Sibylle Neuhoff

Affiliations

Simcyp Division, Certara UK Limited, Sheffield, UK.

Publications (36)

Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.

Clinical pharmacology and therapeutics

Avec: Maciej J Zamek-Gliszczynski , Mitesh Patel , Xinning Yang , Justin D Lutz , Xiaoyan Chu , Kim L R Brouwer , Yurong Lai , Caroline A Lee , Mary F Paine , Yuichi Sugiyama , Kunal S Taskar , Aleksandra Galetin

Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P-glycoprotein-cytochrome P450 3A4 dual substrates.

CPT: pharmacometrics & systems pharmacology

Avec: Xian Pan , Shinji Yamazaki , Mian Zhang , Venkatesh Pilla Reddy

Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator.

CPT: pharmacometrics & systems pharmacology

Avec: Udoamaka Ezuruike , Mian Zhang , Amita Pansari , Mailys De Sousa Mendes , Xian Pan , Iain Gardner

Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective.

Clinical pharmacology and therapeutics

Avec: Kunal S Taskar , Xinning Yang , Mitesh Patel , Kenta Yoshida , Mary F Paine , Kim L R Brouwer , Xiaoyan Chu , Yuichi Sugiyama , Jack Cook , Joseph W Polli , Imad Hanna , Yurong Lai , Maciej Zamek-Gliszczynski , Auteur inconnu

Interlaboratory Variability in the Madin-Darby Canine Kidney Cell Proteome.

Molecular pharmaceutics

Avec: Matthew D Harwood , Katharina Zettl , Manuel Weinheimer , Venkatesh Pilla-Reddy , Hong Shen , Frank Jacobs , Xiaoyan Chu , Felix Huth , Masanori Nakakariya , Paresh P Chothe , Jacek R Wiśniewski

New approach methodologies (NAMs) for human-relevant biokinetics predictions. Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment

ALTEX

Avec: Ans Punt , Hans Bouwmeester , Bas J Blaauboer , Sandra Coecke , Betty Hakkert , Delilah F G Hendriks , Paul Jennings , Nynke I Kramer , Rosalinde Masereeuw , Alicia Paini , Ad A C M Peijnenburg , Martijn Rooseboom , Michael L Shuler , Ian Sorrell , Bart Spee , Marije Strikwold , Andries D Van der Meer , Meike Van der Zande , Mathieu Vinken , Huan Yang , Peter M J Bos , Minne B Heringa

Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients.

Molecular pharmaceutics

Avec: Zubida M Al-Majdoub , Hajar Al Feteisi , Brahim Achour , Stacey Warwood , Amin Rostami-Hodjegan , Jill Barber

The Translation of Movement From the Equine to Rider With Relevance for Hippotherapy.

Journal of equine veterinary science

Avec: Meredith C Donaldson , Anne Marie Holter , Simone Neuhoff , Justin A Arnosky , Beryl W Simpson , Kristine Vernon , Richard W Blob , John D DesJardins

Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions.

Journal of pharmaceutical sciences

Avec: Taleah Farasyn , Alexandra Crowe , Oliver Hatley , Khondoker Alam , Jean Kanyo , TuKiet T Lam , Kai Ding , Wei Yue

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH).

Clinical pharmacology and therapeutics

Avec: William A Murphy , Jeffry Adiwidjaja , Noora Sjöstedt , Kyunghee Yang , James J Beaudoin , Jessica Spires , Scott Q Siler , Kim L R Brouwer

Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.

Clinical pharmacology and therapeutics

Avec: Xiaoyan Chu , Bhagwat Prasad , Kenta Yoshida , James Steven Leeder , Dwaipayan Mukherjee , Kunal Taskar , Manthena V S Varma , Xinyuan Zhang , Xinning Yang , Aleksandra Galetin

Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD.

Hepatology communications

Avec: William A Murphy , Anna Mae Diehl , Matthew Shane Loop , Dong Fu , Cynthia D Guy , Manal F Abdelmalek , Georgia Sofia Karachaliou , Noora Sjöstedt , Paavo Honkakoski , Kim L R Brouwer

The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Matthew D Harwood , Mian Zhang , Shriram M Pathak ,

Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling.

CPT: pharmacometrics & systems pharmacology

Avec: Kosuke Doki , Amin Rostami-Hodjegan , Masato Homma

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions.

Pharmaceutics

Avec: Irina E Antonescu , Maria Karlgren , Maria L Pedersen , Ivailo Simoff , Christel A S Bergström , Per Artursson , Bente Steffansen , Carsten Uhd Nielsen

Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interaction Potential of Vemurafenib Using R-Value and Physiologically-Based Pharmacokinetic Models.

Journal of pharmaceutical sciences

Avec: Ruhul Kayesh , Taleah Farasyn , Alexandra Crowe , Qiang Liu , Sonia Pahwa , Khondoker Alam , Oliver Hatley , Kai Ding , Wei Yue

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach.

