Edmund R S Kunji

Affiliations

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. jh@mrc-mbu.cam.ac.uk ek@mrc-mbu.cam.ac.uk walker@mrc-mbu.cam.ac.uk.

ORCID: 0000-0002-0610-4500

Publications (27)

Comment on "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry".

Science (New York, N.Y.)

Avec: Judy Hirst , John E Walker

Exome sequencing identifies a disease variant of the mitochondrial ATP-Mg/Pi carrier SLC25A25 in two families with kidney stones.

Molecular genetics & genomic medicine

Avec: M Reza Jabalameli , Fiona M Fitzpatrick , Roberto Colombo , Sarah A Howles , Gary Leggatt , Valerie Walker , Akira Wiberg , Sarah Ennis

Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle.

Nature communications

Avec: Vasiliki Mavridou , Martin S King , Sotiria Tavoulari , Jonathan J Ruprecht , Shane M Palmer ,

Structural insight into mitochondrial β-barrel outer membrane protein biogenesis.

Nature communications

Avec: Kathryn A Diederichs , Xiaodan Ni , Sarah E Rollauer , Istvan Botos , Xiaofeng Tan , Martin S King , Jiansen Jiang , Susan K Buchanan

The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology.

Physiology (Bethesda, Md.)

Avec: Martin S King , Jonathan J Ruprecht , Chancievan Thangaratnarajah

Structural basis of purine nucleotide inhibition of human uncoupling protein 1.

Science advances

Avec: Scott A Jones , Prerana Gogoi , Jonathan J Ruprecht , Martin S King , Yang Lee , Thomas Zögg , Els Pardon , Deepak Chand , Stefan Steimle , Danielle M Copeman , Camila A Cotrim , Jan Steyaert , Paul G Crichton , Vera Moiseenkova-Bell ,

Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition.

Acta physiologica (Oxford, England)

Avec: Sotiria Tavoulari , Maximilian Sichrovsky ,

Synthetic syntrophy for adenine nucleotide cross-feeding between metabolically active nanoreactors.

Nature nanotechnology

Avec: Laura Heinen , Marco van den Noort , Martin S King , Bert Poolman

Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport.

Molecular metabolism

Avec: Sotiria Tavoulari , Denis Lacabanne , Gonçalo C Pereira , Chancievan Thangaratnarajah , Martin S King , Jiuya He , Roy Chowdhury , Lisa Tilokani , Shane M Palmer , Julien Prudent , John E Walker ,

Correction: Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

Genetics in medicine : official journal of the American College of Medical Genetics

Avec: V Boczonadi , M S King , A C Smith , M Olahova , B Bansagi , A Roos , F Eyassu , C Borchers , V Ramesh , H Lochmüller , T Polvikoski , R G Whittaker , A Pyle , H Griffin , R W Taylor , P F Chinnery , A J Robinson , E R S Kunji , R Horvath

Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis.

Trends in biochemical sciences

Avec: Scott A Jones , Jonathan J Ruprecht , Paul G Crichton ,

A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite

eLife

Avec: Eva Pyrihová , Martin S King , Alannah C King , M Rey Toleco , Mark van der Giezen ,

Structural Mechanism of Transport of Mitochondrial Carriers.

Annual review of biochemistry

Avec: J J Ruprecht , E R S Kunji

Thermostability Assays: a Generic and Versatile Tool for Studying the Functional and Structural Properties of Membrane Proteins in Detergents.

Methods in molecular biology (Clifton, N.J.)

Avec: Steven P D Harborne , Martin S King ,

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier.

Cell

Avec: Jonathan J Ruprecht , Martin S King , Thomas Zögg , Antoniya A Aleksandrova , Els Pardon , Paul G Crichton , Jan Steyaert ,

Expression and Purification of Membrane Proteins in Saccharomyces cerevisiae.

Methods in molecular biology (Clifton, N.J.)

Avec: Martin S King ,

Structure, substrate binding, and symmetry of the mitochondrial ADP/ATP carrier in its matrix-open state.

Biophysical journal

Avec: Joel José Montalvo-Acosta , Jonathan J Ruprecht , François Dehez , Christophe Chipot

Pathogenic variants of the mitochondrial aspartate/glutamate carrier causing citrin deficiency.

Trends in endocrinology and metabolism: TEM

Avec: Sotiria Tavoulari , Denis Lacabanne , Chancievan Thangaratnarajah ,

TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia.

