Harald Weinstabl

Affiliations

Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer, Gasse 5-Wien, 11, 1121, Vienna.

Publications (19)

Chembiochem : a European journal of chemical biology

Avec: Giorgia Toscano , Theresa Höfurthner , Benjamin Nagl , Andreas Beier , Moriz Mayer , Leonhard Geist , Darryl B McConnell , Harald Weinstabl , Robert Konrat , Roman J Lichtenecker

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice.

GeroScience

Avec: Georgia L Nolt , Alexander R Keeble , Yuan Wen , Aubrey C Strong , Nicholas T Thomas , Taylor R Valentino , Camille R Brightwell , Kevin A Murach , Sini Patrizia , Harald Weinstabl , Andreas Gollner , John J McCarthy , Christopher S Fry , Michael Franti , Antonio Filareto , Charlotte A Peterson , Cory M Dungan

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor

Journal of medicinal chemistry

Avec: Harald Weinstabl , Matthias Treu , Joerg Rinnenthal , Stephan K Zahn , Peter Ettmayer , Gerd Bader , Georg Dahmann , Dirk Kessler , Klaus Rumpel , Nikolai Mischerikow , Fabio Savarese , Thomas Gerstberger , Moriz Mayer , Andreas Zoephel , Renate Schnitzer , Wolfgang Sommergruber , Paola Martinelli , Heribert Arnhof , Biljana Peric-Simov , Karin S Hofbauer , Géraldine Garavel , Yvonne Scherbantin , Sophie Mitzner , Thomas N Fett , Guido Scholz , Jens Bruchhaus , Michelle Burkard , Roland Kousek , Tuncay Ciftci , Bernadette Sharps , Andreas Schrenk , Christoph Harrer , Daniela Haering , Bernhard Wolkerstorfer , Xuechun Zhang , Xiaobing Lv , Alicia Du , Dongyang Li , Yali Li , Jens Quant , Mark Pearson , Darryl B McConnell

Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.

ChemMedChem

Avec: Andreas Gollner , Harald Weinstabl , Julian E Fuchs , Dorothea Rudolph , Geraldine Garavel , Karin S Hofbauer , Jale Karolyi-Oezguer , Gerhard Gmaschitz , Wolfgang Hela , Nina Kerres , Elisabeth Grondal , Patrick Werni , Juergen Ramharter , Joachim Broeker , Darryl B McConnell

BacPROTACs mediate targeted protein degradation in bacteria.

Cell

Avec: Francesca E Morreale , Stefan Kleine , Julia Leodolter , Sabryna Junker , David M Hoi , Stepan Ovchinnikov , Anastasia Okun , Juliane Kley , Robert Kurzbauer , Lukas Junk , Somraj Guha , David Podlesainski , Uli Kazmaier , Guido Boehmelt , Harald Weinstabl , Klaus Rumpel , Volker M Schmiedel , Markus Hartl , David Haselbach , Anton Meinhart , Markus Kaiser , Tim Clausen

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Nature chemical biology

Avec: William Farnaby , Manfred Koegl , Michael J Roy , Claire Whitworth , Emelyne Diers , Nicole Trainor , David Zollman , Steffen Steurer , Jale Karolyi-Oezguer , Carina Riedmueller , Teresa Gmaschitz , Johannes Wachter , Christian Dank , Michael Galant , Bernadette Sharps , Klaus Rumpel , Elisabeth Traxler , Thomas Gerstberger , Renate Schnitzer , Oliver Petermann , Peter Greb , Harald Weinstabl , Gerd Bader , Andreas Zoephel , Alexander Weiss-Puxbaum , Katharina Ehrenhöfer-Wölfer , Simon Wöhrle , Guido Boehmelt , Joerg Rinnenthal , Heribert Arnhof , Nicola Wiechens , Meng-Ying Wu , Tom Owen-Hughes , Peter Ettmayer , Mark Pearson , Darryl B McConnell , Alessio Ciulli

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS

Journal of medicinal chemistry

Avec: Joachim Bröker , Alex G Waterson , Chris Smethurst , Dirk Kessler , Jark Böttcher , Moriz Mayer , Gerhard Gmaschitz , Jason Phan , Andrew Little , Jason R Abbott , Qi Sun , Michael Gmachl , Dorothea Rudolph , Heribert Arnhof , Klaus Rumpel , Fabio Savarese , Thomas Gerstberger , Nikolai Mischerikow , Matthias Treu , Lorenz Herdeis , Tobias Wunberg , Andreas Gollner , Harald Weinstabl , Andreas Mantoulidis , Oliver Krämer , Darryl B McConnell , Stephen W Fesik

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.

Nature communications

Avec: Lukas Junk , Volker M Schmiedel , Somraj Guha , Katharina Fischel , Peter Greb , Kristin Vill , Violetta Krisilia , Lasse van Geelen , Klaus Rumpel , Parvinder Kaur , Ramya V Krishnamurthy , Shridhar Narayanan , Radha Krishan Shandil , Mayas Singh , Christiane Kofink , Andreas Mantoulidis , Philipp Biber , Gerhard Gmaschitz , Uli Kazmaier , Anton Meinhart , Julia Leodolter , David Hoi , Sabryna Junker , Francesca Ester Morreale , Tim Clausen , Rainer Kalscheuer , Harald Weinstabl , Guido Boehmelt

Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules.

Molecular cancer therapeutics

Avec: Andreas Gollner , Dorothea Rudolph , Ulrike Weyer-Czernilofsky , Rosa Baumgartinger , Peter Jung , Harald Weinstabl , Jürgen Ramharter , Rolf Grempler , Jens Quant , Jörg Rinnenthal , Alejandro Pérez Pitarch , Bojana Golubovic , Daniel Gerlach , Gerd Bader , Kristiane Wetzel , Sebastian Otto , Christian Mandl , Guido Boehmelt , Darryl B McConnell , Norbert Kraut , Patrizia Sini

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Nature chemical biology

Electrochemical Umpolung C-H Functionalization of Oxindoles.

The Journal of organic chemistry

Avec: Miryam Pastor , Marie Vayer , Harald Weinstabl , Nuno Maulide

Confounding Factors in Targeted Degradation of Short-Lived Proteins.

ACS chemical biology

Avec: Vesna Vetma , Laura Casares Perez , Ján Eliaš , Andrea Stingu , Anju Kombara , Teresa Gmaschitz , Nina Braun , Tuncay Ciftci , Georg Dahmann , Emelyne Diers , Thomas Gerstberger , Peter Greb , Giorgia Kidd , Christiane Kofink , Ilaria Puoti , Valentina Spiteri , Nicole Trainor , Harald Weinstabl , Yvonne Westermaier , Claire Whitworth , Alessio Ciulli , William Farnaby , Kirsten McAulay , Aileen B Frost , Nicola Chessum , Manfred Koegl

Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis-Beirut Reaction.

Organic process research & development

Avec: Juergen Ramharter , Michael Kulhanek , Maike Dettling , Gerhard Gmaschitz , Jale Karolyi-Oezguer , Harald Weinstabl , Andreas Gollner

Targeting cancer with small-molecule pan-KRAS degraders.

Science (New York, N.Y.)

Avec: Johannes Popow , William Farnaby , Andreas Gollner , Christiane Kofink , Gerhard Fischer , Melanie Wurm , David Zollman , Andre Wijaya , Nikolai Mischerikow , Carina Hasenoehrl , Polina Prokofeva , Heribert Arnhof , Silvia Arce-Solano , Sammy Bell , Georg Boeck , Emelyne Diers , Aileen B Frost , Jake Goodwin-Tindall , Jale Karolyi-Oezguer , Shakil Khan , Theresa Klawatsch , Manfred Koegl , Roland Kousek , Barbara Kratochvil , Katrin Kropatsch , Arnel A Lauber , Ross McLennan , Sabine Olt , Daniel Peter , Oliver Petermann , Vanessa Roessler , Peggy Stolt-Bergner , Patrick Strack , Eva Strauss , Nicole Trainor , Vesna Vetma , Claire Whitworth , Siying Zhong , Jens Quant , Harald Weinstabl , Bernhard Kuster , Peter Ettmayer , Alessio Ciulli

Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.

