Ryutaro Kanada

Affiliations

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Electronic address: kanada.ryutaro.nw@daiichisankyo.co.jp.

Publications (16)

4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors.

Bioorganic & medicinal chemistry letters

Avec: Ryutaro Kanada , Takashi Suzuki , Takeshi Murata , Masaki Miyazaki , Takashi Shimada , Mutsumi Kuroha , Megumi Minami , Saito Higuchi , Yuichi Tominaga , Hiroyuki Naito

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare

Proceedings of the National Academy of Sciences of the United States of America

Avec: Shinnosuke Ikemura , Hiroyuki Yasuda , Shingo Matsumoto , Mayumi Kamada , Junko Hamamoto , Keita Masuzawa , Keigo Kobayashi , Tadashi Manabe , Daisuke Arai , Ichiro Nakachi , Ichiro Kawada , Kota Ishioka , Morio Nakamura , Ho Namkoong , Katsuhiko Naoki , Fumie Ono , Mitsugu Araki , Ryo Kanada , Biao Ma , Yuichiro Hayashi , Sachiyo Mimaki , Kiyotaka Yoh , Susumu S Kobayashi , Takashi Kohno , Yasushi Okuno , Koichi Goto , Katsuya Tsuchihara , Kenzo Soejima

Coarse-Grained Diffraction Template Matching Model to Retrieve Multiconformational Models for Biomolecule Structures from Noisy Diffraction Patterns.

Journal of chemical information and modeling

Avec: Atsushi Tokuhisa , Ryo Kanada , Shuntaro Chiba , Kei Terayama , Yuta Isaka , Biao Ma , Narutoshi Kamiya , Yasushi Okuno

Nucleosome Crowding in Chromatin Slows the Diffusion but Can Promote Target Search of Proteins.

Biophysical journal

Avec: Ryo Kanada , Tsuyoshi Terakawa , Hiroo Kenzaki , Shoji Takada

Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity.

NPJ precision oncology

Avec: Takahiro Yoshizawa , Ken Uchibori , Mitsugu Araki , Shigeyuki Matsumoto , Biao Ma , Ryo Kanada , Yosuke Seto , Tomoko Oh-Hara , Sumie Koike , Ryo Ariyasu , Satoru Kitazono , Hironori Ninomiya , Kengo Takeuchi , Noriko Yanagitani , Satoshi Takagi , Kazuma Kishi , Naoya Fujita , Yasushi Okuno , Makoto Nishio , Ryohei Katayama

Semi-Implicit Time Integration with Hessian Eigenvalue Corrections for a Larger Time Step in Molecular Dynamics Simulations.

Journal of chemical theory and computation

Avec: Takumi Washio , Ryo Kanada , Xiaoke Cui , Jun-Ichi Okada , Seiryo Sugiura , Shoji Takada , Toshiaki Hisada

High-Precision Atomic Charge Prediction for Protein Systems Using Fragment Molecular Orbital Calculation and Machine Learning.

Journal of chemical information and modeling

Avec: Koichiro Kato , Tomohide Masuda , Chiduru Watanabe , Naoki Miyagawa , Hideo Mizouchi , Shumpei Nagase , Kikuko Kamisaka , Kanji Oshima , Satoshi Ono , Hiroshi Ueda , Atsushi Tokuhisa , Ryo Kanada , Masateru Ohta , Mitsunori Ikeguchi , Yasushi Okuno , Kaori Fukuzawa , Teruki Honma

Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring.

Bioorganic & medicinal chemistry letters

Avec: Ryutaro Kanada , Yoshiko Kagoshima , Masayoshi Asano , Takashi Suzuki , Takeshi Murata , Makoto Haruta , Mizuki Takahashi , Osamu Ubukata , Kazuyuki Hashimoto , Kenichi Obata , Kawori Kihara , Mutsumi Kuroha , Toshihiro Banjo , Noriko Togashi , Kazumi Sato , Yuka Yamamoto , Kanae Suzuki , Takeshi Isoyama , Yuichi Tominaga , Saito Higuchi , Hiroyuki Naito

Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.

Journal of medicinal chemistry

Avec: Ryutaro Kanada , Yoshiko Kagoshima , Takashi Suzuki , Akifumi Nakamura , Hideaki Funami , Jun Watanabe , Masayoshi Asano , Mizuki Takahashi , Osamu Ubukata , Kanae Suzuki , Tomoya Aikawa , Kazumi Sato , Megumi Goto , Genzui Setsu , Kentaro Ito , Kawori Kihara , Mutsumi Kuroha , Takashi Kohno , Hideaki Ogiwara , Takeshi Isoyama , Yuichi Tominaga , Saito Higuchi , Hiroyuki Naito

A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.

