J Weisner

Affiliations

Department of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.

ORCID: http://orcid.org/0000-0002-6103-7371

Publications (16)

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in

Cancer research

Avec: Jörn Weisner , Ina Landel , Christoph Reintjes , Niklas Uhlenbrock , Marija Trajkovic-Arsic , Niklas Dienstbier , Julia Hardick , Swetlana Ladigan , Marius Lindemann , Steven Smith , Lena Quambusch , Rebekka Scheinpflug , Laura Depta , Rajesh Gontla , Anke Unger , Heiko Müller , Matthias Baumann , Carsten Schultz-Fademrecht , Georgia Günther , Abdelouahid Maghnouj , Matthias P Müller , Michael Pohl , Christian Teschendorf , Heiner Wolters , Richard Viebahn , Andrea Tannapfel , Waldemar Uhl , Jan G Hengstler , Stephan A Hahn , Jens T Siveke , Daniel Rauh

Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.

Journal of medicinal chemistry

Avec: Jonas Lategahn , Hannah L Tumbrink , Carsten Schultz-Fademrecht , Alena Heimsoeth , Lisa Werr , Janina Niggenaber , Marina Keul , Fatma Parmaksiz , Matthias Baumann , Sascha Menninger , Eldar Zent , Ina Landel , Jörn Weisner , Kirujan Jeyakumar , Leonie Heyden , Nicole Russ , Fabienne Müller , Carina Lorenz , Johannes Brägelmann , Inga Spille , Tobias Grabe , Matthias P Müller , Johannes M Heuckmann , Bert M Klebl , Peter Nussbaumer , Martin L Sos , Daniel Rauh

Cellular model system to dissect the isoform-selectivity of Akt inhibitors.

Nature communications

Avec: Lena Quambusch , Laura Depta , Ina Landel , Melissa Lubeck , Tonia Kirschner , Jonas Nabert , Niklas Uhlenbrock , Jörn Weisner , Michael Kostka , Laura M Levy , Carsten Schultz-Fademrecht , Franziska Glanemann , Kristina Althoff , Matthias P Müller , Jens T Siveke , Daniel Rauh

A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2.

RSC medicinal chemistry

Avec: Shubhendu Palei , Jörn Weisner , Melina Vogt , Rajesh Gontla , Benjamin Buchmuller , Christiane Ehrt , Tobias Grabe , Silke Kleinbölting , Matthias Müller , Guido H Clever , Daniel Rauh , Daniel Summerer

Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises.

Journal of medicinal chemistry

Avec: Kosmas Alexandros Pervanidis , Giovanni Danilo D'Angelo , Jörn Weisner , Sven Brandherm , Daniel Rauh

Conformational selection vs. induced fit: insights into the binding mechanisms of p38α MAP Kinase inhibitors.

Chemical communications (Cambridge, England)

Avec: Patrick Roser , Jörn Weisner , Juliane Stehle , Daniel Rauh , Malte Drescher

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach.

ChemMedChem

Avec: Leandi van der Westhuizen , Jörn Weisner , Abu Taher , Ina Landel , Lena Quambusch , Marius Lindemann , Niklas Uhlenbrock , Matthias P Müller , Ivan R Green , Stephen C Pelly , Daniel Rauh , Willem A L van Otterlo

Correction: A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2.

RSC medicinal chemistry

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.

Nature communications

Avec: A Teuber , T Schulz , B S Fletcher , R Gontla , T Mühlenberg , M-L Zischinsky , J Niggenaber , J Weisner , S B Kleinbölting , J Lategahn , S Sievers , M P Müller , S Bauer , D Rauh

Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.

Chemical science

Avec: Niklas Uhlenbrock , Steven Smith , Jörn Weisner , Ina Landel , Marius Lindemann , Thien Anh Le , Julia Hardick , Rajesh Gontla , Rebekka Scheinpflug , Paul Czodrowski , Petra Janning , Laura Depta , Lena Quambusch , Matthias P Müller , Bernd Engels , Daniel Rauh

Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.

Angewandte Chemie (International ed. in English)

Avec: Lena Quambusch , Ina Landel , Laura Depta , Jörn Weisner , Niklas Uhlenbrock , Matthias P Müller , Franziska Glanemann , Kristina Althoff , Jens T Siveke , Daniel Rauh

Insights into the Conformational Plasticity of the Protein Kinase Akt1 by Multi-Lateral Dipolar Spectroscopy.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Juliane Stehle , Jörn Weisner , Leanne Eichhorn , Daniel Rauh , Malte Drescher

2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Avec: Miriam Schehr , Chiara Ianes , Jörn Weisner , Linda Heintze , Matthias P Müller , Christian Pichlo , Julia Charl , Elena Brunstein , Julia Ewert , Marc Lehr , Ulrich Baumann , Daniel Rauh , Uwe Knippschild , Christian Peifer , Rainer Herges

Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.

Journal of medicinal chemistry

Avec: Jonas Lategahn , Julia Hardick , Tobias Grabe , Janina Niggenaber , Kirujan Jeyakumar , Marina Keul , Hannah L Tumbrink , Christian Becker , Luke Hodson , Tonia Kirschner , Philip Klövekorn , Julia Ketzer , Matthias Baumann , Susanne Terheyden , Anke Unger , Jörn Weisner , Matthias P Müller , Willem A L van Otterlo , Sebastian Bauer , Daniel Rauh

Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions.

