Takeshi Isoyama

Affiliations

Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Publications (23)

Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity.

Bioorganic & medicinal chemistry

Avec: Hideaki Kageji , Takayuki Momose , Masayuki Ebisawa , Yusuke Nakazawa , Hiroyuki Okada , Noriko Togashi , Yasuhito Nagamoto , Wataru Obuchi , Isao Yasumatsu , Kawori Kihara , Kumiko Hiramoto , Megumi Minami , Naomi Kasanuki , Takeshi Isoyama , Hiroyuki Naito , Naoki Tanaka

Rattractor-Instant guidance of a rat into a virtual cage using the deep brain stimulation.

PloS one

Avec: Naoki Sudo , Sei-Etsu Fujiwara , Takashi Isoyama , Osamu Fukayama

Effect of Intravesical Bacilli Calmette-Guerin Therapy After Second Transurethral Resection in Stage Ta T1 High-Grade Bladder Cancer.

Yonago acta medica

Avec: Yusuke Kimura , Masashi Honda , Shuichi Morizane , Katsuya Hikita , Tadahiro Isoyama , Koji Ono , Tsutomu Koumi , Chihiro Takahashi , Atsushi Takenaka

Spontaneous regression of metastatic renal cell carcinoma after cytoreductive nephrectomy: A case report.

Urology case reports

Avec: Kuniyasu Muraoka , Yuri Nishikawa , Tadahiro Isoyama

U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Kyriakos P Papadopoulos , Erkut Borazanci , Alice T Shaw , Ryohei Katayama , Yuki Shimizu , Viola W Zhu , Thomas Yang Sun , Heather A Wakelee , Russell Madison , Alexa B Schrock , Giorgio Senaldi , Naoki Nakao , Hiroyuki Hanzawa , Masaya Tachibana , Takeshi Isoyama , Kenji Nakamaru , Chenhui Deng , Meijing Li , Frank Fan , Qinying Zhao , Yanfei Gao , Takashi Seto , Pasi A Jänne , Sai-Hong Ignatius Ou

Villous adenoma of the urachus obscuring urachal adenocarcinoma: A case report.

Urology case reports

Avec: Yuri Nishikawa , Kuniyasu Muraoka , Tadahiro Isoyama

Apathy in Alzheimer's Disease Correlates with the Dopamine Transporter Level in the Caudate Nuclei.

Dementia and geriatric cognitive disorders extra

Avec: Niki Udo , Naoki Hashimoto , Takuya Toyonaga , Tomoyuki Isoyama , Yuka Oyanagi , Hisashi Narita , Tohru Shiga , Shin Nakagawa , Ichiro Kusumi

Stability Enhancement by Hydrophobic Anchoring and a Cross-Linked Structure of a Phospholipid Copolymer Film for Medical Devices.

ACS applied materials & interfaces

Avec: Kazuto Uchida , Tsukuru Masuda , Shintaro Hara , Youichi Matsuo , Yuwei Liu , Hiroyuki Aoki , Yoshihiko Asano , Kazuki Miyata , Takeshi Fukuma , Toshiya Ono , Takashi Isoyama , Madoka Takai

The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models.

Nature communications

Avec: Ryohei Katayama , Bo Gong , Noriko Togashi , Masaya Miyamoto , Masaki Kiga , Shiho Iwasaki , Yasuki Kamai , Yuichi Tominaga , Yasuyuki Takeda , Yoshiko Kagoshima , Yuki Shimizu , Yosuke Seto , Tomoko Oh-Hara , Sumie Koike , Naoki Nakao , Hiroyuki Hanzawa , Kengo Watanabe , Satoshi Yoda , Noriko Yanagitani , Aaron N Hata , Alice T Shaw , Makoto Nishio , Naoya Fujita , Takeshi Isoyama

Characterization of Urate Metabolism and Complications of Patients with Renal Hypouricemia.

Internal medicine (Tokyo, Japan)

Avec: Satoshi Miyazaki , Toshihiro Hamada , Tadahiro Isoyama , Shinichi Okada , Katsuyuki Tomita , Yusuke Endo , Masanari Kuwabara , Shinobu Sugihara , Kazuhide Ogino , Haruaki Ninomiya , Kimiyoshi Ichida , Kazuhiro Yamamoto , Atsushi Takenaka , Ichiro Hisatome

Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in the elderly: case report and literature review.

