Georg Meisl

Affiliations

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK . Email: dk10012@cam.ac.uk.

Publications (66)

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.

Chemical science

Avec: Jason C Sang , Ji-Eun Lee , Alexander J Dear , Suman De , Alana M Thackray , Raymond Bujdoso , Tuomas P J Knowles , David Klenerman

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.

Life science alliance

Avec: Matthias M Schneider , Marc Emmenegger , Catherine K Xu , Itzel Condado Morales , Priscilla Turelli , Chryssa Zografou , Manuela R Zimmermann , Beat M Frey , Sebastian Fiedler , Viola Denninger , Raphaël Pb Jacquat , Lidia Madrigal , Alison Ilsley , Vasilis Kosmoliaptsis , Heike Fiegler , Didier Trono , Tuomas Pj Knowles , Adriano Aguzzi

Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation.

Journal of the American Chemical Society

Avec: Manuela R Zimmermann , Subhas C Bera , Sourav Dasadhikari , Shamasree Ghosh , Sara Linse , Kanchan Garai , Tuomas P J Knowles

Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2.

ACS infectious diseases

Avec: Viola Denninger , Catherine K Xu , Alexey S Morgunov , Sebastian Fiedler , Alison Ilsley , Marc Emmenegger , Anisa Y Malik , Monika A Piziorska , Matthias M Schneider , Sean R A Devenish , Vasilis Kosmoliaptsis , Adriano Aguzzi , Heike Fiegler , Tuomas P J Knowles

Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.

ACS chemical neuroscience

Avec: Sarah R Ball , Julius S P Adamson , Michael A Sullivan , Manuela R Zimmermann , Victor Lo , Maximo Sanz-Hernandez , Xiaofan Jiang , Ann H Kwan , André D J McKenzie , Eryn L Werry , Tuomas P J Knowles , Michael Kassiou , Matthew H Todd , Peter J Rutledge , Margaret Sunde

The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.

The Journal of chemical physics

Avec: T B Thompson , G Meisl , T P J Knowles , A Goriely

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.

Communications biology

Avec: Rebecca Frankel , Mattias Törnquist , Oskar Hansson , Ulf Andreasson , Henrik Zetterberg , Kaj Blennow , Birgitta Frohm , Tommy Cedervall , Tuomas P J Knowles , Thom Leiding , Sara Linse

Trodusquemine enhances Aβ

Nature communications

Avec: Ryan Limbocker , Sean Chia , Francesco S Ruggeri , Michele Perni , Roberta Cascella , Gabriella T Heller , Benedetta Mannini , Johnny Habchi , Thomas C T Michaels , Pavan K Challa , Minkoo Ahn , Samuel T Casford , Nilumi Fernando , Catherine K Xu , Nina D Kloss , Samuel I A Cohen , Janet R Kumita , Cristina Cecchi , Michael Zasloff , Sara Linse , Tuomas P J Knowles , Fabrizio Chiti , Michele Vendruscolo , Christopher M Dobson

α-Synuclein strains target distinct brain regions and cell types.

Nature neuroscience

Avec: Angus Lau , Raphaella W L So , Heather H C Lau , Jason C Sang , Alejandro Ruiz-Riquelme , Shelaine C Fleck , Erica Stuart , Sindhu Menon , Naomi P Visanji , Rania Faidi , Maria M Marano , Cian Schmitt-Ulms , Zhilan Wang , Paul E Fraser , Anurag Tandon , Bradley T Hyman , Holger Wille , Martin Ingelsson , David Klenerman , Joel C Watts

The catalytic nature of protein aggregation.

The Journal of chemical physics

Avec: Alexander J Dear , Thomas C T Michaels , Manuela R Zimmermann , Sara Linse , Tuomas P J Knowles

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils.

ACS nano

Avec: Francesco Simone Ruggeri , Patrick Flagmeier , Janet R Kumita , Dimitri Y Chirgadze , Marie N Bongiovanni , Tuomas P J Knowles , Christopher M Dobson

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.

Frontiers in neuroscience

Avec: Ryan Limbocker , Roxine Staats , Sean Chia , Francesco S Ruggeri , Benedetta Mannini , Catherine K Xu , Michele Perni , Roberta Cascella , Alessandra Bigi , Liam R Sasser , Natalie R Block , Aidan K Wright , Ryan P Kreiser , Edward T Custy , Silvia Errico , Johnny Habchi , Patrick Flagmeier , Tadas Kartanas , Jared E Hollows , Lam T Nguyen , Kathleen LeForte , Denise Barbut , Janet R Kumita , Cristina Cecchi , Michael Zasloff , Tuomas P J Knowles , Christopher M Dobson , Fabrizio Chiti , Michele Vendruscolo

Identification of on- and off-pathway oligomers in amyloid fibril formation.

Chemical science

Avec: Alexander J Dear , Anđela Šarić , Thomas C T Michaels , Magnus Kjaergaard , Sara Linse , Tuomas P J Knowles

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.

