William Farnaby

Affiliations
  • Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee, James Black Centre , Dow Street , Dundee DD1 5EH , United Kingdom.

Publications (12)

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.

ACS chemical biology
Avec: Michael J Roy , Sandra Winkler , Scott J Hughes , Claire Whitworth , Michael Galant , William Farnaby , Klaus Rumpel , Alessio Ciulli

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Nature chemical biology
Avec: William Farnaby , Manfred Koegl , Michael J Roy , Claire Whitworth , Emelyne Diers , Nicole Trainor , David Zollman , Steffen Steurer , Jale Karolyi-Oezguer , Carina Riedmueller , Teresa Gmaschitz , Johannes Wachter , Christian Dank , Michael Galant , Bernadette Sharps , Klaus Rumpel , Elisabeth Traxler , Thomas Gerstberger , Renate Schnitzer , Oliver Petermann , Peter Greb , Harald Weinstabl , Gerd Bader , Andreas Zoephel , Alexander Weiss-Puxbaum , Katharina Ehrenhöfer-Wölfer , Simon Wöhrle , Guido Boehmelt , Joerg Rinnenthal , Heribert Arnhof , Nicola Wiechens , Meng-Ying Wu , Tom Owen-Hughes , Peter Ettmayer , Mark Pearson , Darryl B McConnell , Alessio Ciulli

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders.

Nature communications
Avec: Alena Kroupova , Valentina A Spiteri , Zoe J Rutter , Hirotake Furihata , Darren Darren , Sarath Ramachandran , Sohini Chakraborti , Kevin Haubrich , Julie Pethe , Denzel Gonzales , Andre J Wijaya , Maria Rodriguez-Rios , Manon Sturbaut , Dylan M Lynch , William Farnaby , Mark A Nakasone , David Zollman , Alessio Ciulli

Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).

Journal of medicinal chemistry
Avec: Tatsuki Koike , Masato Yoshikawa , Haruhi Kamisaki Ando , William Farnaby , Toshiya Nishi , Etsurou Watanabe , Jason Yano , Maki Miyamoto , Shigeru Kondo , Tsuyoshi Ishii , Takanobu Kuroita

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Nature chemical biology
Avec: William Farnaby , Manfred Koegl , Michael J Roy , Claire Whitworth , Emelyne Diers , Nicole Trainor , David Zollman , Steffen Steurer , Jale Karolyi-Oezguer , Carina Riedmueller , Teresa Gmaschitz , Johannes Wachter , Christian Dank , Michael Galant , Bernadette Sharps , Klaus Rumpel , Elisabeth Traxler , Thomas Gerstberger , Renate Schnitzer , Oliver Petermann , Peter Greb , Harald Weinstabl , Gerd Bader , Andreas Zoephel , Alexander Weiss-Puxbaum , Katharina Ehrenhöfer-Wölfer , Simon Wöhrle , Guido Boehmelt , Joerg Rinnenthal , Heribert Arnhof , Nicola Wiechens , Meng-Ying Wu , Tom Owen-Hughes , Peter Ettmayer , Mark Pearson , Darryl B McConnell , Alessio Ciulli

Transforming targeted cancer therapy with PROTACs: A forward-looking perspective.

Current opinion in pharmacology
Avec: William Farnaby , Manfred Koegl , Darryl B McConnell , Alessio Ciulli

Confounding Factors in Targeted Degradation of Short-Lived Proteins.

ACS chemical biology
Avec: Vesna Vetma , Laura Casares Perez , Ján Eliaš , Andrea Stingu , Anju Kombara , Teresa Gmaschitz , Nina Braun , Tuncay Ciftci , Georg Dahmann , Emelyne Diers , Thomas Gerstberger , Peter Greb , Giorgia Kidd , Christiane Kofink , Ilaria Puoti , Valentina Spiteri , Nicole Trainor , Harald Weinstabl , Yvonne Westermaier , Claire Whitworth , Alessio Ciulli , William Farnaby , Kirsten McAulay , Aileen B Frost , Nicola Chessum , Manfred Koegl

Targeting cancer with small-molecule pan-KRAS degraders.

