Hypoxia-inducible factor 1-alpha acts as a bridge factor for crosstalk between ERK1/2 and caspases in hypoxia-induced apoptosis of cementoblasts.
Adipokines
/ metabolism
Animals
Apoptosis
/ drug effects
Caspases
/ metabolism
Cell Hypoxia
/ drug effects
Cobalt
/ pharmacology
Dental Cementum
/ metabolism
Gene Expression
Hypoxia
/ genetics
Hypoxia-Inducible Factor 1, alpha Subunit
/ genetics
Mice
Mitogen-Activated Protein Kinase 1
/ metabolism
Mitogen-Activated Protein Kinase 3
/ metabolism
Necrosis
/ drug therapy
Protein Kinase Inhibitors
/ pharmacology
Signal Transduction
adipokines
apoptosis
cementoblasts
cobalt (II) chloride
hypoxia
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
22
08
2021
received:
10
06
2021
accepted:
01
09
2021
pubmed:
16
9
2021
medline:
26
2
2022
entrez:
15
9
2021
Statut:
ppublish
Résumé
Hypoxia-induced apoptosis of cementoblasts (OCCM-30) may be harmful to orthodontic treatment. Hypoxia-inducible factor 1-alpha (HIF-1α) mediates the biological effects during hypoxia. Little is known about the survival mechanism capable to counteract cementoblast apoptosis. We aimed to investigate the potential roles of HIF-1α, as well as the protein-protein interactions with ERK1/2, using an in-vitro model of chemical-mimicked hypoxia and adipokines. Here, OCCM-30 were co-stimulated with resistin, visfatin or ghrelin under CoCl
Identifiants
pubmed: 34523215
doi: 10.1111/jcmm.16920
pmc: PMC8505834
doi:
Substances chimiques
Adipokines
0
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Protein Kinase Inhibitors
0
Cobalt
3G0H8C9362
Mapk1 protein, mouse
EC 2.7.11.24
Mapk3 protein, mouse
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Caspases
EC 3.4.22.-
cobaltous chloride
EVS87XF13W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9710-9723Informations de copyright
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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