A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice.
ADAM Proteins
/ genetics
Animals
CD8-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Cigarette Smoking
Disease Models, Animal
Humans
Lung
/ immunology
Lymphocyte Depletion
Macrophages, Alveolar
/ immunology
Membrane Proteins
/ genetics
Mice
Mice, Knockout
Mitochondria
/ metabolism
Pneumonia
/ immunology
Pulmonary Disease, Chronic Obstructive
/ immunology
Signal Transduction
TOR Serine-Threonine Kinases
/ metabolism
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
17
02
2020
accepted:
06
07
2020
revised:
21
06
2020
pubmed:
22
7
2020
medline:
30
11
2021
entrez:
22
7
2020
Statut:
ppublish
Résumé
A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by cells implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), but its contributions to COPD are unknown. To address this gap, ADAM15 levels were measured in samples from cigarette smoke (CS)-versus air-exposed wild-type (WT) mice. CS-induced COPD-like disease was compared in CS-exposed WT, Adam15
Identifiants
pubmed: 32690871
doi: 10.1038/s41385-020-0325-3
pii: S1933-0219(22)00135-0
pmc: PMC8422911
mid: NIHMS1733978
doi:
Substances chimiques
Membrane Proteins
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
ADAM Proteins
EC 3.4.24.-
Adam15 protein, mouse
EC 3.4.24.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
342-356Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140839
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL147437
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL068111
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111475
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL063137
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL111835
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086814
Pays : United States
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