PPAR Beta/Delta and the Hallmarks of Cancer.
angiogenesis
cellular metabolism
growth suppressors
immortality
immune system
metastasis
peroxisome proliferator-activated receptor
proliferation
resistance to cell death
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 05 2020
04 05 2020
Historique:
received:
20
04
2020
revised:
30
04
2020
accepted:
01
05
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
24
2
2021
Statut:
epublish
Résumé
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma have been identified. They all form heterodimers with retinoic X receptors to activate or repress downstream target genes dependent on the presence/absence of ligands and coactivators or corepressors. PPARs differ in their tissue expression profile, ligands and specific agonists and antagonists. PPARs attract attention as potential therapeutic targets for a variety of diseases. PPAR alpha and gamma agonists are in clinical use for the treatment of dyslipidemias and diabetes. For both receptors, several clinical trials as potential therapeutic targets for cancer are ongoing. In contrast, PPAR beta/delta has been suggested as a therapeutic target for metabolic syndrome. However, potential risks in the settings of cancer are less clear. A variety of studies have investigated PPAR beta/delta expression or activation/inhibition in different cancer cell models in vitro, but the relevance for cancer growth in vivo is less well documented and controversial. In this review, we summarize critically the knowledge of PPAR beta/delta functions for the different hallmarks of cancer biological capabilities, which interplay to determine cancer growth.
Identifiants
pubmed: 32375405
pii: cells9051133
doi: 10.3390/cells9051133
pmc: PMC7291220
pii:
doi:
Substances chimiques
PPAR delta
0
PPAR-beta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer Res. 2000 Nov 15;60(22):6353-8
pubmed: 11103797
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
J Cancer Res Clin Oncol. 2011 Jan;137(1):29-39
pubmed: 20221637
Cardiovasc Res. 2012 Dec 1;96(3):504-12
pubmed: 22886847
Nat Commun. 2014 Dec 16;5:5852
pubmed: 25510679
Circ Res. 2008 Feb 1;102(2):193-200
pubmed: 18007025
Carcinogenesis. 2011 Aug;32(8):1251-8
pubmed: 21586513
Nature. 2016 Mar 3;531(7592):53-8
pubmed: 26935695
Mol Cell Biol. 1996 Sep;16(9):4604-13
pubmed: 8756616
J Biol Chem. 2010 Oct 29;285(44):33797-804
pubmed: 20592029
Int J Mol Sci. 2018 Sep 20;19(10):
pubmed: 30241392
EMBO Mol Med. 2014 Jan;6(1):80-98
pubmed: 24203162
EMBO J. 2007 Aug 8;26(15):3686-98
pubmed: 17641685
Cancer Res. 2019 Mar 1;79(5):954-969
pubmed: 30679176
Biochem Pharmacol. 2000 Jan 1;59(1):47-53
pubmed: 10605934
Nat Immunol. 2018 Dec;19(12):1330-1340
pubmed: 30420624
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19069-74
pubmed: 17148604
Cancer Res. 2006 Apr 15;66(8):4394-401
pubmed: 16618765
Cell Metab. 2017 May 2;25(5):1186-1193.e4
pubmed: 28467934
Surgery. 2012 Jul;152(1):90-106
pubmed: 22521259
Biochimie. 2017 May;136:55-58
pubmed: 27914902
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Proc Natl Acad Sci U S A. 1993 May 1;90(9):4304-8