Molecular pharmaceutics

Avec: Irina E Antonescu , Karina F Rasmussen , Xavier Fretté , Maria Karlgren , Christel A S Bergström , Carsten Uhd Nielsen , Bente Steffansen

Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin.

FEBS letters

Avec: Zubida M Al-Majdoub , Brahim Achour , Narciso Couto , Martyn Howard , Yasmine Elmorsi , Daniel Scotcher , Sarah Alrubia , Eman El-Khateeb , Areti-Maria Vasilogianni , Noura Alohali , Lutz Schmitt , Amin Rostami-Hodjegan , Jill Barber

How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study.

Clinical pharmacology and therapeutics

Avec: Olha Shuklinova , Sebastian Polak

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta.

Pharmaceutics

Avec: Valerio Taggi , Mario Riera Romo , Micheline Piquette-Miller , Henriette E Meyer Zu Schwabedissen ,

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21.

Metabolites

Avec: Caroline Sychterz , Iain Gardner , Manting Chiang , Ramakrishna Rachumallu , Vidya Perera , Samira Merali , Brian J Schmidt , Lu Gaohua

Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics.

The AAPS journal

Avec: Marilyn N Martinez , Jonathan P Mochel , Devendra Pade

Food constituent- and herb-drug interactions in oncology: Influence of quantitative modelling on Drug labelling.

British journal of clinical pharmacology

Avec: Venkatesh Pilla Reddy , Heeseung Jo ,

Physiologically-Based Pharmacokinetic Model of Morphine and Morphine-3-Glucuronide in Nonalcoholic Steatohepatitis.

Clinical pharmacology and therapeutics

Avec: Noora Sjöstedt , Kim L R Brouwer

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition.

The AAPS journal

Avec: Yukiko Murata , Amin Rostami-Hodjegan , Hiroyuki Takita , Zubida M Al-Majdoub , Kayode Ogungbenro

Application of proteomic data in the translation of in vitro observations to associated clinical outcomes.

Drug discovery today. Technologies

Avec: Matthew D Harwood , Amin Rostami-Hodjegan , Brahim Achour

Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

CPT: pharmacometrics & systems pharmacology

Avec: Peter J Kilford , Kuan-Fu Chen , Kim Crewe , Iain Gardner , Oliver Hatley , Alice Ban Ke , Mian Zhang , Karen Rowland Yeo

Physiologically Based Pharmacokinetic Modeling for Maribavir to Inform Dosing in Drug-Drug Interaction Scenarios with CYP3A4 Inducers and Inhibitors.

Journal of clinical pharmacology

Avec: Grace Chen , Kefeng Sun , Ingrid Michon , Zoe Barter , Lipika Ghosh , Katarina Ilic , Ivy H Song

Performance fatigability in adults with spinal muscular atrophy treated long-term with nusinersen.

Muscle & nerve

Avec: Benjamin Stolte , Svenja Neuhoff , Jaqueline Lipka , Melina Schlag , Otgonzul von Velsen , Teresa Kruse , Cornelius Deuschl , Christoph Kleinschnitz , Tim Hagenacker

A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Mailys De Sousa Mendes , Alexandra L Orton , Helen E Humphries , Barry Jones , Iain Gardner , Venkatesh Pilla Reddy

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates.

Clinical pharmacology and therapeutics

Avec: Ming-Liang Tan , Ping Zhao , Lei Zhang , Yunn-Fang Ho , Manthena V S Varma , Thomas D Nolin , Aleksandra Galetin , Shiew-Mei Huang

Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.

Clinical pharmacology and therapeutics

Avec: Kunal S Taskar , Venkatesh Pilla Reddy , Howard Burt , Maria M Posada , Manthena Varma , Ming Zheng , Mohammed Ullah , Arian Emami Riedmaier , Ken-Ichi Umehara , Jan Snoeys , Masanori Nakakariya , Xiaoyan Chu , Maud Beneton , Yuan Chen , Felix Huth , Rangaraj Narayanan , Dwaipayan Mukherjee , Vaishali Dixit , Yuichi Sugiyama ,

Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.

Clinical pharmacology and therapeutics

Avec: Kim L R Brouwer , Raymond Evers , Elizabeth Hayden , Shuiying Hu , Cindy Yanfei Li , Henriette E Meyer Zu Schwabedissen , Stefan Oswald , Micheline Piquette-Miller , Chitra Saran , Noora Sjöstedt , Jason A Sprowl , Simone H Stahl , Wei Yue

Non-specific binding of compounds in

Xenobiotica; the fate of foreign compounds in biological systems

Avec: Iain Gardner , Mandy Xu , Chunyan Han , Yi Wang , Xingjin Jiao , Masoud Jamei , Hiba Khalidi , Peter Kilford , Roz Southall , David B Turner , Helen Musther , Barry Jones , Simon Taylor

Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework.

CPT: pharmacometrics & systems pharmacology

Avec: Mattie Hartauer , William A Murphy , Kim L R Brouwer , Roz Southall ,

A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator.

CPT: pharmacometrics & systems pharmacology

Avec: Liam Curry , Sarah Alrubia , Frederic Y Bois , Ruth Clayton , Eman El-Khateeb , Trevor N Johnson , Muhammad Faisal , Kris Wragg , Amin Rostami-Hodjegan

Réseau de co-auteurs

Kim L R Brouwer 7 collaborations

Amin Rostami-Hodjegan 6 collaborations

Xiaoyan Chu 5 collaborations

Iain Gardner 5 collaborations

Mian Zhang 4 collaborations

Venkatesh Pilla Reddy 4 collaborations

Noora Sjöstedt 4 collaborations

Xinning Yang 3 collaborations

Yuichi Sugiyama 3 collaborations

Kunal S Taskar 3 collaborations

Aleksandra Galetin 3 collaborations

Matthew D Harwood 3 collaborations

Zubida M Al-Majdoub 3 collaborations

Brahim Achour 3 collaborations

Oliver Hatley 3 collaborations

Wei Yue 3 collaborations

William A Murphy 3 collaborations

Mitesh Patel 2 collaborations

Yurong Lai 2 collaborations

Mary F Paine 2 collaborations

Xian Pan 2 collaborations

Mailys De Sousa Mendes 2 collaborations

Kenta Yoshida 2 collaborations

Felix Huth 2 collaborations

Masanori Nakakariya 2 collaborations

Jill Barber 2 collaborations

Taleah Farasyn 2 collaborations

Alexandra Crowe 2 collaborations

Khondoker Alam 2 collaborations

Kai Ding 2 collaborations

Dwaipayan Mukherjee 2 collaborations

Manthena V S Varma 2 collaborations

Irina E Antonescu 2 collaborations

Maria Karlgren 2 collaborations

Christel A S Bergström 2 collaborations

Bente Steffansen 2 collaborations

Carsten Uhd Nielsen 2 collaborations

Sarah Alrubia 2 collaborations

Eman El-Khateeb 2 collaborations

Micheline Piquette-Miller 2 collaborations

Henriette E Meyer Zu Schwabedissen 2 collaborations

Barry Jones 2 collaborations

Roz Southall 2 collaborations

Maciej J Zamek-Gliszczynski 1 collaboration

Justin D Lutz 1 collaboration

Caroline A Lee 1 collaboration

Shinji Yamazaki 1 collaboration

Udoamaka Ezuruike 1 collaboration

Amita Pansari 1 collaboration

Jack Cook 1 collaboration

Joseph W Polli 1 collaboration

Imad Hanna 1 collaboration

Maciej Zamek-Gliszczynski 1 collaboration

None None 1 collaboration

Katharina Zettl 1 collaboration

Manuel Weinheimer 1 collaboration

Venkatesh Pilla-Reddy 1 collaboration

Hong Shen 1 collaboration

Frank Jacobs 1 collaboration

Paresh P Chothe 1 collaboration

Jacek R Wiśniewski 1 collaboration

Ans Punt 1 collaboration

Hans Bouwmeester 1 collaboration

Bas J Blaauboer 1 collaboration

Sandra Coecke 1 collaboration

Betty Hakkert 1 collaboration

Delilah F G Hendriks 1 collaboration

Paul Jennings 1 collaboration

Nynke I Kramer 1 collaboration

Rosalinde Masereeuw 1 collaboration

Alicia Paini 1 collaboration

Ad A C M Peijnenburg 1 collaboration

Martijn Rooseboom 1 collaboration

Michael L Shuler 1 collaboration

Ian Sorrell 1 collaboration

Bart Spee 1 collaboration

Marije Strikwold 1 collaboration

Andries D Van der Meer 1 collaboration

Meike Van der Zande 1 collaboration

Mathieu Vinken 1 collaboration

Huan Yang 1 collaboration

Peter M J Bos 1 collaboration

Minne B Heringa 1 collaboration

Hajar Al Feteisi 1 collaboration

Stacey Warwood 1 collaboration

Meredith C Donaldson 1 collaboration

Anne Marie Holter 1 collaboration

Simone Neuhoff 1 collaboration

Justin A Arnosky 1 collaboration

Beryl W Simpson 1 collaboration

Kristine Vernon 1 collaboration

Richard W Blob 1 collaboration

John D DesJardins 1 collaboration

Jean Kanyo 1 collaboration

TuKiet T Lam 1 collaboration

Jeffry Adiwidjaja 1 collaboration

Kyunghee Yang 1 collaboration

