An Endogenous Ligand of Aryl Hydrocarbon Receptor 6-Formylindolo[3,2-b]Carbazole (FICZ) Is a Signaling Molecule in Neurogenesis of Adult Hippocampal Neurons.
Animals
Azo Compounds
/ pharmacology
Basic Helix-Loop-Helix Transcription Factors
/ genetics
Carbazoles
/ metabolism
Doublecortin Protein
Heterocyclic Compounds, 3-Ring
/ pharmacology
Hippocampus
/ cytology
Learning
Male
Mice
Mice, Inbred BALB C
Nerve Tissue Proteins
/ genetics
Neurogenesis
Neurons
/ cytology
Pyrazoles
/ pharmacology
Receptors, Aryl Hydrocarbon
/ metabolism
Wnt Signaling Pathway
AHR
FICZ
Learning and memory
Neurogenesis
Wnt/ß-catenin
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
05
12
2019
accepted:
05
02
2020
pubmed:
11
2
2020
medline:
5
1
2021
entrez:
11
2
2020
Statut:
ppublish
Résumé
Neurogenesis is a dynamic and physiologic developmental process that affects learning and hippocampal dependent memory. It is regulated by multi-cellular micro-environment and different types of transcription factors. The neurogenesis effects of endogenously activated aryl hydrocarbon receptor (AHR) by its endogenous ligand, 6-formylindolo[3,2-b] carbazole (FICZ), and its interactions with the Wnt/β-catenin signaling pathway were the main purpose of this study. In accordance, learning and hippocampus-dependent memory were examined. Male BALB/C mice received FICZ, CH223191, and XAV-939 in a single dose of 100 μg/kg, 1 mg/kg, and 5 mg/kg of body weight respectively via intraperitoneal (IP) injection. qRT-PCR for gene analyses and protein assay on the 7th and 28th days were performed. To assess the hippocampal dependent memory, they also underwent contextual fear conditioning on the 28th day after treatment. Our results showed that FICZ treatment led to elevation of the proneural transcription factors ASCL1 and Ngn2, immature neural marker DCX, differentiation neurons marker, NeuN, as well as β-catenin at mRNA and protein levels. We also indicated that hippocampal dependent memory and learning task were improved by FICZ treatment and impaired by the AHR and Wnt/ß-catenin inhibition. In this study for the first time, we demonstrated that the endogenous ligand of AHR, FICZ, has a positive effect on short- and long-term memory as well as learning skills. This ability is possibly mediated by the AHR-Wnt/ß-catenin cross-talk.
Identifiants
pubmed: 32040828
doi: 10.1007/s12031-020-01506-x
pii: 10.1007/s12031-020-01506-x
doi:
Substances chimiques
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide
0
6-formylindolo(3,2-b)carbazole
0
Ascl1 protein, mouse
0
Azo Compounds
0
Basic Helix-Loop-Helix Transcription Factors
0
Carbazoles
0
Dcx protein, mouse
0
Doublecortin Protein
0
Heterocyclic Compounds, 3-Ring
0
Nerve Tissue Proteins
0
Neurog2 protein, mouse
0
Pyrazoles
0
Receptors, Aryl Hydrocarbon
0
XAV939
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
806-817Subventions
Organisme : Shiraz University of Medical Sciences
ID : Grant number: 15168
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