Nick Geukens

Affiliations

PharmAbs - The KU Leuven Antibody Center, KU Leuven - University of Leuven, Leuven, Belgium.

Publications (29)

DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct Exposure.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Liesl Jacobs , Elien De Smidt , Nick Geukens , Paul Declerck , Kevin Hollevoet

Electroporation outperforms in vivo-jetPEI for intratumoral DNA-based reporter gene transfer.

Scientific reports

Avec: Liesl Jacobs , Elien De Smidt , Nick Geukens , Paul Declerck , Kevin Hollevoet

Tuning the Surface Interactions between Single Cells and an OSTE+ Microwell Array for Enhanced Single Cell Manipulation.

ACS applied materials & interfaces

Avec: Jolien Breukers , Sara Horta , Caroline Struyfs , Dragana Spasic , Hendrik B Feys , Nick Geukens , Karin Thevissen , Bruno P A Cammue , Karen Vanhoorelbeke , Jeroen Lammertyn

Development and validation of a microfluidic multiplex immunoassay for the determination of levels and avidity of serum antibodies to tetanus, diphtheria and pertussis antigens.

Journal of immunological methods

Avec: Debby Thomas , Doreen Dillaerts , Maaike Cockx , Louanne Ampofo , Joseph She , Isabelle Desombere , Nick Geukens , Xavier Bossuyt

Combined deficient response to polysaccharide-based and protein-based vaccines predicts a severe clinical phenotype.

Clinical chemistry and laboratory medicine

Avec: Maaike Cockx , Filomeen Haerynck , Levi Hoste , Rik Schrijvers , Jutte Van der Werff Ten Bosch , Doreen Dillaerts , Debby Thomas , Heidi Schaballie , Giorgia Bucciol , Wiert Robberechts , Dina Patel , Guy Berbers , Isabelle Desombere , Nick Geukens , Isabelle Meyts , Xavier Bossuyt

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms.

Frontiers in molecular biosciences

Avec: Joke Verelst , Nick Geukens , Sabiha Eddarkaoui , Dorien Vliegen , Elien De Smidt , Joëlle Rosseels , Vanessa Franssens , Sofie Molenberghs , Cindy Francois , Erik Stoops , Maria Bjerke , Sebastiaan Engelborghs , Mohamed Laghmouchi , Sofie Carmans , Luc Buée , Eugeen Vanmechelen , Joris Winderickx , Debby Thomas

Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells.

Engineering in life sciences

Avec: Benno Verbelen , Tiziana Girardi , Sergey O Sulima , Stijn Vereecke , Paulien Verstraete , Jelle Verbeeck , Jonathan Royaert , Sonia Cinque , Lorenzo Montanaro , Marianna Penzo , Maya Imbrechts , Nick Geukens , Thomas Geuens , Koen Dierckx , Daniele Pepe , Kim Kampen , Kim De Keersmaecker

Detection of Breast Cancer-Specific Extracellular Vesicles with Fiber-Optic SPR Biosensor.

International journal of molecular sciences

Avec: Yagmur Yildizhan , Kaat Driessens , Hong Shen Kevin Tsao , Robin Boiy , Debby Thomas , Nick Geukens , An Hendrix , Jeroen Lammertyn , Dragana Spasic

Evaluation of Immuno-Rolling Circle Amplification for Multiplex Detection and Profiling of Antigen-Specific Antibody Isotypes.

Analytical chemistry

Avec: Sara Horta , Felix Neumann , Shu-Hao Yeh , Christoffer Mattsson Langseth , Kadri Kangro , Jolien Breukers , Narayanan Madaboosi , Nick Geukens , Karen Vanhoorelbeke , Mats Nilsson , Jeroen Lammertyn

Improved Potency and Safety of DNA-Encoded Antibody Therapeutics Through Plasmid Backbone and Expression Cassette Engineering.