Science (New York, N.Y.)
Avec: Johannes Popow , William Farnaby , Andreas Gollner , Christiane Kofink , Gerhard Fischer , Melanie Wurm , David Zollman , Andre Wijaya , Nikolai Mischerikow , Carina Hasenoehrl , Polina Prokofeva , Heribert Arnhof , Silvia Arce-Solano , Sammy Bell , Georg Boeck , Emelyne Diers , Aileen B Frost , Jake Goodwin-Tindall , Jale Karolyi-Oezguer , Shakil Khan , Theresa Klawatsch , Manfred Koegl , Roland Kousek , Barbara Kratochvil , Katrin Kropatsch , Arnel A Lauber , Ross McLennan , Sabine Olt , Daniel Peter , Oliver Petermann , Vanessa Roessler , Peggy Stolt-Bergner , Patrick Strack , Eva Strauss , Nicole Trainor , Vesna Vetma , Claire Whitworth , Siying Zhong , Jens Quant , Harald Weinstabl , Bernhard Kuster , Peter Ettmayer , Alessio Ciulli

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.

Scientific reports
Avec: Toshiya Nishi , Shinichi Kondo , Maki Miyamoto , Sayuri Watanabe , Shigeo Hasegawa , Shigeru Kondo , Jason Yano , Etsurou Watanabe , Tsuyoshi Ishi , Masato Yoshikawa , Haruhi Kamisaki Ando , William Farnaby , Shinji Fujimoto , Eiji Sunahara , Momoko Ohori , Matthew J During , Takanobu Kuroita , Tatsuki Koike

Breaking free from the crystal lattice: Structural biology in solution to study protein degraders.

Current opinion in structural biology
Avec: Kevin Haubrich , Valentina A Spiteri , William Farnaby , Frank Sobott , Alessio Ciulli

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.

Nature communications
Avec: Christiane Kofink , Nicole Trainor , Barbara Mair , Simon Wöhrle , Melanie Wurm , Nikolai Mischerikow , Michael J Roy , Gerd Bader , Peter Greb , Géraldine Garavel , Emelyne Diers , Ross McLennan , Claire Whitworth , Vesna Vetma , Klaus Rumpel , Maximilian Scharnweber , Julian E Fuchs , Thomas Gerstberger , Yunhai Cui , Gabriela Gremel , Paolo Chetta , Stefan Hopf , Nicole Budano , Joerg Rinnenthal , Gerhard Gmaschitz , Moriz Mayer , Manfred Koegl , Alessio Ciulli , Harald Weinstabl , William Farnaby

Crystallization of VHL-based PROTAC-induced ternary complexes.

