Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease.
Angiotensin I
/ genetics
Angiotensin II
/ genetics
Angiotensin-Converting Enzyme 2
/ genetics
Animals
Blood Pressure
/ genetics
Gene Expression Regulation
Humans
Hypertension
/ genetics
Kidney Tubules, Proximal
/ enzymology
Mice
Mice, Knockout
Peptide Fragments
/ genetics
Receptor, Angiotensin, Type 1
/ genetics
Receptor, Angiotensin, Type 2
/ genetics
Renal Insufficiency, Chronic
/ genetics
Renin-Angiotensin System
/ genetics
Signal Transduction
Water-Electrolyte Balance
/ genetics
Angiotensin
Cre Lox P
Hypertension
Immune system
Intercalated cells
Kidney
Macrophages
Mouse models
Principal cells
Proximal tubule
T cells
Vasculature
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
21
06
2020
revised:
05
01
2021
accepted:
20
03
2021
pubmed:
31
3
2021
medline:
15
12
2021
entrez:
30
3
2021
Statut:
ppublish
Résumé
Kidney disease, blood pressure determination, hypertension pathogenesis, and the renin-angiotensin system (RAS) are inextricably linked. Hence, understanding the RAS is pivotal to unraveling the pathophysiology of hypertension and the determinants to maintaining normal blood pressure. The RAS has been the subject of intense investigation for over a century. Moreover, medications that block the RAS are mainstay therapies in clinical medicine and have been shown to reduce morbidity and mortality in patients with diabetes, cardiovascular, and kidney diseases. The main effector peptide of the RAS is the interaction of the octapeptide- Ang II with its receptor. The type 1 angiotensin receptor (AT
Identifiants
pubmed: 33781840
pii: S0303-7207(21)00103-9
doi: 10.1016/j.mce.2021.111259
pii:
doi:
Substances chimiques
Peptide Fragments
0
Receptor, Angiotensin, Type 1
0
Receptor, Angiotensin, Type 2
0
Angiotensin II
11128-99-7
Angiotensin I
9041-90-1
Ace2 protein, mouse
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
angiotensin I (1-7)
IJ3FUK8MOF
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111259Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.