MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages.
Animals
Bone Marrow
Cell Lineage
Diet, High-Fat
/ adverse effects
Dietary Fats
Docosahexaenoic Acids
Eicosapentaenoic Acid
Fatty Acids
Fatty Acids, Monounsaturated
/ pharmacology
Hematopoiesis
Hematopoietic Stem Cells
/ cytology
Immune System
/ physiopathology
Male
Mice, Inbred C57BL
Obesity
/ prevention & control
Stem Cell Niche
MUFAs
dietary fatty acids
hematopoiesis
obesity
progenitor cells
stem cells
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
27
05
2021
received:
21
12
2020
pubmed:
17
6
2021
medline:
29
12
2021
entrez:
16
6
2021
Statut:
ppublish
Résumé
The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to extramedullary compartments in the obesity is not yet fully understood. C57BL/6J mice are randomly assigned to isocaloric high-fat diets (HFDs) formulate with dietary fats rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs fortified with eicosapentaenoic and docosahexaenoic acids for 20 weeks, followed by profiling of the obese metabolic phenotype and immunophenotypic features of immune cells in blood, spleen, and BM. All HFDs induce an obese phenotype, but it becomes largely less disruptive after the HFDs are enriched in MUFAs, which also induce signs of granulopoiesis and an expansion of long-term hematopoietic stem and granulocyte-macrophage progenitor cells in BM. In contrast, a HFD enriched in SFAs disturbs the fitness of medullary lymphocytes and promotes monopoiesis in favor of pro-inflammatory activated subsets. The reshaping of the fatty acid pools with MUFAs from the diet serves to manipulate the generation and trafficking of immune cells that are biased during obesity. These findings reveal a novel strategy by which dietary MUFAs may be instrumental in combating HFD-induced dysfunctional immune systems.
Identifiants
pubmed: 34132459
doi: 10.1002/mnfr.202001203
doi:
Substances chimiques
Dietary Fats
0
Fatty Acids
0
Fatty Acids, Monounsaturated
0
Docosahexaenoic Acids
25167-62-8
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2001203Informations de copyright
© 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
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