Cell

Avec: David M Hoi , Sabryna Junker , Lukas Junk , Kristin Schwechel , Katharina Fischel , David Podlesainski , Paige M E Hawkins , Lasse van Geelen , Farnusch Kaschani , Julia Leodolter , Francesca Ester Morreale , Stefan Kleine , Somraj Guha , Klaus Rumpel , Volker M Schmiedel , Harald Weinstabl , Anton Meinhart , Richard J Payne , Markus Kaiser , Markus Hartl , Guido Boehmelt , Uli Kazmaier , Rainer Kalscheuer , Tim Clausen

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.

Nature communications

Avec: Christiane Kofink , Nicole Trainor , Barbara Mair , Simon Wöhrle , Melanie Wurm , Nikolai Mischerikow , Michael J Roy , Gerd Bader , Peter Greb , Géraldine Garavel , Emelyne Diers , Ross McLennan , Claire Whitworth , Vesna Vetma , Klaus Rumpel , Maximilian Scharnweber , Julian E Fuchs , Thomas Gerstberger , Yunhai Cui , Gabriela Gremel , Paolo Chetta , Stefan Hopf , Nicole Budano , Joerg Rinnenthal , Gerhard Gmaschitz , Moriz Mayer , Manfred Koegl , Alessio Ciulli , Harald Weinstabl , William Farnaby

European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in Europe.

ChemMedChem

Avec: Amjad Ali , Marcus Bauser , Sophie Bertrand , Wesley Blackaby , Christoph Boss , Martin Bossart , Adrian Hall , Hayley Binch , Werngard Czechtizky , Harrie Gijsen , Helmut Haning , Ingo V Hartung , Paul Kilburn , Gilbert Lassalle , Ulrich Lücking , Jürgen Mack , Martin Missbach , Leena Otsomaa , Antoni Torrens , Michael Wagner , Magnus Walter , Harald Weinstabl , Luc van Hijfte , Franz von Nussbaum

Synthesis of a

Journal of biomolecular NMR

Avec: Theresa Höfurthner , Giorgia Toscano , Georg Kontaxis , Andreas Beier , Moriz Mayer , Leonhard Geist , Darryl B McConnell , Harald Weinstabl , Roman Lichtenecker , Robert Konrat

Synthesis of Complex Tetracyclic Fused Scaffolds Enabled by (3 + 2) Cycloaddition.

Organic letters

Avec: Vincent Porte , Branca C van Veen , Haoqi Zhang , Paolo Piacentini , Sergio Armentia Matheu , Sophie Woolford , Kevin R Sokol , Saad Shaaban , Harald Weinstabl , Nuno Maulide