Human gene therapy

Avec: Giles Vermeire , Elien De Smidt , Nick Geukens , James A Williams , Paul Declerck , Kevin Hollevoet

Next generation point-of-care test for therapeutic drug monitoring of adalimumab in patients diagnosed with autoimmune diseases.

Biosensors & bioelectronics

Avec: Henry Ordutowski , Francesco Dal Dosso , Wout De Wispelaere , Charlotte Van Tricht , Séverine Vermeire , Nick Geukens , Ann Gils , Dragana Spasic , Jeroen Lammertyn

High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium.

Viruses

Avec: Bas Calcoen , Nico Callewaert , Aline Vandenbulcke , Winnie Kerstens , Maya Imbrechts , Thomas Vercruysse , Kai Dallmeier , Johan Van Weyenbergh , Piet Maes , Xavier Bossuyt , Dorinja Zapf , Kersten Dieckmann , Kim Callebaut , Hendrik Jan Thibaut , Karen Vanhoorelbeke , Simon F De Meyer , Wim Maes , Nick Geukens

Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model.

iScience

Avec: Maya Imbrechts , Wim Maes , Louanne Ampofo , Nathalie Van den Berghe , Bas Calcoen , Dominique Van Looveren , Winnie Kerstens , Madina Rasulova , Thomas Vercruysse , Sam Noppen , Rana Abdelnabi , Caroline Foo , Kevin Hollevoet , Piet Maes , Xin Zhang , Dirk Jochmans , Karen Ven , Jeroen Lammertyn , Karen Vanhoorelbeke , Nico Callewaert , Paul De Munter , Dominique Schols , Hendrik Jan Thibaut , Johan Neyts , Paul Declerck , Nick Geukens

Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium.

Cell reports

Avec: Heather M Callaway , Kathryn M Hastie , Sharon L Schendel , Haoyang Li , Xiaoying Yu , Jeremy Shek , Tierra Buck , Sean Hui , Dan Bedinger , Camille Troup , S Moses Dennison , Kan Li , Michael D Alpert , Charles C Bailey , Sharon Benzeno , Jody L Bonnevier , Jin-Qiu Chen , Charm Chen , Hyeseon Cho , Peter D Crompton , Vincent Dussupt , Kevin C Entzminger , Yassine Ezzyat , Jonathan K Fleming , Nick Geukens , Amy E Gilbert , Yongjun Guan , Xiaojian Han , Christopher J Harvey , Julia M Hatler , Bryan Howie , Chao Hu , Ailong Huang , Maya Imbrechts , Aishun Jin , Nik Kamachi , Gladys Keitany , Mark Klinger , Jay K Kolls , Shelly J Krebs , Tingting Li , Feiyan Luo , Toshiaki Maruyama , Michael A Meehl , Letzibeth Mendez-Rivera , Andrea Musa , C J Okumura , Benjamin E R Rubin , Aaron K Sato , Meiying Shen , Anirudh Singh , Shuyi Song , Joshua Tan , Jeffrey M Trimarchi , Dhruvkumar P Upadhyay , Yingming Wang , Lei Yu , Tom Z Yuan , Erik Yusko , Bjoern Peters , Georgia Tomaras , Erica Ollmann Saphire

Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice.

Pharmaceutics

Avec: Marie-Lynn Cuypers , Nick Geukens , Kevin Hollevoet , Paul Declerck , Maarten Dewilde

FLUIDOT: A Modular Microfluidic Platform for Single-Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining.

Small methods

Avec: Jolien Breukers , Karen Ven , Caroline Struyfs , Louanne Ampofo , Iene Rutten , Maya Imbrechts , Francesca Pollet , Julie Van Lent , Winnie Kerstens , Sam Noppen , Dominique Schols , Paul De Munter , Hendrik Jan Thibaut , Karen Vanhoorelbeke , Dragana Spasic , Paul Declerck , Bruno P A Cammue , Nick Geukens , Karin Thevissen , Jeroen Lammertyn

Complementarity determining regions in SARS-CoV-2 hybrid immunity.

Frontiers in immunology

Avec: Glynis Frans , Doreen Dillaerts , Tom Dehaemers , Jan Van Elslande , Jonas De Leeuw , Lise Boon , Wim Maes , Nico Callewaert , Bas Calcoen , Lina Ancheva , Maaike Cockx , Nick Geukens , Kusay Arat , Rita Derua , Pieter Vermeersch , Sebastien Christian Carpentier , Xavier Bossuyt

Antinuclear antibodies in individuals with COVID-19 reflect underlying disease: Identification of new autoantibodies in systemic sclerosis (CDK9) and malignancy (RNF20, RCC1, TRIP13).

Autoimmunity reviews

Avec: Xavier Bossuyt , Jean-Baptiste Vulsteke , Jan Van Elslande , Lise Boon , Greet Wuyts , Silke Willebrords , Glynis Frans , Nick Geukens , Sebastien Carpentier , Sabine Tejpar , Hans Wildiers , Daniel Blockmans , Ellen De Langhe , Pieter Vermeersch , Rita Derua

PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding.

Antiviral research

Avec: Evelien Vanderlinden , Arnaud Boonen , Sam Noppen , Geert Schoofs , Maya Imbrechts , Nick Geukens , Robert Snoeck , Annelies Stevaert , Lieve Naesens , Graciela Andrei , Dominique Schols

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Acta neuropathologica communications

Avec: Yann Fichou , Youssra K Al-Hilaly , François Devred , Caroline Smet-Nocca , Philipp O Tsvetkov , Joke Verelst , Joris Winderickx , Nick Geukens , Eugeen Vanmechelen , Audrey Perrotin , Louise Serpell , Bernard J Hanseeuw , Miguel Medina , Luc Buée , Isabelle Landrieu

Expanding a Portfolio of (FO-) SPR Surface Chemistries with the Co(III)-NTA Oriented Immobilization of His

ACS sensors

Avec: Jia-Huan Qu , Sara Horta , Filip Delport , Machteld Sillen , Nick Geukens , Da-Wen Sun , Karen Vanhoorelbeke , Paul Declerck , Jeroen Lammertyn , Dragana Spasic

Miniaturized single-cell technologies for monoclonal antibody discovery.

Lab on a chip

Avec: Julie Van Lent , Jolien Breukers , Karen Ven , Louanne Ampofo , Sara Horta , Francesca Pollet , Maya Imbrechts , Nick Geukens , Karen Vanhoorelbeke , Paul Declerck , Jeroen Lammertyn

Innovative FO-SPR Label-free Strategy for Detecting Anti-RBD Antibodies in COVID-19 Patient Serum and Whole Blood.

ACS sensors

Avec: Jia-Huan Qu , Karen Leirs , Wim Maes , Maya Imbrechts , Nico Callewaert , Katrien Lagrou , Nick Geukens , Jeroen Lammertyn , Dragana Spasic

Point-of-care therapeutic drug monitoring of adalimumab by integrating a FO-SPR biosensor in a self-powered microfluidic cartridge.

Biosensors & bioelectronics

Avec: Jia-Huan Qu , Henry Ordutowski , Charlotte Van Tricht , Ruben Verbruggen , Alicia Barcenas Gallardo , Mattijs Bulcaen , Marta Ciwinska , Carolina Gutierrez Cisneros , Christophe Devriese , Sona Guluzade , Xander Janssens , Sophie Kornblum , Yuansheng Lu , Nika Marolt , Chezhiyan Nanjappan , Eline Rutten , Eline Vanhauwaert , Nick Geukens , Debby Thomas , Francesco Dal Dosso , Saba Safdar , Dragana Spasic , Jeroen Lammertyn

DNA-based delivery of anti-DR5 Nanobodies improves exposure and anti-tumor efficacy over protein-based administration.