Science advances

Avec: Eric Hidari , Kieren Allinson , Timothy Rittman , Sarah L DeVos , Justin S Sanchez , Catherine K Xu , Karen E Duff , Keith A Johnson , James B Rowe , Bradley T Hyman , Tuomas P J Knowles , David Klenerman

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.

Molecules (Basel, Switzerland)

Avec: Catherine K Xu , Marta Castellana-Cruz , Serene W Chen , Zhen Du , Aviad Levin , Benedetta Mannini , Laura S Itzhaki , Tuomas P J Knowles , Christopher M Dobson , Nunilo Cremades , Janet R Kumita

α-Synuclein oligomers form by secondary nucleation.

Nature communications

Avec: Catherine K Xu , Ewa A Andrzejewska , Georg Krainer , Alexander J Dear , Marta Castellana-Cruz , Soma Turi , Irina A Edu , Giorgio Vivacqua , Raphaël P B Jacquat , William E Arter , Maria Grazia Spillantini , Michele Vendruscolo , Sara Linse , Tuomas P J Knowles

Surface effects on functional amyloid formation.

Nanoscale

Avec: Alexander J Dear , Christopher G Taylor , Umberto Capasso Palmiero , Susanne Nordby Stubbe , Qian Liu , Paolo Arosio , Sara Linse , Tuomas P J Knowles , Maria Andreasen

Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy.

Frontiers in immunology

Avec: Ashley Priddey , Michael Xin Hua Chen-Xu , Daniel James Cooper , Serena MacMillan , Catherine K Xu , Myra Hosmillo , Ian G Goodfellow , Rafael Kollyfas , Rainer Doffinger , John R Bradley , Irina I Mohorianu , Rachel Jones , Tuomas P J Knowles , Rona Smith , Vasilis Kosmoliaptsis

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers.

Biomacromolecules

Avec: Seyyed Abolghasem Ghadami , Sean Chia , Francesco Simone Ruggeri , Francesco Bemporad , Johnny Habchi , Roberta Cascella , Christopher M Dobson , Michele Vendruscolo , Tuomas P J Knowles , Fabrizio Chiti

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

ACS chemical neuroscience

Avec: Tanja Weiffert , Patrick Flagmeier , Suman De , Christopher J R Dunning , Birgitta Frohm , Henrik Zetterberg , Kaj Blennow , Erik Portelius , David Klenerman , Christopher M Dobson , Tuomas P J Knowles , Sara Linse

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in

Biomolecules

Avec: Zahra Najarzadeh , Hossein Mohammad-Beigi , Jannik Nedergaard Pedersen , Gunna Christiansen , Thorbjørn Vincent Sønderby , Seyed Abbas Shojaosadati , Dina Morshedi , Kristian Strømgaard , Duncan Sutherland , Jan Skov Pedersen , Daniel E Otzen

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in

Proceedings of the National Academy of Sciences of the United States of America

Avec: Tessa Sinnige , Thomas C T Michaels , Michele Vendruscolo , Tuomas P J Knowles , Richard I Morimoto

Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum.

ACS infectious diseases

Avec: Sebastian Fiedler , Monika A Piziorska , Viola Denninger , Alexey S Morgunov , Alison Ilsley , Anisa Y Malik , Matthias M Schneider , Sean R A Devenish , Vasilis Kosmoliaptsis , Adriano Aguzzi , Heike Fiegler , Tuomas P J Knowles

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.

Nature structural & molecular biology

Avec: Sara Linse , Tom Scheidt , Katja Bernfur , Michele Vendruscolo , Christopher M Dobson , Samuel I A Cohen , Eimantas Sileikis , Martin Lundqvist , Fang Qian , Tiernan O'Malley , Thierry Bussiere , Paul H Weinreb , Catherine K Xu , Sean R A Devenish , Tuomas P J Knowles , Oskar Hansson

Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Thomas C T Michaels , Andela Šarić , Gabriella T Heller , Samo Curk , Paolo Arosio , Sara Linse , Christopher M Dobson , Michele Vendruscolo , Tuomas P J Knowles

Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers.

Chembiochem : a European journal of chemical biology

Avec: Santiago Enrique Sanchez , Daniel R Whiten , Francesco Simone Ruggeri , Eric Hidari , David Klenerman

The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Tom Scheidt , Jacqueline A Carozza , Carl C Kolbe , Francesco A Aprile , Olga Tkachenko , Mathias M J Bellaiche , Quentin A E Peter , Therese W Herling , Samuel Ness , Marta Castellana-Cruz , Justin L P Benesch , Michele Vendruscolo , Christopher M Dobson , Paolo Arosio , Tuomas P J Knowles

Influence of denaturants on amyloid β42 aggregation kinetics.

Frontiers in neuroscience

Avec: Tanja Weiffert , Samo Curk , Risto Cukalevski , Anđela Šarić , Tuomas P J Knowles , Sara Linse

Characterization of full-length p53 aggregates and their kinetics of formation.