International cancer conference journal

Avec: Toshihiko Masago , Susumu Kobayakawa , Yuu Ohtani , Kenjirou Taniguchi , Takuji Naka , Naoto Kuroda , Chihiro Takahashi , Tadahiro Isoyama , Takehiro Sejima

Blind Speech Watermarking Method with Frame Self-Synchronization Based on Spread-Spectrum Using Linear Prediction Residue.

Entropy (Basel, Switzerland)

Avec: Takuto Isoyama , Shunsuke Kidani , Masashi Unoki

Quantitative evaluation of skin barrier function using water evaporation time related to transepidermal water loss.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

Avec: Shin-Ichiro Seno , Hideaki Shimazu , Hiroko Kobayashi , Eiki Kogure , Atsushi Watanabe , Takashi Isoyama

Design of a hybrid left ventricular assist device with a new wireless charging system.

Artificial organs

Avec: Hideyuki Horie , Takashi Isoyama , Kazushi Ishiyama

Design of an Innovative Wireless Left Ventricular Assist Device Driven by either Extracorporeal Magnets or an Intracorporeal Battery Pack.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Avec: Hideyuki Horie , Takashi Isoyama , Kazushi Ishiyama

Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi-center study.

International journal of urology : official journal of the Japanese Urological Association

Avec: Hiroshi Yamane , Shuichi Morizane , Masashi Honda , Kuniyasu Muraoka , Hirofumi Oono , Tadahiro Isoyama , Koji Ono , Takehiro Sejima , Hiroyuki Kadowaki , Atsushi Takenaka

The Benefits of Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma Require at Least Three Cycles.

Yonago acta medica

Avec: Tetsuya Yumioka , Shuichi Morizane , Kuniyasu Muraoka , Hirofumi Oono , Tadahiro Isoyama , Naoyuki Sakaridani , Koji Ono , Takehiro Sejima , Hiroyuki Kadowaki , Katsuya Hikita , Masashi Honda , Atsushi Takenaka

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model.

Oncotarget

Avec: Takeshi Jimbo , Mana Hatanaka , Takahiro Komatsu , Tomoe Taira , Kentaro Kumazawa , Naoyuki Maeda , Takashi Suzuki , Masahiro Ota , Noriyasu Haginoya , Takeshi Isoyama , Kosaku Fujiwara

Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring.

Bioorganic & medicinal chemistry letters

Avec: Ryutaro Kanada , Yoshiko Kagoshima , Masayoshi Asano , Takashi Suzuki , Takeshi Murata , Makoto Haruta , Mizuki Takahashi , Osamu Ubukata , Kazuyuki Hashimoto , Kenichi Obata , Kawori Kihara , Mutsumi Kuroha , Toshihiro Banjo , Noriko Togashi , Kazumi Sato , Yuka Yamamoto , Kanae Suzuki , Takeshi Isoyama , Yuichi Tominaga , Saito Higuchi , Hiroyuki Naito

Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.

Journal of medicinal chemistry

Avec: Ryutaro Kanada , Yoshiko Kagoshima , Takashi Suzuki , Akifumi Nakamura , Hideaki Funami , Jun Watanabe , Masayoshi Asano , Mizuki Takahashi , Osamu Ubukata , Kanae Suzuki , Tomoya Aikawa , Kazumi Sato , Megumi Goto , Genzui Setsu , Kentaro Ito , Kawori Kihara , Mutsumi Kuroha , Takashi Kohno , Hideaki Ogiwara , Takeshi Isoyama , Yuichi Tominaga , Saito Higuchi , Hiroyuki Naito

Cardiovascular adverse reactions associated with escitalopram in patients with underlying cardiovascular diseases: a systematic review and meta-analysis.

