Activity-induced secretion of semaphorin 3A mediates learning.
AMPA receptors
LTP
axonal guidance molecules
synaptic plasticity
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
16
03
2021
received:
02
09
2020
accepted:
22
03
2021
pubmed:
28
3
2021
medline:
1
7
2021
entrez:
27
3
2021
Statut:
ppublish
Résumé
The semaphorin family is a well-characterized family of secreted or membrane-bound proteins that are involved in activity-independent neurodevelopmental processes, such as axon guidance, cell migration, and immune functions. Although semaphorins have recently been demonstrated to regulate activity-dependent synaptic scaling, their roles in Hebbian synaptic plasticity as well as learning and memory remain poorly understood. Here, using a rodent model, we found that an inhibitory avoidance task, a hippocampus-dependent contextual learning paradigm, increased secretion of semaphorin 3A in the hippocampus. Furthermore, the secreted semaphorin 3A in the hippocampus mediated contextual memory formation likely by driving AMPA receptors into hippocampal synapses via the neuropilin1-plexin A4-semaphorin receptor complex. This signaling process involves alteration of the phosphorylation status of collapsin response mediator protein 2, which has been characterized as a downstream molecule in semaphorin signaling. These findings implicate semaphorin family as a regulator of Hebbian synaptic plasticity and learning.
Identifiants
pubmed: 33772906
doi: 10.1111/ejn.15210
pmc: PMC8252788
doi:
Substances chimiques
Semaphorin-3A
0
Semaphorins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3279-3293Informations de copyright
© 2021 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Références
Nat Biotechnol. 2017 Jan;35(1):38-47
pubmed: 27918547
Neuron. 1998 Nov;21(5):1093-100
pubmed: 9856464
Neural Plast. 2016;2016:6790743
pubmed: 26819770
Neuron. 2006 Mar 2;49(5):663-70
pubmed: 16504942
Science. 2008 Jan 4;319(5859):101-4
pubmed: 18174444
Cell. 1999 Oct 1;99(1):71-80
pubmed: 10520995
Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E7097-E7105
pubmed: 27791080
Nat Med. 2020 Feb;26(2):281-288
pubmed: 31959988
Nat Commun. 2013;4:2760
pubmed: 24217681
Eur J Neurosci. 2021 May;53(10):3279-3293
pubmed: 33772906
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12503-8
pubmed: 21746893
J Neurosci. 2006 Mar 15;26(11):2971-80
pubmed: 16540575
Restor Dent Endod. 2013 Feb;38(1):52-4
pubmed: 23495371
Neuron. 2007 Feb 15;53(4):535-47
pubmed: 17296555
Cell. 1993 Oct 22;75(2):217-27
pubmed: 8402908
Cell. 2001 May 4;105(3):331-43
pubmed: 11348590
Cell. 1997 Aug 22;90(4):739-51
pubmed: 9288753
Science. 2000 Mar 24;287(5461):2262-7
pubmed: 10731148
Neuron. 2005 Feb 17;45(4):513-23
pubmed: 15721238
Cell. 1997 Aug 22;90(4):753-62
pubmed: 9288754
Eur J Rheumatol. 2018 Mar;5(1):58-61
pubmed: 29657877
Neuron. 2009 Feb 12;61(3):340-50
pubmed: 19217372
Int Immunol. 2015 Sep;27(9):459-66
pubmed: 25855660
Cell. 1999 Oct 1;99(1):59-69
pubmed: 10520994
Neuron. 2003 Oct 9;40(2):361-79
pubmed: 14556714
Adv Exp Med Biol. 2007;600:1-11
pubmed: 17607942
J Neurophysiol. 1999 Aug;82(2):526-32
pubmed: 10444652
PLoS One. 2015 Jun 29;10(6):e0131359
pubmed: 26121335
Cold Spring Harb Perspect Biol. 2011 Jun 01;3(6):
pubmed: 21123392
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4475-84
pubmed: 26216953
Cereb Cortex. 2016 Jan;26(1):427-439
pubmed: 26472557
Nature. 2005 Aug 18;436(7053):1020-1024
pubmed: 16107849
Neuron. 1997 Sep;19(3):547-59
pubmed: 9331348
Neuron. 2017 Dec 6;96(5):1084-1098.e7
pubmed: 29154130
J Neurosci. 2012 Jun 20;32(25):8554-9
pubmed: 22723695
Annu Rev Neurosci. 2002;25:103-26
pubmed: 12052905
Science. 2005 Apr 1;308(5718):83-8
pubmed: 15746389
Curr Opin Cell Biol. 2001 Oct;13(5):619-26
pubmed: 11544032
Cell. 2003 Mar 7;112(5):631-43
pubmed: 12628184
Nat Commun. 2014 Mar 06;5:3424
pubmed: 24599038
Science. 2018 Apr 6;360(6384):50-57
pubmed: 29622647
Nat Neurosci. 2008 Jan;11(1):36-44
pubmed: 18059265
Cell Death Differ. 2018 Jul;25(7):1259-1275
pubmed: 29555978
Mol Cell. 2019 Feb 7;73(3):474-489.e5
pubmed: 30595434
Neurosci Res. 2007 Jun;58(2):105-12
pubmed: 17298852
Development. 2014 Sep;141(17):3292-7
pubmed: 25139851
Nat Neurosci. 1998 Oct;1(6):487-93
pubmed: 10196546
Neuron. 2011 Feb 24;69(4):780-92
pubmed: 21338886
Science. 2003 Mar 7;299(5612):1585-8
pubmed: 12624270