Cell-Cell Interactions Drive Metastasis of Circulating Tumor Microemboli.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
03 08 2022
03 08 2022
Historique:
received:
15
03
2022
revised:
27
05
2022
accepted:
13
06
2022
pubmed:
21
7
2022
medline:
5
8
2022
entrez:
20
7
2022
Statut:
ppublish
Résumé
Circulating tumor cells are the cellular mediators of distant metastasis in solid malignancies. Their metastatic potential can be augmented by clustering with other tumor cells or nonmalignant cells, forming circulating tumor microemboli (CTM). Cell-cell interactions are key regulators within CTM that convey enhanced metastatic properties, including improved cell survival, immune evasion, and effective extravasation into distant organs. However, the cellular and molecular mechanism of CTM formation, as well as the biology of interactions between tumor cells and immune cells, platelets, and stromal cells in the circulation, remains to be determined. Here, we review the current literature on cell-cell interactions in homotypic and heterotypic CTM and provide perspectives on therapeutic strategies to attenuate CTM-mediated metastasis by targeting cell-cell interactions.
Identifiants
pubmed: 35856896
pii: 707329
doi: 10.1158/0008-5472.CAN-22-0906
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2661-2671Informations de copyright
©2022 American Association for Cancer Research.