Mikael Akke

Affiliations

Division of Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden.

ORCID: 0000-0002-2395-825X

Publications (27)

Ligand-induced protein transition state stabilization switches the binding pathway from conformational selection to induced fit.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Olof Stenström , Carl Diehl , Kristofer Modig , Mikael Akke

Interplay of halogen bonding and solvation in protein-ligand binding.

iScience

Avec: Maria Luisa Verteramo , Majda Misini Ignjatović , Rohit Kumar , Sven Wernersson , Vilhelm Ekberg , Johan Wallerstein , Göran Carlström , Veronika Chadimová , Hakon Leffler , Fredrik Zetterberg , Derek T Logan , Ulf Ryde , Mikael Akke , Ulf J Nilsson

Stability and Local Unfolding of SOD1 in the Presence of Protein Crowders.

The journal of physical chemistry. B

Avec: Anna Bille , Kristine Steen Jensen , Sandipan Mohanty , Mikael Akke , Anders Irbäck

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Mattias Törnquist , Risto Cukalevski , Ulrich Weininger , Georg Meisl , Tuomas P J Knowles , Thom Leiding , Anders Malmendal , Mikael Akke , Sara Linse

Journal of biomolecular NMR

Avec: Matthias Dreydoppel , Roman J Lichtenecker , Mikael Akke , Ulrich Weininger

Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility.

Biochemistry

Avec: Sven Wernersson , Romel Bobby , Liz Flavell , Alexander G Milbradt , Geoffrey A Holdgate , Kevin J Embrey , Mikael Akke

Minute Additions of DMSO Affect Protein Dynamics Measurements by NMR Relaxation Experiments through Significant Changes in Solvent Viscosity.

Chemphyschem : a European journal of chemical physics and physical chemistry

Avec: Johan Wallerstein , Mikael Akke

Accurate Backbone

Chemphyschem : a European journal of chemical physics and physical chemistry

Avec: Jodi Kraus , Rupal Gupta , Manman Lu , Angela M Gronenborn , Mikael Akke , Tatyana Polenova

Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production.

Nature communications

Avec: Raminta Venskutonytė , Ara Koh , Olof Stenström , Muhammad Tanweer Khan , Annika Lundqvist , Mikael Akke , Fredrik Bäckhed , Karin Lindkvist-Petersson

Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C.

JACS Au

Avec: Johan Wallerstein , Vilhelm Ekberg , Majda Misini Ignjatović , Rohit Kumar , Octav Caldararu , Kristoffer Peterson , Sven Wernersson , Ulrika Brath , Hakon Leffler , Esko Oksanen , Derek T Logan , Ulf J Nilsson , Ulf Ryde , Mikael Akke

Conformational Dynamics of Phytoglobin BvPgb1.2 from

International journal of molecular sciences

Avec: Simon Christensen , Olof Stenström , Mikael Akke , Leif Bülow

Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor.

Science advances

Avec: C Köhler , G Carlström , A Gunnarsson , U Weininger , S Tångefjord , V Ullah , M Lepistö , U Karlsson , T Papavoine , K Edman , M Akke

Rotamer Jumps, Proton Exchange, and Amine Inversion Dynamics of Dimethylated Lysine Residues in Proteins Resolved by pH-Dependent

The journal of physical chemistry. B

Avec: Ulrich Weininger , Kristofer Modig , Hiroaki Ishida , Hans J Vogel , Mikael Akke

Backbone

Biomolecular NMR assignments

Avec: Sven Wernersson , Viktoria Bågenholm , Cecilia Persson , Santosh Kumar Upadhyay , Henrik Stålbrand , Mikael Akke

Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding.

Journal of the American Chemical Society

Avec: Maria Luisa Verteramo , Olof Stenström , Majda Misini Ignjatović , Octav Caldararu , Martin A Olsson , Francesco Manzoni , Hakon Leffler , Esko Oksanen , Derek T Logan , Ulf J Nilsson , Ulf Ryde , Mikael Akke

Transition-State Compressibility and Activation Volume of Transient Protein Conformational Fluctuations.

JACS Au

Avec: Matthias Dreydoppel , Britta Dorn , Kristofer Modig , Mikael Akke , Ulrich Weininger

Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled

Magnetic resonance (Gottingen, Germany)

Avec: Sven Wernersson , Göran Carlström , Andreas Jakobsson , Mikael Akke

Cosolvent Dimethyl Sulfoxide Influences Protein-Ligand Binding Kinetics via Solvent Viscosity Effects: Revealing the Success Rate of Complex Formation Following Diffusive Protein-Ligand Encounter.

Biochemistry

Avec: Sven Wernersson , Simon Birgersson , Mikael Akke

Proton Transfer Kinetics in Histidine Side Chains Determined by pH-Dependent Multi-Nuclear NMR Relaxation.

Journal of the American Chemical Society

Avec: Heiner N Raum , Kristofer Modig , Mikael Akke , Ulrich Weininger

Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data.

Journal of the American Chemical Society

Avec: Kristine Steen Jensen , Sara Linse , Mathias Nilsson , Mikael Akke , Anders Malmendal

Rapid NMR Relaxation Measurements Using Optimal Nonuniform Sampling of Multidimensional Accordion Data Analyzed by a Sparse Reconstruction Method.