James J Beaudoin 1 collaboration

Jessica Spires 1 collaboration

Scott Q Siler 1 collaboration

Bhagwat Prasad 1 collaboration

James Steven Leeder 1 collaboration

Kunal Taskar 1 collaboration

Xinyuan Zhang 1 collaboration

Anna Mae Diehl 1 collaboration

Matthew Shane Loop 1 collaboration

Dong Fu 1 collaboration

Cynthia D Guy 1 collaboration

Manal F Abdelmalek 1 collaboration

Georgia Sofia Karachaliou 1 collaboration

Paavo Honkakoski 1 collaboration

Shriram M Pathak 1 collaboration

Kosuke Doki 1 collaboration

Masato Homma 1 collaboration

Maria L Pedersen 1 collaboration

Ivailo Simoff 1 collaboration

Per Artursson 1 collaboration

Ruhul Kayesh 1 collaboration

Qiang Liu 1 collaboration

Sonia Pahwa 1 collaboration

Karina F Rasmussen 1 collaboration

Xavier Fretté 1 collaboration

Narciso Couto 1 collaboration

Martyn Howard 1 collaboration

Yasmine Elmorsi 1 collaboration

Daniel Scotcher 1 collaboration

Areti-Maria Vasilogianni 1 collaboration

Noura Alohali 1 collaboration

Lutz Schmitt 1 collaboration

Olha Shuklinova 1 collaboration

Sebastian Polak 1 collaboration

Valerio Taggi 1 collaboration

Mario Riera Romo 1 collaboration

Caroline Sychterz 1 collaboration

Manting Chiang 1 collaboration

Ramakrishna Rachumallu 1 collaboration

Vidya Perera 1 collaboration

Samira Merali 1 collaboration

Brian J Schmidt 1 collaboration

Lu Gaohua 1 collaboration

Marilyn N Martinez 1 collaboration

Jonathan P Mochel 1 collaboration

Devendra Pade 1 collaboration

Heeseung Jo 1 collaboration

Yukiko Murata 1 collaboration

Hiroyuki Takita 1 collaboration

Kayode Ogungbenro 1 collaboration

Peter J Kilford 1 collaboration

Kuan-Fu Chen 1 collaboration

Kim Crewe 1 collaboration

Alice Ban Ke 1 collaboration

Karen Rowland Yeo 1 collaboration

Grace Chen 1 collaboration

Kefeng Sun 1 collaboration

Ingrid Michon 1 collaboration

Zoe Barter 1 collaboration

Lipika Ghosh 1 collaboration

Katarina Ilic 1 collaboration

Ivy H Song 1 collaboration

Benjamin Stolte 1 collaboration

Svenja Neuhoff 1 collaboration

Jaqueline Lipka 1 collaboration

Melina Schlag 1 collaboration

Otgonzul von Velsen 1 collaboration

Teresa Kruse 1 collaboration

Cornelius Deuschl 1 collaboration

Christoph Kleinschnitz 1 collaboration

Tim Hagenacker 1 collaboration

Alexandra L Orton 1 collaboration

Helen E Humphries 1 collaboration

Ming-Liang Tan 1 collaboration

Ping Zhao 1 collaboration

Lei Zhang 1 collaboration

Yunn-Fang Ho 1 collaboration

Thomas D Nolin 1 collaboration

Shiew-Mei Huang 1 collaboration

Howard Burt 1 collaboration

Maria M Posada 1 collaboration

Manthena Varma 1 collaboration

Ming Zheng 1 collaboration

Mohammed Ullah 1 collaboration

Arian Emami Riedmaier 1 collaboration

Ken-Ichi Umehara 1 collaboration

Jan Snoeys 1 collaboration

Maud Beneton 1 collaboration

Yuan Chen 1 collaboration

Rangaraj Narayanan 1 collaboration

Vaishali Dixit 1 collaboration

Raymond Evers 1 collaboration

Elizabeth Hayden 1 collaboration

Shuiying Hu 1 collaboration

Cindy Yanfei Li 1 collaboration

Stefan Oswald 1 collaboration

Chitra Saran 1 collaboration

Jason A Sprowl 1 collaboration

Simone H Stahl 1 collaboration

Mandy Xu 1 collaboration

Chunyan Han 1 collaboration

Yi Wang 1 collaboration

Xingjin Jiao 1 collaboration

Masoud Jamei 1 collaboration

Hiba Khalidi 1 collaboration

Peter Kilford 1 collaboration

David B Turner 1 collaboration

Helen Musther 1 collaboration

Simon Taylor 1 collaboration

Mattie Hartauer 1 collaboration

Liam Curry 1 collaboration

Frederic Y Bois 1 collaboration

Ruth Clayton 1 collaboration

Trevor N Johnson 1 collaboration

Muhammad Faisal 1 collaboration

Kris Wragg 1 collaboration