Janina Niggenaber

Affiliations

Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: daniel.rauh@tu-dortmund.de ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.

ORCID: 0000-0003-2942-263X

Publications (7)

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.

Nature communications

Avec: A Teuber , T Schulz , B S Fletcher , R Gontla , T Mühlenberg , M-L Zischinsky , J Niggenaber , J Weisner , S B Kleinbölting , J Lategahn , S Sievers , M P Müller , S Bauer , D Rauh

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.

Chemical science

Avec: Jonas Lategahn , Marina Keul , Philip Klövekorn , Hannah L Tumbrink , Matthias P Müller , Luke Hodson , Maren Flaßhoff , Julia Hardick , Tobias Grabe , Julian Engel , Carsten Schultz-Fademrecht , Matthias Baumann , Julia Ketzer , Thomas Mühlenberg , Wolf Hiller , Georgia Günther , Anke Unger , Heiko Müller , Alena Heimsoeth , Christopher Golz , Bernhard Blank-Landeshammer , Laxmikanth Kollipara , René P Zahedi , Carsten Strohmann , Jan G Hengstler , Willem A L van Otterlo , Sebastian Bauer , Daniel Rauh

Structure Defines Function: Clinically Relevant Mutations in ErbB Kinases.

Journal of medicinal chemistry

Avec: Julia Hardick , Jonas Lategahn , Daniel Rauh

Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands.

ACS medicinal chemistry letters

Avec: Leonie Heyden , Tobias Grabe , Matthias P Müller , Jonas Lategahn , Daniel Rauh

Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.

Journal of medicinal chemistry

Avec: Jonas Lategahn , Hannah L Tumbrink , Carsten Schultz-Fademrecht , Alena Heimsoeth , Lisa Werr , Marina Keul , Fatma Parmaksiz , Matthias Baumann , Sascha Menninger , Eldar Zent , Ina Landel , Jörn Weisner , Kirujan Jeyakumar , Leonie Heyden , Nicole Russ , Fabienne Müller , Carina Lorenz , Johannes Brägelmann , Inga Spille , Tobias Grabe , Matthias P Müller , Johannes M Heuckmann , Bert M Klebl , Peter Nussbaumer , Martin L Sos , Daniel Rauh

Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.

Journal of medicinal chemistry

Avec: Jonas Lategahn , Julia Hardick , Tobias Grabe , Kirujan Jeyakumar , Marina Keul , Hannah L Tumbrink , Christian Becker , Luke Hodson , Tonia Kirschner , Philip Klövekorn , Julia Ketzer , Matthias Baumann , Susanne Terheyden , Anke Unger , Jörn Weisner , Matthias P Müller , Willem A L van Otterlo , Sebastian Bauer , Daniel Rauh

Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines.

ACS medicinal chemistry letters

Avec: Tobias Grabe , Kirujan Jeyakumar , Tom Schulz , Sandra Koska , Silke Kleinbölting , Michael Edmund Beck , Matthias P Müller , Daniel Rauh

Réseau de co-auteurs

Daniel Rauh 6 collaborations

Jonas Lategahn 5 collaborations

Matthias P Müller 5 collaborations

Tobias Grabe 5 collaborations

Marina Keul 3 collaborations

Hannah L Tumbrink 3 collaborations

Julia Hardick 3 collaborations

Matthias Baumann 3 collaborations

Kirujan Jeyakumar 3 collaborations

Philip Klövekorn 2 collaborations

Luke Hodson 2 collaborations

Carsten Schultz-Fademrecht 2 collaborations

Julia Ketzer 2 collaborations

Anke Unger 2 collaborations

Alena Heimsoeth 2 collaborations

Willem A L van Otterlo 2 collaborations

Sebastian Bauer 2 collaborations

Leonie Heyden 2 collaborations

Jörn Weisner 2 collaborations

A Teuber 1 collaboration

T Schulz 1 collaboration

B S Fletcher 1 collaboration

R Gontla 1 collaboration

T Mühlenberg 1 collaboration

M-L Zischinsky 1 collaboration

J Niggenaber 1 collaboration

J Weisner 1 collaboration

S B Kleinbölting 1 collaboration

J Lategahn 1 collaboration

S Sievers 1 collaboration

M P Müller 1 collaboration

S Bauer 1 collaboration

D Rauh 1 collaboration

Maren Flaßhoff 1 collaboration

Julian Engel 1 collaboration

Thomas Mühlenberg 1 collaboration

Wolf Hiller 1 collaboration

Georgia Günther 1 collaboration

Heiko Müller 1 collaboration

Christopher Golz 1 collaboration

Bernhard Blank-Landeshammer 1 collaboration

Laxmikanth Kollipara 1 collaboration

René P Zahedi 1 collaboration

Carsten Strohmann 1 collaboration

Jan G Hengstler 1 collaboration

Lisa Werr 1 collaboration

Fatma Parmaksiz 1 collaboration

Sascha Menninger 1 collaboration

Eldar Zent 1 collaboration

Ina Landel 1 collaboration

Nicole Russ 1 collaboration

Fabienne Müller 1 collaboration

Carina Lorenz 1 collaboration

Johannes Brägelmann 1 collaboration

Inga Spille 1 collaboration

Johannes M Heuckmann 1 collaboration

Bert M Klebl 1 collaboration

Peter Nussbaumer 1 collaboration

Martin L Sos 1 collaboration

Christian Becker 1 collaboration

Tonia Kirschner 1 collaboration

Susanne Terheyden 1 collaboration

Tom Schulz 1 collaboration

Sandra Koska 1 collaboration

Silke Kleinbölting 1 collaboration

Michael Edmund Beck 1 collaboration