Scoliosis in Children Treated With Photon Craniospinal Irradiation for Medulloblastoma.
Cerebellar Neoplasms
/ radiotherapy
Child
Child, Preschool
Craniospinal Irradiation
/ adverse effects
Female
Hemiplegia
/ complications
Humans
Incidence
Male
Medulloblastoma
/ radiotherapy
Paresis
/ complications
Photons
/ adverse effects
Radiotherapy Dosage
Risk Factors
Scoliosis
/ diagnostic imaging
Journal
International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
10
05
2020
revised:
24
09
2020
accepted:
28
09
2020
entrez:
31
1
2021
pubmed:
1
2
2021
medline:
22
7
2021
Statut:
ppublish
Résumé
Scoliosis is a well-recognized complication after abdominal radiation therapy but not reported frequently after craniospinal irradiation (CSI). We examined the incidence and risk factors for scoliosis after CSI in long-term survivors with medulloblastoma. The records of patients with medulloblastoma seen at one institution from 1996 to 2006 were analyzed for the use of CSI and development of scoliosis as documented on physical examination and spinal imaging. We identified 35 children with medulloblastoma who were ≤12 years of age at time of CSI with a median 14.3 years (range, 5.8-19.3 years) of follow-up. Twenty-seven (77.1%) were male, and median age at CSI was 6.8 years (range, 2.8-12 years). The cumulative incidence of scoliosis at 15 years was 34.6%. The median time to develop scoliosis was 7.1 years (range, 5-11.7 years) after CSI. Treatment with high dose CSI (34.2-40 Gy) and presence of hemiplegia or hemiparesis were found to be risk factors for development of scoliosis. Scoliosis is an underreported complication of photon craniospinal irradiation.
Identifiants
pubmed: 33516438
pii: S0360-3016(20)34357-1
doi: 10.1016/j.ijrobp.2020.09.055
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
712-717Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.