Biophysical journal

Avec: Linda Julian , Jason C Sang , Yunzhao Wu , Jack H Brelstaff , Alyssa Miller , Matthew R Cheetham , Michele Vendruscolo , Tuomas P J Knowles , Francesco Simone Ruggeri , Clare Bryant , Susana Ros , Kevin M Brindle , David Klenerman

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.

Cell reports

Avec: Eleni Dimou , Taxiarchis Katsinelos , Benjamin J Tuck , Sophie Keeling , Annabel E Smith , Eric Hidari , Jeff Y L Lam , Melanie Burke , Sofia Lövestam , Rohan T Ranasinghe , William A McEwan , David Klenerman

Self-replication of A

Proceedings of the National Academy of Sciences of the United States of America

Avec: Samo Curk , Johannes Krausser , Daan Frenkel , Sara Linse , Thomas C T Michaels , Tuomas P J Knowles , Anđela Šarić

Maximum entropy determination of mammalian proteome dynamics.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Alexander J Dear , Gonzalo A Garcia , Galen A Collins , Tuomas P J Knowles , Alfred L Goldberg

Kinetic diversity of amyloid oligomers.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Alexander J Dear , Thomas C T Michaels , David Klenerman , Si Wu , Sarah Perrett , Sara Linse , Christopher M Dobson , Tuomas P J Knowles

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide.

Nature chemistry

Avec: Thomas C T Michaels , Andela Šarić , Samo Curk , Katja Bernfur , Paolo Arosio , Alexander J Dear , Samuel I A Cohen , Christopher M Dobson , Michele Vendruscolo , Sara Linse , Tuomas P J Knowles

Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins.

The journal of physical chemistry. B

Avec: Carlos Perez , Tatiana Miti , Filip Hasecke , Wolfgang Hoyer , Martin Muschol , Ghanim Ullah

Physical Determinants of Amyloid Assembly in Biofilm Formation.

mBio

Avec: Maria Andreasen , Jonathan D Taylor , Thomas C T Michaels , Aviad Levin , Daniel E Otzen , Matthew R Chapman , Christopher M Dobson , Steve J Matthews , Tuomas P J Knowles

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Dev Thacker , Kalyani Sanagavarapu , Birgitta Frohm , Tuomas P J Knowles , Sara Linse

In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers.

PloS one

Avec: Enrico Zurlo , Pravin Kumar , Alexander J Dear , Dipro Mondal , Mireille M A E Claessens , Tuomas P J Knowles , Martina Huber

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Mattias Törnquist , Risto Cukalevski , Ulrich Weininger , Tuomas P J Knowles , Thom Leiding , Anders Malmendal , Mikael Akke , Sara Linse

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.

Frontiers in molecular biosciences

Avec: Diana C Rodriguez Camargo , Sean Chia , Joseph Menzies , Benedetta Mannini , Martin Lundqvist , Christin Pohl , Katja Bernfur , Veronica Lattanzi , Johnny Habchi , Samuel Ia Cohen , Tuomas P J Knowles , Michele Vendruscolo , Sara Linse

Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on α-synuclein amyloid formation.

Chemical science

Avec: Jiangtao Zhou , Francesco S Ruggeri , Manuela R Zimmermann , Giovanni Longo , Sergey K Sekatskii , Tuomas P J Knowles , Giovanni Dietler

Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.

Chemical science

Avec: Jonathan Pansieri , Igor A Iashchishyn , Hussein Fakhouri , Lucija Ostojić , Mantas Malisauskas , Greta Musteikyte , Vytautas Smirnovas , Matthias M Schneider , Tom Scheidt , Catherine K Xu , Tuomas P J Knowles , Ehud Gazit , Rodolphe Antoine , Ludmilla A Morozova-Roche

Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease.

Frontiers in neuroscience

Avec: Tuomas P J Knowles , David Klenerman

A conformational switch controlling the toxicity of the prion protein.

Nature structural & molecular biology

Avec: Karl Frontzek , Marco Bardelli , Assunta Senatore , Anna Henzi , Regina R Reimann , Seden Bedir , Marika Marino , Rohanah Hussain , Simon Jurt , Mattia Pedotti , Federica Mazzola , Giuliano Siligardi , Oliver Zerbe , Marco Losa , Tuomas Knowles , Asvin Lakkaraju , Caihong Zhu , Petra Schwarz , Simone Hornemann , Matthew G Holt , Luca Simonelli , Luca Varani , Adriano Aguzzi

