The β-Blocker Carvedilol Prevented Ultraviolet-Mediated Damage of Murine Epidermal Cells and 3D Human Reconstructed Skin.
Adrenergic beta-Antagonists
/ pharmacology
Animals
Carvedilol
/ pharmacology
Cell Culture Techniques
Cell Transformation, Neoplastic
/ drug effects
Cytokines
/ metabolism
DNA Damage
/ drug effects
Dinoprostone
/ metabolism
Epidermal Cells
/ drug effects
Humans
Hydrogen Peroxide
Inflammation Mediators
Mice
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Ultraviolet Rays
/ adverse effects
CPD
H2O2
PGE2
ROS
carcinogenesis
carvedilol
chemoprevention
ultraviolet
β-blocker
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Jan 2020
25 Jan 2020
Historique:
received:
13
12
2019
revised:
17
01
2020
accepted:
24
01
2020
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
6
11
2020
Statut:
epublish
Résumé
The β-blocker carvedilol prevents ultraviolet (UV)-induced skin cancer, but the mechanism is unknown. Since carvedilol possesses antioxidant activity, this study investigated whether carvedilol prevents oxidative photodamage of skin, a precursor event in skin carcinogenesis. The effects of carvedilol, metoprolol (a β-blocker without antioxidant property), and 4-hydroxycarbazole (4-OHC, a carvedilol synthesis intermediate and a free radical scavenger) were compared on UV- or H
Identifiants
pubmed: 31991834
pii: ijms21030798
doi: 10.3390/ijms21030798
pmc: PMC7037760
pii:
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Cytokines
0
Inflammation Mediators
0
Reactive Oxygen Species
0
Carvedilol
0K47UL67F2
Hydrogen Peroxide
BBX060AN9V
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R15 CA227946
Pays : United States
Organisme : NIH HHS
ID : R15CA227946
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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