Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 08 2022
17 08 2022
Historique:
received:
13
05
2022
accepted:
04
08
2022
entrez:
17
8
2022
pubmed:
18
8
2022
medline:
20
8
2022
Statut:
epublish
Résumé
Diabetic patients have an increased risk of fracture and an increased occurrence of impaired fracture healing. Diabetic and hyperglycaemic conditions have been shown to impair the cellular response to hypoxia, via an inhibited hypoxia inducible factor (HIF)-1α pathway. We investigated, using an in vitro hyperglycaemia bone tissue engineering model (and a multidisciplinary bone characterisation approach), the differing effects of glucose levels, hypoxia and chemicals known to stabilise HIF-1α (CoCl
Identifiants
pubmed: 35977987
doi: 10.1038/s41598-022-18067-1
pii: 10.1038/s41598-022-18067-1
pmc: PMC9385857
doi:
Substances chimiques
Hypoxia-Inducible Factor 1, alpha Subunit
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13944Informations de copyright
© 2022. The Author(s).
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