Molecular Aspects of Pruritus Pathogenesis in Psoriasis.
itch
itching
palmoplantar pustulosis
pruritus
psoriasis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jan 2021
16 Jan 2021
Historique:
received:
27
12
2020
revised:
11
01
2021
accepted:
13
01
2021
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
10
4
2021
Statut:
epublish
Résumé
Psoriasis is a chronic, systemic inflammatory disease with a genetic background that involves almost 3% of the general population worldwide. Approximately, 70-90% of patients with psoriasis suffer from pruritus, an unpleasant sensation that provokes a desire to scratch. Despite the enormous progress in understanding the mechanisms that cause psoriasis, the pathogenesis of psoriasis-related pruritus still remains unclear. In order to improve patients' quality of life, development of more effective and safer antipruritic therapies is necessary. In turn to make it possible, better understanding of complexed and multifactorial pathogenesis of this symptom is needed. In this article we have systematized the current knowledge about pruritus origin in psoriasis.
Identifiants
pubmed: 33467067
pii: ijms22020858
doi: 10.3390/ijms22020858
pmc: PMC7830783
pii:
doi:
Substances chimiques
Cytokines
0
Lipocalin-2
0
Neuropeptides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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