdr , Zsófia Kutil , Erik Andris , Jakub Ptáček , Adéla Novotná , Zora Nováková , Barbora Havlínová , Werner Tueckmantel , Helena Dráberová , Pavel Majer , Mike Schutkowski , Alan Kozikowski , Lubomír Rulíšek , Cyril Bařinka

Galectin-3-binding protein inhibits extracellular heparan 6-

bioRxiv : the preprint server for biology

Avec: Aswini Panigrahi , Julius Benicky , Reem Aljuhani , Pritha Mukherjee , Zora Nováková , Cyril Bařinka , Radoslav Goldman

Réseau de co-auteurs

Zsófia Kutil 6 collaborations

Zora Nováková 6 collaborations

Sida Shen 5 collaborations

Alan P Kozikowski 5 collaborations

Guiping Zhang 4 collaborations

Mike Schutkowski 4 collaborations

Chad A Zimprich 3 collaborations

Matthew B Robers 3 collaborations

Maurício T Tavares 3 collaborations

Matthes Zessin 3 collaborations

Marat Meleshin 3 collaborations

Wolfgang Sippl 3 collaborations

Sudath Hapuarachchige 3 collaborations

Martin G Pomper 3 collaborations

Dmitri Artemov 3 collaborations

Melissa Hadley 2 collaborations

Kseniya Ustinova 2 collaborations

Satish Noonepalle 2 collaborations

Alejandro Villagra 2 collaborations

Veronick Benoy 2 collaborations

Ludo Van Den Bosch 2 collaborations

James H Eubanks 2 collaborations

Jana Mikešová 2 collaborations

Alan Kozikowski 2 collaborations

Colin T Huang 2 collaborations

Shawn E Lupold 2 collaborations

Kathleen Gabrielson 2 collaborations

Venu Raman 2 collaborations

Jiří Pavlíček 2 collaborations

Lubomír Rulíšek 2 collaborations

Aswini Panigrahi 2 collaborations

Julius Benicky 2 collaborations

Reem Aljuhani 2 collaborations

Pritha Mukherjee 2 collaborations

Radoslav Goldman 2 collaborations

Jakub Ptáček 2 collaborations

Jiri Pavlicek 1 collaboration

Tessa Knox 1 collaboration

Mauricio T Tavares 1 collaboration

Marta Pardo 1 collaboration

Dora Szarics 1 collaboration

Richard S Jope 1 collaboration

Glenda Alquicer 1 collaboration

Michal Svoboda 1 collaboration

Guangming Zhang 1 collaboration

Maria A Cavasin 1 collaboration

Lucia Motlova 1 collaboration

Timothy A McKinsey 1 collaboration

Veronika Krchlíková 1 collaboration

Josef Geryk 1 collaboration

Ebba Nexo 1 collaboration

Sergey N Fedosov 1 collaboration

Jan Kosla 1 collaboration

Dana Kučerová 1 collaboration

Markéta Reinišová 1 collaboration

Jiří Hejnar 1 collaboration

Daniel Elleder 1 collaboration

Madeline C Donnelly 1 collaboration

Xin Guo 1 collaboration

Lucas Praetorius 1 collaboration

Cristina Picci 1 collaboration

Brett Langley 1 collaboration

Jingming Zhang 1 collaboration

Anastasia Rakhimbekova 1 collaboration

Xiaojiang Duan 1 collaboration

Qingqing Yin 1 collaboration

Catherine A Foss 1 collaboration

Yan Fan 1 collaboration

Yangyang Xu 1 collaboration

Xuesong Li 1 collaboration

Xuekang Cai 1 collaboration

Zsofia Kutil 1 collaboration

Pengyuan Wang 1 collaboration

Zhi Yang 1 collaboration

Ning Zhang 1 collaboration

Yiguang Wang 1 collaboration

Xing Yang 1 collaboration

Daniel Bím 1 collaboration

Michal Navrátil 1 collaboration

Ondrej Gutten 1 collaboration

Jan Konvalinka 1 collaboration

Martin Culka 1 collaboration

Václav Navrátil 1 collaboration

Anastassia N Alexandrova 1 collaboration

Ioanna Liatsou 1 collaboration

Betelhem Assefa 1 collaboration

Wathsala Liyanage 1 collaboration

Sharmane Surasinghe 1 collaboration

Marek Kravec 1 collaboration

Ondrej Šedo 1 collaboration

Jana Nedvědová 1 collaboration

Miroslav Micka 1 collaboration

Marie Šulcová 1 collaboration

Nikodém Zezula 1 collaboration

Kristína Gömöryová 1 collaboration

David Potěšil 1 collaboration

Ranjani Sri Ganji 1 collaboration

Sara Bologna 1 collaboration

Igor Červenka 1 collaboration

Zbyněk Zdráhal 1 collaboration

Jakub Harnoš 1 collaboration

Konstantinos Tripsianes 1 collaboration

Carsten Janke 1 collaboration

Vítězslav Bryja 1 collaboration

Ehab Ghazy 1 collaboration

Diana Kalbas 1 collaboration

Martin Marek 1 collaboration

Christophe Romier 1 collaboration

Jan Stránský 1 collaboration

Glaucio M Ferreira 1 collaboration

Guido Pelaez 1 collaboration

Benjamin P M Lake 1 collaboration

Ryan G Wylie 1 collaboration

Anthony F Rullo 1 collaboration

Klára Klimešová 1 collaboration

Hana Petržílková 1 collaboration

David Staněk 1 collaboration

Lucia Motlová 1 collaboration

Ivan Šnajdr 1 collaboration

Erik Andris 1 collaboration

Adéla Novotná 1 collaboration

Barbora Havlínová 1 collaboration

Werner Tueckmantel 1 collaboration

Helena Dráberová 1 collaboration

Pavel Majer 1 collaboration