Sam Noppen

Affiliations

Laboratorium Virologie en Chemotherapie (Rega Instituut), Rega - Herestraat 49 - bus 1043, 3000 Leuven, Belgium.

Publications (25)

N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents.

Medicinal chemistry (Shariqah (United Arab Emirates))

Avec: Ana Marzo-Mas , Laura Conesa-Milián , Sam Noppen , Sandra Liekens , Eva Falomir , Juan Murga , Miguel Carda , Juan A Marco

Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutants.

Antiviral research

Avec: Emiel Vanhulle , Jordi Doijen , Joren Stroobants , Becky Provinciael , Sam Noppen , Dominique Schols , Annelies Stevaert , Kurt Vermeire

Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway.

The Journal of general virology

Avec: Pieter Vrijens , Sam Noppen , Talitha Boogaerts , Els Vanstreels , Roberto Ronca , Paola Chiodelli , Manon Laporte , Evelien Vanderlinden , Sandra Liekens , Annelies Stevaert , Lieve Naesens

SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening.

Antiviral research

Avec: Emiel Vanhulle , Joren Stroobants , Becky Provinciael , Anita Camps , Sam Noppen , Piet Maes , Kurt Vermeire

Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity.

Cell communication and signaling : CCS

Avec: Luna Dillemans , Karen Yu , Alexandra De Zutter , Sam Noppen , Mieke Gouwy , Nele Berghmans , Lisa Verhallen , Mirre De Bondt , Lotte Vanbrabant , Stef Brusselmans , Erik Martens , Dominique Schols , Patrick Verschueren , Mette M Rosenkilde , Pedro Elias Marques , Sofie Struyf , Paul Proost

Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics.

Pharmaceutics

Avec: Laura Rué , Tom Jaspers , Isabelle M S Degors , Sam Noppen , Dominique Schols , Bart De Strooper , Maarten Dewilde

Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome.

PLoS pathogens

Avec: Hendrik Possemiers , Thao-Thy Pham , Marion Coens , Emilie Pollenus , Sofie Knoops , Sam Noppen , Leen Vandermosten , Sigrid D'haese , Luna Dillemans , Fran Prenen , Dominique Schols , Blandine Franke-Fayard , Philippe E Van den Steen

Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Marta Ruiz-Santaquiteria , Beatriz M Illescas , Rana Abdelnabi , Arnaud Boonen , Alberto Mills , Olaia Martí-Marí , Sam Noppen , Johan Neyts , Dominique Schols , Federico Gago , Ana San-Félix , María-José Camarasa , Nazario Martín

Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.

European journal of medicinal chemistry

Avec: Olaia Martí-Marí , Belén Martínez-Gualda , Irene Fernández-Barahona , Alberto Mills , Rana Abdelnabi , Sam Noppen , Johan Neyts , Dominique Schols , María-José Camarasa , Fernando Herranz , Federico Gago , Ana San-Félix

Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide.

Frontiers in immunology

Avec: Nathalie Vanderheijden , Annelies Stevaert , Jiexiong Xie , Xiaolei Ren , Cyril Barbezange , Sam Noppen , Isabelle Desombere , Bruno Verhasselt , Peter Geldhof , Nick Vereecke , Veerle Stroobants , Dayoung Oh , Merijn Vanhee , Lieve M J Naesens , Hans J Nauwynck

Labyrinthopeptin A1 inhibits dengue and Zika virus infection by interfering with the viral phospholipid membrane.

Virology

Avec: Merel Oeyen , Eef Meyen , Sam Noppen , Sandra Claes , Jordi Doijen , Kurt Vermeire , Roderich D Süssmuth , Dominique Schols

Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases.

Frontiers in immunology

Avec: Jennifer Vandooren , Rafaela Vaz Sousa Pereira , Estefania Ugarte-Berzal , Vasily Rybakin , Sam Noppen , Melissa R Stas , Eline Bernaerts , Eva Ganseman , Mieke Metzemaekers , Dominique Schols , Paul Proost , Ghislain Opdenakker

Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface.

