ARID1A promotes genomic stability through protecting telomere cohesion.
Animals
Apoptosis
/ genetics
Cell Cycle Proteins
/ genetics
Cell Line
Cell Line, Tumor
Chromosomal Proteins, Non-Histone
/ genetics
DNA Copy Number Variations
DNA-Binding Proteins
Female
Genomic Instability
Humans
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Mice, Transgenic
Mutation
Nuclear Proteins
/ genetics
Ovarian Neoplasms
/ genetics
Telomere
/ genetics
Transcription Factors
/ genetics
Transplantation, Heterologous
/ methods
Tumor Burden
/ genetics
Cohesins
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 09 2019
06 09 2019
Historique:
received:
25
04
2019
accepted:
19
08
2019
entrez:
8
9
2019
pubmed:
8
9
2019
medline:
31
12
2019
Statut:
epublish
Résumé
ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A inactivation causes defects in telomere cohesion, which selectively eliminates gross chromosome aberrations during mitosis. ARID1A promotes the expression of cohesin subunit STAG1 that is specifically required for telomere cohesion. ARID1A inactivation causes telomere damage that can be rescued by STAG1 expression. Colony formation capability of single cells in G
Identifiants
pubmed: 31492885
doi: 10.1038/s41467-019-12037-4
pii: 10.1038/s41467-019-12037-4
pmc: PMC6731242
doi:
Substances chimiques
ARID1A protein, human
0
Cell Cycle Proteins
0
Chromosomal Proteins, Non-Histone
0
DNA-Binding Proteins
0
Nuclear Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4067Subventions
Organisme : NCI NIH HHS
ID : R01 CA173481
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031862
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA228991
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211199
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202919
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA140652
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA239128
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221838
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA160331
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163377
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA221757
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA183929
Pays : United States
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