Cancer cell international

Avec: Masashi Numata , Noriyasu Haginoya , Machiko Shiroishi , Tsuyoshi Hirata , Aiko Sato-Otsubo , Kenji Yoshikawa , Yoshimi Takata , Reina Nagase , Yoshinori Kashimoto , Makoto Suzuki , Nina Schulte , Gernot Polier , Akiko Kurimoto , Yumiko Tomoe , Akiko Toyota , Tomoko Yoneyama , Emi Imai , Kenji Watanabe , Tomoaki Hamada , Ryutaro Kanada , Jun Watanabe , Yoshiko Kagoshima , Eri Tokumaru , Kenji Murata , Takayuki Baba , Taeko Shinozaki , Masami Ohtsuka , Koichi Goto , Tsuyoshi Karibe , Takao Deguchi , Yoshihiro Gocho , Masanori Yoshida , Daisuke Tomizawa , Motohiro Kato , Shinji Tsutsumi , Mayumi Kitagawa , Yuki Abe

Exploring Successful Parameter Region for Coarse-Grained Simulation of Biomolecules by Bayesian Optimization and Active Learning.

Biomolecules

Avec: Ryo Kanada , Atsushi Tokuhisa , Koji Tsuda , Yasushi Okuno , Kei Terayama

Stabilization Mechanism for a Nonfibrillar Amyloid β Oligomer Based on Formation of a Hydrophobic Core Determined by Dissipative Particle Dynamics.

ACS chemical neuroscience

Avec: Ryoko Kawai , Shuntaro Chiba , Koji Okuwaki , Ryo Kanada , Hideo Doi , Masahiro Ono , Yuji Mochizuki , Yasushi Okuno

Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.

EBioMedicine

Avec: Koutaroh Okada , Mitsugu Araki , Takuya Sakashita , Biao Ma , Ryo Kanada , Noriko Yanagitani , Atsushi Horiike , Sumie Koike , Tomoko Oh-Hara , Kana Watanabe , Keiichi Tamai , Makoto Maemondo , Makoto Nishio , Takeshi Ishikawa , Yasushi Okuno , Naoya Fujita , Ryohei Katayama

Enhanced Conformational Sampling with an Adaptive Coarse-Grained Elastic Network Model Using Short-Time All-Atom Molecular Dynamics.

Journal of chemical theory and computation

Avec: Ryo Kanada , Kei Terayama , Atsushi Tokuhisa , Shigeyuki Matsumoto , Yasushi Okuno

Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy.

Journal of computational chemistry

Avec: Kenichiro Takaba , Chiduru Watanabe , Atsushi Tokuhisa , Yoshinobu Akinaga , Biao Ma , Ryo Kanada , Mitsugu Araki , Yasushi Okuno , Yusuke Kawashima , Hirotomo Moriwaki , Norihito Kawashita , Teruki Honma , Kaori Fukuzawa , Shigenori Tanaka

A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping.

Frontiers in physiology

Avec: Kazunori Yoneda , Ryo Kanada , Jun-Ichi Okada , Masahiro Watanabe , Seiryo Sugiura , Toshiaki Hisada , Takumi Washio