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

iScience

Avec: Marc Emmenegger , Elena De Cecco , David Lamparter , Raphaël P B Jacquat , Julien Riou , Dominik Menges , Tala Ballouz , Daniel Ebner , Matthias M Schneider , Itzel Condado Morales , Berre Doğançay , Jingjing Guo , Anne Wiedmer , Julie Domange , Marigona Imeri , Rita Moos , Chryssa Zografou , Leyla Batkitar , Lidia Madrigal , Dezirae Schneider , Chiara Trevisan , Andres Gonzalez-Guerra , Alessandra Carrella , Irina L Dubach , Catherine K Xu , Vasilis Kosmoliaptsis , Tomas Malinauskas , Nicola Burgess-Brown , Ray Owens , Stephanie Hatch , Juthathip Mongkolsapaya , Gavin R Screaton , Katharina Schubert , John D Huck , Feimei Liu , Florence Pojer , Kelvin Lau , David Hacker , Elsbeth Probst-Müller , Carlo Cervia , Jakob Nilsson , Onur Boyman , Lanja Saleh , Katharina Spanaus , Arnold von Eckardstein , Dominik J Schaer , Nenad Ban , Ching-Ju Tsai , Jacopo Marino , Gebhard F X Schertler , Nadine Ebert , Volker Thiel , Jochen Gottschalk , Beat M Frey , Regina R Reimann , Simone Hornemann , Aaron M Ring , Tuomas P J Knowles , Milo A Puhan , Christian L Althaus , Ioannis Xenarios , David I Stuart , Adriano Aguzzi

The thermodynamics of neurodegenerative disease.

Biophysics reviews

Avec:

Dynamics and Control of Peptide Self-Assembly and Aggregation.

Advances in experimental medicine and biology

Avec: Thomas C T Michaels , Paolo Arosio , Michele Vendruscolo , Christopher M Dobson , Tuomas P J Knowles

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.

Scientific reports

Avec: Kalyani Sanagavarapu , Elisabeth Nüske , Irem Nasir , Jasper N Immink , Pietro Sormanni , Michele Vendruscolo , Tuomas P J Knowles , Anders Malmendal , Celia Cabaleiro-Lago , Sara Linse

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide.

Nature chemistry

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.

Current opinion in neurobiology

Avec: Tuomas Pj Knowles , David Klenerman

Autoantibodies against the prion protein in individuals with

Neurology

Avec: Karl Frontzek , Manfredi Carta , Marco Losa , Mirka Epskamp , Alice Anane , Jean-Philippe Brandel , Ulrike Camenisch , Joaquín Castilla , Stéphane Haïk , Tuomas Knowles , Ewald Lindner , Andreas Lutterotti , Eric Vallabh Minikel , Ignazio Roiter , Jiri G Safar , Raquel Sanchez-Valle , Dana Žáková , Simone Hornemann , Adriano Aguzzi , Auteur inconnu

Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation.

ACS chemical neuroscience

Avec: Diana C Rodriguez Camargo , Eimantas Sileikis , Sean Chia , Emil Axell , Katja Bernfur , Rodrigo L Cataldi , Samuel I A Cohen , Johnny Habchi , Tuomas P J Knowles , Michele Vendruscolo , Sara Linse

Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules.

ACS nano

Avec: Dor Zaguri , Manuela R Zimmermann , Aviad Levin , Sigal Rencus-Lazar , Tuomas P J Knowles , Ehud Gazit

Scaling analysis reveals the mechanism and rates of prion replication in vivo.

Nature structural & molecular biology

Avec: Timothy Kurt , Itzel Condado-Morales , Cyrus Bett , Silvia Sorce , Mario Nuvolone , Thomas C T Michaels , Daniel Heinzer , Merve Avar , Samuel I A Cohen , Simone Hornemann , Adriano Aguzzi , Christopher M Dobson , Christina J Sigurdson , Tuomas P J Knowles

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells.

Communications biology

Avec: Jason C Sang , Eric Hidari , Rohan T Ranasinghe , Maria Grazia Spillantini , David Klenerman

Pulsed Hydrogen-Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer's Disease Mutants.

ACS chemical neuroscience

Avec: Eva Illes-Toth , Don L Rempel , Tuomas P J Knowles , Michael L Gross

The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.

Communications biology

Avec: Azad Farzadfard , Jannik Nedergaard Pedersen , Arun Kumar Somavarapu , Parvez Alam , Louise Goksøyr , Morten Agertoug Nielsen , Adam Frederik Sander , Tuomas P J Knowles , Jan Skov Pedersen , Daniel Erik Otzen

Design of amyloidogenic peptide traps.

Nature chemical biology

Avec: Danny D Sahtoe , Ewa A Andrzejewska , Hannah L Han , Enrico Rennella , Matthias M Schneider , Maggie Ahlrichs , Justin Decarreau , Hannah Nguyen , Alex Kang , Paul Levine , Mila Lamb , Xinting Li , Asim K Bera , Lewis E Kay , Tuomas P J Knowles , David Baker

Uncovering the universality of self-replication in protein aggregation and its link to disease.

Science advances

Avec: Catherine K Xu , Jonathan D Taylor , Thomas C T Michaels , Aviad Levin , Daniel Otzen , David Klenerman , Steve Matthews , Sara Linse , Maria Andreasen , Tuomas P J Knowles

Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants.

iScience

Avec: Marc Emmenegger , Sebastian Fiedler , Silvio D Brugger , Sean R A Devenish , Alexey S Morgunov , Alison Ilsley , Francesco Ricci , Anisa Y Malik , Thomas Scheier , Leyla Batkitar , Lidia Madrigal , Marco Rossi , Andrew K Lynn , Lanja Saleh , Arnold von Eckardstein , Tuomas P J Knowles , Adriano Aguzzi

Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum.

Biosensors & bioelectronics

Avec: Matthias M Schneider , Tom Scheidt , Ashley J Priddey , Catherine K Xu , Mengsha Hu , Sean R A Devenish , Christopher M Dobson , Vasilis Kosmoliaptsis , Tuomas P J Knowles

Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts.

ACS chemical neuroscience

Avec: Robert I Horne , Michael A Metrick , Wing Man , Dillon J Rinauro , Z Faidon Brotzakis , Sean Chia , Michele Vendruscolo

Phase Separation and Fibrillization of Human Annexin A7 Are Mediated by Its Proline-Rich Domain.

Biochemistry

Avec: Chenrong Yu , Spencer L Nelson , Rodolfo Ghirlando , Lalit Deshmukh

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.

Chemical science

Avec: Alexander J Dear , Xiangyu Teng , Sarah R Ball , Joshua Lewin , Robert I Horne , Daniel Clow , Alisdair Stevenson , Natasha Harper , Kim Yahya , Xiaoting Yang , Suzanne C Brewerton , John Thomson , Thomas C T Michaels , Sara Linse , Tuomas P J Knowles , Johnny Habchi ,

Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces.

ACS chemical neuroscience

Avec: Alexander J Dear , Dev Thacker , Stefan Wennmalm , Lei Ortigosa-Pascual , Ewa A Andrzejewska , Sara Linse , Tuomas P J Knowles

Kinetic models reveal the interplay of protein production and aggregation.

Chemical science

Avec: Jiapeng Wei , Alexander Dear , Matthijs Oosterhuis , Ronald Melki , Cecilia Emanuelsson , Sara Linse , Tuomas P J Knowles