International journal of molecular sciences

Avec: Kelly Bugatti , Andrea Sartori , Lucia Battistini , Crescenzo Coppa , Emiel Vanhulle , Sam Noppen , Becky Provinciael , Lieve Naesens , Annelies Stevaert , Alessandro Contini , Kurt Vermeire , Franca Zanardi

FO-SPR biosensor calibrated with recombinant extracellular vesicles enables specific and sensitive detection directly in complex matrices.

Journal of extracellular vesicles

Avec: Yagmur Yildizhan , Venkata Suresh Vajrala , Edward Geeurickx , Charles Declerck , Nevena Duskunovic , Delphine De Sutter , Sam Noppen , Filip Delport , Dominique Schols , Johannes V Swinnen , Sven Eyckerman , An Hendrix , Jeroen Lammertyn , Dragana Spasic

Development of a Novel SPR Assay to Study CXCR4-Ligand Interactions.

Biosensors

Avec: Arnaud Boonen , Abhimanyu K Singh , Anneleen Van Hout , Kalyan Das , Tom Van Loy , Sam Noppen , Dominique Schols

Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood-Brain Barrier System.

Viruses

Avec: Antonios Fikatas , Jonas Dehairs , Sam Noppen , Jordi Doijen , Frank Vanderhoydonc , Eef Meyen , Johannes V Swinnen , Christophe Pannecouque , Dominique Schols

Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model.

iScience

Avec: Maya Imbrechts , Wim Maes , Louanne Ampofo , Nathalie Van den Berghe , Bas Calcoen , Dominique Van Looveren , Winnie Kerstens , Madina Rasulova , Thomas Vercruysse , Sam Noppen , Rana Abdelnabi , Caroline Foo , Kevin Hollevoet , Piet Maes , Xin Zhang , Dirk Jochmans , Karen Ven , Jeroen Lammertyn , Karen Vanhoorelbeke , Nico Callewaert , Paul De Munter , Dominique Schols , Hendrik Jan Thibaut , Johan Neyts , Paul Declerck , Nick Geukens

FLUIDOT: A Modular Microfluidic Platform for Single-Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining.

Small methods

Avec: Jolien Breukers , Karen Ven , Caroline Struyfs , Louanne Ampofo , Iene Rutten , Maya Imbrechts , Francesca Pollet , Julie Van Lent , Winnie Kerstens , Sam Noppen , Dominique Schols , Paul De Munter , Hendrik Jan Thibaut , Karen Vanhoorelbeke , Dragana Spasic , Paul Declerck , Bruno P A Cammue , Nick Geukens , Karin Thevissen , Jeroen Lammertyn

PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding.

Antiviral research

Avec: Evelien Vanderlinden , Arnaud Boonen , Sam Noppen , Geert Schoofs , Maya Imbrechts , Nick Geukens , Robert Snoeck , Annelies Stevaert , Lieve Naesens , Graciela Andrei , Dominique Schols

Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes.

Antimicrobial agents and chemotherapy

Avec: Antonios Fikatas , Peter Vervaeke , Belén Martínez-Gualda , Olaia Martí-Marí , Sam Noppen , Eef Meyen , María-José Camarasa , Ana San-Félix , Christophe Pannecouque , Dominique Schols

A unique class of lignin derivatives displays broad anti-HIV activity by interacting with the viral envelope.

Virus research

Avec: Merel Oeyen , Sam Noppen , Emiel Vanhulle , Sandra Claes , Bernt O Myrvold , Kurt Vermeire , Dominique Schols

Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity.

The Biochemical journal

Avec: Vasily Rybakin , Melissa Stas , Estefania Ugarte-Berzal , Sam Noppen , Jennifer Vandooren , Ilse Van Aelst , Sandra Liekens , Paul Proost , Ghislain Opdenakker

Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.

MedChemComm

Avec: Ana C S Gondim , Suzete Roberta da Silva , Leen Mathys , Sam Noppen , Sandra Liekens , Alexandre Holanda Sampaio , Celso S Nagano , Cintia Renata Costa Rocha , Kyria S Nascimento , Benildo S Cavada , Peter J Sadler , Jan Balzarini

Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.

