The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
Animals
Cysteine Endopeptidases
/ metabolism
Deubiquitinating Enzyme CYLD
/ metabolism
Deubiquitinating Enzymes
/ metabolism
Female
HEK293 Cells
HeLa Cells
Humans
Inflammation
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
NF-kappa B
/ metabolism
Polyubiquitin
/ metabolism
Proteasome Endopeptidase Complex
/ metabolism
Signal Transduction
/ physiology
Transcription Factor RelA
Tumor Necrosis Factor-alpha
/ metabolism
Ubiquitin
/ metabolism
Ubiquitin-Protein Ligases
/ metabolism
Ubiquitination
CYLD
NF-kappa B (NF-KB)
NF-κB pathway
autoimmunity
cellular immune response
inflammation
mind bomb E3 ubiquitin protein ligase 2
mind bomb homologue 2 (MIB2)
multiple familial trichoepithelioma (MFT)
protein array
ubiquitin
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
received:
09
07
2019
pubmed:
2
8
2019
medline:
13
5
2020
entrez:
2
8
2019
Statut:
ppublish
Résumé
The tumor suppressor CYLD is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth-promoting NF-κB pathway. Missense mutations in the
Identifiants
pubmed: 31366726
pii: S0021-9258(20)32096-2
doi: 10.1074/jbc.RA119.010119
pmc: PMC6755803
doi:
Substances chimiques
NF-kappa B
0
RELA protein, human
0
Transcription Factor RelA
0
Tumor Necrosis Factor-alpha
0
Ubiquitin
0
Polyubiquitin
120904-94-1
MIB2 protein, human
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
CYLD protein, human
EC 3.4.19.12
CYLD protein, mouse
EC 3.4.19.12
Deubiquitinating Enzyme CYLD
EC 3.4.19.12
Deubiquitinating Enzymes
EC 3.4.19.12
Cysteine Endopeptidases
EC 3.4.22.-
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14135-14148Informations de copyright
© 2019 Uematsu et al.
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