Réseau de co-auteurs

Tuomas P J Knowles 52 collaborations

Sara Linse 24 collaborations

Michele Vendruscolo 16 collaborations

Christopher M Dobson 16 collaborations

Thomas C T Michaels 14 collaborations

Catherine K Xu 13 collaborations

Alexander J Dear 12 collaborations

David Klenerman 12 collaborations

Adriano Aguzzi 8 collaborations

Matthias M Schneider 7 collaborations

Manuela R Zimmermann 6 collaborations

Vasilis Kosmoliaptsis 6 collaborations

Sean Chia 6 collaborations

Johnny Habchi 6 collaborations

Samuel I A Cohen 6 collaborations

Paolo Arosio 6 collaborations

Sean R A Devenish 5 collaborations

Katja Bernfur 5 collaborations

Samo Curk 5 collaborations

Jason C Sang 4 collaborations

Marc Emmenegger 4 collaborations

Sebastian Fiedler 4 collaborations

Alison Ilsley 4 collaborations

Benedetta Mannini 4 collaborations

Janet R Kumita 4 collaborations

Francesco Simone Ruggeri 4 collaborations

Eric Hidari 4 collaborations

Aviad Levin 4 collaborations

Tom Scheidt 4 collaborations

Simone Hornemann 4 collaborations

Viola Denninger 3 collaborations

Lidia Madrigal 3 collaborations

Heike Fiegler 3 collaborations

Alexey S Morgunov 3 collaborations

Anisa Y Malik 3 collaborations

Birgitta Frohm 3 collaborations

Francesco S Ruggeri 3 collaborations

Roberta Cascella 3 collaborations

Fabrizio Chiti 3 collaborations

Patrick Flagmeier 3 collaborations

Anđela Šarić 3 collaborations

Marta Castellana-Cruz 3 collaborations

Ewa A Andrzejewska 3 collaborations

Maria Andreasen 3 collaborations

Andela Šarić 3 collaborations

Suman De 2 collaborations

Itzel Condado Morales 2 collaborations

Chryssa Zografou 2 collaborations

Beat M Frey 2 collaborations

Tuomas Pj Knowles 2 collaborations

Monika A Piziorska 2 collaborations

Sarah R Ball 2 collaborations

Mattias Törnquist 2 collaborations

Oskar Hansson 2 collaborations

Henrik Zetterberg 2 collaborations

Kaj Blennow 2 collaborations

Thom Leiding 2 collaborations

Ryan Limbocker 2 collaborations

Michele Perni 2 collaborations

Gabriella T Heller 2 collaborations

Cristina Cecchi 2 collaborations

Michael Zasloff 2 collaborations

Bradley T Hyman 2 collaborations

Raphaël P B Jacquat 2 collaborations

Maria Grazia Spillantini 2 collaborations

Tanja Weiffert 2 collaborations

Jannik Nedergaard Pedersen 2 collaborations

Jan Skov Pedersen 2 collaborations

Daniel E Otzen 2 collaborations

Eimantas Sileikis 2 collaborations

Martin Lundqvist 2 collaborations

Risto Cukalevski 2 collaborations

Rohan T Ranasinghe 2 collaborations

Jonathan D Taylor 2 collaborations

Dev Thacker 2 collaborations

Kalyani Sanagavarapu 2 collaborations

Anders Malmendal 2 collaborations

Diana C Rodriguez Camargo 2 collaborations

Ehud Gazit 2 collaborations

Karl Frontzek 2 collaborations

Regina R Reimann 2 collaborations

Marco Losa 2 collaborations

Tuomas Knowles 2 collaborations

Leyla Batkitar 2 collaborations

Lanja Saleh 2 collaborations

Arnold von Eckardstein 2 collaborations

Robert I Horne 2 collaborations

Ji-Eun Lee 1 collaboration

Alana M Thackray 1 collaboration

Raymond Bujdoso 1 collaboration

Priscilla Turelli 1 collaboration

Raphaël Pb Jacquat 1 collaboration

Didier Trono 1 collaboration

Subhas C Bera 1 collaboration

Sourav Dasadhikari 1 collaboration

Shamasree Ghosh 1 collaboration

Kanchan Garai 1 collaboration

Julius S P Adamson 1 collaboration

Michael A Sullivan 1 collaboration

Victor Lo 1 collaboration

Maximo Sanz-Hernandez 1 collaboration

Xiaofan Jiang 1 collaboration

Ann H Kwan 1 collaboration

André D J McKenzie 1 collaboration

Eryn L Werry 1 collaboration

Michael Kassiou 1 collaboration

Matthew H Todd 1 collaboration

Peter J Rutledge 1 collaboration

Margaret Sunde 1 collaboration

T B Thompson 1 collaboration

G Meisl 1 collaboration

T P J Knowles 1 collaboration

A Goriely 1 collaboration

Rebecca Frankel 1 collaboration

Ulf Andreasson 1 collaboration

Tommy Cedervall 1 collaboration

Pavan K Challa 1 collaboration

Minkoo Ahn 1 collaboration

Samuel T Casford 1 collaboration

Nilumi Fernando 1 collaboration

Nina D Kloss 1 collaboration

Angus Lau 1 collaboration

Raphaella W L So 1 collaboration

Heather H C Lau 1 collaboration

Alejandro Ruiz-Riquelme 1 collaboration

Shelaine C Fleck 1 collaboration

Erica Stuart 1 collaboration

Sindhu Menon 1 collaboration

Naomi P Visanji 1 collaboration

Rania Faidi 1 collaboration

Maria M Marano 1 collaboration

Cian Schmitt-Ulms 1 collaboration

Zhilan Wang 1 collaboration

Paul E Fraser 1 collaboration

Anurag Tandon 1 collaboration

Holger Wille 1 collaboration

Martin Ingelsson 1 collaboration

Joel C Watts 1 collaboration