PloS one

Avec: Bianca Wiedemann , Dominic Kamps , Laura Depta , Jörn Weisner , Jana Cvetreznik , Stefano Tomassi , Sascha Gentz , Jan-Erik Hoffmann , Matthias P Müller , Oliver Koch , Leif Dehmelt , Daniel Rauh

Synthesis of Asymmetric Ionic Hybrid Detergents enables Micelles with Scalable Properties including Cell Compatibility.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Virginia Wycisk , Jan-Simon Behnke , Lena Nielinger , Marc Seewald , Jörn Weisner , Markus Binsch , Marc-Christian Wagner , Tobias Raisch , Leonhard Hagen Urner

Réseau de co-auteurs

Jörn Weisner 15 collaborations

Daniel Rauh 14 collaborations

Matthias P Müller 9 collaborations

Ina Landel 6 collaborations

Niklas Uhlenbrock 5 collaborations

Lena Quambusch 5 collaborations

Laura Depta 5 collaborations

Rajesh Gontla 4 collaborations

Tobias Grabe 4 collaborations

Julia Hardick 3 collaborations

Marius Lindemann 3 collaborations

Matthias Baumann 3 collaborations

Carsten Schultz-Fademrecht 3 collaborations

Jens T Siveke 3 collaborations

Steven Smith 2 collaborations

Rebekka Scheinpflug 2 collaborations

Anke Unger 2 collaborations

Jonas Lategahn 2 collaborations

Hannah L Tumbrink 2 collaborations

Janina Niggenaber 2 collaborations

Marina Keul 2 collaborations

Kirujan Jeyakumar 2 collaborations

Tonia Kirschner 2 collaborations

Franziska Glanemann 2 collaborations

Kristina Althoff 2 collaborations

Shubhendu Palei 2 collaborations

Melina Vogt 2 collaborations

Benjamin Buchmuller 2 collaborations

Christiane Ehrt 2 collaborations

Silke Kleinbölting 2 collaborations

Matthias Müller 2 collaborations

Guido H Clever 2 collaborations

Daniel Summerer 2 collaborations

Juliane Stehle 2 collaborations

Malte Drescher 2 collaborations

Willem A L van Otterlo 2 collaborations

Christoph Reintjes 1 collaboration

Marija Trajkovic-Arsic 1 collaboration

Niklas Dienstbier 1 collaboration

Swetlana Ladigan 1 collaboration

Heiko Müller 1 collaboration

Georgia Günther 1 collaboration

Abdelouahid Maghnouj 1 collaboration

Michael Pohl 1 collaboration

Christian Teschendorf 1 collaboration

Heiner Wolters 1 collaboration

Richard Viebahn 1 collaboration

Andrea Tannapfel 1 collaboration

Waldemar Uhl 1 collaboration

Jan G Hengstler 1 collaboration

Stephan A Hahn 1 collaboration

Alena Heimsoeth 1 collaboration

Lisa Werr 1 collaboration

Fatma Parmaksiz 1 collaboration

Sascha Menninger 1 collaboration

Eldar Zent 1 collaboration

Leonie Heyden 1 collaboration

Nicole Russ 1 collaboration

Fabienne Müller 1 collaboration

Carina Lorenz 1 collaboration

Johannes Brägelmann 1 collaboration

Inga Spille 1 collaboration

Johannes M Heuckmann 1 collaboration

Bert M Klebl 1 collaboration

Peter Nussbaumer 1 collaboration

Martin L Sos 1 collaboration

Melissa Lubeck 1 collaboration

Jonas Nabert 1 collaboration

Michael Kostka 1 collaboration

Laura M Levy 1 collaboration

Kosmas Alexandros Pervanidis 1 collaboration

Giovanni Danilo D'Angelo 1 collaboration

Sven Brandherm 1 collaboration

Patrick Roser 1 collaboration

Leandi van der Westhuizen 1 collaboration

Abu Taher 1 collaboration

Ivan R Green 1 collaboration

Stephen C Pelly 1 collaboration

A Teuber 1 collaboration

T Schulz 1 collaboration

B S Fletcher 1 collaboration

R Gontla 1 collaboration

T Mühlenberg 1 collaboration

M-L Zischinsky 1 collaboration

J Niggenaber 1 collaboration

S B Kleinbölting 1 collaboration

J Lategahn 1 collaboration

S Sievers 1 collaboration

M P Müller 1 collaboration

S Bauer 1 collaboration

D Rauh 1 collaboration

Thien Anh Le 1 collaboration

Paul Czodrowski 1 collaboration

Petra Janning 1 collaboration

Bernd Engels 1 collaboration

Leanne Eichhorn 1 collaboration

Miriam Schehr 1 collaboration

Chiara Ianes 1 collaboration

Linda Heintze 1 collaboration

Christian Pichlo 1 collaboration

Julia Charl 1 collaboration

Elena Brunstein 1 collaboration

Julia Ewert 1 collaboration

Marc Lehr 1 collaboration

Ulrich Baumann 1 collaboration

Uwe Knippschild 1 collaboration

Christian Peifer 1 collaboration

Rainer Herges 1 collaboration

Christian Becker 1 collaboration

Luke Hodson 1 collaboration

Philip Klövekorn 1 collaboration

Julia Ketzer 1 collaboration

Susanne Terheyden 1 collaboration

Sebastian Bauer 1 collaboration

Bianca Wiedemann 1 collaboration

Dominic Kamps 1 collaboration

Jana Cvetreznik 1 collaboration

Stefano Tomassi 1 collaboration

Sascha Gentz 1 collaboration

Jan-Erik Hoffmann 1 collaboration

Oliver Koch 1 collaboration

Leif Dehmelt 1 collaboration

Virginia Wycisk 1 collaboration

Jan-Simon Behnke 1 collaboration

Lena Nielinger 1 collaboration

Marc Seewald 1 collaboration

Markus Binsch 1 collaboration

Marc-Christian Wagner 1 collaboration

Tobias Raisch 1 collaboration

Leonhard Hagen Urner 1 collaboration