An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness.
Animals
Apoptosis
Borohydrides
Boron
Boron Compounds
/ therapeutic use
Boron Neutron Capture Therapy
/ methods
Cellular Senescence
/ radiation effects
DNA Damage
/ radiation effects
Humans
Isotopes
Ligands
Lung Neoplasms
/ radiotherapy
Mice
Neoplasm Metastasis
Neoplasm Transplantation
Neoplasms
/ therapy
Neoplastic Stem Cells
/ radiation effects
Oxygen
/ chemistry
Tumor Microenvironment
10B microdistribution
cancer stemness
quiescent tumor cell
tumor heterogeneity
Journal
Journal of radiation research
ISSN: 1349-9157
Titre abrégé: J Radiat Res
Pays: England
ID NLM: 0376611
Informations de publication
Date de publication:
16 Nov 2020
16 Nov 2020
Historique:
received:
01
05
2020
revised:
04
06
2020
pubmed:
1
7
2020
medline:
28
9
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Based on our previously published reports concerning the response of quiescent (Q) tumor cell populations to boron neutron capture therapy (BNCT), the heterogeneous microdistribution of 10B in tumors, which is influenced by the tumor microenvironment and the characteristics of the 10B delivery carriers, has been shown to limit the therapeutic effect of BNCT on local tumors. It was also clarified that the characteristics of 10B-carriers for BNCT and the type of combined treatment in BNCT can also affect the potential for distant lung metastases from treated local tumors. We reviewed the findings concerning the response of Q tumor cell populations to BNCT, mainly focusing on reports we have published so far, and we identified the mode of BNCT that currently offers the best therapeutic gain from the viewpoint of both controlling local tumor and suppressing the potential for distant lung metastasis. In addition, based on the finding that oxygenated Q tumor cells showed a large capacity to recover from DNA damage after cancer therapy, the interrelationship among the characteristics in Q tumor cell populations, tumor heterogeneity and cancer stemness was also discussed.
Identifiants
pubmed: 32601693
pii: 5864862
doi: 10.1093/jrr/rraa048
pmc: PMC7674684
doi:
Substances chimiques
Borohydrides
0
Boron Compounds
0
Isotopes
0
Ligands
0
Boron
N9E3X5056Q
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
876-885Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.
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