Dimitri Y Chirgadze 1 collaboration

Marie N Bongiovanni 1 collaboration

Roxine Staats 1 collaboration

Alessandra Bigi 1 collaboration

Liam R Sasser 1 collaboration

Natalie R Block 1 collaboration

Aidan K Wright 1 collaboration

Ryan P Kreiser 1 collaboration

Edward T Custy 1 collaboration

Silvia Errico 1 collaboration

Tadas Kartanas 1 collaboration

Jared E Hollows 1 collaboration

Lam T Nguyen 1 collaboration

Kathleen LeForte 1 collaboration

Denise Barbut 1 collaboration

Magnus Kjaergaard 1 collaboration

Kieren Allinson 1 collaboration

Timothy Rittman 1 collaboration

Sarah L DeVos 1 collaboration

Justin S Sanchez 1 collaboration

Karen E Duff 1 collaboration

Keith A Johnson 1 collaboration

James B Rowe 1 collaboration

Serene W Chen 1 collaboration

Zhen Du 1 collaboration

Laura S Itzhaki 1 collaboration

Nunilo Cremades 1 collaboration

Georg Krainer 1 collaboration

Soma Turi 1 collaboration

Irina A Edu 1 collaboration

Giorgio Vivacqua 1 collaboration

William E Arter 1 collaboration

Christopher G Taylor 1 collaboration

Umberto Capasso Palmiero 1 collaboration

Susanne Nordby Stubbe 1 collaboration

Qian Liu 1 collaboration

Ashley Priddey 1 collaboration

Michael Xin Hua Chen-Xu 1 collaboration

Daniel James Cooper 1 collaboration

Serena MacMillan 1 collaboration

Myra Hosmillo 1 collaboration

Ian G Goodfellow 1 collaboration

Rafael Kollyfas 1 collaboration

Rainer Doffinger 1 collaboration

John R Bradley 1 collaboration

Irina I Mohorianu 1 collaboration

Rachel Jones 1 collaboration

Rona Smith 1 collaboration

Seyyed Abolghasem Ghadami 1 collaboration

Francesco Bemporad 1 collaboration

Christopher J R Dunning 1 collaboration

Erik Portelius 1 collaboration

Zahra Najarzadeh 1 collaboration

Hossein Mohammad-Beigi 1 collaboration

Gunna Christiansen 1 collaboration

Thorbjørn Vincent Sønderby 1 collaboration

Seyed Abbas Shojaosadati 1 collaboration

Dina Morshedi 1 collaboration

Kristian Strømgaard 1 collaboration

Duncan Sutherland 1 collaboration

Tessa Sinnige 1 collaboration

Richard I Morimoto 1 collaboration

Fang Qian 1 collaboration

Tiernan O'Malley 1 collaboration

Thierry Bussiere 1 collaboration

Paul H Weinreb 1 collaboration

Santiago Enrique Sanchez 1 collaboration

Daniel R Whiten 1 collaboration

Jacqueline A Carozza 1 collaboration

Carl C Kolbe 1 collaboration

Francesco A Aprile 1 collaboration

Olga Tkachenko 1 collaboration

Mathias M J Bellaiche 1 collaboration

Quentin A E Peter 1 collaboration

Therese W Herling 1 collaboration

Samuel Ness 1 collaboration

Justin L P Benesch 1 collaboration

Linda Julian 1 collaboration

Yunzhao Wu 1 collaboration

Jack H Brelstaff 1 collaboration

Alyssa Miller 1 collaboration

Matthew R Cheetham 1 collaboration

Clare Bryant 1 collaboration

Susana Ros 1 collaboration

Kevin M Brindle 1 collaboration

Eleni Dimou 1 collaboration

Taxiarchis Katsinelos 1 collaboration

Benjamin J Tuck 1 collaboration

Sophie Keeling 1 collaboration

Annabel E Smith 1 collaboration

Jeff Y L Lam 1 collaboration

Melanie Burke 1 collaboration

Sofia Lövestam 1 collaboration

William A McEwan 1 collaboration

Johannes Krausser 1 collaboration

Daan Frenkel 1 collaboration

Gonzalo A Garcia 1 collaboration

Galen A Collins 1 collaboration

Alfred L Goldberg 1 collaboration

Si Wu 1 collaboration

Sarah Perrett 1 collaboration

Carlos Perez 1 collaboration

Tatiana Miti 1 collaboration

Filip Hasecke 1 collaboration

Wolfgang Hoyer 1 collaboration

Martin Muschol 1 collaboration

Ghanim Ullah 1 collaboration

Matthew R Chapman 1 collaboration

Steve J Matthews 1 collaboration

Enrico Zurlo 1 collaboration

Pravin Kumar 1 collaboration

Dipro Mondal 1 collaboration

Mireille M A E Claessens 1 collaboration

Martina Huber 1 collaboration

Ulrich Weininger 1 collaboration

Mikael Akke 1 collaboration

Joseph Menzies 1 collaboration

Christin Pohl 1 collaboration

Veronica Lattanzi 1 collaboration

Samuel Ia Cohen 1 collaboration

Jiangtao Zhou 1 collaboration

Giovanni Longo 1 collaboration

Sergey K Sekatskii 1 collaboration

Giovanni Dietler 1 collaboration

Jonathan Pansieri 1 collaboration

Igor A Iashchishyn 1 collaboration

Hussein Fakhouri 1 collaboration

Lucija Ostojić 1 collaboration

Mantas Malisauskas 1 collaboration

Greta Musteikyte 1 collaboration

Vytautas Smirnovas 1 collaboration

Rodolphe Antoine 1 collaboration

Ludmilla A Morozova-Roche 1 collaboration

Marco Bardelli 1 collaboration

Assunta Senatore 1 collaboration

Anna Henzi 1 collaboration

Seden Bedir 1 collaboration

Marika Marino 1 collaboration

Rohanah Hussain 1 collaboration

Simon Jurt 1 collaboration