Réseau de co-auteurs

Ryo Kanada 12 collaborations

Yasushi Okuno 9 collaborations

Biao Ma 5 collaborations

Atsushi Tokuhisa 5 collaborations

Mitsugu Araki 4 collaborations

Takashi Suzuki 3 collaborations

Mutsumi Kuroha 3 collaborations

Saito Higuchi 3 collaborations

Yuichi Tominaga 3 collaborations

Hiroyuki Naito 3 collaborations

Kei Terayama 3 collaborations

Yoshiko Kagoshima 3 collaborations

Takeshi Murata 2 collaborations

Takashi Kohno 2 collaborations

Koichi Goto 2 collaborations

Shuntaro Chiba 2 collaborations

Shoji Takada 2 collaborations

Shigeyuki Matsumoto 2 collaborations

Tomoko Oh-Hara 2 collaborations

Sumie Koike 2 collaborations

Noriko Yanagitani 2 collaborations

Naoya Fujita 2 collaborations

Makoto Nishio 2 collaborations

Ryohei Katayama 2 collaborations

Takumi Washio 2 collaborations

Jun-Ichi Okada 2 collaborations

Seiryo Sugiura 2 collaborations

Toshiaki Hisada 2 collaborations

Chiduru Watanabe 2 collaborations

Kaori Fukuzawa 2 collaborations

Teruki Honma 2 collaborations

Masayoshi Asano 2 collaborations

Mizuki Takahashi 2 collaborations

Osamu Ubukata 2 collaborations

Kawori Kihara 2 collaborations

Kazumi Sato 2 collaborations

Kanae Suzuki 2 collaborations

Takeshi Isoyama 2 collaborations

Jun Watanabe 2 collaborations

Masaki Miyazaki 1 collaboration

Takashi Shimada 1 collaboration

Megumi Minami 1 collaboration

Shinnosuke Ikemura 1 collaboration

Hiroyuki Yasuda 1 collaboration

Shingo Matsumoto 1 collaboration

Mayumi Kamada 1 collaboration

Junko Hamamoto 1 collaboration

Keita Masuzawa 1 collaboration

Keigo Kobayashi 1 collaboration

Tadashi Manabe 1 collaboration

Daisuke Arai 1 collaboration

Ichiro Nakachi 1 collaboration

Ichiro Kawada 1 collaboration

Kota Ishioka 1 collaboration

Morio Nakamura 1 collaboration

Ho Namkoong 1 collaboration

Katsuhiko Naoki 1 collaboration

Fumie Ono 1 collaboration

Yuichiro Hayashi 1 collaboration

Sachiyo Mimaki 1 collaboration

Kiyotaka Yoh 1 collaboration

Susumu S Kobayashi 1 collaboration

Katsuya Tsuchihara 1 collaboration

Kenzo Soejima 1 collaboration

Yuta Isaka 1 collaboration

Narutoshi Kamiya 1 collaboration

Tsuyoshi Terakawa 1 collaboration

Hiroo Kenzaki 1 collaboration

Takahiro Yoshizawa 1 collaboration

Ken Uchibori 1 collaboration

Yosuke Seto 1 collaboration

Ryo Ariyasu 1 collaboration

Satoru Kitazono 1 collaboration

Hironori Ninomiya 1 collaboration

Kengo Takeuchi 1 collaboration

Satoshi Takagi 1 collaboration

Kazuma Kishi 1 collaboration

Xiaoke Cui 1 collaboration

Koichiro Kato 1 collaboration

Tomohide Masuda 1 collaboration

Naoki Miyagawa 1 collaboration

Hideo Mizouchi 1 collaboration

Shumpei Nagase 1 collaboration

Kikuko Kamisaka 1 collaboration

Kanji Oshima 1 collaboration

Satoshi Ono 1 collaboration

Hiroshi Ueda 1 collaboration

Masateru Ohta 1 collaboration

Mitsunori Ikeguchi 1 collaboration

Makoto Haruta 1 collaboration

Kazuyuki Hashimoto 1 collaboration

Kenichi Obata 1 collaboration

Toshihiro Banjo 1 collaboration

Noriko Togashi 1 collaboration

Yuka Yamamoto 1 collaboration

Akifumi Nakamura 1 collaboration

Hideaki Funami 1 collaboration

Tomoya Aikawa 1 collaboration

Megumi Goto 1 collaboration

Genzui Setsu 1 collaboration

Kentaro Ito 1 collaboration

Hideaki Ogiwara 1 collaboration

Masashi Numata 1 collaboration

Noriyasu Haginoya 1 collaboration

Machiko Shiroishi 1 collaboration

Tsuyoshi Hirata 1 collaboration

Aiko Sato-Otsubo 1 collaboration

Kenji Yoshikawa 1 collaboration

Yoshimi Takata 1 collaboration

Reina Nagase 1 collaboration

Yoshinori Kashimoto 1 collaboration

Makoto Suzuki 1 collaboration

Nina Schulte 1 collaboration

Gernot Polier 1 collaboration

Akiko Kurimoto 1 collaboration

Yumiko Tomoe 1 collaboration

Akiko Toyota 1 collaboration

Tomoko Yoneyama 1 collaboration

Emi Imai 1 collaboration

Kenji Watanabe 1 collaboration

Tomoaki Hamada 1 collaboration

Eri Tokumaru 1 collaboration

Kenji Murata 1 collaboration

Takayuki Baba 1 collaboration

Taeko Shinozaki 1 collaboration

Masami Ohtsuka 1 collaboration

Tsuyoshi Karibe 1 collaboration

Takao Deguchi 1 collaboration

Yoshihiro Gocho 1 collaboration

Masanori Yoshida 1 collaboration

Daisuke Tomizawa 1 collaboration

Motohiro Kato 1 collaboration

Shinji Tsutsumi 1 collaboration

Mayumi Kitagawa 1 collaboration

Yuki Abe 1 collaboration

Koji Tsuda 1 collaboration

Ryoko Kawai 1 collaboration

Koji Okuwaki 1 collaboration

Hideo Doi 1 collaboration

Masahiro Ono 1 collaboration

Yuji Mochizuki 1 collaboration

Koutaroh Okada 1 collaboration

Takuya Sakashita 1 collaboration

Atsushi Horiike 1 collaboration

Kana Watanabe 1 collaboration

Keiichi Tamai 1 collaboration

Makoto Maemondo 1 collaboration

Takeshi Ishikawa 1 collaboration

Kenichiro Takaba 1 collaboration

Yoshinobu Akinaga 1 collaboration

Yusuke Kawashima 1 collaboration

Hirotomo Moriwaki 1 collaboration

Norihito Kawashita 1 collaboration

Shigenori Tanaka 1 collaboration

Kazunori Yoneda 1 collaboration

Masahiro Watanabe 1 collaboration