Deep sequencing of small non-coding RNA highlights brain-specific expression patterns and RNA cleavage.
Adaptation, Physiological
/ genetics
Adrenal Glands
/ metabolism
Amygdala
/ metabolism
Animals
Conditioning, Operant
Fear
/ physiology
Gene Expression Regulation
Genome
High-Throughput Nucleotide Sequencing
Hippocampus
/ metabolism
Hypothalamus
/ metabolism
Hypoxia
/ genetics
Memory
/ physiology
Molecular Sequence Annotation
Organ Specificity
RNA Cleavage
RNA, Small Untranslated
/ classification
Stress, Physiological
/ genetics
Swine
3´-tiRNA
5´-tiRNA
Amygdala
HPA axis
Hippocampus
Sncrna
Journal
RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
23
8
2019
medline:
1
5
2020
entrez:
22
8
2019
Statut:
ppublish
Résumé
With the advance of high-throughput sequencing technology numerous new regulatory small RNAs have been identified, that broaden the variety of processing mechanisms and functions of non-coding RNA. Here we explore small non-coding RNA (sncRNA) expression in central parts of the physiological stress and anxiety response system. Therefore, we characterize the sncRNA profile of tissue samples from Amygdala, Hippocampus, Hypothalamus and Adrenal Gland, obtained from 20 pigs. Our analysis reveals that all tissues but Amygdala and Hippocampus possess distinct, tissue-specific expression pattern of miRNA that are associated with Hypoxia, stress responses as well as memory and fear conditioning. In particular, we observe marked differences in the expression profile of limbic tissues compared to those associated to the HPA/stress axis, with a surprisingly high aggregation of 3´-tRNA halves in Amygdala and Hippocampus. Since regulation of sncRNA and RNA cleavage plays a pivotal role in the central nervous system, our work provides seminal insights in the role/involvement of sncRNA in the transcriptional and post-transcriptional regulation of negative emotion, stress and coping behaviour in pigs, and mammals in general.
Identifiants
pubmed: 31432767
doi: 10.1080/15476286.2019.1657743
pmc: PMC6844574
doi:
Substances chimiques
RNA, Small Untranslated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1764-1774Références
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