AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome.
Aldo-Keto Reductases
/ antagonists & inhibitors
Animals
COVID-19
/ complications
Case-Control Studies
Cells, Cultured
Cytokine Release Syndrome
/ genetics
Cytokines
/ metabolism
Enzyme Inhibitors
/ pharmacology
Humans
Macrophages
/ drug effects
Mice
Patient Acuity
RAW 264.7 Cells
Respiratory Distress Syndrome
/ genetics
SARS-CoV-2
/ physiology
Transcriptome
COVID-19
cytokines
drug treatment
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Feb 2022
08 Feb 2022
Historique:
received:
20
01
2022
revised:
02
02
2022
accepted:
04
02
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
17
2
2022
Statut:
epublish
Résumé
Preventing the cytokine storm observed in COVID-19 is a crucial goal for reducing the occurrence of severe acute respiratory failure and improving outcomes. Here, we identify Aldo-Keto Reductase 1B10 (AKR1B10) as a key enzyme involved in the expression of pro-inflammatory cytokines. The analysis of transcriptomic data from lung samples of patients who died from COVID-19 demonstrates an increased expression of the gene encoding AKR1B10. Measurements of the AKR1B10 protein in sera from hospitalised COVID-19 patients suggests a significant link between AKR1B10 levels and the severity of the disease. In macrophages and lung cells, the over-expression of AKR1B10 induces the expression of the pro-inflammatory cytokines Interleukin-6 (
Identifiants
pubmed: 35163833
pii: ijms23031911
doi: 10.3390/ijms23031911
pmc: PMC8836815
pii:
doi:
Substances chimiques
Cytokines
0
Enzyme Inhibitors
0
AKR1B10 protein, human
EC 1.1.1.-
Aldo-Keto Reductases
EC 1.1.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : French National Cancer Institute
ID : INCa_13641
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