Cancer gene therapy

Avec: Giles Vermeire , Elien De Smidt , Peter Casteels , Nick Geukens , Paul Declerck , Kevin Hollevoet

Bridging the Clinical Gap for DNA-Based Antibody Therapy Through Translational Studies in Sheep.

Human gene therapy

Avec: Kevin Hollevoet , Stéphanie De Vleeschauwer , Elien De Smidt , Giles Vermeire , Nick Geukens , Paul Declerck

Co(III)-NTA Mediated Antigen Immobilization on a Fiber Optic-SPR Biosensor for Detection of Autoantibodies in Autoimmune Diseases: Application in Immune-Mediated Thrombotic Thrombocytopenic Purpura.

Analytical chemistry

Avec: Sara Horta , Jia-Huan Qu , Charlotte Dekimpe , Quintijn Bonnez , Aline Vandenbulcke , Edwige Tellier , Gilles Kaplanski , Filip Delport , Nick Geukens , Jeroen Lammertyn , Karen Vanhoorelbeke

Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response.

Cancer gene therapy

Avec: Liesl Jacobs , Lidia Yshii , Steffie Junius , Nick Geukens , Adrian Liston , Kevin Hollevoet , Paul Declerck

Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model.

Frontiers in oncology

Avec: Kevin Hollevoet , Debby Thomas , Griet Compernolle , Giles Vermeire , Elien De Smidt , Stéphanie De Vleeschauwer , Trevor R F Smith , Paul D Fisher , Maarten Dewilde , Nick Geukens , Paul Declerck

Réseau de co-auteurs

Paul Declerck 12 collaborations

Jeroen Lammertyn 11 collaborations

Kevin Hollevoet 9 collaborations

Karen Vanhoorelbeke 8 collaborations

Maya Imbrechts 8 collaborations

Elien De Smidt 7 collaborations

Dragana Spasic 7 collaborations

Debby Thomas 6 collaborations

Sara Horta 5 collaborations

Xavier Bossuyt 5 collaborations

Jolien Breukers 4 collaborations

Louanne Ampofo 4 collaborations

Giles Vermeire 4 collaborations

Nico Callewaert 4 collaborations

Wim Maes 4 collaborations

Jia-Huan Qu 4 collaborations

Liesl Jacobs 3 collaborations

Doreen Dillaerts 3 collaborations

Maaike Cockx 3 collaborations

Bas Calcoen 3 collaborations

Winnie Kerstens 3 collaborations

Hendrik Jan Thibaut 3 collaborations

Sam Noppen 3 collaborations

Karen Ven 3 collaborations

Dominique Schols 3 collaborations

Caroline Struyfs 2 collaborations

Karin Thevissen 2 collaborations

Bruno P A Cammue 2 collaborations

Isabelle Desombere 2 collaborations

Joke Verelst 2 collaborations

Luc Buée 2 collaborations

Eugeen Vanmechelen 2 collaborations

Joris Winderickx 2 collaborations

Henry Ordutowski 2 collaborations

Francesco Dal Dosso 2 collaborations

Charlotte Van Tricht 2 collaborations

Aline Vandenbulcke 2 collaborations

Thomas Vercruysse 2 collaborations

Piet Maes 2 collaborations

Paul De Munter 2 collaborations

Maarten Dewilde 2 collaborations

Francesca Pollet 2 collaborations

Julie Van Lent 2 collaborations

Glynis Frans 2 collaborations

Jan Van Elslande 2 collaborations

Lise Boon 2 collaborations

Rita Derua 2 collaborations

Pieter Vermeersch 2 collaborations

Filip Delport 2 collaborations

Stéphanie De Vleeschauwer 2 collaborations

Hendrik B Feys 1 collaboration

Joseph She 1 collaboration

Filomeen Haerynck 1 collaboration

Levi Hoste 1 collaboration

Rik Schrijvers 1 collaboration

Jutte Van der Werff Ten Bosch 1 collaboration

Heidi Schaballie 1 collaboration

Giorgia Bucciol 1 collaboration

Wiert Robberechts 1 collaboration

Dina Patel 1 collaboration

Guy Berbers 1 collaboration

Isabelle Meyts 1 collaboration

Sabiha Eddarkaoui 1 collaboration

Dorien Vliegen 1 collaboration

Joëlle Rosseels 1 collaboration

Vanessa Franssens 1 collaboration

Sofie Molenberghs 1 collaboration

Cindy Francois 1 collaboration

Erik Stoops 1 collaboration

Maria Bjerke 1 collaboration

Sebastiaan Engelborghs 1 collaboration

Mohamed Laghmouchi 1 collaboration

Sofie Carmans 1 collaboration

Benno Verbelen 1 collaboration

Tiziana Girardi 1 collaboration

Sergey O Sulima 1 collaboration

Stijn Vereecke 1 collaboration

Paulien Verstraete 1 collaboration

Jelle Verbeeck 1 collaboration

Jonathan Royaert 1 collaboration

Sonia Cinque 1 collaboration

Lorenzo Montanaro 1 collaboration

Marianna Penzo 1 collaboration

Thomas Geuens 1 collaboration

Koen Dierckx 1 collaboration

Daniele Pepe 1 collaboration

Kim Kampen 1 collaboration

Kim De Keersmaecker 1 collaboration

Yagmur Yildizhan 1 collaboration

Kaat Driessens 1 collaboration

Hong Shen Kevin Tsao 1 collaboration

Robin Boiy 1 collaboration

An Hendrix 1 collaboration

Felix Neumann 1 collaboration

Shu-Hao Yeh 1 collaboration

Christoffer Mattsson Langseth 1 collaboration

Kadri Kangro 1 collaboration

Narayanan Madaboosi 1 collaboration

Mats Nilsson 1 collaboration

James A Williams 1 collaboration

Wout De Wispelaere 1 collaboration

Séverine Vermeire 1 collaboration

Ann Gils 1 collaboration

Kai Dallmeier 1 collaboration

Johan Van Weyenbergh 1 collaboration

Dorinja Zapf 1 collaboration

Kersten Dieckmann 1 collaboration

Kim Callebaut 1 collaboration

Simon F De Meyer 1 collaboration

Nathalie Van den Berghe 1 collaboration

Dominique Van Looveren 1 collaboration

Madina Rasulova 1 collaboration

Rana Abdelnabi 1 collaboration

Caroline Foo 1 collaboration

Xin Zhang 1 collaboration

Dirk Jochmans 1 collaboration

Johan Neyts 1 collaboration

Heather M Callaway 1 collaboration

