Cathepsin S-Mediated Negative Regulation of Wnt5a/SC35 Activation Contributes to Ischemia-Induced Neovascularization in Aged Mice.
Age Factors
Animals
Cathepsins
/ deficiency
Cells, Cultured
Disease Models, Animal
Endothelial Progenitor Cells
/ enzymology
Extracellular Signal-Regulated MAP Kinases
/ metabolism
Hindlimb
Human Umbilical Vein Endothelial Cells
/ enzymology
Humans
Ischemia
/ enzymology
Male
Mice, Inbred C57BL
Mice, Knockout
Muscle, Skeletal
/ blood supply
Neovascularization, Physiologic
Nitric Oxide Synthase Type III
/ metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt
/ metabolism
Serine-Arginine Splicing Factors
/ metabolism
Signal Transduction
TOR Serine-Threonine Kinases
/ metabolism
Wnt-5a Protein
/ metabolism
Aging
Angiogenesis
Cathepsin S
SC35
Wnt5a
Journal
Circulation journal : official journal of the Japanese Circulation Society
ISSN: 1347-4820
Titre abrégé: Circ J
Pays: Japan
ID NLM: 101137683
Informations de publication
Date de publication:
25 11 2019
25 11 2019
Historique:
pubmed:
28
10
2019
medline:
1
9
2020
entrez:
25
10
2019
Statut:
ppublish
Résumé
Given that cathepsin S (CatS) gained attention due to its enzymatic and non-enzymatic functions in signaling, the role of CatS in ischemia-induced angiogenesis of aged mice was explored.Methods and Results:To study the role of CatS in the decline in aging-related vascular regeneration capacity, a hindlimb ischemia model was applied to aged wild-type (CatS These findings demonstrated that the impairment of ischemia-induced neovascularization in aged CatS
Sections du résumé
BACKGROUND
Given that cathepsin S (CatS) gained attention due to its enzymatic and non-enzymatic functions in signaling, the role of CatS in ischemia-induced angiogenesis of aged mice was explored.Methods and Results:To study the role of CatS in the decline in aging-related vascular regeneration capacity, a hindlimb ischemia model was applied to aged wild-type (CatS
CONCLUSIONS
These findings demonstrated that the impairment of ischemia-induced neovascularization in aged CatS
Identifiants
pubmed: 31645525
doi: 10.1253/circj.CJ-19-0325
doi:
Substances chimiques
SRSF2 protein, mouse
0
Wnt-5a Protein
0
Wnt5a protein, mouse
0
Serine-Arginine Splicing Factors
170974-22-8
Nitric Oxide Synthase Type III
EC 1.14.13.39
Nos3 protein, mouse
EC 1.14.13.39
mTOR protein, mouse
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
Cathepsins
EC 3.4.-
cathepsin S
EC 3.4.22.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM