Complex regulation of ecto-5'-nucleotidase/CD73 and A
A(1)R
A(2A)R
Adenosine
Astrocytes
Chronic neuroinflammation
Ecto-5′-nucleotidase/CD73
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
29
11
2018
revised:
01
04
2019
accepted:
03
04
2019
pubmed:
8
4
2019
medline:
24
3
2020
entrez:
8
4
2019
Statut:
ppublish
Résumé
The review summarizes available data regarding the complex regulation of CD73 at the neurovascular unit (NVU) during neuroinflammation. Based on available data we propose the biphasic pattern of CD73 regulation at NVU, with an early attenuation and a postponed up-regulation of CD73 activity. Transient attenuation of CD73 activity on leukocyte/vascular endothelium and leukocyte/astrocyte surface, required for the initiation of a neuroinflammatory response, may be effectuated either by catalytic inhibition of CD73 and/or by shedding of the CD73 molecule from the cell surface, while postponed induction of CD73 is effectuated by transcriptional up-regulation of Nt5e and posttranslational modifications. Neuroinflammatory conditions are also associated with significant enhancement and gain-of-function of A
Identifiants
pubmed: 30954629
pii: S1043-6618(18)31909-1
doi: 10.1016/j.phrs.2019.04.007
pii:
doi:
Substances chimiques
GPI-Linked Proteins
0
Receptor, Adenosine A2A
0
5'-Nucleotidase
EC 3.1.3.5
NT5E protein, human
EC 3.1.3.5
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-115Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.