Kathryn M Hastie 1 collaboration

Sharon L Schendel 1 collaboration

Haoyang Li 1 collaboration

Xiaoying Yu 1 collaboration

Jeremy Shek 1 collaboration

Tierra Buck 1 collaboration

Sean Hui 1 collaboration

Dan Bedinger 1 collaboration

Camille Troup 1 collaboration

S Moses Dennison 1 collaboration

Kan Li 1 collaboration

Michael D Alpert 1 collaboration

Charles C Bailey 1 collaboration

Sharon Benzeno 1 collaboration

Jody L Bonnevier 1 collaboration

Jin-Qiu Chen 1 collaboration

Charm Chen 1 collaboration

Hyeseon Cho 1 collaboration

Peter D Crompton 1 collaboration

Vincent Dussupt 1 collaboration

Kevin C Entzminger 1 collaboration

Yassine Ezzyat 1 collaboration

Jonathan K Fleming 1 collaboration

Amy E Gilbert 1 collaboration

Yongjun Guan 1 collaboration

Xiaojian Han 1 collaboration

Christopher J Harvey 1 collaboration

Julia M Hatler 1 collaboration

Bryan Howie 1 collaboration

Chao Hu 1 collaboration

Ailong Huang 1 collaboration

Aishun Jin 1 collaboration

Nik Kamachi 1 collaboration

Gladys Keitany 1 collaboration

Mark Klinger 1 collaboration

Jay K Kolls 1 collaboration

Shelly J Krebs 1 collaboration

Tingting Li 1 collaboration

Feiyan Luo 1 collaboration

Toshiaki Maruyama 1 collaboration

Michael A Meehl 1 collaboration

Letzibeth Mendez-Rivera 1 collaboration

Andrea Musa 1 collaboration

C J Okumura 1 collaboration

Benjamin E R Rubin 1 collaboration

Aaron K Sato 1 collaboration

Meiying Shen 1 collaboration

Anirudh Singh 1 collaboration

Shuyi Song 1 collaboration

Joshua Tan 1 collaboration

Jeffrey M Trimarchi 1 collaboration

Dhruvkumar P Upadhyay 1 collaboration

Yingming Wang 1 collaboration

Lei Yu 1 collaboration

Tom Z Yuan 1 collaboration

Erik Yusko 1 collaboration

Bjoern Peters 1 collaboration

Georgia Tomaras 1 collaboration

Erica Ollmann Saphire 1 collaboration

Marie-Lynn Cuypers 1 collaboration

Iene Rutten 1 collaboration

Tom Dehaemers 1 collaboration

Jonas De Leeuw 1 collaboration

Lina Ancheva 1 collaboration

Kusay Arat 1 collaboration

Sebastien Christian Carpentier 1 collaboration

Jean-Baptiste Vulsteke 1 collaboration

Greet Wuyts 1 collaboration

Silke Willebrords 1 collaboration

Sebastien Carpentier 1 collaboration

Sabine Tejpar 1 collaboration

Hans Wildiers 1 collaboration

Daniel Blockmans 1 collaboration

Ellen De Langhe 1 collaboration

Evelien Vanderlinden 1 collaboration

Arnaud Boonen 1 collaboration

Geert Schoofs 1 collaboration

Robert Snoeck 1 collaboration

Annelies Stevaert 1 collaboration

Lieve Naesens 1 collaboration

Graciela Andrei 1 collaboration

Yann Fichou 1 collaboration

Youssra K Al-Hilaly 1 collaboration

François Devred 1 collaboration

Caroline Smet-Nocca 1 collaboration

Philipp O Tsvetkov 1 collaboration

Audrey Perrotin 1 collaboration

Louise Serpell 1 collaboration

Bernard J Hanseeuw 1 collaboration

Miguel Medina 1 collaboration

Isabelle Landrieu 1 collaboration

Machteld Sillen 1 collaboration

Da-Wen Sun 1 collaboration

Karen Leirs 1 collaboration

Katrien Lagrou 1 collaboration

Ruben Verbruggen 1 collaboration

Alicia Barcenas Gallardo 1 collaboration

Mattijs Bulcaen 1 collaboration

Marta Ciwinska 1 collaboration

Carolina Gutierrez Cisneros 1 collaboration

Christophe Devriese 1 collaboration

Sona Guluzade 1 collaboration

Xander Janssens 1 collaboration

Sophie Kornblum 1 collaboration

Yuansheng Lu 1 collaboration

Nika Marolt 1 collaboration

Chezhiyan Nanjappan 1 collaboration

Eline Rutten 1 collaboration

Eline Vanhauwaert 1 collaboration

Saba Safdar 1 collaboration

Peter Casteels 1 collaboration

Charlotte Dekimpe 1 collaboration

Quintijn Bonnez 1 collaboration

Edwige Tellier 1 collaboration

Gilles Kaplanski 1 collaboration

Lidia Yshii 1 collaboration

Steffie Junius 1 collaboration

Adrian Liston 1 collaboration

Griet Compernolle 1 collaboration

Trevor R F Smith 1 collaboration

Paul D Fisher 1 collaboration