Journal of medicinal chemistry

Avec: Belén Martínez-Gualda , Liang Sun , Olaia Martí-Marí , Sam Noppen , Rana Abdelnabi , Carol M Bator , Ernesto Quesada , Leen Delang , Carmen Mirabelli , Hyunwook Lee , Dominique Schols , Johan Neyts , Susan Hafenstein , María-José Camarasa , Federico Gago , Ana San-Félix

Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors†.

Journal of medicinal chemistry

Avec: Olaia Martí-Marí , Belén Martínez-Gualda , Sofía de la Puente-Secades , Alberto Mills , Ernesto Quesada , Rana Abdelnabi , Liang Sun , Arnaud Boonen , Sam Noppen , Johan Neyts , Dominique Schols , María-José Camarasa , Federico Gago , Ana San-Félix

Réseau de co-auteurs

Dominique Schols 18 collaborations

Annelies Stevaert 5 collaborations

Kurt Vermeire 5 collaborations

Rana Abdelnabi 5 collaborations

Olaia Martí-Marí 5 collaborations

Johan Neyts 5 collaborations

Ana San-Félix 5 collaborations

María-José Camarasa 5 collaborations

Sandra Liekens 4 collaborations

Emiel Vanhulle 4 collaborations

Arnaud Boonen 4 collaborations

Federico Gago 4 collaborations

Belén Martínez-Gualda 4 collaborations

Jordi Doijen 3 collaborations

Becky Provinciael 3 collaborations

Lieve Naesens 3 collaborations

Paul Proost 3 collaborations

Alberto Mills 3 collaborations

Eef Meyen 3 collaborations

Jeroen Lammertyn 3 collaborations

Maya Imbrechts 3 collaborations

Nick Geukens 3 collaborations

Joren Stroobants 2 collaborations

Evelien Vanderlinden 2 collaborations

Piet Maes 2 collaborations

Luna Dillemans 2 collaborations

Merel Oeyen 2 collaborations

Sandra Claes 2 collaborations

Jennifer Vandooren 2 collaborations

Estefania Ugarte-Berzal 2 collaborations

Vasily Rybakin 2 collaborations

Ghislain Opdenakker 2 collaborations

Johannes V Swinnen 2 collaborations

Dragana Spasic 2 collaborations

Antonios Fikatas 2 collaborations

Christophe Pannecouque 2 collaborations

Louanne Ampofo 2 collaborations

Winnie Kerstens 2 collaborations

Karen Ven 2 collaborations

Karen Vanhoorelbeke 2 collaborations

Paul De Munter 2 collaborations

Hendrik Jan Thibaut 2 collaborations

Paul Declerck 2 collaborations

Liang Sun 2 collaborations

Ernesto Quesada 2 collaborations

Ana Marzo-Mas 1 collaboration

Laura Conesa-Milián 1 collaboration

Eva Falomir 1 collaboration

Juan Murga 1 collaboration

Miguel Carda 1 collaboration

Juan A Marco 1 collaboration

Pieter Vrijens 1 collaboration

Talitha Boogaerts 1 collaboration

Els Vanstreels 1 collaboration

Roberto Ronca 1 collaboration

Paola Chiodelli 1 collaboration

Manon Laporte 1 collaboration

Anita Camps 1 collaboration

Karen Yu 1 collaboration

Alexandra De Zutter 1 collaboration

Mieke Gouwy 1 collaboration

Nele Berghmans 1 collaboration

Lisa Verhallen 1 collaboration

Mirre De Bondt 1 collaboration

Lotte Vanbrabant 1 collaboration

Stef Brusselmans 1 collaboration

Erik Martens 1 collaboration

Patrick Verschueren 1 collaboration

Mette M Rosenkilde 1 collaboration

Pedro Elias Marques 1 collaboration

Sofie Struyf 1 collaboration

Laura Rué 1 collaboration

Tom Jaspers 1 collaboration

Isabelle M S Degors 1 collaboration

Bart De Strooper 1 collaboration

Maarten Dewilde 1 collaboration