Réseau de co-auteurs

Darryl B McConnell 8 collaborations

Klaus Rumpel 8 collaborations

Andreas Gollner 6 collaborations

Thomas Gerstberger 6 collaborations

Guido Boehmelt 6 collaborations

Moriz Mayer 5 collaborations

Gerd Bader 5 collaborations

Heribert Arnhof 5 collaborations

Jale Karolyi-Oezguer 5 collaborations

Gerhard Gmaschitz 5 collaborations

William Farnaby 5 collaborations

Manfred Koegl 5 collaborations

Claire Whitworth 5 collaborations

Emelyne Diers 5 collaborations

Nicole Trainor 5 collaborations

Peter Greb 5 collaborations

Alessio Ciulli 5 collaborations

Joerg Rinnenthal 4 collaborations

Peter Ettmayer 4 collaborations

Nikolai Mischerikow 4 collaborations

Christiane Kofink 4 collaborations

Andreas Zoephel 3 collaborations

Renate Schnitzer 3 collaborations

Bernadette Sharps 3 collaborations

Jens Quant 3 collaborations

Mark Pearson 3 collaborations

Dorothea Rudolph 3 collaborations

Julia Leodolter 3 collaborations

Sabryna Junker 3 collaborations

Lukas Junk 3 collaborations

Somraj Guha 3 collaborations

Uli Kazmaier 3 collaborations

Volker M Schmiedel 3 collaborations

Anton Meinhart 3 collaborations

Tim Clausen 3 collaborations

Michael J Roy 3 collaborations

David Zollman 3 collaborations

Teresa Gmaschitz 3 collaborations

Oliver Petermann 3 collaborations

Simon Wöhrle 3 collaborations

Vesna Vetma 3 collaborations

Giorgia Toscano 2 collaborations

Theresa Höfurthner 2 collaborations

Andreas Beier 2 collaborations

Leonhard Geist 2 collaborations

Robert Konrat 2 collaborations

Matthias Treu 2 collaborations

Georg Dahmann 2 collaborations

Dirk Kessler 2 collaborations

Fabio Savarese 2 collaborations

Karin S Hofbauer 2 collaborations

Géraldine Garavel 2 collaborations

Roland Kousek 2 collaborations

Tuncay Ciftci 2 collaborations

Julian E Fuchs 2 collaborations

Juergen Ramharter 2 collaborations

Stefan Kleine 2 collaborations

David M Hoi 2 collaborations

David Podlesainski 2 collaborations

Markus Hartl 2 collaborations

Markus Kaiser 2 collaborations

Steffen Steurer 2 collaborations

Carina Riedmueller 2 collaborations

Johannes Wachter 2 collaborations

Christian Dank 2 collaborations

Michael Galant 2 collaborations

Elisabeth Traxler 2 collaborations

Alexander Weiss-Puxbaum 2 collaborations

Katharina Ehrenhöfer-Wölfer 2 collaborations

Nicola Wiechens 2 collaborations

Meng-Ying Wu 2 collaborations

Tom Owen-Hughes 2 collaborations

Andreas Mantoulidis 2 collaborations

Katharina Fischel 2 collaborations

Lasse van Geelen 2 collaborations

Francesca Ester Morreale 2 collaborations

Rainer Kalscheuer 2 collaborations

Nuno Maulide 2 collaborations

Aileen B Frost 2 collaborations

Melanie Wurm 2 collaborations

Ross McLennan 2 collaborations

Benjamin Nagl 1 collaboration

Roman J Lichtenecker 1 collaboration

Georgia L Nolt 1 collaboration

Alexander R Keeble 1 collaboration

Yuan Wen 1 collaboration

Aubrey C Strong 1 collaboration

Nicholas T Thomas 1 collaboration

Taylor R Valentino 1 collaboration

Camille R Brightwell 1 collaboration

Kevin A Murach 1 collaboration

Sini Patrizia 1 collaboration

John J McCarthy 1 collaboration

Christopher S Fry 1 collaboration

Michael Franti 1 collaboration

Antonio Filareto 1 collaboration

Charlotte A Peterson 1 collaboration

Cory M Dungan 1 collaboration

Stephan K Zahn 1 collaboration

Wolfgang Sommergruber 1 collaboration

Paola Martinelli 1 collaboration

Biljana Peric-Simov 1 collaboration

Yvonne Scherbantin 1 collaboration

Sophie Mitzner 1 collaboration

Thomas N Fett 1 collaboration

Guido Scholz 1 collaboration

Jens Bruchhaus 1 collaboration

Michelle Burkard 1 collaboration

Andreas Schrenk 1 collaboration

Christoph Harrer 1 collaboration

Daniela Haering 1 collaboration

Bernhard Wolkerstorfer 1 collaboration

Xuechun Zhang 1 collaboration

Xiaobing Lv 1 collaboration

Alicia Du 1 collaboration

Dongyang Li 1 collaboration

Yali Li 1 collaboration

Geraldine Garavel 1 collaboration

Wolfgang Hela 1 collaboration

Nina Kerres 1 collaboration

Elisabeth Grondal 1 collaboration

