Mitochondrial Heteroplasmy Shifting as a Potential Biomarker of Cancer Progression.
cancer
heteroplasmy
heteroplasmy shifting
mitochondrial DNA
mitochondrial mutations
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jul 2021
09 Jul 2021
Historique:
received:
24
05
2021
revised:
25
06
2021
accepted:
28
06
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
11
8
2021
Statut:
epublish
Résumé
Cancer is a serious health problem with a high mortality rate worldwide. Given the relevance of mitochondria in numerous physiological and pathological mechanisms, such as adenosine triphosphate (ATP) synthesis, apoptosis, metabolism, cancer progression and drug resistance, mitochondrial genome (mtDNA) analysis has become of great interest in the study of human diseases, including cancer. To date, a high number of variants and mutations have been identified in different types of tumors, which coexist with normal alleles, a phenomenon named heteroplasmy. This mechanism is considered an intermediate state between the fixation or elimination of the acquired mutations. It is suggested that mutations, which confer adaptive advantages to tumor growth and invasion, are enriched in malignant cells. Notably, many recent studies have reported a heteroplasmy-shifting phenomenon as a potential shaper in tumor progression and treatment response, and we suggest that each cancer type also has a unique mitochondrial heteroplasmy-shifting profile. So far, a plethora of data evidencing correlations among heteroplasmy and cancer-related phenotypes are available, but still, not authentic demonstrations, and whether the heteroplasmy or the variation in mtDNA copy number (mtCNV) in cancer are cause or consequence remained unknown. Further studies are needed to support these findings and decipher their clinical implications and impact in the field of drug discovery aimed at treating human cancer.
Identifiants
pubmed: 34298989
pii: ijms22147369
doi: 10.3390/ijms22147369
pmc: PMC8304746
pii:
doi:
Substances chimiques
Biomarkers
0
DNA Restriction Enzymes
EC 3.1.21.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto Nacional de Medicina Genómica
ID : 24/2016/I
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