Adipose-Derived Mesenchymal Stem Cells do not Affect the Invasion and Migration Potential of Oral Squamous Carcinoma Cells.
Adipose Tissue
/ metabolism
Bone Marrow
/ metabolism
Bone Marrow Cells
/ cytology
Carcinoma, Squamous Cell
/ pathology
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Coculture Techniques
Culture Media, Conditioned
/ pharmacology
DNA Methylation
/ drug effects
Head and Neck Neoplasms
/ pathology
Humans
Long Interspersed Nucleotide Elements
/ drug effects
Mesenchymal Stem Cells
/ cytology
Mouth Neoplasms
/ pathology
Neoplasm Invasiveness
/ physiopathology
Squamous Cell Carcinoma of Head and Neck
/ metabolism
Tongue Neoplasms
/ pathology
Tumor Microenvironment
/ drug effects
adipose tissue
bone marrow
invasion
mesenchymal stem cells
migration
oral squamous cell carcinoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Sep 2020
04 Sep 2020
Historique:
received:
28
07
2020
revised:
01
09
2020
accepted:
02
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
11
3
2021
Statut:
epublish
Résumé
Mesenchymal stem cells (MSCs) are commonly isolated from bone marrow and adipose tissue. Depending on the tissue of origin, MSCs have different characteristics and physiological effects. In various cancer studies, MSCs have been found to have either tumor-promoting or tumor-inhibiting action. This study investigated the effect of adipose tissue-MSCs (AT-MSCs) and bone marrow-MSCs (BM-MSCs) on global long interspersed nuclear element-1 (LINE-1) methylation, the expression level of microenvironment remodeling genes and cell proliferation, migration and invasion of oral tongue squamous cell carcinoma (OTSCC). Additionally, we studied the effect of human tongue squamous carcinoma (HSC-3)-conditioned media on LINE-1 methylation and the expression of microenvironment remodeling genes in AT-MSCs and BM-MSCs. Conditioned media from HSC-3 or MSCs did not affect LINE-1 methylation level in either cancer cells or MSCs, respectively. In HSC-3 cells, no effect of MSCs-conditioned media was detected on the expression of
Identifiants
pubmed: 32899628
pii: ijms21186455
doi: 10.3390/ijms21186455
pmc: PMC7555061
pii:
doi:
Substances chimiques
Culture Media, Conditioned
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Lasten Syöpäsäätiö Väreen
ID : -
Organisme : Suomen Hammaslääkäriseura Apollonia
ID : -
Organisme : Jane ja Aatos Erkon Säätiö
ID : -
Organisme : Sigrid Juséliuksen Säätiö
ID : -
Organisme : Syöpäjärjestöt
ID : -
Organisme : University of Helsinki project funding
ID : WBS490302
Organisme : Doctoral Programme in Oral Sciences (FINDOS)
ID : -
Organisme : Doctoral Programme in Clinical Research (KLTO)
ID : -
Organisme : Finnish-Norwegian medical foundation
ID : -
Organisme : Selma and Maja-Lisa Selander Foundation
ID : -
Organisme : Helsinki University Hospital State funding for university-level health research
ID : -
Organisme : Oulu University Hospital MRC grant
ID : -
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