Hendrik Possemiers 1 collaboration

Thao-Thy Pham 1 collaboration

Marion Coens 1 collaboration

Emilie Pollenus 1 collaboration

Sofie Knoops 1 collaboration

Leen Vandermosten 1 collaboration

Sigrid D'haese 1 collaboration

Fran Prenen 1 collaboration

Blandine Franke-Fayard 1 collaboration

Philippe E Van den Steen 1 collaboration

Marta Ruiz-Santaquiteria 1 collaboration

Beatriz M Illescas 1 collaboration

Nazario Martín 1 collaboration

Irene Fernández-Barahona 1 collaboration

Fernando Herranz 1 collaboration

Nathalie Vanderheijden 1 collaboration

Jiexiong Xie 1 collaboration

Xiaolei Ren 1 collaboration

Cyril Barbezange 1 collaboration

Isabelle Desombere 1 collaboration

Bruno Verhasselt 1 collaboration

Peter Geldhof 1 collaboration

Nick Vereecke 1 collaboration

Veerle Stroobants 1 collaboration

Dayoung Oh 1 collaboration

Merijn Vanhee 1 collaboration

Lieve M J Naesens 1 collaboration

Hans J Nauwynck 1 collaboration

Roderich D Süssmuth 1 collaboration

Rafaela Vaz Sousa Pereira 1 collaboration

Melissa R Stas 1 collaboration

Eline Bernaerts 1 collaboration

Eva Ganseman 1 collaboration

Mieke Metzemaekers 1 collaboration

Kelly Bugatti 1 collaboration

Andrea Sartori 1 collaboration

Lucia Battistini 1 collaboration

Crescenzo Coppa 1 collaboration

Alessandro Contini 1 collaboration

Franca Zanardi 1 collaboration

Yagmur Yildizhan 1 collaboration

Venkata Suresh Vajrala 1 collaboration

Edward Geeurickx 1 collaboration

Charles Declerck 1 collaboration

Nevena Duskunovic 1 collaboration

Delphine De Sutter 1 collaboration

Filip Delport 1 collaboration

Sven Eyckerman 1 collaboration

An Hendrix 1 collaboration

Abhimanyu K Singh 1 collaboration

Anneleen Van Hout 1 collaboration

Kalyan Das 1 collaboration

Tom Van Loy 1 collaboration

Jonas Dehairs 1 collaboration

Frank Vanderhoydonc 1 collaboration

Wim Maes 1 collaboration

Nathalie Van den Berghe 1 collaboration

Bas Calcoen 1 collaboration

Dominique Van Looveren 1 collaboration

Madina Rasulova 1 collaboration

Thomas Vercruysse 1 collaboration

Caroline Foo 1 collaboration

Kevin Hollevoet 1 collaboration

Xin Zhang 1 collaboration

Dirk Jochmans 1 collaboration

Nico Callewaert 1 collaboration

Jolien Breukers 1 collaboration

Caroline Struyfs 1 collaboration

Iene Rutten 1 collaboration

Francesca Pollet 1 collaboration

Julie Van Lent 1 collaboration

Bruno P A Cammue 1 collaboration

Karin Thevissen 1 collaboration

Geert Schoofs 1 collaboration

Robert Snoeck 1 collaboration

Graciela Andrei 1 collaboration

Peter Vervaeke 1 collaboration

Bernt O Myrvold 1 collaboration

Melissa Stas 1 collaboration

Ilse Van Aelst 1 collaboration

Ana C S Gondim 1 collaboration

Suzete Roberta da Silva 1 collaboration

Leen Mathys 1 collaboration

Alexandre Holanda Sampaio 1 collaboration

Celso S Nagano 1 collaboration

Cintia Renata Costa Rocha 1 collaboration

Kyria S Nascimento 1 collaboration

Benildo S Cavada 1 collaboration

Peter J Sadler 1 collaboration

Jan Balzarini 1 collaboration

Carol M Bator 1 collaboration

Leen Delang 1 collaboration

Carmen Mirabelli 1 collaboration

Hyunwook Lee 1 collaboration

Susan Hafenstein 1 collaboration

Sofía de la Puente-Secades 1 collaboration