The journal of physical chemistry. A

Avec: Göran Carlström , Filip Elvander , Johan Swärd , Andreas Jakobsson , Mikael Akke

Adsorption of unfolded Cu/Zn superoxide dismutase onto hydrophobic surfaces catalyzes its formation of amyloid fibrils.

Protein engineering, design & selection : PEDS

Avec: Mohammad Ashhar I Khan , Ulrich Weininger , Sven Kjellström , Shashank Deep , Mikael Akke

Mapping the energy landscape of protein-ligand binding

RSC chemical biology

Avec: Olof Stenström , Carl Diehl , Kristofer Modig , Ulf J Nilsson , Mikael Akke

Characterizing Fast Conformational Exchange of Aromatic Rings Using Residual Dipolar Couplings: Distinguishing Jumplike Flips from Other Exchange Mechanisms.

The journal of physical chemistry. B

Avec: Matthias Dreydoppel , Mikael Akke , Ulrich Weininger

Identification of Distinct Soluble States During Fibril Formation Using Multilinear Analysis of NMR Diffusion Data.

Methods in molecular biology (Clifton, N.J.)

Avec: Kristine Steen Jensen , Mathias Nilsson , Mikael Akke , Anders Malmendal

NMR Studies of Aromatic Ring Flips to Probe Conformational Fluctuations in Proteins.

The journal of physical chemistry. B

Avec: Mikael Akke , Ulrich Weininger

Biochemistry

Avec: Roza Kalabekova , Caitlin M Quinn , Kumar Tekwani Movellan , Angela M Gronenborn , Mikael Akke , Tatyana Polenova

Réseau de co-auteurs

Ulrich Weininger 8 collaborations

Sven Wernersson 6 collaborations

Olof Stenström 5 collaborations

Kristofer Modig 5 collaborations

Ulf J Nilsson 4 collaborations

Majda Misini Ignjatović 3 collaborations

Johan Wallerstein 3 collaborations

Göran Carlström 3 collaborations

Hakon Leffler 3 collaborations

Derek T Logan 3 collaborations

Ulf Ryde 3 collaborations

Kristine Steen Jensen 3 collaborations

Anders Malmendal 3 collaborations

Matthias Dreydoppel 3 collaborations

Carl Diehl 2 collaborations

Maria Luisa Verteramo 2 collaborations

Rohit Kumar 2 collaborations

Vilhelm Ekberg 2 collaborations

Sara Linse 2 collaborations

Angela M Gronenborn 2 collaborations

Tatyana Polenova 2 collaborations

Octav Caldararu 2 collaborations

Esko Oksanen 2 collaborations

Andreas Jakobsson 2 collaborations

Mathias Nilsson 2 collaborations

Veronika Chadimová 1 collaboration

Fredrik Zetterberg 1 collaboration

Anna Bille 1 collaboration

Sandipan Mohanty 1 collaboration

Anders Irbäck 1 collaboration

Mattias Törnquist 1 collaboration

Risto Cukalevski 1 collaboration

Georg Meisl 1 collaboration

Tuomas P J Knowles 1 collaboration

Thom Leiding 1 collaboration

Roman J Lichtenecker 1 collaboration

Romel Bobby 1 collaboration

Liz Flavell 1 collaboration

Alexander G Milbradt 1 collaboration

Geoffrey A Holdgate 1 collaboration

Kevin J Embrey 1 collaboration

Jodi Kraus 1 collaboration

Rupal Gupta 1 collaboration

Manman Lu 1 collaboration

Raminta Venskutonytė 1 collaboration

Ara Koh 1 collaboration

Muhammad Tanweer Khan 1 collaboration

Annika Lundqvist 1 collaboration

Fredrik Bäckhed 1 collaboration

Karin Lindkvist-Petersson 1 collaboration

Kristoffer Peterson 1 collaboration

Ulrika Brath 1 collaboration

Simon Christensen 1 collaboration

Leif Bülow 1 collaboration

C Köhler 1 collaboration

G Carlström 1 collaboration

A Gunnarsson 1 collaboration

U Weininger 1 collaboration

S Tångefjord 1 collaboration

V Ullah 1 collaboration

M Lepistö 1 collaboration

U Karlsson 1 collaboration

T Papavoine 1 collaboration

K Edman 1 collaboration

M Akke 1 collaboration

Hiroaki Ishida 1 collaboration

Hans J Vogel 1 collaboration

Viktoria Bågenholm 1 collaboration

Cecilia Persson 1 collaboration

Santosh Kumar Upadhyay 1 collaboration

Henrik Stålbrand 1 collaboration

Martin A Olsson 1 collaboration

Francesco Manzoni 1 collaboration

Britta Dorn 1 collaboration

Simon Birgersson 1 collaboration

Heiner N Raum 1 collaboration

Filip Elvander 1 collaboration

Johan Swärd 1 collaboration

Mohammad Ashhar I Khan 1 collaboration

Sven Kjellström 1 collaboration

Shashank Deep 1 collaboration

Roza Kalabekova 1 collaboration

Caitlin M Quinn 1 collaboration

Kumar Tekwani Movellan 1 collaboration