A SARS-CoV-2 Delta Variant Case Manifesting as Extensive Placental Infection and Fetal Transmission.
Delta variant
Placental infection
SARS-CoV-2
Vertical transmission
Journal
Gynecologic and obstetric investigation
ISSN: 1423-002X
Titre abrégé: Gynecol Obstet Invest
Pays: Switzerland
ID NLM: 7900587
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
02
2022
accepted:
28
03
2022
pubmed:
9
5
2022
medline:
23
6
2022
entrez:
8
5
2022
Statut:
ppublish
Résumé
Studies indicate a very low rate of SARS-CoV-2 detection in the placenta or occasionally a low rate of vertical transmission in COVID-19 pregnancy. SARS-CoV-2 Delta variant has become a dominant strain over the world and possesses higher infectivity due to mutations in its spike receptor-binding motif. To determine whether SARS-CoV-2 Delta variant has increased potential for placenta infection and vertical transmission, we analyzed SARS-CoV-2 infection in the placenta, umbilical cord, and fetal membrane from a case where an unvaccinated mother and her neonate were COVID-19 positive. A 35-year-old primigravida with COVID-19 underwent an emergent cesarean delivery due to placental abruption in the setting of premature rupture of membranes. The neonate tested positive for SARS-CoV-2 within the first 24 h, and then again on days of life 2, 6, 13, and 21. The placenta exhibited intervillositis, increased fibrin deposition, and syncytiotrophoblast necrosis. Sequencing of viral RNA from fixed placental tissue revealed SAR-CoV-2 B.1.167.2 (Delta) variant. Both spike protein and viral RNA were abundantly present in syncytiotrophoblasts, cytotrophoblasts, umbilical cord vascular endothelium, and fetal membranes. We report with strong probability the first SARS-CoV-2 Delta variant transplacental transmission. Placental cells exhibited extensive apoptosis, senescence, and ferroptosis after SARS-CoV-2 Delta infection.
Identifiants
pubmed: 35526532
pii: 000524905
doi: 10.1159/000524905
pmc: PMC9233045
mid: NIHMS1807299
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-172Subventions
Organisme : NICHD NIH HHS
ID : R01 HD099843
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD100195
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD102206
Pays : United States
Informations de copyright
© 2022 S. Karger AG, Basel.
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