pubmed: 8387214
Proteomics. 2007 Apr;7(8):1208-16
pubmed: 17380536
FASEB J. 2015 Jun;29(6):2359-70
pubmed: 25713055
Toxicology. 2008 Dec 5;254(1-2):112-7
pubmed: 18950674
Cell Rep. 2014 Nov 6;9(3):1047-60
pubmed: 25437559
Pharmacol Ther. 2010 Mar;125(3):423-35
pubmed: 20026355
Int J Cancer. 2015 Sep 1;137(5):1224-34
pubmed: 25683336
Cardiovasc Res. 2009 Jul 1;83(1):61-71
pubmed: 19351742
Cancer Res. 2002 Jun 1;62(11):3282-8
pubmed: 12036946
Mol Cancer Ther. 2014 Apr;13(4):1008-17
pubmed: 24464939
Diabetes. 2012 Dec;61(12):3285-93
pubmed: 22933110
Dig Liver Dis. 2015 Jan;47(1):62-7
pubmed: 25277864
Leukemia. 2017 Sep;31(9):1905-1914
pubmed: 28050012
Int J Mol Sci. 2018 Oct 26;19(11):
pubmed: 30373124
Cells. 2019 Jan 11;8(1):
pubmed: 30641926
Mol Carcinog. 2014 Nov;53(11):926-37
pubmed: 24610641
Int J Cancer. 2018 Dec 1;143(11):2985-2996
pubmed: 30204243
Cancer Cell. 2004 Sep;6(3):285-95
pubmed: 15380519
Cell Metab. 2008 Jan;7(1):11-20
pubmed: 18177721
Carcinogenesis. 2006 May;27(5):1105-12
pubmed: 16418176
Int J Cancer. 2004 Dec 20;112(6):909-19
pubmed: 15316938
Toxicology. 2008 Jan 14;243(1-2):236-43
pubmed: 18054822
Br J Pharmacol. 2014 Jun;171(12):3089-102
pubmed: 24527778
J Immunol. 2001 Jun 15;166(12):7543-8
pubmed: 11390509
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9968-73
pubmed: 12909723
Oncogene. 2008 Jun 12;27(26):3662-72
pubmed: 18212735
Nature. 2018 Jan 4;553(7686):96-100
pubmed: 29258294
Int J Cancer. 2016 Mar 1;138(5):1058-66
pubmed: 25784597
Mol Pharmacol. 2008 Nov;74(5):1399-406
pubmed: 18678619
Mol Endocrinol. 2008 Feb;22(2):523-9
pubmed: 17975020
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12890-5
pubmed: 17652168
Tumour Biol. 2016 Nov;37(11):14789-14802
pubmed: 27638828
J Pathol. 2007 Mar;211(4):481-8
pubmed: 17294421
Mol Cell. 1999 Mar;3(3):397-403
pubmed: 10198642
Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E297-304
pubmed: 18492772
Eur J Pharmacol. 2002 Jan 25;435(2-3):143-51
pubmed: 11821020
J Invest Dermatol. 2008 Aug;128(8):1940-9
pubmed: 18305567
Angiogenesis. 2009;12(3):209-20
pubmed: 19247789
Oncogene. 2014 Nov 13;33(46):5348-59
pubmed: 24213576
Biochem Biophys Res Commun. 1999 Dec 29;266(3):718-22
pubmed: 10603309
Biochimie. 2017 May;136:90-99
pubmed: 27916645
Toxicology. 2016 Jul 1;363-364:1-9
pubmed: 27427494
Sci Rep. 2016 Sep 29;6:34317
pubmed: 27680392
Cancer Res. 2013 Aug 1;73(15):4770-80
pubmed: 23722546
J Natl Cancer Inst. 2009 May 20;101(10):762-7
pubmed: 19436036
Mol Cancer Ther. 2010 Dec;9(12):3267-77
pubmed: 21159610
Cell. 1990 Jun 29;61(7):1257-69
pubmed: 2163761
Int J Mol Sci. 2016 Jun 24;17(7):
pubmed: 27347932
Cancer Res. 2005 May 1;65(9):3950-7
pubmed: 15867396
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):63-9
pubmed: 17068288
PLoS One. 2013 Apr 08;8(4):e60715
pubmed: 23593291
Mol Endocrinol. 2008 Jun;22(6):1394-402
pubmed: 18323470
J Cell Mol Med. 2015 Aug;19(8):1887-99
pubmed: 25754218
Cell Metab. 2008 Jun;7(6):485-95
pubmed: 18522830
Biochem Pharmacol. 2012 Dec 15;84(12):1627-34
pubmed: 23000914
Cell. 2008 Aug 8;134(3):405-15