Frontiers in psychiatry

Avec: Kenichi Kimura , Hisashi Narita , Hissei Imai , Hisashi Akiyama , Shuhei Ishikawa , Ryo Sawagashira , Tomoyuki Isoyama , Mariko Nohara , Michiyo Kawamura , Yukari Kono , Takuya Saito , Ichiro Kusumi

Impact of Hyper- and Hypo-Uricemia on Kidney Function.

Biomedicines

Avec: Junichiro Miake , Ichiro Hisatome , Katsuyuki Tomita , Tadahiro Isoyama , Shinobu Sugihara , Masanari Kuwabara , Kazuhide Ogino , Haruaki Ninomiya

Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation.

Bioorganic & medicinal chemistry letters

Avec: Hideaki Kageji , Takayuki Momose , Yasuhito Nagamoto , Noriko Togashi , Isao Yasumatsu , Yosuke Nishikawa , Kawori Kihara , Kumiko Hiramoto , Megumi Minami , Naomi Kasanuki , Takeshi Isoyama , Hiroyuki Naito

Réseau de co-auteurs

Tadahiro Isoyama 8 collaborations

Takashi Isoyama 5 collaborations

Noriko Togashi 4 collaborations

Kawori Kihara 4 collaborations

Hiroyuki Naito 4 collaborations

Atsushi Takenaka 4 collaborations

Kuniyasu Muraoka 4 collaborations

Masashi Honda 3 collaborations

Shuichi Morizane 3 collaborations

Koji Ono 3 collaborations

Yuichi Tominaga 3 collaborations

Yoshiko Kagoshima 3 collaborations

Takehiro Sejima 3 collaborations

Takashi Suzuki 3 collaborations

Hideaki Kageji 2 collaborations

Takayuki Momose 2 collaborations

Yasuhito Nagamoto 2 collaborations

Isao Yasumatsu 2 collaborations

Kumiko Hiramoto 2 collaborations

Megumi Minami 2 collaborations

Naomi Kasanuki 2 collaborations

Katsuya Hikita 2 collaborations

Chihiro Takahashi 2 collaborations

Yuri Nishikawa 2 collaborations

Alice T Shaw 2 collaborations

Ryohei Katayama 2 collaborations

Yuki Shimizu 2 collaborations

Naoki Nakao 2 collaborations

Hiroyuki Hanzawa 2 collaborations

Tomoyuki Isoyama 2 collaborations

Hisashi Narita 2 collaborations

Ichiro Kusumi 2 collaborations

Katsuyuki Tomita 2 collaborations

Masanari Kuwabara 2 collaborations

Shinobu Sugihara 2 collaborations

Kazuhide Ogino 2 collaborations

Haruaki Ninomiya 2 collaborations

Ichiro Hisatome 2 collaborations

Hideyuki Horie 2 collaborations

Kazushi Ishiyama 2 collaborations

Hirofumi Oono 2 collaborations

Hiroyuki Kadowaki 2 collaborations

Ryutaro Kanada 2 collaborations

Masayoshi Asano 2 collaborations

Mizuki Takahashi 2 collaborations

Osamu Ubukata 2 collaborations

Mutsumi Kuroha 2 collaborations

Kazumi Sato 2 collaborations

Kanae Suzuki 2 collaborations

Saito Higuchi 2 collaborations

Masayuki Ebisawa 1 collaboration

Yusuke Nakazawa 1 collaboration

Hiroyuki Okada 1 collaboration

Wataru Obuchi 1 collaboration

Naoki Tanaka 1 collaboration

Naoki Sudo 1 collaboration

Sei-Etsu Fujiwara 1 collaboration

Osamu Fukayama 1 collaboration

Yusuke Kimura 1 collaboration

Tsutomu Koumi 1 collaboration

Kyriakos P Papadopoulos 1 collaboration

Erkut Borazanci 1 collaboration

Viola W Zhu 1 collaboration

Thomas Yang Sun 1 collaboration

Heather A Wakelee 1 collaboration

Russell Madison 1 collaboration

Alexa B Schrock 1 collaboration

Giorgio Senaldi 1 collaboration

Masaya Tachibana 1 collaboration