Methods in enzymology
Avec: Andre J Wijaya , William Farnaby , Alessio Ciulli

Réseau de co-auteurs

Alessio Ciulli 10 collaborations
Claire Whitworth 6 collaborations
Manfred Koegl 6 collaborations
Emelyne Diers 5 collaborations
Nicole Trainor 5 collaborations
Harald Weinstabl 5 collaborations
Michael J Roy 4 collaborations
Klaus Rumpel 4 collaborations
David Zollman 4 collaborations
Thomas Gerstberger 4 collaborations
Peter Greb 4 collaborations
Michael Galant 3 collaborations
Jale Karolyi-Oezguer 3 collaborations
Teresa Gmaschitz 3 collaborations
Oliver Petermann 3 collaborations
Gerd Bader 3 collaborations
Simon Wöhrle 3 collaborations
Joerg Rinnenthal 3 collaborations
Heribert Arnhof 3 collaborations
Peter Ettmayer 3 collaborations
Darryl B McConnell 3 collaborations
Vesna Vetma 3 collaborations
Christiane Kofink 3 collaborations
Steffen Steurer 2 collaborations
Carina Riedmueller 2 collaborations
Johannes Wachter 2 collaborations
Christian Dank 2 collaborations
Bernadette Sharps 2 collaborations
Elisabeth Traxler 2 collaborations
Renate Schnitzer 2 collaborations
Andreas Zoephel 2 collaborations
Alexander Weiss-Puxbaum 2 collaborations
Katharina Ehrenhöfer-Wölfer 2 collaborations
Guido Boehmelt 2 collaborations
Nicola Wiechens 2 collaborations
Meng-Ying Wu 2 collaborations
Tom Owen-Hughes 2 collaborations
Mark Pearson 2 collaborations
Valentina A Spiteri 2 collaborations
Kevin Haubrich 2 collaborations
Andre J Wijaya 2 collaborations
Tatsuki Koike 2 collaborations
Masato Yoshikawa 2 collaborations
Haruhi Kamisaki Ando 2 collaborations
Toshiya Nishi 2 collaborations
Etsurou Watanabe 2 collaborations
Jason Yano 2 collaborations
Maki Miyamoto 2 collaborations
Shigeru Kondo 2 collaborations
Takanobu Kuroita 2 collaborations
Aileen B Frost 2 collaborations
Melanie Wurm 2 collaborations
Nikolai Mischerikow 2 collaborations
Ross McLennan 2 collaborations
Sandra Winkler 1 collaboration
Scott J Hughes 1 collaboration
Alena Kroupova 1 collaboration
Zoe J Rutter 1 collaboration
Hirotake Furihata 1 collaboration
Darren Darren 1 collaboration
Sarath Ramachandran 1 collaboration
Sohini Chakraborti 1 collaboration
Julie Pethe 1 collaboration
Denzel Gonzales 1 collaboration
Maria Rodriguez-Rios 1 collaboration
Manon Sturbaut 1 collaboration
Dylan M Lynch 1 collaboration
Mark A Nakasone 1 collaboration
Tsuyoshi Ishii 1 collaboration
Laura Casares Perez 1 collaboration
Ján Eliaš 1 collaboration
Andrea Stingu 1 collaboration
Anju Kombara 1 collaboration
Nina Braun 1 collaboration
Tuncay Ciftci 1 collaboration
Georg Dahmann 1 collaboration
Giorgia Kidd 1 collaboration
Ilaria Puoti 1 collaboration
Valentina Spiteri 1 collaboration
Yvonne Westermaier 1 collaboration
Kirsten McAulay 1 collaboration
Nicola Chessum 1 collaboration
Johannes Popow 1 collaboration
Andreas Gollner 1 collaboration
Gerhard Fischer 1 collaboration
Andre Wijaya 1 collaboration
Carina Hasenoehrl 1 collaboration
Polina Prokofeva 1 collaboration
Silvia Arce-Solano 1 collaboration
Sammy Bell 1 collaboration
Georg Boeck 1 collaboration
Jake Goodwin-Tindall 1 collaboration
Shakil Khan 1 collaboration
Theresa Klawatsch 1 collaboration
Roland Kousek 1 collaboration
Barbara Kratochvil 1 collaboration
Katrin Kropatsch 1 collaboration
Arnel A Lauber 1 collaboration
Sabine Olt 1 collaboration
Daniel Peter 1 collaboration
Vanessa Roessler 1 collaboration
Peggy Stolt-Bergner 1 collaboration
Patrick Strack 1 collaboration
Eva Strauss 1 collaboration
Siying Zhong 1 collaboration
Jens Quant 1 collaboration
Bernhard Kuster 1 collaboration
Shinichi Kondo 1 collaboration
Sayuri Watanabe 1 collaboration
Shigeo Hasegawa 1 collaboration
Tsuyoshi Ishi 1 collaboration
Shinji Fujimoto 1 collaboration
Eiji Sunahara 1 collaboration
Momoko Ohori 1 collaboration
Matthew J During 1 collaboration
Frank Sobott 1 collaboration
Barbara Mair 1 collaboration
Géraldine Garavel 1 collaboration
Maximilian Scharnweber 1 collaboration
Julian E Fuchs 1 collaboration
Yunhai Cui 1 collaboration
Gabriela Gremel 1 collaboration
Paolo Chetta 1 collaboration
Stefan Hopf 1 collaboration
Nicole Budano 1 collaboration
Gerhard Gmaschitz 1 collaboration
Moriz Mayer 1 collaboration