Brain : a journal of neurology

Avec: Luis Carlos Tábara , Fatema Al-Salmi , Reza Maroofian , Amna Mohammed Al-Futaisi , Fathiya Al-Murshedi , Joanna Kennedy , Jacob O Day , Thomas Courtin , Aisha Al-Khayat , Hamid Galedari , Neda Mazaheri , Margherita Protasoni , Mark Johnson , Joseph S Leslie , Claire G Salter , Lettie E Rawlins , James Fasham , Almundher Al-Maawali , Nikol Voutsina , Perrine Charles , Laura Harrold , Boris Keren , Barbara Vona , Gholamreza Jelodar , Alireza Sedaghat , Gholamreza Shariati , Henry Houlden , Andrew H Crosby , Julien Prudent , Emma L Baple

Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site.

Science advances

Avec: Vasiliki Mavridou , Martin S King , Andre Bazzone , Roger Springett ,

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.

Trends in biochemical sciences

Avec: Jonathan J Ruprecht ,

The mitochondrial ADP/ATP carrier exists and functions as a monomer.

Biochemical Society transactions

Avec: Jonathan J Ruprecht

Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition.

Theranostics

Avec: Stephany Jaiquel Baron , Martin S King , Tom J J Schirris

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer.

Molecular metabolism

Avec: Sotiria Tavoulari , Tom J J Schirris , Vasiliki Mavridou , Chancievan Thangaratnarajah , Martin S King , Daniel T D Jones , Shujing Ding , Ian M Fearnley ,

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis.

Molecular metabolism

Avec: Riccardo Cavalieri , Marlou Klein Hazebroek , Camila A Cotrim , Yang Lee , Martin Jastroch , Susanne Keipert , Paul G Crichton

The Concise Guide to PHARMACOLOGY 2023/24: Transporters.

British journal of pharmacology

Avec: Stephen P H Alexander , Doriano Fabbro , Eamonn Kelly , Alistair A Mathie , John A Peters , Emma L Veale , Jane F Armstrong , Elena Faccenda , Simon D Harding , Jamie A Davies , Laura Amarosi , Catriona M H Anderson , Philip M Beart , Stefan Broer , Paul A Dawson , Gergely Gyimesi , Bruno Hagenbuch , James R Hammond , Jules C Hancox , Michal Hershfinkel , Ken-Ichi Inui , Yoshikatsu Kanai , Stephan Kemp , Gavin Stewart , Sotiria Tavoulari , David T Thwaites , Tiziano Verri

The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools.

Archives of biochemistry and biophysics

Avec: Justyna Zítek , Martin S King , Priscila Peña-Diaz , Eva Pyrihová , Alannah C King , Vladimír Hampl