Kenji Nakamaru 1 collaboration

Chenhui Deng 1 collaboration

Meijing Li 1 collaboration

Frank Fan 1 collaboration

Qinying Zhao 1 collaboration

Yanfei Gao 1 collaboration

Takashi Seto 1 collaboration

Pasi A Jänne 1 collaboration

Sai-Hong Ignatius Ou 1 collaboration

Niki Udo 1 collaboration

Naoki Hashimoto 1 collaboration

Takuya Toyonaga 1 collaboration

Yuka Oyanagi 1 collaboration

Tohru Shiga 1 collaboration

Shin Nakagawa 1 collaboration

Kazuto Uchida 1 collaboration

Tsukuru Masuda 1 collaboration

Shintaro Hara 1 collaboration

Youichi Matsuo 1 collaboration

Yuwei Liu 1 collaboration

Hiroyuki Aoki 1 collaboration

Yoshihiko Asano 1 collaboration

Kazuki Miyata 1 collaboration

Takeshi Fukuma 1 collaboration

Toshiya Ono 1 collaboration

Madoka Takai 1 collaboration

Bo Gong 1 collaboration

Masaya Miyamoto 1 collaboration

Masaki Kiga 1 collaboration

Shiho Iwasaki 1 collaboration

Yasuki Kamai 1 collaboration

Yasuyuki Takeda 1 collaboration

Yosuke Seto 1 collaboration

Tomoko Oh-Hara 1 collaboration

Sumie Koike 1 collaboration

Kengo Watanabe 1 collaboration

Satoshi Yoda 1 collaboration

Noriko Yanagitani 1 collaboration

Aaron N Hata 1 collaboration

Makoto Nishio 1 collaboration

Naoya Fujita 1 collaboration

Satoshi Miyazaki 1 collaboration

Toshihiro Hamada 1 collaboration

Shinichi Okada 1 collaboration

Yusuke Endo 1 collaboration

Kimiyoshi Ichida 1 collaboration

Kazuhiro Yamamoto 1 collaboration

Toshihiko Masago 1 collaboration

Susumu Kobayakawa 1 collaboration

Yuu Ohtani 1 collaboration

Kenjirou Taniguchi 1 collaboration

Takuji Naka 1 collaboration

Naoto Kuroda 1 collaboration

Takuto Isoyama 1 collaboration

Shunsuke Kidani 1 collaboration

Masashi Unoki 1 collaboration

Shin-Ichiro Seno 1 collaboration

Hideaki Shimazu 1 collaboration

Hiroko Kobayashi 1 collaboration

Eiki Kogure 1 collaboration

Atsushi Watanabe 1 collaboration

Hiroshi Yamane 1 collaboration

Tetsuya Yumioka 1 collaboration

Naoyuki Sakaridani 1 collaboration

Takeshi Jimbo 1 collaboration

Mana Hatanaka 1 collaboration

Takahiro Komatsu 1 collaboration

Tomoe Taira 1 collaboration

Kentaro Kumazawa 1 collaboration

Naoyuki Maeda 1 collaboration

Masahiro Ota 1 collaboration

Noriyasu Haginoya 1 collaboration

Kosaku Fujiwara 1 collaboration

Takeshi Murata 1 collaboration

Makoto Haruta 1 collaboration

Kazuyuki Hashimoto 1 collaboration

Kenichi Obata 1 collaboration

Toshihiro Banjo 1 collaboration

Yuka Yamamoto 1 collaboration

Akifumi Nakamura 1 collaboration

Hideaki Funami 1 collaboration

Jun Watanabe 1 collaboration

Tomoya Aikawa 1 collaboration

Megumi Goto 1 collaboration

Genzui Setsu 1 collaboration

Kentaro Ito 1 collaboration

Takashi Kohno 1 collaboration

Hideaki Ogiwara 1 collaboration

Kenichi Kimura 1 collaboration

Hissei Imai 1 collaboration

Hisashi Akiyama 1 collaboration

Shuhei Ishikawa 1 collaboration

Ryo Sawagashira 1 collaboration

Mariko Nohara 1 collaboration

Michiyo Kawamura 1 collaboration

Yukari Kono 1 collaboration

Takuya Saito 1 collaboration

Junichiro Miake 1 collaboration

Yosuke Nishikawa 1 collaboration