Mattia Pedotti 1 collaboration

Federica Mazzola 1 collaboration

Giuliano Siligardi 1 collaboration

Oliver Zerbe 1 collaboration

Asvin Lakkaraju 1 collaboration

Caihong Zhu 1 collaboration

Petra Schwarz 1 collaboration

Matthew G Holt 1 collaboration

Luca Simonelli 1 collaboration

Luca Varani 1 collaboration

Elena De Cecco 1 collaboration

David Lamparter 1 collaboration

Julien Riou 1 collaboration

Dominik Menges 1 collaboration

Tala Ballouz 1 collaboration

Daniel Ebner 1 collaboration

Berre Doğançay 1 collaboration

Jingjing Guo 1 collaboration

Anne Wiedmer 1 collaboration

Julie Domange 1 collaboration

Marigona Imeri 1 collaboration

Rita Moos 1 collaboration

Dezirae Schneider 1 collaboration

Chiara Trevisan 1 collaboration

Andres Gonzalez-Guerra 1 collaboration

Alessandra Carrella 1 collaboration

Irina L Dubach 1 collaboration

Tomas Malinauskas 1 collaboration

Nicola Burgess-Brown 1 collaboration

Ray Owens 1 collaboration

Stephanie Hatch 1 collaboration

Juthathip Mongkolsapaya 1 collaboration

Gavin R Screaton 1 collaboration

Katharina Schubert 1 collaboration

John D Huck 1 collaboration

Feimei Liu 1 collaboration

Florence Pojer 1 collaboration

Kelvin Lau 1 collaboration

David Hacker 1 collaboration

Elsbeth Probst-Müller 1 collaboration

Carlo Cervia 1 collaboration

Jakob Nilsson 1 collaboration

Onur Boyman 1 collaboration

Katharina Spanaus 1 collaboration

Dominik J Schaer 1 collaboration

Nenad Ban 1 collaboration

Ching-Ju Tsai 1 collaboration

Jacopo Marino 1 collaboration

Gebhard F X Schertler 1 collaboration

Nadine Ebert 1 collaboration

Volker Thiel 1 collaboration

Jochen Gottschalk 1 collaboration

Aaron M Ring 1 collaboration

Milo A Puhan 1 collaboration

Christian L Althaus 1 collaboration

Ioannis Xenarios 1 collaboration

David I Stuart 1 collaboration

Elisabeth Nüske 1 collaboration

Irem Nasir 1 collaboration

Jasper N Immink 1 collaboration

Pietro Sormanni 1 collaboration

Celia Cabaleiro-Lago 1 collaboration

Manfredi Carta 1 collaboration

Mirka Epskamp 1 collaboration

Alice Anane 1 collaboration

Jean-Philippe Brandel 1 collaboration

Ulrike Camenisch 1 collaboration

Joaquín Castilla 1 collaboration

Stéphane Haïk 1 collaboration

Ewald Lindner 1 collaboration

Andreas Lutterotti 1 collaboration

Eric Vallabh Minikel 1 collaboration

Ignazio Roiter 1 collaboration

Jiri G Safar 1 collaboration

Raquel Sanchez-Valle 1 collaboration

Dana Žáková 1 collaboration

None None 1 collaboration

Emil Axell 1 collaboration

Rodrigo L Cataldi 1 collaboration

Dor Zaguri 1 collaboration

Sigal Rencus-Lazar 1 collaboration

Timothy Kurt 1 collaboration

Itzel Condado-Morales 1 collaboration

Cyrus Bett 1 collaboration

Silvia Sorce 1 collaboration

Mario Nuvolone 1 collaboration

Daniel Heinzer 1 collaboration

Merve Avar 1 collaboration

Christina J Sigurdson 1 collaboration

Eva Illes-Toth 1 collaboration

Don L Rempel 1 collaboration

Michael L Gross 1 collaboration

Azad Farzadfard 1 collaboration

Arun Kumar Somavarapu 1 collaboration

Parvez Alam 1 collaboration

Louise Goksøyr 1 collaboration

Morten Agertoug Nielsen 1 collaboration

Adam Frederik Sander 1 collaboration

Daniel Erik Otzen 1 collaboration

Danny D Sahtoe 1 collaboration

Hannah L Han 1 collaboration

Enrico Rennella 1 collaboration

Maggie Ahlrichs 1 collaboration

Justin Decarreau 1 collaboration

Hannah Nguyen 1 collaboration

Alex Kang 1 collaboration

Paul Levine 1 collaboration

Mila Lamb 1 collaboration

Xinting Li 1 collaboration

Asim K Bera 1 collaboration

Lewis E Kay 1 collaboration

David Baker 1 collaboration

Daniel Otzen 1 collaboration

Steve Matthews 1 collaboration

Silvio D Brugger 1 collaboration

Francesco Ricci 1 collaboration

Thomas Scheier 1 collaboration

Marco Rossi 1 collaboration

Andrew K Lynn 1 collaboration

Ashley J Priddey 1 collaboration

Mengsha Hu 1 collaboration

Michael A Metrick 1 collaboration

Wing Man 1 collaboration

Dillon J Rinauro 1 collaboration

Z Faidon Brotzakis 1 collaboration

Chenrong Yu 1 collaboration

Spencer L Nelson 1 collaboration

Rodolfo Ghirlando 1 collaboration

Lalit Deshmukh 1 collaboration

Xiangyu Teng 1 collaboration

Joshua Lewin 1 collaboration

Daniel Clow 1 collaboration

Alisdair Stevenson 1 collaboration

Natasha Harper 1 collaboration

Kim Yahya 1 collaboration

Xiaoting Yang 1 collaboration

Suzanne C Brewerton 1 collaboration

John Thomson 1 collaboration

Stefan Wennmalm 1 collaboration

Lei Ortigosa-Pascual 1 collaboration

Jiapeng Wei 1 collaboration

Alexander Dear 1 collaboration

Matthijs Oosterhuis 1 collaboration

Ronald Melki 1 collaboration

Cecilia Emanuelsson 1 collaboration