Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, Md, 21201, USA; Department of Medicine, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, Md, 21201, USA.