Lipid Signaling in Ocular Neovascularization.

Animals Choroidal Neovascularization / metabolism Corneal Neovascularization / metabolism Eye / metabolism Humans Lipids / physiology Neovascularization, Pathologic / metabolism Retinal Neovascularization / metabolism Signal Transduction / physiology Vascular Endothelial Growth Factor A / metabolism
age-related macular degeneration angiogenesis diabetic retinopathy glycerophospholipid growth factors and cytokines lysophosphatidic acid polyunsaturated fatty acid prostaglandin sphingolipid sphingosine 1-phosphate

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
04 Jul 2020
Historique:
received: 17 06 2020
revised: 02 07 2020
accepted: 02 07 2020
entrez: 9 7 2020
pubmed: 9 7 2020
medline: 20 2 2021
Statut: epublish

Résumé

Vasculogenesis and angiogenesis play a crucial role in embryonic development. Pathological neovascularization in ocular tissues can lead to vision-threatening vascular diseases, including proliferative diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, choroidal neovascularization, and corneal neovascularization. Neovascularization involves various cellular processes and signaling pathways and is regulated by angiogenic factors such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF). Modulating these circuits may represent a promising strategy to treat ocular neovascular diseases. Lipid mediators derived from membrane lipids are abundantly present in most tissues and exert a wide range of biological functions by regulating various signaling pathways. In particular, glycerophospholipids, sphingolipids, and polyunsaturated fatty acids exert potent pro-angiogenic or anti-angiogenic effects, according to the findings of numerous preclinical and clinical studies. In this review, we summarize the current knowledge regarding the regulation of ocular neovascularization by lipid mediators and their metabolites. A better understanding of the effects of lipid signaling in neovascularization may provide novel therapeutic strategies to treat ocular neovascular diseases and other human disorders.

Identifiants

DOI: 10.3390/ijms21134758 PMID: 32635437 PMC: PMC7369954
pubmed: 32635437
pii: ijms21134758
doi: 10.3390/ijms21134758
pmc: PMC7369954
pii:
doi:

Substances chimiques

Lipids 0
Vascular Endothelial Growth Factor A 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Ryo Terao (R)

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
ORCID: 0000-0001-6182-4343

Hiroki Kaneko (H)

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Néovascularisation choroïdienne › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Néovascularisation cornéenne › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › Organes des sens › Oeil › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › Lipides › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Néovascularisation rétinienne › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Lipid Signaling in Ocular Neovascularization.
Recherchemedicale.com › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › Lipid Signaling in Ocular Neovascularization.