Patrick Werni 1 collaboration

Joachim Broeker 1 collaboration

Francesca E Morreale 1 collaboration

Stepan Ovchinnikov 1 collaboration

Anastasia Okun 1 collaboration

Juliane Kley 1 collaboration

Robert Kurzbauer 1 collaboration

David Haselbach 1 collaboration

Joachim Bröker 1 collaboration

Alex G Waterson 1 collaboration

Chris Smethurst 1 collaboration

Jark Böttcher 1 collaboration

Jason Phan 1 collaboration

Andrew Little 1 collaboration

Jason R Abbott 1 collaboration

Qi Sun 1 collaboration

Michael Gmachl 1 collaboration

Lorenz Herdeis 1 collaboration

Tobias Wunberg 1 collaboration

Oliver Krämer 1 collaboration

Stephen W Fesik 1 collaboration

Kristin Vill 1 collaboration

Violetta Krisilia 1 collaboration

Parvinder Kaur 1 collaboration

Ramya V Krishnamurthy 1 collaboration

Shridhar Narayanan 1 collaboration

Radha Krishan Shandil 1 collaboration

Mayas Singh 1 collaboration

Philipp Biber 1 collaboration

David Hoi 1 collaboration

Ulrike Weyer-Czernilofsky 1 collaboration

Rosa Baumgartinger 1 collaboration

Peter Jung 1 collaboration

Jürgen Ramharter 1 collaboration

Rolf Grempler 1 collaboration

Jörg Rinnenthal 1 collaboration

Alejandro Pérez Pitarch 1 collaboration

Bojana Golubovic 1 collaboration

Daniel Gerlach 1 collaboration

Kristiane Wetzel 1 collaboration

Sebastian Otto 1 collaboration

Christian Mandl 1 collaboration

Norbert Kraut 1 collaboration

Patrizia Sini 1 collaboration

Miryam Pastor 1 collaboration

Marie Vayer 1 collaboration

Laura Casares Perez 1 collaboration

Ján Eliaš 1 collaboration

Andrea Stingu 1 collaboration

Anju Kombara 1 collaboration

Nina Braun 1 collaboration

Giorgia Kidd 1 collaboration

Ilaria Puoti 1 collaboration

Valentina Spiteri 1 collaboration

Yvonne Westermaier 1 collaboration

Kirsten McAulay 1 collaboration

Nicola Chessum 1 collaboration

Michael Kulhanek 1 collaboration

Maike Dettling 1 collaboration

Johannes Popow 1 collaboration

Gerhard Fischer 1 collaboration

Andre Wijaya 1 collaboration

Carina Hasenoehrl 1 collaboration

Polina Prokofeva 1 collaboration

Silvia Arce-Solano 1 collaboration

Sammy Bell 1 collaboration

Georg Boeck 1 collaboration

Jake Goodwin-Tindall 1 collaboration

Shakil Khan 1 collaboration

Theresa Klawatsch 1 collaboration

Barbara Kratochvil 1 collaboration

Katrin Kropatsch 1 collaboration

Arnel A Lauber 1 collaboration

Sabine Olt 1 collaboration

Daniel Peter 1 collaboration

Vanessa Roessler 1 collaboration

Peggy Stolt-Bergner 1 collaboration

Patrick Strack 1 collaboration

Eva Strauss 1 collaboration

Siying Zhong 1 collaboration

Bernhard Kuster 1 collaboration

Kristin Schwechel 1 collaboration

Paige M E Hawkins 1 collaboration

Farnusch Kaschani 1 collaboration

Richard J Payne 1 collaboration

Barbara Mair 1 collaboration

Maximilian Scharnweber 1 collaboration

Yunhai Cui 1 collaboration

Gabriela Gremel 1 collaboration

Paolo Chetta 1 collaboration

Stefan Hopf 1 collaboration

Nicole Budano 1 collaboration

Amjad Ali 1 collaboration

Marcus Bauser 1 collaboration

Sophie Bertrand 1 collaboration

Wesley Blackaby 1 collaboration

Christoph Boss 1 collaboration

Martin Bossart 1 collaboration

Adrian Hall 1 collaboration

Hayley Binch 1 collaboration

Werngard Czechtizky 1 collaboration

Harrie Gijsen 1 collaboration

Helmut Haning 1 collaboration

Ingo V Hartung 1 collaboration

Paul Kilburn 1 collaboration

Gilbert Lassalle 1 collaboration

Ulrich Lücking 1 collaboration

Jürgen Mack 1 collaboration

Martin Missbach 1 collaboration

Leena Otsomaa 1 collaboration

Antoni Torrens 1 collaboration

Michael Wagner 1 collaboration

Magnus Walter 1 collaboration

Luc van Hijfte 1 collaboration

Franz von Nussbaum 1 collaboration

Georg Kontaxis 1 collaboration

Roman Lichtenecker 1 collaboration

Vincent Porte 1 collaboration

Branca C van Veen 1 collaboration

Haoqi Zhang 1 collaboration

Paolo Piacentini 1 collaboration

Sergio Armentia Matheu 1 collaboration

Sophie Woolford 1 collaboration

Kevin R Sokol 1 collaboration

Saad Shaaban 1 collaboration