pubmed: 18674809
Mol Carcinog. 2017 May;56(5):1472-1483
pubmed: 27996177
Cancer Lett. 2003 Feb 10;190(1):1-12
pubmed: 12536071
Eur J Pharmacol. 2019 Jan 5;842:248-254
pubmed: 30391747
Sci Rep. 2014 Jun 24;4:5412
pubmed: 24958459
Cancer Res. 2008 Aug 15;68(16):6578-86
pubmed: 18701481
Br J Pharmacol. 2000 Mar;129(5):823-34
pubmed: 10696077
Invest Ophthalmol Vis Sci. 2013 Jun 19;54(6):4197-207
pubmed: 23716627
PLoS One. 2016 Feb 10;11(2):e0148510
pubmed: 26862756
Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2688-2700
pubmed: 30251659
J Biol Chem. 1999 Jun 11;274(24):17042-8
pubmed: 10358055
PLoS One. 2011 Jan 13;6(1):e16215
pubmed: 21297860
J Biol Chem. 2014 Jul 18;289(29):20102-19
pubmed: 24898257
Oncotarget. 2018 Jan 27;9(13):11109-11118
pubmed: 29541400
Dig Dis Sci. 2009 May;54(5):1108-14
pubmed: 18720000
Mol Carcinog. 2009 Oct;48(10):942-52
pubmed: 19415698
Nucleic Acids Res. 2015 May 26;43(10):5033-51
pubmed: 25934804
Oncotarget. 2015 May 30;6(15):13416-33
pubmed: 25968567
Expert Opin Ther Pat. 2020 Jan;30(1):1-13
pubmed: 31825687
PPAR Res. 2013;2013:121956
pubmed: 23737761
Int J Mol Sci. 2019 Oct 11;20(20):
pubmed: 31614690
Cancer Res. 2007 Apr 1;67(7):3185-91
pubmed: 17409426
Biochem Soc Trans. 2011 Dec;39(6):1601-5
pubmed: 22103494
JCI Insight. 2017 Jan 12;2(1):e91419
pubmed: 28097239
J Biol Chem. 2007 Dec 21;282(51):37064-73
pubmed: 17965024
Nature. 2008 Jul 31;454(7204):656-60
pubmed: 18594512
Eur J Pharmacol. 2016 Mar 15;775:35-42
pubmed: 26852954
Int J Oncol. 2013 Sep;43(3):746-54
pubmed: 23807031
Oncogene. 2012 Feb 23;31(8):1013-23
pubmed: 21765467
Am J Pathol. 2002 Apr;160(4):1229-38
pubmed: 11943708
Cell. 1999 Oct 29;99(3):335-45
pubmed: 10555149
FEBS Lett. 2005 Jul 4;579(17):3829-36
pubmed: 15978581
Science. 2003 Oct 17;302(5644):453-7
pubmed: 12970571
Scand J Immunol. 2006 May;63(5):330-7
pubmed: 16640656
J Biol Chem. 2011 Dec 30;286(52):44585-93
pubmed: 22072715
Cancer Res. 2019 Sep 1;79(17):4480-4490
pubmed: 31239272
J Pathol. 2011 Aug;224(4):575-88
pubmed: 21598253
Atherosclerosis. 2009 Feb;202(2):446-54
pubmed: 18585719
J Biol Chem. 2010 Jun 18;285(25):19106-15
pubmed: 20424164
J Leukoc Biol. 2009 Jul;86(1):115-22
pubmed: 19389799
Oncogenesis. 2016 Jun 06;5(6):e232
pubmed: 27270614
J Allergy Clin Immunol. 2015 Jun;135(6):1625-35.e5
pubmed: 25556996
Br J Cancer. 2005 Aug 8;93(3):310-8
pubmed: 16012519
Prostaglandins Other Lipid Mediat. 2009 Apr;88(3-4):97-100
pubmed: 19101649
Carcinogenesis. 2008 Jan;29(1):169-76
pubmed: 17893232
Genomics. 2004 Dec;84(6):1014-20
pubmed: 15533718
Cells. 2020 Feb 03;9(2):
pubmed: 32028670
J Biol Chem. 1999 Mar 5;274(10):6718-25
pubmed: 10037770
J Cell Biol. 1994 May;125(4):917-28
pubmed: 7514607
Int J Oncol. 2007 Sep;31(3):607-11
pubmed: 17671688
Oncol Res. 2019 Aug 8;27(8):923-933
pubmed: 30982495
PPAR Res. 2010;2010:
pubmed: 20847935
Br J Cancer. 2006 Oct 9;95(7):889-95
pubmed: 16969348
Oncotarget. 2017 Oct 6;8(55):94091-94103
pubmed: 29212212
Biochem J. 2012 May 15;444(1):27-38
pubmed: 22335598
PLoS One. 2012;7(9):e46126
pubmed: 23049957
Circ Res. 2007 Mar 16;100(5):e59-71
pubmed: 17303761
Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R779-87
pubmed: 16614054
Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1481-7
pubmed: 16645156
Cancer Lett. 2010 Feb 28;288(2):219-25
pubmed: 19660859
J Biol Chem. 2001 Dec 7;276(49):46260-7
pubmed: 11551955
Pflugers Arch. 2010 Apr;459(5):689-703
pubmed: 20066433
Pflugers Arch. 2008 Feb;455(5):839-47
pubmed: 17912546
Cell. 1998 Feb 6;92(3):401-13
pubmed: 9476899
Cells. 2019 Dec 12;8(12):
pubmed: 31842402
Oncotarget. 2015 Nov 3;6(34):36319-37
pubmed: 26431381
Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):315-21
pubmed: 18048767
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Nat Commun. 2015 Nov 23;6:8794
pubmed: 26592976
J Biol Chem. 1999 Mar 26;274(13):9116-21
pubmed: 10085162
Circ Res. 2008 Feb 1;102(2):146-7
pubmed: 18239142
Biochem Biophys Res Commun. 2011 Mar 25;406(4):564-9
pubmed: 21352808
PLoS One. 2012;7(9):e46009
pubmed: 23049921
Cancer Res. 2013 Jul 15;73(14):4349-61
pubmed: 23811944
Int J Oncol. 2012 Sep;41(3):839-48
pubmed: 22710759
Eur J Dermatol. 2015 Apr;25 Suppl 1:4-11
pubmed: 26287030
Front Pharmacol. 2018 Jun 28;9:648
pubmed: 30002625
Dig Dis Sci. 2011 Apr;56(4):1194-200
pubmed: 20824502
Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21
pubmed: 12699745
Int J Mol Med. 2013 May;31(5):1003-10
pubmed: 23525285
Cancer Res. 2003 Apr 15;63(8):1748-51
pubmed: 12702555
Science. 1956 Aug 10;124(3215):269-70
pubmed: 13351639
Mol Carcinog. 2011 Nov;50(11):884-900
pubmed: 21400612
Cancer Res. 2006 Dec 15;66(24):11859-68
pubmed: 17178883
FASEB J. 2003 Jul;17(10):1364-6
pubmed: 12738801
Nat Med. 2013 May;19(5):608-13
pubmed: 23542786
Toxicol Sci. 2010 Jan;113(1):27-36
pubmed: 19748995
Cell Cycle. 2013 May 15;12(10):1521-35
pubmed: 23598720
Nat Med. 2009 Nov;15(11):1266-72
pubmed: 19838202
PPAR Res. 2016;2016:7631085
pubmed: 27057154
J Exp Med. 2010 Aug 2;207(8):1599-608
pubmed: 20624891
Cancer Res. 2007 Jun 1;67(11):5285-92
pubmed: 17545608
Am J Respir Crit Care Med. 2010 Dec 15;182(12):1506-15
pubmed: 20693380
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6712-7
pubmed: 12740443
PLoS One. 2013 Jul 09;8(7):e68859
pubmed: 23874790
Am J Hum Genet. 1991 May;48(5):997-1003
pubmed: 1673293
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8104-9
pubmed: 9223322
Eur J Pharmacol. 2019 Aug 15;857:172425
pubmed: 31150647
Circulation. 2008 Sep 2;118(10):1021-33
pubmed: 18711014
Cancer Res. 2018 Jan 15;78(2):399-409
pubmed: 29187400
Am J Respir Cell Mol Biol. 2008 Dec;39(6):689-96
pubmed: 18566335
Jpn J Clin Oncol. 2010 May;40(5):377-87
pubmed: 20395243
Nat Med. 2004 May;10(5):481-3
pubmed: 15048110
Front Cell Neurosci. 2015 Mar 18;9:78
pubmed: 25852474
Cell. 2003 Apr 18;113(2):159-70
pubmed: 12705865
J Natl Cancer Inst. 2014 Apr;106(4):dju052
pubmed: 24681603
J Clin Invest. 2006 Mar;116(3):571-80
pubmed: 16511589
Am J Cancer Res. 2014 Nov 19;4(6):674-82
pubmed: 25520859
Acta Neuropathol Commun. 2013 Aug 02;1:43
pubmed: 24252308
Nat Med. 2004 Mar;10(3):245-7
pubmed: 14758356
Science. 1956 Feb 24;123(3191):309-14
pubmed: 13298683