Autophagy in inflammation, infection, and immunometabolism.
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
09 03 2021
09 03 2021
Historique:
received:
13
11
2020
revised:
05
12
2020
accepted:
25
01
2021
entrez:
10
3
2021
pubmed:
11
3
2021
medline:
14
9
2021
Statut:
ppublish
Résumé
Autophagy is a quality-control, metabolic, and innate immunity process. Normative autophagy affects many cell types, including hematopoietic as well as non-hematopoietic, and promotes health in model organisms and humans. When autophagy is perturbed, this has repercussions on diseases with inflammatory components, including infections, autoimmunity and cancer, metabolic disorders, neurodegeneration, and cardiovascular and liver diseases. As a cytoplasmic degradative pathway, autophagy protects from exogenous hazards, including infection, and from endogenous sources of inflammation, including molecular aggregates and damaged organelles. The focus of this review is on the role of autophagy in inflammation, including type I interferon responses and inflammasome outputs, from molecules to immune cells. A special emphasis is given to the intersections of autophagy with innate immunity, immunometabolism, and functions of organelles such as mitochondria and lysosomes that act as innate immunity and immunometabolic signaling platforms.
Identifiants
pubmed: 33691134
pii: S1074-7613(21)00041-8
doi: 10.1016/j.immuni.2021.01.018
pmc: PMC8026106
mid: NIHMS1668312
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
437-453Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121176
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111935
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI042999
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The author declares no competing interests.
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