Réseau de co-auteurs

Martin S King 14 collaborations

Jonathan J Ruprecht 8 collaborations

Sotiria Tavoulari 6 collaborations

Chancievan Thangaratnarajah 4 collaborations

Paul G Crichton 4 collaborations

Vasiliki Mavridou 3 collaborations

John E Walker 2 collaborations

Shane M Palmer 2 collaborations

Scott A Jones 2 collaborations

Yang Lee 2 collaborations

Thomas Zögg 2 collaborations

Els Pardon 2 collaborations

Camila A Cotrim 2 collaborations

Jan Steyaert 2 collaborations

Denis Lacabanne 2 collaborations

Julien Prudent 2 collaborations

E R S Kunji 2 collaborations

Eva Pyrihová 2 collaborations

Alannah C King 2 collaborations

Tom J J Schirris 2 collaborations

Judy Hirst 1 collaboration

M Reza Jabalameli 1 collaboration

Fiona M Fitzpatrick 1 collaboration

Roberto Colombo 1 collaboration

Sarah A Howles 1 collaboration

Gary Leggatt 1 collaboration

Valerie Walker 1 collaboration

Akira Wiberg 1 collaboration

Sarah Ennis 1 collaboration

Kathryn A Diederichs 1 collaboration

Xiaodan Ni 1 collaboration

Sarah E Rollauer 1 collaboration

Istvan Botos 1 collaboration

Xiaofeng Tan 1 collaboration

Jiansen Jiang 1 collaboration

Susan K Buchanan 1 collaboration

Prerana Gogoi 1 collaboration

Deepak Chand 1 collaboration

Stefan Steimle 1 collaboration

Danielle M Copeman 1 collaboration

Vera Moiseenkova-Bell 1 collaboration

Maximilian Sichrovsky 1 collaboration

Laura Heinen 1 collaboration

Marco van den Noort 1 collaboration

Bert Poolman 1 collaboration

Gonçalo C Pereira 1 collaboration

Jiuya He 1 collaboration

Roy Chowdhury 1 collaboration

Lisa Tilokani 1 collaboration

V Boczonadi 1 collaboration

M S King 1 collaboration

A C Smith 1 collaboration

M Olahova 1 collaboration

B Bansagi 1 collaboration

A Roos 1 collaboration

F Eyassu 1 collaboration

C Borchers 1 collaboration

V Ramesh 1 collaboration

H Lochmüller 1 collaboration

T Polvikoski 1 collaboration

R G Whittaker 1 collaboration

A Pyle 1 collaboration

H Griffin 1 collaboration

R W Taylor 1 collaboration

P F Chinnery 1 collaboration

A J Robinson 1 collaboration

R Horvath 1 collaboration

M Rey Toleco 1 collaboration

Mark van der Giezen 1 collaboration

J J Ruprecht 1 collaboration

Steven P D Harborne 1 collaboration

Antoniya A Aleksandrova 1 collaboration

Joel José Montalvo-Acosta 1 collaboration

François Dehez 1 collaboration

Christophe Chipot 1 collaboration

Luis Carlos Tábara 1 collaboration

Fatema Al-Salmi 1 collaboration

Reza Maroofian 1 collaboration

Amna Mohammed Al-Futaisi 1 collaboration

Fathiya Al-Murshedi 1 collaboration

Joanna Kennedy 1 collaboration

Jacob O Day 1 collaboration

Thomas Courtin 1 collaboration

Aisha Al-Khayat 1 collaboration

Hamid Galedari 1 collaboration

Neda Mazaheri 1 collaboration

Margherita Protasoni 1 collaboration

Mark Johnson 1 collaboration

Joseph S Leslie 1 collaboration

Claire G Salter 1 collaboration

Lettie E Rawlins 1 collaboration

James Fasham 1 collaboration

Almundher Al-Maawali 1 collaboration

Nikol Voutsina 1 collaboration

Perrine Charles 1 collaboration

Laura Harrold 1 collaboration

Boris Keren 1 collaboration

Barbara Vona 1 collaboration

Gholamreza Jelodar 1 collaboration

Alireza Sedaghat 1 collaboration

Gholamreza Shariati 1 collaboration

Henry Houlden 1 collaboration

Andrew H Crosby 1 collaboration

Emma L Baple 1 collaboration

Andre Bazzone 1 collaboration

Roger Springett 1 collaboration

Stephany Jaiquel Baron 1 collaboration

Daniel T D Jones 1 collaboration

Shujing Ding 1 collaboration

Ian M Fearnley 1 collaboration

Riccardo Cavalieri 1 collaboration

Marlou Klein Hazebroek 1 collaboration

Martin Jastroch 1 collaboration

Susanne Keipert 1 collaboration

Stephen P H Alexander 1 collaboration

Doriano Fabbro 1 collaboration

Eamonn Kelly 1 collaboration

Alistair A Mathie 1 collaboration

John A Peters 1 collaboration

Emma L Veale 1 collaboration

Jane F Armstrong 1 collaboration

Elena Faccenda 1 collaboration

Simon D Harding 1 collaboration

Jamie A Davies 1 collaboration

Laura Amarosi 1 collaboration

Catriona M H Anderson 1 collaboration

Philip M Beart 1 collaboration

Stefan Broer 1 collaboration

Paul A Dawson 1 collaboration

Gergely Gyimesi 1 collaboration

Bruno Hagenbuch 1 collaboration

James R Hammond 1 collaboration

Jules C Hancox 1 collaboration

Michal Hershfinkel 1 collaboration

Ken-Ichi Inui 1 collaboration

Yoshikatsu Kanai 1 collaboration

Stephan Kemp 1 collaboration

Gavin Stewart 1 collaboration

David T Thwaites 1 collaboration

Tiziano Verri 1 collaboration

Justyna Zítek 1 collaboration

Priscila Peña-Diaz 1 collaboration

Vladimír Hampl 1 collaboration