Histomorphological aspects of cadaveric skin and its possible use in forensic genetics.
Cadaveric skin
chromatin
forensic genetics
forensic pathology
putrefactive phenomena
Journal
Medicine, science, and the law
ISSN: 2042-1818
Titre abrégé: Med Sci Law
Pays: England
ID NLM: 0400721
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
pubmed:
25
6
2020
medline:
29
5
2021
entrez:
25
6
2020
Statut:
ppublish
Résumé
The skin is rarely considered as good biological material for successful DNA typing when a corpse is found in a leathery, mummified or partially skeletonised state, as bones and teeth are the gold standard in these cases. This study evaluates the histomorphological aspects of nuclear chromatin (Lillie's staining) in leathery and mummified skin samples as an indicator for possible successful DNA typing. Chromatin was found in samples that underwent mummification or partial skeletonisation but not in samples in a wet type of post-mortem transformation, such as saponification or leathery transformation. As a preliminary result, a positive detection of DNA profiles was only observed in 1-year-old mummified or partially skeletonised samples. These findings suggest that specific areas of skin, even from severely deteriorated cadavers, can show nuclear chromatin and DNA. These preliminary results raise the potential use of skin samples as an alternative source of DNA in highly degraded corpses.
Identifiants
pubmed: 32576087
doi: 10.1177/0025802420934662
doi:
Substances chimiques
Chromatin
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM